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1. 发明申请

US20180085576A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
公开(公告)号：US20180085576A1
公开(公告)日：2018-03-29
申请号：US15696376
申请日：2017-09-06
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36 , A61N1/372 , A61B5/145 , A61B5/00 , A61B5/053 , A61B5/03 , A61B5/11
CPC分类号： A61B5/0031 , A61B5/037 , A61B5/0538 , A61B5/1116 , A61B5/14539 , A61B5/4211 , A61B5/4836 , A61N1/36007 , A61N1/3606 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/37235
摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

2. 发明授权

US09827425B2 Methods and systems of electrode polarity switching in electrical stimulation therapy 有权
公开(公告)号：US09827425B2
公开(公告)日：2017-11-28
申请号：US14475736
申请日：2014-09-03
申请人： EndoStim, Inc.
发明人： Ofer Glasberg , Shai Policker , Virender K. Sharma , Paul V. Goode , Bevil Hogg
IPC分类号： A61N1/36 , A61B5/00
CPC分类号： A61N1/3615 , A61B5/4233 , A61B5/4238 , A61B5/4836 , A61B5/6871 , A61N1/36007 , A61N1/36132 , A61N1/36139 , A61N1/36185
摘要： Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.

3. 发明申请

US20160001071A1 Device and Implantation System for Electrical Stimulation of Biological Systems 有权
公开(公告)号：US20160001071A1
公开(公告)日：2016-01-07
申请号：US14665226
申请日：2015-03-23
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Edy Sofer , Paul V. Goode , Bevil Hogg , Shai Policker , Matthew Joseph Gani , Jay Miazga , Kaila Raby
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36007 , A61B5/0538 , A61B5/1116 , A61B5/4836 , A61N1/0517 , A61N1/3606 , A61N1/36139 , A61N1/3614 , A61N1/36171 , A61N1/36175 , A61N1/36178
摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow, have improved energy storage requirements, enable improved LES function while concurrently delivering additional health benefits, and enable improved LES function post stimulation termination.

4. 发明申请

US20140222106A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
标题翻译：用于电刺激生物系统的装置和植入系统
公开(公告)号：US20140222106A1
公开(公告)日：2014-08-07
申请号：US14175927
申请日：2014-02-07
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/14539 , A61B5/6852 , A61B5/6861 , A61B5/687 , A61B2562/0247 , A61N1/0517 , A61N1/3606 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175
摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
摘要翻译：本说明书公开了用于治疗GERD的装置和方法。具有GERD的个体可以通过在患者的下食管括约肌内植入刺激装置并且根据某些预定义的方案对患者的下食管括约肌施加电刺激来治疗。目前公开的设备具有简化的设计，因为它们不需要能够感测人何时从事湿式吞咽并具有改进的能量存储要求的感测系统。

5. 发明申请

US20190076648A1 Systems and Methods For Treating Gastroesophageal Reflux Disease 审中-公开
公开(公告)号：US20190076648A1
公开(公告)日：2019-03-14
申请号：US16041426
申请日：2018-07-20
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Shai Policker
IPC分类号： A61N1/36 , G06F19/00 , A61N1/00 , A61N1/05 , A61N1/378 , G16H15/00 , A61N1/372 , A61B17/34 , G16H20/40
CPC分类号： A61N1/36007 , A61B17/3468 , A61B17/3478 , A61N1/00 , A61N1/0517 , A61N1/37205 , A61N1/37282 , A61N1/3787 , G06F19/00 , G06F19/34 , G16H15/00 , G16H20/40 , G16Z99/00
摘要： Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.

6. 发明申请

US20170296814A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
公开(公告)号：US20170296814A1
公开(公告)日：2017-10-19
申请号：US15448944
申请日：2017-03-03
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Shai Policker , Bevil Hogg
IPC分类号： A61N1/36 , A61N1/05
摘要： The present specification discloses devices and methodologies for the treatment of achalasia. Individuals with achalasia are treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

7. 发明申请

US20170296813A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
公开(公告)号：US20170296813A1
公开(公告)日：2017-10-19
申请号：US15443983
申请日：2017-02-27
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Edy Sofer , Paul V. Goode , Bevil Hogg , Shai Policker , Matthew Joseph Gani , Jay Miazga , Kaila Raby
IPC分类号： A61N1/36 , A61N1/3614 , A61B5/00 , A61N1/05 , A61B5/11 , A61B5/053
CPC分类号： A61N1/36007 , A61B5/0538 , A61B5/1116 , A61B5/4836 , A61N1/0517 , A61N1/3606 , A61N1/36139 , A61N1/3614 , A61N1/36171 , A61N1/36175 , A61N1/36178
摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow, have improved energy storage requirements, enable improved LES function while concurrently delivering additional health benefits, and enable improved LES function post stimulation termination.

8. 发明申请

US20170036021A1 Device and Implantation System for Electrical Stimulation of Biological Systems 审中-公开
标题翻译：用于电刺激生物系统的装置和植入系统
公开(公告)号：US20170036021A1
公开(公告)日：2017-02-09
申请号：US15332861
申请日：2016-10-24
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Matt Joseph Gani , Paul V. Goode , Bevil Hogg , Jay Miazga , Shai Policker , Kaila Raby
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372 , A61B5/00
摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
摘要翻译：本说明书公开了用于治疗短暂食管下括约肌松弛的装置和方法（tLESR）。具有tESRs的个体可以通过在患者的下食管括约肌内植入刺激装置并根据某些预定义的方案对患者的下食管括约肌施加电刺激来治疗。目前公开的设备具有简化的设计，因为它们不需要能够感测人何时从事湿式吞咽并具有改进的能量存储要求的感测系统。

9. 发明申请

US20160030734A1 Endoscopic Lead Implantation Method 审中-公开
标题翻译：内镜铅植入法
公开(公告)号：US20160030734A1
公开(公告)日：2016-02-04
申请号：US14686996
申请日：2015-04-15
申请人： EndoStim, Inc.
发明人： Virender K. Sharma , Shai Policker , Paul V. Goode , Bevil Hogg
IPC分类号： A61N1/05 , A61B1/00 , A61B7/00 , A61B8/08 , A61B5/06 , A61B6/12
CPC分类号： A61N1/0509 , A61B1/00087 , A61B1/2733 , A61B5/06 , A61B5/064 , A61B6/12 , A61B7/00 , A61B8/00 , A61B8/0841 , A61N1/0517
摘要： A method of implanting electrically conductive leads in the gastrointestinal musculature for stimulation of target tissues involves an endoscopic approach through the esophagus. An endoscope is inserted into the esophagus of a patient. The mucosal surface of the anterior esophagus is punctured in the region encompassing the lower esophageal sphincter (LES). A tunnel is created through the submucosa and exits at the muscularis propria, adventitia, or serosal side of the stomach. The lead is navigated further to the anterior abdominal wall. A first end of the lead remains within the gastrointestinal musculature while a second end of the lead is positioned just outside the anterior abdominal wall. The first end of the lead comprises at least one electrode. An implantable pulse generator (IPG) is implanted and operably connected to the second end of the lead to provide electrical stimulation to target tissues.
摘要翻译：在胃肠肌肉组织中植入导电引线以刺激靶组织的方法涉及通过食道的内窥镜方法。将内窥镜插入患者的食道中。在食管下括约肌（LES）的区域内，前食管的粘膜表面被穿刺。通过粘膜下层产生隧道，并在胃的内固定层，外膜或浆膜侧退出。导线进一步前进到前腹壁。铅的第一端保持在胃肠肌肉组织内，而引线的第二端位于前腹壁正前方。引线的第一端包括至少一个电极。植入式脉冲发生器（IPG）被植入并且可操作地连接到引线的第二端以向靶组织提供电刺激。

10. 发明申请

US20150297885A1 Implantable Electrical Stimulation Leads 审中-公开
标题翻译：可植入电刺激线索
公开(公告)号：US20150297885A1
公开(公告)日：2015-10-22
申请号：US14753402
申请日：2015-06-29
申请人： EndoStim, Inc.
发明人： Paul V. Goode , Ofer Glasberg , Virender K. Sharma , Shai Policker , Alejandro Nieponice
IPC分类号： A61N1/05 , A61B17/04 , A61B17/00
CPC分类号： A61N1/0509 , A61B17/00234 , A61B17/0469 , A61B2017/00296 , A61B2017/00818 , A61F5/0026
摘要： Implantable electrical stimulation leads for the treatment of biological conditions include a lead body with an electrical connector at one end and multiple in-line electrodes at the other end. The lead body has a length ranging from 350 mm to 630 mm to allow for implantation from an incision site further removed from the final positioning site of the electrodes. One lead has a suture loop extending from the most distal electrode for pulling the lead through the working channel of an endoscope. Another lead has a length of suture with a free end attached to the most distal electrode. Yet another lead has a length of suture attached to the most distal electrode at one end and a needle at the other end. The needle has a curve designed to facilitate maneuvering in confined anatomy. The lead having the needle is designed to be implanted laparoscopically.
摘要翻译：用于治疗生物条件的可植入电刺激引线包括在一端具有电连接器的引线体和另一端的多个线内电极。引线体具有350mm至630mm的长度，以允许从电极的最终定位位置进一步移除的切割部位进行植入。一个引线具有从最远端电极延伸的缝合线，用于将引线牵引通过内窥镜的工作通道。另一个引线具有长度的缝合线，其自由端连接到最远侧的电极。另一个引线具有一段长度的缝合线，其一端附接到最远端电极，另一端具有针。针有一条曲线，旨在便于在狭窄的解剖结构中进行操纵。具有针头的引线被设计成在腹腔镜下植入。

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