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1. 发明申请

US20180085576A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
公开(公告)号：US20180085576A1
公开(公告)日：2018-03-29
申请号：US15696376
申请日：2017-09-06
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36 , A61N1/372 , A61B5/145 , A61B5/00 , A61B5/053 , A61B5/03 , A61B5/11
CPC分类号： A61B5/0031 , A61B5/037 , A61B5/0538 , A61B5/1116 , A61B5/14539 , A61B5/4211 , A61B5/4836 , A61N1/36007 , A61N1/3606 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/37235
摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

2. 发明授权

US09827425B2 Methods and systems of electrode polarity switching in electrical stimulation therapy 有权
公开(公告)号：US09827425B2
公开(公告)日：2017-11-28
申请号：US14475736
申请日：2014-09-03
申请人： EndoStim, Inc.
发明人： Ofer Glasberg , Shai Policker , Virender K. Sharma , Paul V. Goode , Bevil Hogg
IPC分类号： A61N1/36 , A61B5/00
CPC分类号： A61N1/3615 , A61B5/4233 , A61B5/4238 , A61B5/4836 , A61B5/6871 , A61N1/36007 , A61N1/36132 , A61N1/36139 , A61N1/36185
摘要： Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.

3. 发明申请

US20160001071A1 Device and Implantation System for Electrical Stimulation of Biological Systems 有权
公开(公告)号：US20160001071A1
公开(公告)日：2016-01-07
申请号：US14665226
申请日：2015-03-23
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Edy Sofer , Paul V. Goode , Bevil Hogg , Shai Policker , Matthew Joseph Gani , Jay Miazga , Kaila Raby
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36007 , A61B5/0538 , A61B5/1116 , A61B5/4836 , A61N1/0517 , A61N1/3606 , A61N1/36139 , A61N1/3614 , A61N1/36171 , A61N1/36175 , A61N1/36178
摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow, have improved energy storage requirements, enable improved LES function while concurrently delivering additional health benefits, and enable improved LES function post stimulation termination.

4. 发明申请

US20140222106A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
标题翻译：用于电刺激生物系统的装置和植入系统
公开(公告)号：US20140222106A1
公开(公告)日：2014-08-07
申请号：US14175927
申请日：2014-02-07
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/14539 , A61B5/6852 , A61B5/6861 , A61B5/687 , A61B2562/0247 , A61N1/0517 , A61N1/3606 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175
摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
摘要翻译：本说明书公开了用于治疗GERD的装置和方法。具有GERD的个体可以通过在患者的下食管括约肌内植入刺激装置并且根据某些预定义的方案对患者的下食管括约肌施加电刺激来治疗。目前公开的设备具有简化的设计，因为它们不需要能够感测人何时从事湿式吞咽并具有改进的能量存储要求的感测系统。

5. 发明授权

US11058876B2 Device and implantation system for electrical stimulation of biological systems 有权
公开(公告)号：US11058876B2
公开(公告)日：2021-07-13
申请号：US15696376
申请日：2017-09-06
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36 , A61B5/145 , A61B5/00 , A61N1/372 , A61B5/03 , A61B5/0538 , A61B5/11
摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

6. 发明授权

US10426955B2 Methods for implanting electrodes and treating a patient with gastreosophageal reflux disease 有权
公开(公告)号：US10426955B2
公开(公告)日：2019-10-01
申请号：US15332861
申请日：2016-10-24
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36 , A61N1/372 , A61B5/00 , A61N1/05
摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

7. 发明授权

US09925367B2 Laparoscopic lead implantation method 有权
公开(公告)号：US09925367B2
公开(公告)日：2018-03-27
申请号：US14548855
申请日：2014-11-20
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Shai Policker , Paul V. Goode , Ofer Glasberg
IPC分类号： A61N1/05 , A61B1/313
CPC分类号： A61N1/0509 , A61B1/3132 , A61B17/0401 , A61B2017/00818 , A61B2017/00827 , A61B2017/0417 , A61N1/0517
摘要： A method of laparoscopically implanting an electrically stimulating lead proximate the lower esophageal sphincter (LES) of a patient includes delivering the lead through a port of a laparoscope inserted into the abdominal cavity of the patient through an incision in the abdominal wall. The stimulating electrode is implanted in or proximate the muscularis layer of the lower esophageal wall to treat esophageal reflux disease (GERD). The lead includes a needle and suture at its distal end for pulling the electrode into the muscular wall of the LES. Clips are applied to the suture attached to the distal end of the lead to prevent retrograde movement of the electrode. The lead also includes an anchoring member for anchoring the portion of the lead proximal to the electrode. The method and lead used with the method allow the surgeon to work within the confined anatomy present at the gastroesophageal junction and prevents backwards movement and dislodgment of the electrode. The implantation procedure can be combined with a hiatal hernia repair to repair the hernia and prevent recurrence of a hiatal hernia.

8. 发明申请

US20170128716A1 Implantable Electrical Stimulation Leads 审中-公开
公开(公告)号：US20170128716A1
公开(公告)日：2017-05-11
申请号：US15296604
申请日：2016-10-18
申请人： EndoStim, Inc.
发明人： Paul V. Goode , Ofer Glasberg , Virender K. Sharma
IPC分类号： A61N1/05 , A61B18/08 , A61N1/36 , A61B1/00 , A61F5/00
CPC分类号： A61N1/0509 , A61B1/00082 , A61B1/00087 , A61B18/082 , A61B2017/0034 , A61B2018/00595 , A61F5/0026 , A61N1/36007
摘要： An implantable electrical stimulation lead for the treatment of biological conditions includes a lead body with an electrical connector at one end and a pair of monopolar branches at the other end. The lead body has a length ranging from 390 mm to 490 mm to allow for implantation from an incision site further removed from the final positioning site of the electrodes. The branches have lengths ranging from 50 mm to 120 mm for the both branches. These lengths facilitate successful laparoscopic implantation at sites with confined anatomy, such as, near the gastroesophageal junction. The branches include needles and sutures at their ends for suturing anchors positioned on the branches to surrounding tissue. The needles have curves designed to facilitate maneuvering in confined anatomy. A separate lead includes a suture loop connecting the ends of the first and second branches rather than needles. The loop is used to pull the lead through the working channel of an endoscope. The anchors on the lead are porous and allow for the ingrowth of surrounding tissue for fixing the branches in place.

9. 发明申请

US20150119646A1 Lead Implantation Method 有权
标题翻译：铅植入法
公开(公告)号：US20150119646A1
公开(公告)日：2015-04-30
申请号：US14548855
申请日：2014-11-20
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Shai Policker , Paul V. Goode , Ofer Glasberg
IPC分类号： A61N1/05 , A61N1/08 , A61B1/06 , A61B1/313
CPC分类号： A61N1/0509 , A61B1/3132 , A61B17/0401 , A61B2017/00818 , A61B2017/00827 , A61B2017/0417 , A61N1/0517
摘要： A method of laparoscopically implanting an electrically stimulating lead proximate the lower esophageal sphincter (LES) of a patient includes delivering the lead through a port of a laparoscope inserted into the abdominal cavity of the patient through an incision in the abdominal wall. The stimulating electrode is implanted in or proximate the muscularis layer of the lower esophageal wall to treat esophageal reflux disease (GERD). The lead includes a needle and suture at its distal end for pulling the electrode into the muscular wall of the LES. Clips are applied to the suture attached to the distal end of the lead to prevent retrograde movement of the electrode. The lead also includes an anchoring member for anchoring the portion of the lead proximal to the electrode. The method and lead used with the method allow the surgeon to work within the confined anatomy present at the gastroesophageal junction and prevents backwards movement and dislodgment of the electrode. The implantation procedure can be combined with a hiatal hernia repair to repair the hernia and prevent recurrence of a hiatal hernia.
摘要翻译：将腹腔镜植入电刺激引导件靠近患者的下食管括约肌（LES）的方法包括通过腹壁中的切口将引线通过插入到患者腹腔中的腹腔镜的端口输送。将刺激电极植入食管下壁的肌层或其附近，以治疗食管反流病（GERD）。引线包括在其远端的针和缝合线，用于将电极拉入LES的肌肉壁。将夹子施加到附接到引线的远端的缝合线以防止电极的逆行移动。导线还包括用于将导线部分靠近电极的部分固定的固定部件。与该方法一起使用的方法和引线允许外科医生在存在于胃食管结合处的受限解剖结构内工作，并防止电极的向后移动和移动。植入手术可以与疝修补术相结合，修复疝气并防止再狭窄的疝气。

10. 发明申请

US20150066109A1 Methods and Systems of Electrode Polarity Switching in Electrical Stimulation Therapy 有权
标题翻译：电刺激治疗电极极性切换的方法与系统
公开(公告)号：US20150066109A1
公开(公告)日：2015-03-05
申请号：US14475736
申请日：2014-09-03
申请人： EndoStim, Inc.
发明人： Ofer Glasberg , Shai Policker , Virender K. Sharma , Paul V. Goode , Bevil Hogg
IPC分类号： A61N1/36
CPC分类号： A61N1/3615 , A61B5/4233 , A61B5/4238 , A61B5/4836 , A61B5/6871 , A61N1/36007 , A61N1/36132 , A61N1/36139 , A61N1/36185
摘要： Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.
摘要翻译：用于电刺激身体组织以改善功能或减少症状的方法提供具有两个或更多个电极的电刺激系统，其能够独立于超极化（去极化）状态被切换到极化极化状态。通过极性切换产生超极化电极和极极化电极的多重组合，以确定通过症状报告和临床诊断测试确定的具有最佳性能的极性配置。极性切换手动触发或编程为自动切换。确定提供产生最大益处的电刺激的配置允许系统在一个或多个极化极化状态下操作，从而减少能量需求，组织耐受性和组织疲劳。

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