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1. 发明授权

US08965470B2 Micro-invasive method for painless detection of analytes in extracellular space 有权
公开(公告)号：US08965470B2
公开(公告)日：2015-02-24
申请号：US12219228
申请日：2008-07-17
申请人： Eric Jules Raskas
发明人： Eric Jules Raskas
IPC分类号： A61B5/1455 , G01N21/85 , A61B5/145 , A61B5/1459 , A61B5/00 , A61B10/00
CPC分类号： G01N21/8507 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/6825 , A61B10/0045 , A61B2010/008 , A61B2562/12 , B33Y80/00
摘要： A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.

2. 发明授权

US07409238B2 Micro-invasive method for painless detection of analytes in extracellular space 有权
标题翻译：用于无细胞检测细胞外空间分析物的微创方法
公开(公告)号：US07409238B2
公开(公告)日：2008-08-05
申请号：US11104666
申请日：2005-04-13
申请人： Eric Jules Raskas
发明人： Eric Jules Raskas
IPC分类号： A61B5/1455
CPC分类号： G01N21/8507 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/6825 , A61B10/0045 , A61B2010/008 , A61B2562/12 , B33Y80/00
摘要： A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.
摘要翻译：一种检测细胞间空间中的至少一种分析物的方法包括将微针穿过角质层朝向受试者皮肤层的基底插入细胞间空间的步骤，其包含具有至少一种待检测分析物的间质液所述微探针的尖端处的直径不大于约10-50微米。该方法还包括光学测试邻近微探针远端的细胞外空间中的预定分析物，而不抽取间质液样品。优选地，微探针主体包括覆盖微探针本体的远端光学尖端的传感器层，传感器层适于与待组织液中待检测的预定分析物相互作用，以及响应于传感器层与预定分析物以信号检测所述预定分析物。

3. 发明授权

US06904301B2 Micro-invasive method for painless detection of analytes in extracellular space 有权
公开(公告)号：US06904301B2
公开(公告)日：2005-06-07
申请号：US10335010
申请日：2002-12-31
申请人： Eric Jules Raskas
发明人： Eric Jules Raskas
IPC分类号： G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B6/00 , A61B10/00 , G01N21/27 , G01N21/85 , G01N33/483 , G01N33/487
CPC分类号： G01N21/8507 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/6825 , A61B10/0045 , A61B2010/008 , A61B2562/12 , B33Y80/00
摘要： A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.

4. 发明申请

US20090093693A1 Micro-invasive method for painless detection of analytes in extracellular space 有权
标题翻译：用于无细胞检测细胞外空间分析物的微创方法
公开(公告)号：US20090093693A1
公开(公告)日：2009-04-09
申请号：US12219228
申请日：2008-07-17
申请人： Eric Jules Raskas
发明人： Eric Jules Raskas
IPC分类号： A61B5/1459
CPC分类号： G01N21/8507 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/6825 , A61B10/0045 , A61B2010/008 , A61B2562/12 , B33Y80/00
摘要： A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.
摘要翻译：一种检测细胞间空间中的至少一种分析物的方法包括将微针穿过角质层朝向受试者皮肤层的基底插入细胞间空间的步骤，其包含具有至少一种待检测分析物的间质液所述微探针的尖端处的直径不大于约10-50微米。该方法还包括光学测试邻近微探针远端的细胞外空间中的预定分析物，而不抽取间质液样品。优选地，微探针主体包括覆盖微探针本体的远端光学尖端的传感器层，传感器层适于与待组织液中待检测的预定分析物相互作用，以及响应于传感器层与预定分析物以信号检测所述预定分析物。

5. 发明授权

US06535753B1 Micro-invasive method for painless detection of analytes in extra-cellular space 有权
标题翻译：用于无细胞检测细胞外空间分析物的微创方法
公开(公告)号：US06535753B1
公开(公告)日：2003-03-18
申请号：US09668703
申请日：2000-09-22
申请人： Eric Jules Raskas
发明人： Eric Jules Raskas
IPC分类号： A61B500
CPC分类号： G01N21/8507 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/6825 , A61B10/0045 , A61B2010/008 , A61B2562/12 , B33Y80/00
摘要： A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.
摘要翻译：一种检测细胞间空间中的至少一种分析物的方法包括将微针穿过角质层朝向受试者皮肤层的基底插入细胞间空间的步骤，其包含具有至少一种待检测分析物的间质液所述微探针的尖端处的直径不大于约10-50微米。该方法还包括光学测试邻近微探针远端的细胞外空间中的预定分析物，而不抽取间质液样品。优选地，微探针主体包括覆盖微探针本体的远端光学尖端的传感器层，传感器层适于与待组织液中待检测的预定分析物相互作用，以及响应于传感器层与预定分析物以信号检测所述预定分析物。

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