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    • 9. 发明授权
    • Carboxylic acid-modified EDOT for bioconjugation
    • 用于生物共轭的羧酸改性的EDOT
    • US07708908B2
    • 2010-05-04
    • US12038138
    • 2008-02-27
    • Jinsang KimJae Cheol ChoLaura K. PovlichDavid C. Martin
    • Jinsang KimJae Cheol ChoLaura K. PovlichDavid C. Martin
    • H01B1/12C08G75/00C07D333/10G01N31/00
    • C07D495/04
    • An electroconductive carboxylic acid functionalized monomer corresponding to Formula (I), wherein A represents a hydrogen or a carboxyl group. Polymerized monomers of Formula (I) conjugated with a biomolecule result in conjugated PEDOT polymers of Formula (III) wherein A is a hydrogen or a carboxylic acid group and B is a biomolecule selected from the group consisting of a peptide, a protein, a lipid, a carbohydrate and a polynucleotide. The biomolecule conjugated polymers can be disposed onto an electrically conductive substrate wherein the substrate has a first layer of PEDOT polymerized on a surface of the substrate and a second layer of biomolecule conjugated PEDOT polymer of Formula (III) polymerized on the first layer of PEDOT. The first and second layers form a charge transport material in electrical communication with the conductive substrate. The electrically conductive substrate further comprises a dopant.
    • 对应于式(I)的导电羧酸官能化单体,其中A表示氢或羧基。 与生物分子缀合的式(I)的聚合单体导致式(III)的共轭PEDOT聚合物,其中A是氢或羧酸基团,B是选自肽,蛋白质,脂质的生物分子 ,碳水化合物和多核苷酸。 生物分子共轭聚合物可以设置在导电基底上,其中基底具有在基底表面上聚合的第一层PEDOT和在第一层PEDOT上聚合的式(III)的生物分子共轭PEDOT聚合物的第二层。 第一和第二层形成与导电基底电连通的电荷传输材料。 导电衬底还包括掺杂剂。