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1. 发明申请

US20140301620A1 METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 有权
标题翻译：通过光束扫描对光学成像或上传光学仪器的方法和系统
公开(公告)号：US20140301620A1
公开(公告)日：2014-10-09
申请号：US14243508
申请日：2014-04-02
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： G06T7/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

2. 发明授权

US09646377B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
公开(公告)号：US09646377B2
公开(公告)日：2017-05-09
申请号：US14243508
申请日：2014-04-02
申请人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett Eugene Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/00 , G06T7/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

3. 发明授权

US09087368B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
标题翻译：用于光学成像或上皮腔内器官的方法和系统通过其束扫描
公开(公告)号：US09087368B2
公开(公告)日：2015-07-21
申请号：US11625135
申请日：2007-01-19
申请人： Guillermo J. Tearney , Milen Shishkov , Brett E. Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett E. Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/06 , G06T7/00 , A61B5/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

4. 发明授权

US5571098A Laser surgical devices 失效
标题翻译：激光手术器械
公开(公告)号：US5571098A
公开(公告)日：1996-11-05
申请号：US332942
申请日：1994-11-01
申请人： Yacov Domankevitz , Norman S. Nishioka
发明人： Yacov Domankevitz , Norman S. Nishioka
IPC分类号： A61B17/32 , A61B18/22 , A61B17/36
CPC分类号： A61B17/3211 , A61B18/22
摘要： A method and device for first irradiating a region of tissue with a radiation source, and then incising the region with a mechanical cutting instrument (e.g., a scalpel). Irradiation allows for effective heating of the tissue, which results in blood vessel contraction or coagulation of the blood before the actual incision is made; once the tissue is incised, the resulting flow of blood is low.
摘要翻译：一种用于首先用辐射源照射组织区域，然后用机械切割仪器（例如，解剖刀）切割该区域的方法和装置。照射允许组织的有效加热，这在实际切口之前导致血管收缩或凝血; 一旦组织被切开，血液的流动就低。

5. 发明授权

US5843000A Optical biopsy forceps and method of diagnosing tissue 失效
标题翻译：光学活检钳和诊断组织的方法
公开(公告)号：US5843000A
公开(公告)日：1998-12-01
申请号：US643912
申请日：1996-05-07
申请人： Norman S. Nishioka , Kevin T. Schomacker
发明人： Norman S. Nishioka , Kevin T. Schomacker
IPC分类号： A61B5/00 , A61B1/00 , A61B10/00 , A61B10/06 , A61B17/00 , A61B19/00
CPC分类号： A61B10/06 , A61B2017/00061 , A61B2090/3614
摘要： An integrated optical biopsy forceps device and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws pivotally mounted at the distal end of the catheter body and controlled by control wires extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.
摘要翻译：一种综合的光学活检钳装置和通过在身体内的部位进行光学分析和活检取样来进行组织鉴定的方法。该装置包括用于引入身体并导航到感兴趣区域的细长导管体。光纤从其近端可以连接到电光谱分析设备的远端延伸穿过该设备，用于从尖端的位置处的组织照射和接收光能。该装置的远端具有枢转地安装在导管主体的远端处的一对切割爪，并通过延伸穿过导管主体的控制线控制到近端处的控制手柄或由光纤。该装置可以被光谱地引导到身体内的感兴趣部位。纤维尖端在钳口的接触和切割区域与颚骨同轴地定位，并且随着颚关闭而缩回，使得活检样品准确地在被光纤观察的位置处被拍摄。

6. 发明授权

US07103401B2 Colonic polyp discrimination by tissue fluorescence and fiberoptic probe 有权
标题翻译：通过组织荧光和光纤探针的结肠息肉鉴别
公开(公告)号：US07103401B2
公开(公告)日：2006-09-05
申请号：US10192820
申请日：2002-07-10
申请人： Kevin T. Schomacker , Norman S. Nishioka , Alex R. Zelenchuk
发明人： Kevin T. Schomacker , Norman S. Nishioka , Alex R. Zelenchuk
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/4255
摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, about 403 nm, about 414 nm, and about 431 nm. The intensities of the 403 nm and 414 mn radiation are normalized using the 431 nm intensity. A score is determined using the ratios in a linear discriminant analysis (LDA). The tissue under examination is resected or not, based on the outcome of the LDA.
摘要翻译：用于原位鉴别健康和患病组织的系统和方法。使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。在三个选定的波长，约403nm，约414nm和约431nm处观察到响应辐射。使用431nm强度对403nm和414mn辐射的强度进行归一化。使用线性判别分析（LDA）中的比率确定得分。根据LDA的结果，检查的组织被切除或不切除。

7. 发明授权

US5967968A Apparatus and method for determining the size of an object during endoscopy 失效
标题翻译：内窥镜检查中用于确定物体尺寸的装置和方法
公开(公告)号：US5967968A
公开(公告)日：1999-10-19
申请号：US105392
申请日：1998-06-25
申请人： Norman S. Nishioka
发明人： Norman S. Nishioka
IPC分类号： A61B5/107 , G01B9/04 , A61B1/00
CPC分类号： G01B9/04 , A61B5/1076
摘要： An endoscopic imaging system for viewing an object within a patient's body cavity includes: an endoscope for viewing an image of the object, the endoscope comprising a distal end, an instrument channel extending therethrough, and a lens at the distal end adjacent the instrument channel; and an elongate probe configured to be inserted through the instrument channel and contact the object, the probe comprising a plurality of unevenly spaced graduations along its length, each graduation indicating a size factor used to scale the image produced by the endoscope. The invention also relates to a method of determining the size of an object in a patient's body cavity including the steps of: generating an image of the object using an instrument; extending a probe having a series of unevenly spaced graduations from the instrument to the object; identifying the graduation on the probe visible in the image nearest to the instrument; and scaling the image viewed by the endoscope by a size factor corresponding to the identified graduation.
摘要翻译：一种用于观察患者体腔内的物体的内窥镜成像系统，包括：用于观察物体的图像的内窥镜，所述内窥镜包括远端，穿过其延伸的器械通道和与所述器械通道相邻的远端处的透镜; 以及细长探针，其构造成插入通过所述仪器通道并接触所述物体，所述探针沿着其长度包括多个不均匀间隔的刻度，每个刻度指示用于缩放由所述内窥镜产生的图像的尺寸因子。本发明还涉及一种确定患者体腔中的物体的尺寸的方法，包括以下步骤：使用仪器产生物体的图像; 将具有一系列不均匀分离的刻度的探针从所述仪器延伸到所述物体; 确定探针上的毕业在最接近仪器的图像中可见; 并且将由内窥镜观看的图像缩放与所识别的刻度对应的尺寸因子。

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