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1. 发明申请

US20120307966A1 APPARATUS FOR PHASE-CONTRAST IMAGING COMPRISING A DISPLACEABLE X-RAY DETECTOR ELEMENT AND METHOD 有权
标题翻译：包含可移位X射线探测器元件和方法的相位对比成像装置
公开(公告)号：US20120307966A1
公开(公告)日：2012-12-06
申请号：US13514383
申请日：2010-12-03
申请人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sabastian Siegmund Schusser , Thomas Koehler
发明人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sabastian Siegmund Schusser , Thomas Koehler
IPC分类号： G01N23/04
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484
摘要： The present invention relates to X-ray image acquisition technology in general. Employing phase-contrast imaging for X-ray image acquisition may significantly enhance the quality and information content of images acquired. However, phase-contrast information may only be obtainable in a small detector region, possibly being too small for a sufficient field of rotation view for specialized X-ray imaging applications. Accordingly, an apparatus for phase-contrast imaging is provided that may allow the acquisition of an enlarged field of view. According to the present invention an apparatus (1) for phase-contrast imaging is provided, comprising an X-ray source (2), an X-ray detector (12) element having a detector size, a beam splitter grating (8) and an analyzer grating (10). An object (6) is arrangeable between the X-ray source (2) and the X-ray detector (12). The beam splitter grating (8) and the analyzer grating (10) are arrangeable between the X-ray source (2) and the X-ray detector (12). X-ray source (2), the beam splitter grating (8), the analyzer grating (10) and the X-ray detector (12) are operatively coupled such that a phase-contrast image of the object (6) is obtainable. The apparatus (1) is adapted for acquiring a phase-contrast image having a field of view larger than the detector size. The X-ray detector element (12) is displaceable and by the displacement of the X-ray detector (12) a phase-contrast image of the field of view is obtainable.
摘要翻译：本发明一般涉及X射线图像获取技术。采用X射线图像获取的相位对比成像可显着提高获取图像的质量和信息内容。然而，相位对比度信息只能在小的检测器区域中获得，对于专门的X射线成像应用，可能对于足够的旋转视场来说太小。因此，提供了一种用于相位对比成像的装置，其可以允许获取放大的视场。根据本发明，提供了一种用于相位对比成像的装置（1），包括具有检测器尺寸的X射线源（2），X射线检测器（12）元件，分束器光栅（8）和分析器光栅（10）。物体（6）可布置在X射线源（2）和X射线检测器（12）之间。分束器光栅（8）和分析器光栅（10）可布置在X射线源（2）和X射线检测器（12）之间。 X射线源（2），分束器光栅（8），分析器光栅（10）和X射线检测器（12）可操作地耦合，使得可以获得物体（6）的相位对比度图像。装置（1）适于获取具有大于检测器尺寸的视场的相位对比度图像。 X射线检测器元件（12）可移动，并且通过X射线检测器（12）的移位，可以获得视场的相位对比图像。

2. 发明授权

US09066649B2 Apparatus for phase-contrast imaging comprising a displaceable X-ray detector element and method 有权
标题翻译：包括可移位的X射线检测器元件和方法的用于相位对比成像的装置
公开(公告)号：US09066649B2
公开(公告)日：2015-06-30
申请号：US13514383
申请日：2010-12-03
申请人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sebastian Siegmund Schusser , Thomas Koehler
发明人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sebastian Siegmund Schusser , Thomas Koehler
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484
摘要： An X-ray image acquisition apparatus employing phase-contrast imaging with enlarged field of view includes an X-ray source, an X-ray detector element having a detector size, a beam splitter grating and an analyzer grating. An object is arrangeable between the X-ray source and detector. The beam splitter grating and the analyzer grating are arrangeable between the X-ray source and detector. The X-ray source, the beam splitter grating, the analyzer grating and the X-ray detector are operatively coupled such that a phase-contrast image of the object is obtainable. The apparatus is configure to acquire a phase-contrast image having a field of view larger than the detector size. The X-ray detector element is displaceable where, by the displacement of the X-ray detector, a phase-contrast image of the enlarged field of view is obtainable.
摘要翻译：采用具有放大视场的相位对比成像的X射线图像获取装置包括X射线源，具有检测器尺寸的X射线检测器元件，分束器光栅和分析器光栅。 X射线源和检测器之间可以配置一个物体。分束器光栅和分析器光栅可以在X射线源和检测器之间布置。 X射线源，分束器光栅，分析器光栅和X射线检测器可操作地耦合，使得可以获得物体的相差图像。该装置被配置为获取具有大于检测器尺寸的视场的相位对比度图像。 X射线检测器元件可移动，其中通过X射线检测器的位移可以获得放大视场的相位对比图像。

3. 发明授权

US09084528B2 Phase contrast imaging 有权
标题翻译：相位成像
公开(公告)号：US09084528B2
公开(公告)日：2015-07-21
申请号：US13514682
申请日：2010-12-03
申请人： Dieter Geller , Klaus Juergen Engel , Gereon Vogtmeier , Thomas Koehler , Ewald Roessl
发明人： Dieter Geller , Klaus Juergen Engel , Gereon Vogtmeier , Thomas Koehler , Ewald Roessl
IPC分类号： G01N23/04 , A61B6/00
CPC分类号： A61B6/00 , A61B6/4291 , A61B6/4441 , A61B6/484
摘要： X-ray devices for Phase Contrast Imaging (PCI) are often built up with the help of gratings. For large field-of-views (FOV), production cost and complexity of these gratings could increase significantly as they need to have a focused geometry. Instead of a pure PCI with a large FOV, this invention suggests to combine a traditional absorption X-ray-imaging system with large-FOV with an insertable low-cost PCI system with small-FOV, The invention supports the user to direct the PCI system with reduced FOV to a region that he regards as most interesting for performing a PCI scan thus eliminating X-ray dose exposure for scanning regions not interesting for a radiologist. The PCI scan may be generated on the basis of local tomography.
摘要翻译：用于相位对比成像（PCI）的X射线装置通常在光栅的帮助下构建。对于大视野（FOV）来说，这些光栅的生产成本和复杂性可能会因为需要聚焦几何而显着增加。本发明不是采用具有大FOV的纯PCI，而是将传统的吸收X射线成像系统与大型FOV结合，并具有小FOV的可插入低成本PCI系统。本发明支持用户指导PCI 系统将FOV降低到他认为对于执行PCI扫描最有趣的区域，从而消除了用于放射科医生不感兴趣的扫描区域的X射线剂量曝光。可以基于局部断层摄影产生PCI扫描。

4. 发明申请

US20120243658A1 PHASE CONTRAST IMAGING 有权
标题翻译：相位对比成像
公开(公告)号：US20120243658A1
公开(公告)日：2012-09-27
申请号：US13514682
申请日：2010-12-03
申请人： Dieter Geller , Klaus Juergen Engel , Gereon Vogtmeier , Thomas Koehler , Ewald Roessl
发明人： Dieter Geller , Klaus Juergen Engel , Gereon Vogtmeier , Thomas Koehler , Ewald Roessl
IPC分类号： G01N23/04
CPC分类号： A61B6/00 , A61B6/4291 , A61B6/4441 , A61B6/484
摘要： X-ray devices for Phase Contrast Imaging (PCI) are often built up with the help of gratings. For large field-of-views (FOV), production cost and complexity of these gratings could increase significantly as they need to have a focused geometry. Instead of a pure PCI with a large FOV, this invention suggests to combine a traditional absorption X-ray-imaging system with large-FOV with an insertable low-cost PCI system with small-FOV, The invention supports the user to direct the PCI system with reduced FOV to a region that he regards as most interesting for performing a PCI scan thus eliminating X-ray dose exposure for scanning regions not interesting for a radiologist. The PCI scan may be generated on the basis of local tomography.
摘要翻译：用于相位对比成像（PCI）的X射线装置通常在光栅的帮助下构建。对于大视野（FOV）来说，这些光栅的生产成本和复杂性可能会因为需要聚焦几何而显着增加。本发明不是采用具有大FOV的纯PCI，而是将传统的吸收X射线成像系统与大型FOV结合，并具有小FOV的可插入低成本PCI系统。本发明支持用户指导PCI 系统将FOV降低到他认为对于执行PCI扫描最有趣的区域，从而消除了用于放射科医生不感兴趣的扫描区域的X射线剂量曝光。可以基于局部断层摄影产生PCI扫描。

5. 发明申请

US20120250823A1 CALIBRATION OF DIFFERENTIAL PHASE-CONTRAST IMAGING SYSTEMS 审中-公开
标题翻译：差分相位成像系统的校准
公开(公告)号：US20120250823A1
公开(公告)日：2012-10-04
申请号：US13514166
申请日：2010-12-08
申请人： Gereon Vogtmeier , Klaus Juergen Engel , Dieter Geller , Thomas Koehler , Ewald Roessl
发明人： Gereon Vogtmeier , Klaus Juergen Engel , Dieter Geller , Thomas Koehler , Ewald Roessl
IPC分类号： A61B6/02
CPC分类号： A61B6/4291 , A61B6/4092 , A61B6/484 , A61B6/583 , G21K2207/005
摘要： The present invention relates to an X-ray imaging system and a method for differential phase—contrast imaging of an object. To improve calibration of differential phase—contrast imaging systems and the alignment of the gratings an X-ray imaging system is provided that comprises an X-ray emitting arrangement providing at least partially coherent X-ray radiation and an X-ray detection arrangement comprising a phase-shift diffraction grating, a phase analyzer grating, and an X-ray image detector, all arranged along an optical axis. For stepping, the gratings and/or the X-ray emitting arrangement are provided with at least two actuators arranged opposite to each other with reference to the optical axis. For calibration, calibration projections are acquired without an object, wherein, the emitted X-ray radiation or one of the gratings is stepwise displaced with a calibration displacement value. For examination, measurement projections are acquired with an object, wherein the emitted X-ray radiation or one of the gratings is stepwise displaced with a measurement, a calibration projection is associated to each of the measurement projections by registering the latter with the calibration projections.
摘要翻译：本发明涉及一种用于物体的差分相位对比成像的X射线成像系统和方法。为了改进差分相位对比成像系统的校准和光栅的对准，提供了一种X射线成像系统，其包括提供至少部分相干X射线辐射的X射线发射装置和包括相移衍射光栅，相位分析器光栅和X射线图像检测器，均沿着光轴排列。对于步进，光栅和/或X射线发射装置设置有相对于光轴彼此相对布置的至少两个致动器。对于校准，在没有物体的情况下获取校准投影，其中，所发射的X射线辐射或其中一个光栅以校准位移值逐步位移。为了进行检查，用物体获取测量投影，其中所发射的X射线辐射或其中一个光栅通过测量逐步移位，通过将校准投影与校准投影配准，将校准投影与每个测量投影相关联。

6. 发明授权

US09750465B2 Scanning system for differential phase contrast imaging 有权
公开(公告)号：US09750465B2
公开(公告)日：2017-09-05
申请号：US13514312
申请日：2010-12-08
申请人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier , Thomas Koehler
发明人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier , Thomas Koehler
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4291 , A61B6/484 , A61B6/488 , A61B6/5241
摘要： The invention relates to the field of X-ray differential phase contrast imaging. For scanning large objects and for an improved contrast to noise ratio, an X-ray device (10) for imaging an object (18) is provided. The X-ray device (10) comprises an X-ray emitter arrangement (12) and an X-ray detector arrangement (14), wherein the X-ray emitter arrangement (14) is adapted to emit an X-ray beam (16) through the object (18) onto the X-ray detector arrangement (14). The X-ray beam (16) is at least partial spatial coherent and fan-shaped. The X-ray detector arrangement (14) comprises a phase grating (50) and an absorber grating (52). The X-ray detector arrangement (14) comprises an area detector (54) for detecting X-rays, wherein the X-ray device is adapted to generate image data from the detected X-rays and to extract phase information from the X-ray image data, the phase information relating to a phase shift of X-rays caused by the object (18). The object (18) has a region of interest (32) which is larger than a detection area of the X-ray detector (18) and the X-ray device (10) is adapted to generate image data of the region of interest (32) by moving the object (18) and the X-ray detector arrangement (14) relative to each other.

7. 发明申请

US20120236992A1 SCANNING SYSTEM FOR DIFFERENTIAL PHASE CONTRAST IMAGING 有权
标题翻译：扫描系统进行差分相位成像
公开(公告)号：US20120236992A1
公开(公告)日：2012-09-20
申请号：US13514312
申请日：2010-12-08
申请人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier , Thomas Koehler
发明人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier , Thomas Koehler
IPC分类号： G01N23/04 , B82Y99/00
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4291 , A61B6/484 , A61B6/488 , A61B6/5241
摘要： The invention relates to the field of X-ray differential phase contrast imaging. For scanning large objects and for an improved contrast to noise ration, an X-ray device (10) for imaging an object (18) is provided. The X-ray device (10) comprises an X-ray emitter arrangement (12) and an X-ray detector arrangement (14), wherein the X-ray emitter arrangement (14) is adapted to emit an X-ray beam (16) through the object (18) onto the X-ray detector arrangement (14). The X-ray beam (16) is at least partial spatial coherent and fan-shaped. The X-ray detector arrangement (14) comprises a phase grating (50) and an absorber grating (52). The X-ray detector arrangement (14) comprises an area detector (54) for detecting X-rays, wherein the X-ray device is adapted to generate image data from the detected X-rays and to extract phase information from the X-ray image data, the phase information relating to a phase shift of X-rays caused by the object (18). The object (18) has a region of interest (32) which is larger than a detection area of the X-ray detector (18) and the X-ray device (10) is adapted to generate image data of the region of interest (32) by moving the object (18) and the X-ray detector arrangement (14) relative to each other.
摘要翻译：本发明涉及X射线差分相位成像领域。为了扫描大型物体并改善与噪音比较的对比度，提供了用于对物体（18）成像的X射线装置（10）。 X射线装置（10）包括X射线发射器装置（12）和X射线检测器装置（14），其中X射线发射器装置（14）适于发射X射线束（16））通过物体（18）到X射线检测器装置（14）上。 X射线束（16）至少部分空间相干和扇形。 X射线检测器装置（14）包括相位光栅（50）和吸收光栅（52）。 X射线检测器装置（14）包括用于检测X射线的区域检测器（54），其中X射线装置适于从检测到的X射线产生图像数据，并从X射线图像数据，与由对象（18）引起的X射线的相移相关的相位信息。物体（18）具有大于X射线检测器（18）的检测区域的感兴趣区域（32），并且X射线装置（10）适于产生感兴趣区域的图像数据（ 32）通过相对于彼此移动物体（18）和X射线检测器装置（14）。

8. 发明授权

US08855265B2 Correction method for differential phase contrast imaging 有权
标题翻译：差分相位成像校正方法
公开(公告)号：US08855265B2
公开(公告)日：2014-10-07
申请号：US13319527
申请日：2010-06-10
申请人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier
发明人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier
IPC分类号： G03H5/00 , A61B6/00 , G21K1/06 , G01N23/04
CPC分类号： A61B6/00 , A61B6/4092 , A61B6/4291 , A61B6/484 , G01N23/04 , G21K1/06 , G21K2207/005
摘要： The present invention generally refers to a correction method for grating-based X-ray differential phase contrast imaging (DPCI) as well as to an apparatus which can advantageously be applied in X-ray radiography and tomography for hard X-ray DPCI of a sample object or an anatomical region of interest to be scanned. More precisely, the proposed invention provides a suitable approach that helps to enhance the image quality of an acquired X-ray image which is affected by phase wrapping, e.g. in the resulting Moiré interference pattern of an emitted X-ray beam in the detector plane of a Talbot-Lau type interferometer after diffracting said X-ray beam at a phase-shifting beam splitter grating. This problem, which is further aggravated by noise in the obtained DPCI images, occurs if the phase between two adjacent pixels in the detected X-ray image varies by more than π radians and is effected by a line integration over the object's local phase gradient, which induces a phase offset error of π radians that leads to prominent line artifacts parallel to the direction of said line integration.
摘要翻译：本发明总体上涉及一种用于基于光栅的X射线差分相位对比成像（DPCI）的校正方法以及可以有利地应用于X射线照相术和X射线成像的装置，用于样品的硬X射线DPCI 对象或要扫描的感兴趣的解剖区域。更精确地，所提出的发明提供了一种合适的方法，其有助于增强受到相位包裹影响的获得的X射线图像的图像质量，例如，在衍射在相移分束器光栅上的所述X射线束之后，在Talbot-Lau型干涉仪的检测器平面中产生的发射的X射线束的莫尔干涉图。如果所检测的X射线图像中的两个相邻像素之间的相位变化多于＆pgr，则发生由获得的DPCI图像中的噪声进一步恶化的问题。弧度并且通过对象的局部相位梯度上的线积分实现，其引起相位偏移误差＆pgr; 导致与所述线集成方向平行的突出的线条伪影的弧度。

9. 发明申请

US20120099702A1 CORRECTION METHOD FOR DIFFERENTIAL PHASE CONTRAST IMAGING 有权
标题翻译：用于差分相位成像的校正方法
公开(公告)号：US20120099702A1
公开(公告)日：2012-04-26
申请号：US13319527
申请日：2010-06-10
申请人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier
发明人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier
IPC分类号： G01N23/04
CPC分类号： A61B6/00 , A61B6/4092 , A61B6/4291 , A61B6/484 , G01N23/04 , G21K1/06 , G21K2207/005
摘要： The present invention generally refers to a correction method for grating-based X-ray differential phase contrast imaging (DPCI) as well as to an apparatus which can advantageously be applied in X-ray radiography and tomography for hard X-ray DPCI of a sample object or an anatomical region of interest to be scanned. More precisely, the proposed invention provides a suitable approach that helps to enhance the image quality of an acquired X-ray image which is affected by phase wrapping, e.g. in the resulting Moiré interference pattern of an emitted X-ray beam in the detector plane of a Talbot-Lau type interferometer after diffracting said X-ray beam at a phase-shifting beam splitter grating. This problem, which is further aggravated by noise in the obtained DPCI images, occurs if the phase between two adjacent pixels in the detected X-ray image varies by more than π radians and is effected by a line integration over the object's local phase gradient, which induces a phase offset error of π radians that leads to prominent line artifacts parallel to the direction of said line integration.
摘要翻译：本发明总体上涉及一种用于基于光栅的X射线差分相位对比成像（DPCI）的校正方法以及可以有利地应用于X射线照相术和X射线成像的装置，用于样本的硬X射线DPCI 对象或要扫描的感兴趣的解剖区域。更精确地，所提出的发明提供了一种合适的方法，其有助于增强受到相位包裹影响的获得的X射线图像的图像质量，例如，在衍射在相移分束器光栅上的所述X射线束之后，在Talbot-Lau型干涉仪的检测器平面中产生的发射的X射线束的莫尔干涉图。如果所检测的X射线图像中的两个相邻像素之间的相位变化多于＆pgr，则发生由获得的DPCI图像中的噪声进一步恶化的问题。弧度并且通过对象的局部相位梯度上的线积分实现，其引起相位偏移误差＆pgr; 导致与所述线集成方向平行的突出的线条伪影的弧度。

10. 发明申请

US20130066189A1 NORMATIVE DATASET FOR NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译：神经病学病例的正常数据
公开(公告)号：US20130066189A1
公开(公告)日：2013-03-14
申请号：US13580390
申请日：2011-02-02
申请人： Lyubomir Georgiev Zagorchev , Reinhard Kneser , Dieter Geller , Yuechen Qian , Juergen Weese , Matthew A. Garlinghouse , Robert M. Roth , Thomas W. McAllister
发明人： Lyubomir Georgiev Zagorchev , Reinhard Kneser , Dieter Geller , Yuechen Qian , Juergen Weese , Matthew A. Garlinghouse , Robert M. Roth , Thomas W. McAllister
IPC分类号： A61B6/00
CPC分类号： G06T7/0012 , G06T2207/10081 , G06T2207/10132 , G06T2207/30016
摘要： A system and method for identifying an abnormality of an anatomical structure. The system and method segments, using a processor, the anatomical structure imaged in a volumetric image of a plurality of control patients to produce a control segmentation of the anatomical structures of each of the control patients, obtains a normative dataset by extracting a statistical representation of a morphology of the control segmentations, segments the anatomical structure of a patient being analyzed for abnormalities to produce a patient segmentation and compares the patient segmentation to the normative dataset obtained from the control segmentations.
摘要翻译：用于识别解剖结构异常的系统和方法。使用处理器的系统和方法段在多个控制患者的体积图像中成像的解剖结构以产生每个控制患者的解剖结构的控制分割，通过提取规范数据集来提取统计学表示控制分割的形态，分割被分析异常的患者的解剖结构以产生患者分割，并将患者分割与从控制分割获得的规范数据集进行比较。

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