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1. 发明申请

US20180269048A1 Method to Improve MS/MS Spectral Quality from MRM Triggered IDA 审中-公开
公开(公告)号：US20180269048A1
公开(公告)日：2018-09-20
申请号：US15754770
申请日：2016-08-09
申请人： DH Technologies Development Pte. Ltd.
发明人： Michael Jarvis , Yves Le Blanc , David M. Cox
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/0036 , G01N27/624 , H01J49/0027 , H01J49/004
摘要： Systems and methods are provided for enabling or disabling a DMS device during an IDA method. Each cycle of the method includes a survey scan step, producing a precursor ion mass spectrum, and an MS/MS scan step. During the MS/MS scan step, one or more user-defined MS/MS scans are performed that correspond to compounds of interest found in the precursor ion mass spectrum. With each user-defined MS/MS scan, a DMS enable parameter that determines if the DMS device is enabled or disabled and one or more DMS parameters necessary to enable the DMS device for the corresponding compound of interest are received. During the MS/MS scan step, for each user-defined MS/MS scan, the DMS device is enabled or disabled according to the DMS enable parameter and one or more parameters of the DMS device are set according to the one or more DMS parameters.

2. 发明授权

US09733214B2 Rapid LC mapping of CoV values for SelexION™ technology using MRM-triggered MRM functionality 有权
公开(公告)号：US09733214B2
公开(公告)日：2017-08-15
申请号：US15107455
申请日：2015-02-10
申请人： DH Technologies Development Pte. Ltd.
发明人： Christie L. Hunter , David M. Cox
IPC分类号： H01J49/00 , G01N27/62 , G01N30/72
CPC分类号： G01N27/622 , G01N30/7233 , H01J49/0027 , H01J49/004
摘要： MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.

3. 发明授权

US10309930B2 Dynamic orthogonal analysis method 有权
公开(公告)号：US10309930B2
公开(公告)日：2019-06-04
申请号：US15516387
申请日：2015-09-21
申请人： DH Technologies Development Pte. Ltd.
发明人： John Lawrence Campbell , Eva Duchoslav , Yves Le Blanc , David M. Cox
IPC分类号： H01J49/26 , G01N27/62 , H01J49/00
摘要： Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.

4. 发明授权

US09818590B2 Data quality after demultiplexing of overlapped acquisition windows in tandem mass spectrometry 有权
公开(公告)号：US09818590B2
公开(公告)日：2017-11-14
申请号：US14889139
申请日：2014-06-03
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： David M. Cox , Stephen A. Tate , Lyle Burton
IPC分类号： G01N24/00 , H01J49/04 , H01J49/00
CPC分类号： H01J49/04 , H01J49/0027 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample. A first precursor mass window and the corresponding first product ion spectrum are selected from a plurality of overlapping stepped precursor mass windows and their corresponding product ion spectra. A product ion spectrum is demultiplexed for each overlapped portion of the first precursor mass window producing two or more demultiplexed first product ion spectra for the first precursor mass window. The two or more demultiplexed first product ion spectra are added together producing a reconstructed summed demultiplexed first product ion spectrum. Missing product ions are identified in the summed demultiplexed first product ion spectrum by comparing the summed demultiplexed first product ion spectrum and the first product ion spectrum.

5. 发明申请

US20160349210A1 Rapid LC Mapping of CoV Values for SelexION Technology Using MRM-Triggered MRM Functionality 有权
标题翻译：使用MRM触发的MRM功能快速LC映射SelexION技术的CoV值
公开(公告)号：US20160349210A1
公开(公告)日：2016-12-01
申请号：US15107455
申请日：2015-02-10
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Christie L. Hunter , David M. Cox
IPC分类号： G01N27/62
CPC分类号： G01N27/622 , G01N30/7233 , H01J49/0027 , H01J49/004
摘要： MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.
摘要翻译： MRM触发MRM，其中触发的MRM转换使用相同化合物的移动设备参数值。多个主MRM转换被接收并与每个转换的移动设备参数值一起存储为MRM周期列表。控制信息指示移动设备和质谱仪在质谱仪的MRM周期内询问MRM周期列表上的每个MRM转换。如果MRM转换的乘积离子强度值超过用于主MRM转换的阈值，则将具有不同移动性设备参数值的主MRM转换的多个辅助MRM转换添加到MRM周期列表。所测量的次级MRM转换的强度提供了关于每种化合物的最佳移动性装置参数的信息。

6. 发明申请

US20220359181A1 Method for Mass Spectrometry 有权
公开(公告)号：US20220359181A1
公开(公告)日：2022-11-10
申请号：US17753035
申请日：2020-08-22
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Yves Le Blanc , David M. Cox
IPC分类号： H01J49/04 , H01J49/00 , H01J49/16
摘要： Before a sample is introduced into a liquid sample delivery device, an ion source device receives aqueous mobile phase solution from the liquid sample delivery device and ionizes compounds of the aqueous mobile phase solution, producing an ion beam. A tandem mass spectrometer performs a first neutral loss scan of the ion beam with a first neutral loss value set to a molecular weight of a first known solvent, producing a first intensity, and performs a second neutral loss scan of the ion beam with a second neutral loss value set to a molecular weight of a second known solvent, producing a second intensity. A ratio of the first intensity to the second intensity is calculated. It is determined if the aqueous mobile phase solution is properly being delivered by the liquid sample delivery device based on the ratio.

7. 发明申请

US20170248548A1 Dynamic Orthogonal Analysis Method 审中-公开
公开(公告)号：US20170248548A1
公开(公告)日：2017-08-31
申请号：US15516387
申请日：2015-09-21
申请人： DH Technologies Development Pte. Ltd.
发明人： John Lawrence Campbell , Eva Duchoslav , Yves Le Blanc , David M. Cox
IPC分类号： G01N27/62
CPC分类号： G01N27/624 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/0045
摘要： Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.

8. 发明申请

US20220187260A1 Agnostic Compound Elution Determination 有权
公开(公告)号：US20220187260A1
公开(公告)日：2022-06-16
申请号：US17593349
申请日：2020-03-10
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Nic G. Bloomfield , Lyle Lorrence Burton , John Lawrence Campbell , David M. Cox , Eva Duchoslav , Adam San-Ho Lau
IPC分类号： G01N30/86 , H01J49/16 , H01J49/00 , H01J49/04 , H01J49/42 , H01J49/44 , G01N30/72
摘要： Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.

9. 发明授权

US10204770B2 Method to improve MS/MS spectral quality from MRM triggered IDA 有权
公开(公告)号：US10204770B2
公开(公告)日：2019-02-12
申请号：US15754770
申请日：2016-08-09
申请人： DH Technologies Development Pte. Ltd.
发明人： Michael Jarvis , Yves Le Blanc , David M. Cox
IPC分类号： H01J49/00 , G01N27/62
摘要： Systems and methods are provided for enabling or disabling a DMS device during an IDA method. Each cycle of the method includes a survey scan step, producing a precursor ion mass spectrum, and an MS/MS scan step. During the MS/MS scan step, one or more user-defined MS/MS scans are performed that correspond to compounds of interest found in the precursor ion mass spectrum. With each user-defined MS/MS scan, a DMS enable parameter that determines if the DMS device is enabled or disabled and one or more DMS parameters necessary to enable the DMS device for the corresponding compound of interest are received. During the MS/MS scan step, for each user-defined MS/MS scan, the DMS device is enabled or disabled according to the DMS enable parameter and one or more parameters of the DMS device are set according to the one or more DMS parameters.

10. 发明申请

US20160086783A1 Improved Data Quality after Demultiplexing of Overlapped Acquisition Windows 有权
标题翻译：在重叠获取Windows解复用后提高数据质量
公开(公告)号：US20160086783A1
公开(公告)日：2016-03-24
申请号：US14889139
申请日：2014-06-03
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： David M. Cox , Stephen A. Tate , Lyle Burton
IPC分类号： H01J49/04 , H01J49/00
CPC分类号： H01J49/04 , H01J49/0027 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample. A first precursor mass window and the corresponding first product ion spectrum are selected from a plurality of overlapping stepped precursor mass windows and their corresponding product ion spectra. A product ion spectrum is demultiplexed for each overlapped portion of the first precursor mass window producing two or more demultiplexed first product ion spectra for the first precursor mass window. The two or more demultiplexed first product ion spectra are added together producing a reconstructed summed demultiplexed first product ion spectrum. Missing product ions are identified in the summed demultiplexed first product ion spectrum by comparing the summed demultiplexed first product ion spectrum and the first product ion spectrum.
摘要翻译：提供了系统和方法，用于在顺序窗口采集串联质谱法中解复用重叠的前体离子传输窗口产生的产物离子光谱之后识别缺失的产物离子。对样品进行重叠顺序窗口采集。第一前体质谱窗和相应的第一产物离子谱选自多个重叠的阶梯前体质谱窗及其相应的产物离子光谱。对于第一前体质量窗口的每个重叠部分对产物离子谱进行解复用，产生用于第一前体质谱窗的两个或多个解复用的第一产物离子光谱。将两个或更多个解复用的第一乘积离子光谱相加在一起产生重构的求和的解复用的第一乘积离子谱。通过比较求和的解复用的第一乘积离子谱和第一乘积离子谱，在求和的第一乘积离子谱中确定缺失的产物离子。

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