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1. 发明授权

US08046062B2 Post-shock management of implantable cardiac device features 失效
标题翻译：可植入心脏装置功能的后冲击管理
公开(公告)号：US08046062B2
公开(公告)日：2011-10-25
申请号：US12545643
申请日：2009-08-21
申请人： David J. Yonce , Scott Meyer , David J. Ternes
发明人： David J. Yonce , Scott Meyer , David J. Ternes
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61B5/04525 , A61N1/3712 , A61N1/3943
摘要： Systems and methods of managing features or functions of an implantable cardiac device involve forming a baseline evoked response template prior to delivery of defibrillation therapy to a patient's heart, and acquiring a post-shock evoked response signal subsequent to defibrillation therapy delivery. The baseline evoked response template is compared to the post-shock evoked response signal. A determination is made whether to enable, disable or adjust a cardiac device feature based on the comparison. The cardiac device feature may be a therapy feature, a monitoring feature, or a diagnostic feature.
摘要翻译：管理可植入心脏装置的特征或功能的系统和方法包括在将除颤疗法递送到患者心脏之前形成基线诱发反应模板，以及在除颤治疗递送之后获得后休克诱发反应信号。将基线诱发反应模板与震后诱发反应信号进行比较。基于比较确定是否启用，禁用或调整心脏设备特征。心脏装置特征可以是治疗特征，监测特征或诊断特征。

2. 发明申请

US20090312810A1 Post-Shock Management of Implantable Cardiac Device Features 失效
标题翻译：可植入心脏装置功能的冲击后管理
公开(公告)号：US20090312810A1
公开(公告)日：2009-12-17
申请号：US12545643
申请日：2009-08-21
申请人： David J. Yonce , Scott A. Meyer , David J. Ternes
发明人： David J. Yonce , Scott A. Meyer , David J. Ternes
IPC分类号： A61N1/39 , A61N1/37
CPC分类号： A61N1/3962 , A61B5/04525 , A61N1/3712 , A61N1/3943
摘要： Systems and methods of managing features or functions of an implantable cardiac device involve forming a baseline evoked response template prior to delivery of defibrillation therapy to a patient's heart, and acquiring a post-shock evoked response signal subsequent to defibrillation therapy delivery. The baseline evoked response template is compared to the post-shock evoked response signal. A determination is made whether to enable, disable or adjust a cardiac device feature based on the comparison. The cardiac device feature may be a therapy feature, a monitoring feature, or a diagnostic feature.
摘要翻译：管理可植入心脏装置的特征或功能的系统和方法包括在将除颤疗法递送到患者心脏之前形成基线诱发反应模板，以及在除颤治疗递送之后获得后休克诱发反应信号。将基线诱发反应模板与震后诱发反应信号进行比较。基于比较确定是否启用，禁用或调整心脏设备特征。心脏装置特征可以是治疗特征，监测特征或诊断特征。

3. 发明授权

US07593771B2 Post-shock management of implantable cardiac device features 有权
标题翻译：可植入心脏装置功能的后冲击管理
公开(公告)号：US07593771B2
公开(公告)日：2009-09-22
申请号：US11157244
申请日：2005-06-21
申请人： David J. Yonce , Scott A. Meyer , David J. Ternes
发明人： David J. Yonce , Scott A. Meyer , David J. Ternes
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61B5/04525 , A61N1/3712 , A61N1/3943
摘要： Systems and methods of managing features or functions of an implantable cardiac device involve forming a baseline evoked response template prior to delivery of defibrillation therapy to a patient's heart, and acquiring a post-shock evoked response signal subsequent to defibrillation therapy delivery. The baseline evoked response template is compared to the post-shock evoked response signal. A determination is made whether to enable, disable or adjust a cardiac device feature based on the comparison. The cardiac device feature may be a therapy feature, a monitoring feature, or a diagnostic feature.
摘要翻译：管理可植入心脏装置的特征或功能的系统和方法包括在将除颤疗法递送到患者心脏之前形成基线诱发反应模板，以及在除颤治疗递送之后获得后休克诱发反应信号。将基线诱发反应模板与震后诱发反应信号进行比较。基于比较确定是否启用，禁用或调整心脏设备特征。心脏装置特征可以是治疗特征，监测特征或诊断特征。

4. 发明授权

US07583998B2 Multi-chamber cardiac capture detection using cross chamber sensing 有权
标题翻译：使用交叉腔感测的多室心脏捕获检测
公开(公告)号：US07583998B2
公开(公告)日：2009-09-01
申请号：US11157426
申请日：2005-06-21
申请人： Scott A. Meyer , David J. Yonce , David J. Ternes
发明人： Scott A. Meyer , David J. Yonce , David J. Ternes
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： Methods and systems involve multi-chamber cardiac capture detection utilizing sensing during a cross-chamber refractory period. First and second pacing pulses are delivered to first and second heart chamber. Capture or non-capture of the second heart chamber is determined. Sensing in the first heart chamber is performed to sense for cross-chamber propagation initiated by the second pacing pulse. Capture of the first chamber is detected if capture of the second heart chamber is detected and if the cross-chamber propagation is not detected.
摘要翻译：方法和系统涉及在跨室不应期期间利用感测的多室心脏捕获检测。第一和第二起搏脉冲被输送到第一和第二心室。确定第二心室的捕获或非捕获。执行在第一心室中的感测以感测由第二起搏脉冲发起的交叉腔传播。如果检测到第二心室的捕获并且未检测到横隔室传播，则检测到第一腔室的捕获。

5. 发明授权

US08588906B2 Physiological vibration detection in an implanted medical device 有权
公开(公告)号：US08588906B2
公开(公告)日：2013-11-19
申请号：US12835325
申请日：2010-07-13
申请人： David J. Ternes , Krzysztof Z. Siejko , Stephen Ruble , Jason J. Hamann
发明人： David J. Ternes , Krzysztof Z. Siejko , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/08
CPC分类号： A61N1/36585 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B7/00 , A61B7/003 , A61B2562/0219 , A61N1/3601 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment of an implantable system configured to be implanted in a patient includes an accelerometer, a neural stimulator, and a controller. The neural stimulator is configured to deliver neural stimulation to a neural target. The controller is configured to use the accelerometer to detect laryngeal vibration or coughing, and is configured to deliver a programmed neural stimulation therapy using the neural stimulator and using detected laryngeal vibration or detected coughing as an input to the programmed neural stimulation therapy.

6. 发明申请

US20130226264A1 METHOD AND APPARATUS FOR CONTROLLING NEUROSTIMULATION ACCORDING TO PHYSICAL STATE 审中-公开
标题翻译：用于根据物理状态控制神经元的方法和装置
公开(公告)号：US20130226264A1
公开(公告)日：2013-08-29
申请号：US13858405
申请日：2013-04-08
申请人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
发明人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36135
摘要： A neurostimulation system senses a signal indicative of a patient's physical state such as posture and/or activity level. In various embodiments, a stored value for each of stimulation parameters controlling delivery of neurostimulation is selected according to the patient's physical state. In various embodiments, values of the stimulation parameters are approximately optimized for each of a number of different physical states, and are stored for later selection.
摘要翻译：神经刺激系统感测指示患者的身体状态（例如姿势和/或活动水平）的信号。在各种实施例中，根据患者的身体状态选择控制神经刺激传递的每个刺激参数的存储值。在各种实施例中，刺激参数的值针对多个不同物理状态中的每一个近似优化，并且被存储以供稍后选择。

7. 发明申请

US20130073008A1 POWER SUPPLY MANAGEMENT FOR IMPLANTABLE NEUROSTIMULATION DEVICES 有权
标题翻译：用于可植入神经病学设备的电源管理
公开(公告)号：US20130073008A1
公开(公告)日：2013-03-21
申请号：US13663003
申请日：2012-10-29
申请人： David J. Ternes , Scott Vanderlinde , Ramprasad Vijayagopal , Scot C. Boon
发明人： David J. Ternes , Scott Vanderlinde , Ramprasad Vijayagopal , Scot C. Boon
IPC分类号： A61N1/36
CPC分类号： A61N1/36153 , A61N1/36135 , A61N1/36157
摘要： An apparatus comprises a therapy circuit that provides a neural stimulation current, an impedance measurement circuit that measures a value of impedance at the output of the therapy circuit, a supply voltage generating circuit that provides an adjustable supply voltage value to the therapy circuit including a first supply voltage value when in a first mode, and a control circuit communicatively coupled to the therapy circuit, the impedance measuring circuit, and the supply voltage generating circuit. The control circuit, upon receiving an indication to exit the first mode, initiates an impedance measurement by the impedance measurement circuit, determines the second supply voltage value using the impedance measurement, and initiates a change from the first supply voltage value to the second supply voltage value. The second supply voltage value is sufficient to operate the therapy circuit and to provide a specified load current value to the measured impedance.
摘要翻译：一种装置，包括提供神经刺激电流的治疗电路，测量治疗电路输出端的阻抗值的阻抗测量电路，向治疗电路提供可调电源电压值的电源电压产生电路，该电源电压值包括第一在第一模式下提供电压值，以及通信地耦合到治疗电路，阻抗测量电路和电源电压产生电路的控制电路。控制电路在接收到退出第一模式的指示时，通过阻抗测量电路启动阻抗测量，使用阻抗测量确定第二电源电压值，并且启动从第一电源电压值到第二电源电压的改变值。第二电源电压值足以操作治疗电路并为测量的阻抗提供规定的负载电流值。

8. 发明申请

US20130053926A1 SYSTEMS TO DETECT VAGUS CAPTURE 有权
标题翻译：检测VAGUS捕获的系统
公开(公告)号：US20130053926A1
公开(公告)日：2013-02-28
申请号：US13586432
申请日：2012-08-15
申请人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
发明人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/4035 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： Some embodiments provide a system for delivering neurostimulation. Some system embodiments comprise a lead configured to be implanted in the body, a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve through the lead, an EMG sensing circuit configured to use the lead to sense EMG signals from laryngeal muscle activity, and an evoked muscular response detection circuit configured to use the EMG signals sensed by the EMG sensing circuit to detect evoked laryngeal muscle activity evoked by the neurostimulation pulse.
摘要翻译：一些实施例提供用于递送神经刺激的系统。一些系统实施例包括被配置为植入体内的引线，刺激输出电路，其经配置以通过引线将神经刺激脉冲输送到迷走神经; EMG感测电路，被配置为使用引线来感测来自喉部肌肉活动的EMG信号;以及诱发肌肉反应检测电路，被配置为使用由EMG感测电路感测的EMG信号来检测由神经刺激脉冲诱发的诱发喉部肌肉活动。

9. 发明授权

US08301241B2 Remote pace detection in an implantable medical device 有权
标题翻译：可植入式医疗设备中的远程步调检测
公开(公告)号：US08301241B2
公开(公告)日：2012-10-30
申请号：US12835308
申请日：2010-07-13
申请人： David J. Ternes , Kenneth L. Baker
发明人： David J. Ternes , Kenneth L. Baker
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/024 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/37211 , A61N1/37288 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H40/67
摘要： A system embodiment for stimulating a neural target comprises a neural stimulator, a pace detector, and a controller. The neural stimulator is electrically connected to at least one electrode, and is configured to deliver a neural stimulation signal through the at least one electrode to stimulate the neural target. The pace detector is configured to use at least one electrode to sense cardiac activity and distinguish paced cardiac activity in the sensed cardiac activity from non-paced cardiac activity in the sensed cardiac activity. The controller is configured to control a programmed neural stimulation therapy using the neural stimulator and using detected paced cardiac activity as an input for the neural stimulation therapy.
摘要翻译：用于刺激神经目标的系统实施例包括神经刺激器，步速检测器和控制器。神经刺激器电连接到至少一个电极，并且被配置为通过至少一个电极传递神经刺激信号以刺激神经靶标。脚步检测器被配置为使用至少一个电极来感测心脏活动，并将感测到的心脏活动中的心跳活动与感觉到的心脏活动中的非节奏心脏活动区分开。控制器被配置为使用神经刺激器来控制编程的神经刺激治疗，并使用检测到的起搏心脏活动作为神经刺激治疗的输入。

10. 发明申请

US20110313488A1 AUTOMATIC NEURAL STIMULATION TITRATION SWEEP 有权
标题翻译：自动神经刺激ATION ATION
公开(公告)号：US20110313488A1
公开(公告)日：2011-12-22
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译：各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。神经刺激输出电路被配置为递送神经刺激。控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。控制器被配置为与传感器电路通信。存储器具有存储在其中的指令，可由控制器电路操作。说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数刺激并提供理想的安全余量以防止对神经组织的损伤。

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