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1. 发明授权

US09169327B2 Targeting of podoplanin with lectin for use in the prevention and treatment of cancer 有权
标题翻译：用凝集素对podoplanin进行靶向，用于预防和治疗癌症
公开(公告)号：US09169327B2
公开(公告)日：2015-10-27
申请号：US13218717
申请日：2011-08-26
申请人： Gary S. Goldberg , Yongquan Shen
发明人： Gary S. Goldberg , Yongquan Shen
IPC分类号： A61K38/16 , C07K16/30 , A61K9/00 , A61K38/17 , C07K16/28 , C12Q1/68 , A61K39/00
CPC分类号： C07K14/42 , A61K9/0053 , A61K38/178 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/73 , C07K2319/30 , C07K2319/60 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57484 , G01N2333/47
摘要： Lectin compositions and methods for reducing tumor cell growth and preventing or treating cancer are provided.
摘要翻译：提供凝集素组合物和减少肿瘤细胞生长和预防或治疗癌症的方法。

2. 发明授权

US08114593B2 Cancer biomarker genes and gene products and methods for using the same 有权
标题翻译：癌症生物标志物基因和基因产物及其使用方法
公开(公告)号：US08114593B2
公开(公告)日：2012-02-14
申请号：US12401849
申请日：2009-03-11
申请人： Gary S. Goldberg , Yongquan Shen
发明人： Gary S. Goldberg , Yongquan Shen
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/566 , G01N33/574 , C07K16/18 , C07K16/28 , C07K16/30
CPC分类号： G01N33/57484 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N2500/02
摘要： Using gene expression analysis, specific biomarker genes and gene products have been identified which are activated in transformed cells, but suppressed in nontransformed cells; or suppressed in transformed cells, but activated in transformed cells affected by Contact Normalization. Thus, the present invention features compositions and methods for detecting, diagnosing, treating and prognosing cancer.
摘要翻译：使用基因表达分析，鉴定了转化细胞中活化的特异性生物标记基因和基因产物，但在非转录细胞中被抑制; 或在转化细胞中抑制，但在受接触规范化影响的转化细胞中活化。因此，本发明的特征在于用于检测，诊断，治疗和预测癌症的组合物和方法。

3. 发明申请

US20090232814A1 Cancer biomarker genes and gene products and methods for using the same 有权
标题翻译：癌症生物标志物基因和基因产物及其使用方法
公开(公告)号：US20090232814A1
公开(公告)日：2009-09-17
申请号：US12401849
申请日：2009-03-11
申请人： Gary S. Goldberg , Yongquan Shen
发明人： Gary S. Goldberg , Yongquan Shen
IPC分类号： A61K39/395 , C12Q1/68 , A61K31/7088 , A61K38/56
CPC分类号： G01N33/57484 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N2500/02
摘要： Using gene expression analysis, specific biomarker genes and gene products have been identified which are activated in transformed cells, but suppressed in nontransformed cells; or suppressed in transformed cells, but activated in transformed cells affected by Contact Normalization. Thus, the present invention features compositions and methods for detecting, diagnosing, treating and prognosing cancer.
摘要翻译：使用基因表达分析，鉴定了转化细胞中活化的特异性生物标记基因和基因产物，但在非转录细胞中被抑制; 或在转化细胞中抑制，但在受接触规范化影响的转化细胞中活化。因此，本发明的特征在于用于检测，诊断，治疗和预测癌症的组合物和方法。

4. 发明申请

US20120010152A1 Targeting of Podoplanin with Lectin for Use in the Prevention and Treatment of Cancer 有权
标题翻译：用凝集素预防和治疗Podoplanin的靶向
公开(公告)号：US20120010152A1
公开(公告)日：2012-01-12
申请号：US13218717
申请日：2011-08-26
申请人： Gary S. Goldberg , Yongquan Shen
发明人： Gary S. Goldberg , Yongquan Shen
IPC分类号： A61K38/16 , C12N5/09 , A61P35/00
CPC分类号： C07K14/42 , A61K9/0053 , A61K38/178 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/73 , C07K2319/30 , C07K2319/60 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57484 , G01N2333/47
摘要： Lectin compositions and methods for reducing tumor cell growth and preventing or treating cancer are provided.
摘要翻译：提供凝集素组合物和减少肿瘤细胞生长和预防或治疗癌症的方法。

5. 发明授权

US09448195B2 Electrophysiological recording system and methods of using same 有权
标题翻译：电生理记录系统及其使用方法
公开(公告)号：US09448195B2
公开(公告)日：2016-09-20
申请号：US13810402
申请日：2011-07-15
申请人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
发明人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
IPC分类号： C12M3/00 , C12M1/00 , G01N27/00 , C12M1/12 , C12M1/34
CPC分类号： C12N5/0068 , C12M25/02 , C12M41/46 , C12N2535/00 , C12N2537/00 , G01N27/00
摘要： Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment.
摘要翻译：用于分析培养细胞的电生理记录系统包括记录装置和用于支持电生理记录装置的壳体。该装置具有多孔膜，其具有顶表面和底表面以及在顶表面和底表面之间延伸的多个孔。多孔膜限定设置在顶表面上的第一细胞培养区和设置在底表面上的相对的第二细胞培养区。电生理记录装置具有位于第一绝缘层和第二绝缘层之间的多孔膜上的多个电极。多个电极延伸到多孔膜的第一细胞培养区。记录电极的末端测量在第一和第二细胞培养区内培养的细胞的电学性质，而电极的接触末端位置与数据采集设备电连通。

6. 发明申请

US20130196368A1 Electrophysiological Recording System and Methods of Using Same 有权
标题翻译：电生理记录系统及其使用方法
公开(公告)号：US20130196368A1
公开(公告)日：2013-08-01
申请号：US13810402
申请日：2011-07-15
申请人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
发明人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
IPC分类号： G01N27/00
CPC分类号： C12N5/0068 , C12M25/02 , C12M41/46 , C12N2535/00 , C12N2537/00 , G01N27/00
摘要： Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment.
摘要翻译：用于分析培养细胞的电生理记录系统包括记录装置和用于支持电生理记录装置的壳体。该装置具有多孔膜，其具有顶表面和底表面以及在顶表面和底表面之间延伸的多个孔。多孔膜限定设置在顶表面上的第一细胞培养区和设置在底表面上的相对的第二细胞培养区。电生理记录装置具有位于第一绝缘层和第二绝缘层之间的多孔膜上的多个电极。多个电极延伸到多孔膜的第一细胞培养区。记录电极的末端测量在第一和第二细胞培养区内培养的细胞的电学性质，而电极的接触末端位置与数据采集设备电连通。

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