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    • 2. 发明授权
    • Detecting incomplete fill of biosensors
    • 检测生物传感器的不完全填充
    • US07945394B2
    • 2011-05-17
    • US11597579
    • 2005-06-16
    • Daniel V. BrownChristina Blaschke
    • Daniel V. BrownChristina Blaschke
    • G01F23/00
    • G01N27/3274
    • A method of detecting incomplete filling of an electrochemical biosensor by collecting a series of electrical current values when a constant electrical potential is applied across the working and counter electrodes during a preliminary burn period. The slope of a line determined by linear regression based on the series of current values is used to determine whether or not the biosensor is incompletely filled. If the line has a positive slope, the biosensor is reported to be under filled. If the slope is not positive, the correlation coefficient of the current values is used as a supplemental test to indicate whether or not the biosensor is incompletely filled.
    • 一种通过在预备燃烧期间在工作电极和对电极上施加恒定电位时收集一系列电流值来检测电化学生物传感器的不完全填充的方法。 使用基于一系列当前值的线性回归确定的线的斜率来确定生物传感器是否不完全填充。 如果线路呈正斜率,则报告生物传感器处于充满状态。 如果斜率不正,则使用当前值的相关系数作为补充测试,以指示生物传感器是否未完全填充。
    • 4. 发明申请
    • ELECTROCHEMICAL TEST SENSOR
    • 电化学测试传感器
    • US20110247944A1
    • 2011-10-13
    • US13161953
    • 2011-06-16
    • Daniel V. Brown
    • Daniel V. Brown
    • G01N27/26G01N33/50
    • C12Q1/001
    • An electrochemical test sensor for detecting the concentration of an analyte in a sample. The electrochemical test sensor comprises a base that provides a flow path for the fluid test sample having a counter electrode and a working electrode on its surface in electrical communication with a detector of electrical current. The electrochemical test sensor further includes a reagent layer directly located on the surface of the working electrode. The reagent layer includes an enzyme that is adapted to react with the analyte. The electrochemical test sensor further comprises a lid adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the sample thereto. The capillary space is formed with a three-dimensional portion of the lid.
    • 用于检测样品中分析物浓度的电化学测试传感器。 电化学测试传感器包括一个底座,该底座为流体测试样品提供一个流动路径,该流体测试样品在其表面上与电流检测器电气连通,具有对电极和工作电极。 电化学测试传感器还包括直接位于工作电极表面上的试剂层。 试剂层包括适于与分析物反应的酶。 电化学测试传感器还包括适于与基座配合的盖子,并且辅助形成具有用于将样品引入其的开口的毛细管空间。 毛细管空间形成有盖的三维部分。
    • 5. 发明申请
    • Method for distinguishing electrochemical sensors
    • 区分电化学传感器的方法
    • US20090050491A1
    • 2009-02-26
    • US11989179
    • 2006-08-04
    • Daniel V. Brown
    • Daniel V. Brown
    • G01N27/26
    • C12Q1/006G01N27/3273
    • A method for distinguishing between types of electrochemical test sensors in a meter is disclosed. The method comprises the acts of providing an electrochemical test sensor comprising an enzyme and a chemical additive, contacting the test sensor to the meter to form an electrical connection, applying a potential having a magnitude sufficient to initiate a redox reaction of the chemical additive, and determining which type of electrochemical test sensor is being used based on whether a predetermined signal has been generated after the potential has been applied. The meter is adapted to determine an analyte concentration in a fluid sample.
    • 公开了一种用于区分仪表中的电化学测试传感器的类型的方法。 该方法包括提供包含酶和化学添加剂的电化学测试传感器的动作,将测试传感器接触仪表以形成电连接,施加具有足以引发化学添加剂的氧化还原反应的量级的电位,以及 基于在施加电位之后是否产生了预定信号,确定使用哪种类型的电化学测试传感器。 该仪表适于确定流体样品中的分析物浓度。
    • 7. 发明申请
    • METHOD FOR DISTINGUISHING ELECTROCHEMICAL SENSORS
    • 分析电化学传感器的方法
    • US20120228156A1
    • 2012-09-13
    • US13480096
    • 2012-05-24
    • Daniel V. Brown
    • Daniel V. Brown
    • G01N33/66G01N27/327
    • C12Q1/006G01N27/3273
    • A method for distinguishing between types of electrochemical test sensors in a meter is disclosed. The method comprises the acts of providing an electrochemical test sensor comprising an enzyme and a chemical additive, contacting the test sensor to the meter to form an electrical connection, applying a potential having a magnitude sufficient to initiate a redox reaction of the chemical additive, and determining which type of electrochemical test sensor is being used based on whether a predetermined signal has been generated after the potential has been applied. The meter is adapted to determine an analyte concentration in a fluid sample.
    • 公开了一种用于区分仪表中的电化学测试传感器的类型的方法。 该方法包括提供包含酶和化学添加剂的电化学测试传感器的动作,将测试传感器接触仪表以形成电连接,施加具有足以引发化学添加剂的氧化还原反应的量级的电位,以及 基于在施加电位之后是否产生了预定信号,确定使用哪种类型的电化学测试传感器。 该仪表适于确定流体样品中的分析物浓度。
    • 8. 发明申请
    • Electrochemical test sensor
    • 电化学测试传感器
    • US20080011616A1
    • 2008-01-17
    • US11825231
    • 2007-07-05
    • Daniel V. Brown
    • Daniel V. Brown
    • G01N27/26
    • C12Q1/001
    • An electrochemical test sensor for detecting the concentration of an analyte in a sample. The electrochemical test sensor comprises a base that provides a flow path for the fluid test sample having a counter electrode and a working electrode on its surface in electrical communication with a detector of electrical current. The electrochemical test sensor further includes a reagent layer directly located on the surface of the working electrode. The reagent layer includes an enzyme that is adapted to react with the analyte. The electrochemical test sensor further comprises a lid adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the sample thereto. The capillary space is formed with a three-dimensional portion of the lid.
    • 用于检测样品中分析物浓度的电化学测试传感器。 电化学测试传感器包括一个底座,该底座为流体测试样品提供一个流动路径,该流体测试样品在其表面上与电流检测器电气连通,具有对电极和工作电极。 电化学测试传感器还包括直接位于工作电极表面上的试剂层。 试剂层包括适于与分析物反应的酶。 电化学测试传感器还包括适于与基座配合的盖子,并且辅助形成具有用于将样品引入其的开口的毛细管空间。 毛细管空间形成有盖的三维部分。
    • 10. 发明授权
    • Method for distinguishing electrochemical sensors
    • 区分电化学传感器的方法
    • US08211292B2
    • 2012-07-03
    • US11989179
    • 2006-08-04
    • Daniel V. Brown
    • Daniel V. Brown
    • G01N27/26
    • C12Q1/006G01N27/3273
    • A method for distinguishing between types of electrochemical test sensors in a meter is disclosed. The method comprises the acts of providing an electrochemical test sensor comprising an enzyme and a chemical additive, contacting the test sensor to the meter to form an electrical connection, applying a potential having a magnitude sufficient to initiate a redox reaction of the chemical additive, and determining which type of electrochemical test sensor is being used based on whether a predetermined signal has been generated after the potential has been applied. The meter is adapted to determine an analyte concentration in a fluid sample.
    • 公开了一种用于区分仪表中的电化学测试传感器的类型的方法。 该方法包括提供包含酶和化学添加剂的电化学测试传感器的动作,将测试传感器接触仪表以形成电连接,施加具有足以引发化学添加剂的氧化还原反应的量级的电位,以及 基于在施加电位之后是否产生了预定信号,确定使用哪种类型的电化学测试传感器。 该仪表适于确定流体样品中的分析物浓度。