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1. 发明授权

US09646377B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
公开(公告)号：US09646377B2
公开(公告)日：2017-05-09
申请号：US14243508
申请日：2014-04-02
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/00 , G06T7/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

2. 发明申请

US20140301620A1 METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 有权
标题翻译：通过光束扫描对光学成像或上传光学仪器的方法和系统
公开(公告)号：US20140301620A1
公开(公告)日：2014-10-09
申请号：US14243508
申请日：2014-04-02
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： G06T7/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

3. 发明授权

US07538859B2 Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto 有权
标题翻译：用于使用保形激光治疗程序监测和获得样品的至少一部分的信息并向其提供电磁辐射的方法和系统
公开(公告)号：US07538859B2
公开(公告)日：2009-05-26
申请号：US11670058
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： G01L1/24
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.
摘要翻译：在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。例如，可以在样品的部分中引起温度变化。至少一个第一电磁辐射可以转发到样品附近或部分的部分。可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。例如，可以以特定波长向样品中的部分提供电磁辐射。当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

4. 发明授权

US10426548B2 Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures 有权
公开(公告)号：US10426548B2
公开(公告)日：2019-10-01
申请号：US11670043
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： A61B5/00 , A61B18/22 , A61B18/24 , A61B17/00 , A61B17/22
摘要： According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

5. 发明授权

US09186066B2 Apparatus for applying a plurality of electro-magnetic radiations to a sample 有权
标题翻译：用于将多个电磁辐射施加到样品的装置
公开(公告)号：US09186066B2
公开(公告)日：2015-11-17
申请号：US11670027
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： A61B18/18 , A61B5/00 , A61B18/24 , A61B17/00 , A61B17/22 , A61B18/20 , A61B19/00
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： An apparatus for applying a plurality of electro-magnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.
摘要翻译：提供了一种向样品施加多个电磁辐射的装置。在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。第一波长带可能与第二波长带显着不同。根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。第一区域可以基本上被第二区域包围。根据本发明的另一个示例性实施例，每个通道可以促进辐射的至少一个特定辐射被转发到样品的解剖结构内的样品，辐射被递送到样品的解剖结构中样品。可以基本沿着一条线提供每个区域的中心。

6. 发明授权

US07418169B2 Apparatus for controlling at least one of at least two sections of at least one fiber 有权
标题翻译：用于控制至少一个光纤的至少两个部分中的至少一个的装置
公开(公告)号：US07418169B2
公开(公告)日：2008-08-26
申请号：US11670069
申请日：2007-02-01
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc
IPC分类号： G02B6/26 , G02B6/06
CPC分类号： A61B18/24 , A61B1/00082 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B2017/00057 , A61B2017/22051 , A61B2018/2211 , A61B2018/2272 , G02B23/2423
摘要： An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.
摘要翻译：可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转的电磁辐射。

7. 发明授权

US09087368B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
标题翻译：用于光学成像或上皮腔内器官的方法和系统通过其束扫描
公开(公告)号：US09087368B2
公开(公告)日：2015-07-21
申请号：US11625135
申请日：2007-01-19
申请人： Guillermo J. Tearney , Milen Shishkov , Brett E. Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett E. Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/06 , G06T7/00 , A61B5/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

8. 发明授权

US07366376B2 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：US07366376B2
公开(公告)日：2008-04-29
申请号：US11241907
申请日：2005-09-29
申请人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
发明人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： G02B6/32 , G02B6/12 , G02B6/26 , G02B6/42 , G02B6/44 , G02B6/02 , G02B6/028 , G02B6/032 , G02B6/036
CPC分类号： H04J14/0267 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G02B6/2552 , G02B6/262 , G02B6/2856
摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.
摘要翻译：提供了用于传送至少一个电磁辐射的装置和方法。特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。此外，可以与光纤光学协作地提供透光的光学装置。光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

9. 再颁专利

USRE43875E1 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：USRE43875E1
公开(公告)日：2012-12-25
申请号：US12323228
申请日：2008-11-25
申请人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
发明人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： G02B6/32 , G02B6/12 , G02B6/26 , G02B6/42 , G02B6/44 , G02B6/02 , G02B6/028 , G02B6/032 , G02B6/036
CPC分类号： H04J14/0267 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G02B6/2552 , G02B6/262 , G02B6/2856
摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.
摘要翻译：提供了用于传送至少一个电磁辐射的装置和方法。特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。此外，可以与光纤光学协作地提供透光的光学装置。光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

10. 发明申请

US20120101374A1 SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS 有权
标题翻译：用于提供结构和组成的光学成像的系统，设备，方法，装置和计算机可访问介质
公开(公告)号：US20120101374A1
公开(公告)日：2012-04-26
申请号：US13114845
申请日：2011-05-24
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译：描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。例如，一种布置可以向解剖结构提供至少一个电磁辐射。这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。

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