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1. 发明授权

US06793927B1 Construction of Pasteurella haemolytica vaccines 有权
标题翻译：建立溶血性巴氏杆菌疫苗
公开(公告)号：US06793927B1
公开(公告)日：2004-09-21
申请号：US09210747
申请日：1998-12-15
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39102
CPC分类号： C12N9/1092 , A61K39/102 , C12N9/1007 , C12N9/22 , C12N15/102 , C12N15/74
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
摘要翻译： DNA的甲基化可能是将DNA引入溶血杆菌中的关键步骤。为此目的已经分离并分子克隆了甲基转移酶。使用甲基转移酶已经允许构建定义的，减毒的突变体，用作疫苗以保护牛。

2. 发明授权

US06573093B2 Temperature sensitive plasmids of P. haemolytica 有权
标题翻译：溶血白僵菌的温度敏感质粒
公开(公告)号：US06573093B2
公开(公告)日：2003-06-03
申请号：US09981897
申请日：2001-10-19
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： C12N1500
CPC分类号： C12N15/01 , A61K39/00 , A61K39/102 , C07K14/285 , C12N15/74 , C12R1/01
摘要： Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.
摘要翻译：当用作反刍动物疫苗（例如牛，绵羊和山羊）时，溶血性乳杆菌的突变体具有良好的安全性和有效性，可能患有肺炎巴氏杆菌病。它们可以通过各种途径进行管理。特别优选的是在动物饲料中的用途。突变体不回复，不含有外来DNA，也没有引入抗生素抗性基因。

3. 发明申请

US20160158336A1 Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use 审中-公开
标题翻译：减毒的Mannheimia haemolytica疫苗和制造和使用方法
公开(公告)号：US20160158336A1
公开(公告)日：2016-06-09
申请号：US14934737
申请日：2015-11-06
申请人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Robert E Briggs , Fred M Tatum
发明人： Russell F Bey , Paulraj Kirubakaran Lawrence , Randy R Simonson , Robert E Briggs , Fred M Tatum
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K2039/522 , A61K2039/543 , A61K2039/552 , A61K2039/70 , C07K14/285 , C12N1/36
摘要： The present invention provides attenuated M. haemolytica strains that elicit an immune response in animals against M. haemolytica, compositions comprising said strains, methods of vaccination against M. haemolytica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
摘要翻译：本发明提供减毒的解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军解放军马氏解酒菌株，本发明还提供了多价疫苗，当以有效量向易感“运送发热”或牛呼吸道疾病的动物施用时提供保护性免疫。

4. 再颁专利

USRE38028E1 Molecular genetic construction of vaccine strains of pasteurellaceae 有权
标题翻译：巴氏杆菌科疫苗株的分子遗传构建
公开(公告)号：USRE38028E1
公开(公告)日：2003-03-11
申请号：US09716319
申请日：2000-11-21
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： C12N100
CPC分类号： C07K14/285 , A61K39/00 , C12N9/1007 , C12N9/22 , C12N15/74
摘要： Tools for genetically engineering Pasteurellaceae are provided. Replication-conditional plasmids which are useful for the Pasteurellaceae have been isolated and characterized. The plasmids can be utilized for delivery of DNA segments into the Pasteurellaceae in situations where control of extra-chromosomal replication desired, such as in achieving allelic exchange or site-directed mutagenesis. A restriction endonuclease, HsoI, was isolated from a bovine lung isolate of Haemophilus somnus. The enzyme was found to be a true isoschizomer of HinPI, a commercially available enzyme originally isolated from Haemophilus influenzae PI. Commercially available HhaI methyl transferase was found to protect against cleavage by both enzymes. Methylation of foreign plasmid DNA was found to enhance transformation of Haemophilus somnus in excess of four orders of magnitude.
摘要翻译：提供了基因工程巴斯德氏菌科的工具。已经分离和表征了可用于巴氏杆菌科的复制条件质粒。在需要控制染色体外复制的情况下，例如在实现等位基因交换或定点诱变的情况下，可以将质粒用于将DNA片段递送至巴氏杆菌科。将限制性内切核酸酶HsoI从牛肺分离株嗜血嗜血虫该酶被发现是HinPI的真正的同位异构体，HinPI是最初从流感嗜血杆菌PI中分离的市售酶。发现市售的HhaI甲基转移酶可以防止两种酶切割。发现外源质粒DNA的甲基化可增强嗜睡嗜血杆菌的转化，超过四个数量级。

5. 发明授权

US06495145B2 LktA deletion mutant of P. haemolytica 有权
标题翻译：溶血白僵菌LktA缺失突变体
公开(公告)号：US06495145B2
公开(公告)日：2002-12-17
申请号：US09982232
申请日：2001-10-19
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39102
CPC分类号： C12N15/01 , A61K39/00 , A61K39/102 , C07K14/285 , C12N15/74 , C12R1/01
摘要： Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.
摘要翻译：当用作反刍动物疫苗（例如牛，绵羊和山羊）时，溶血性乳杆菌的突变体具有良好的安全性和有效性，可能患有肺炎巴氏杆菌病。它们可以通过各种途径进行管理。特别优选的是在动物饲料中的用途。突变体不回复，不含有外来DNA，也没有引入抗生素抗性基因。

6. 发明授权

US5849305A Construction of Pasteurella haemolytica vaccines 失效
公开(公告)号：US5849305A
公开(公告)日：1998-12-15
申请号：US643299
申请日：1996-05-08
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74 , A01J21/00 , A01J25/12 , A21C3/00 , A21C11/00
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.

7. 发明授权

US06331303B1 LKTA deletion mutant of P. haemolytica 有权
标题翻译：溶血白僵菌的LKTA缺失突变体
公开(公告)号：US06331303B1
公开(公告)日：2001-12-18
申请号：US09160340
申请日：1998-09-25
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39102
CPC分类号： C12N15/01 , A61K39/00 , A61K39/102 , C07K14/285 , C12N15/74 , C12R1/01
摘要： Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.
摘要翻译：当用作反刍动物疫苗（例如牛，绵羊和山羊）时，溶血性乳杆菌的突变体具有良好的安全性和有效性，可能患有肺炎巴氏杆菌病。它们可以通过各种途径进行管理。特别优选的是在动物饲料中的用途。突变体不回复，不含有外来DNA，也没有引入抗生素抗性基因。

8. 发明授权

US5824525A Construction of Pasteurella haemolytica vaccines 失效
公开(公告)号：US5824525A
公开(公告)日：1998-10-20
申请号：US643301
申请日：1996-05-08
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/102 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/10 , C12N15/54 , C12N15/55 , C12N15/74
CPC分类号： C12N9/1092 , A61K39/102 , C07K14/285 , C12N15/102 , C12N15/74 , C12N9/1007 , C12N9/22
摘要： Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.

9. 发明授权

US06936262B2 LktA deletion mutant of P. haemolytica 有权
标题翻译：溶血白僵菌LktA缺失突变体
公开(公告)号：US06936262B2
公开(公告)日：2005-08-30
申请号：US10055174
申请日：2002-01-25
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： A61K39/00 , A61K39/102 , C07K14/285 , C12N15/01 , C12N15/74 , A61K39/02
CPC分类号： C12R1/01 , A61K39/00 , A61K39/102 , C07K14/285 , C12N15/01 , C12N15/74
摘要： Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.
摘要翻译：当用作反刍动物疫苗（例如牛，绵羊和山羊）时，溶血性乳杆菌的突变体具有良好的安全性和有效性，可能患有肺炎巴氏杆菌病。它们可以通过各种途径进行管理。特别优选的是在动物饲料中的用途。突变体不回复，不含有外来DNA，也没有引入抗生素抗性基因。

10. 发明授权

US5840556A Molecular genetic construction of vaccine strains of pasteurellaceae 失效
标题翻译：巴氏杆菌科疫苗株的分子遗传构建
公开(公告)号：US5840556A
公开(公告)日：1998-11-24
申请号：US770234
申请日：1996-12-19
申请人： Robert E. Briggs , Fred M. Tatum
发明人： Robert E. Briggs , Fred M. Tatum
IPC分类号： C12N15/09 , A61K39/00 , C07K14/285 , C12N1/21 , C12N9/10 , C12N9/22 , C12N15/00 , C12N15/31 , C12N15/63 , C12N15/74 , C12Q1/68 , C12N1/00
CPC分类号： C07K14/285 , C12N15/74 , C12N9/1007 , C12N9/22 , A61K39/00
摘要： Tools for genetically engineering Pasteurellaceae are provided. Replication-conditional plasmids which are useful for the Pasteurellaceae have been isolated and characterized. The plasmids can be utilized for delivery of DNA segments into the Pasteurellaceae in situations where control of extrachromosomal replication desired, such as in achieving allelic exchange or site-directed mutagenesis. A restriction endonuclease, HsoI, was isolated from a bovine lung isolate of Haemophilus somnus. The enzyme was found to be a true isoschizomer of HinPI, a commercially available enzyme originally isolated from Haemophilus influenzae PI. Commercially available HhaI methyl transferase was found to protect against cleavage by both enzymes. Methylation of foreign plasmid DNA was found to enhance transformation of Haemophilus somnus in excess of four orders of magnitude.
摘要翻译：提供了基因工程巴斯德氏菌科的工具。已经分离和表征了可用于巴氏杆菌科的复制条件质粒。在需要控制染色体外复制的情况下，例如在实现等位基因交换或定点诱变的情况下，质粒可用于将DNA片段递送至巴氏杆菌科。从嗜血杆菌的牛肺分离株中分离出限制性内切核酸酶HsoI。该酶被发现是HinPI的真正的同位异构体，HinPI是最初从流感嗜血杆菌PI中分离的市售酶。发现市售的HhaI甲基转移酶可以防止两种酶切割。发现外源质粒DNA的甲基化可增强嗜睡嗜血杆菌的转化，超过四个数量级。

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