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1. 发明授权

US09424459B1 Computerized methods for cell-based pattern recognition 有权
标题翻译：基于细胞的模式识别的计算机化方法
公开(公告)号：US09424459B1
公开(公告)日：2016-08-23
申请号：US14189633
申请日：2014-02-25
申请人： Holger Lange , Joseph Krueger , G. David Young , Trevor Johnson , Frank Voelker
发明人： Holger Lange , Joseph Krueger , G. David Young , Trevor Johnson , Frank Voelker
IPC分类号： G06K9/00 , G06K9/62
CPC分类号： G06K9/6253 , G06K9/00134
摘要： Systems and methods relating to a cell-based pattern recognition tool for microscopy images from tissue sections are described, wherein cell features are extracted and a classifier is built in accordance with a particular application using an interactive training tied to a computerized platform, the result is an application-specific classifier that further processes images in accordance with the specific application, thereby tuning an automated process for cell based pattern recognition.
摘要翻译：描述与用于来自组织切片的显微镜图像的基于细胞的图案识别工具相关的系统和方法，其中提取细胞特征，并且使用与计算机化平台相关联的交互式训练，根据特定应用构建分类器，结果是一种应用专用分类器，其根据具体应用进一步处理图像，从而调整基于小区的模式识别的自动化过程。

2. 发明申请

US20150004630A1 CELL-BASED TISSUE ANALYSIS 有权
标题翻译：基于细胞的组织分析
公开(公告)号：US20150004630A1
公开(公告)日：2015-01-01
申请号：US13934237
申请日：2013-07-03
申请人： Holger Lange , Josheph Krueger , George Young D. , Trevor Johnson , Frank Voelker , Steven Potts
发明人： Holger Lange , Josheph Krueger , George Young D. , Trevor Johnson , Frank Voelker , Steven Potts
IPC分类号： G01N33/50
CPC分类号： G01N33/5005 , G01N15/1463 , G01N2015/1006 , G01N2035/00138 , G06K9/0014 , G06K9/00147 , G06T7/0012 , G06T2207/30024
摘要： Methods for cell-based tissue analysis utilize modern trends in digital microscopy to obtain, process, calibrate, and analyze digital images of tissue sections to quantify cell-based data for improved histological analysis. Using data from multiple images of a common tissue section, or data from images of multiple tissue sections, additional degrees of freedom are realized and the resulting analysis provides added depth to histological analysis of tissue samples. With computerized analytical methods, speed and accuracy of histological analysis is greatly improved.
摘要翻译：基于细胞的组织分析的方法利用数字显微镜中的现代趋势来获得，处理，校准和分析组织切片的数字图像，以量化基于细胞的数据以改善组织学分析。使用来自多个组织部分的多个图像的数据或来自多个组织切片图像的数据，实现了附加的自由度，并且所得到的分析为组织样本的组织学分析提供了附加的深度。采用电脑化分析方法，大大提高了组织学分析的速度和准确性。

3. 发明申请

US20070132516A1 Control unit 失效
公开(公告)号：US20070132516A1
公开(公告)日：2007-06-14
申请号：US10575314
申请日：2004-07-22
申请人： Bernhard Mattes , Siegfried Malicki , Holger Lange , Klaus Ott
发明人： Bernhard Mattes , Siegfried Malicki , Holger Lange , Klaus Ott
IPC分类号： H03L7/00
CPC分类号： G05B19/0428 , G05B2219/24047 , G05B2219/24125 , G05B2219/2637
摘要： A control unit having an oscillator for a processor is described, the control unit storing a temporary absence of oscillation of the oscillator in a first error memory, if oscillation begins again after the absence.

4. 发明授权

US07664300B2 Uterine cervical cancer computer-aided-diagnosis (CAD) 失效
标题翻译：子宫颈癌计算机辅助诊断（CAD）
公开(公告)号：US07664300B2
公开(公告)日：2010-02-16
申请号：US11184046
申请日：2005-02-03
申请人： Holger Lange , Rolf Holger Wolters
发明人： Holger Lange , Rolf Holger Wolters
IPC分类号： G06K9/00 , A61F6/14 , A61F6/06
CPC分类号： A61B5/0059 , A61B5/053 , A61B5/7264 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/3481 , G06T7/0012 , G06T7/30 , G06T2207/10016 , G06T2207/10024 , G06T2207/30004
摘要： Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.
摘要翻译：根据本发明的子宫颈癌计算机辅助诊断（CAD）包括一个核心处理系统，其自动分析从子宫颈获得的数据，并提供组织和患者诊断以及检查的充分性。数据可以包括但不限于彩色静止图像或视频，反射率和荧光多光谱或超光谱图像，相干光学断层摄影图像和阻抗测量，在使用和不使用造影剂如3- 5％乙酸，Lugol碘或5-氨基乙酰丙酸。核心处理系统基于开放，模块化和基于特征的架构，专为多数据，多传感器和多功能融合而设计。核心处理系统可以嵌入到不同的CAD系统实现中。例如：用于宫颈癌筛查的CAD系统可以在非常简单的版本中由手持装置组成，其仅在施加3-5％乙酸后才获得子宫颈的一个数字RGB图像，并自动提供患者诊断。用作阴道镜附件的CAD系统可以提供与阴道镜相关的所有功能，并且可以由计算机提供从临床工作流程自动化到自动化患者诊断和治疗推荐的所有功能。

5. 发明申请

US20080240558A1 Method of automated image color calibration 失效
标题翻译：自动图像色彩校准方法
公开(公告)号：US20080240558A1
公开(公告)日：2008-10-02
申请号：US12077659
申请日：2008-03-19
申请人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
发明人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
IPC分类号： G06K9/00
CPC分类号： H04N1/6033 , H04N1/00045 , H04N1/401 , H04N1/6086
摘要： A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.
摘要翻译：一种自动图像校准方法，用于校正不均匀照明并校准简单，快速，自动，准确和可靠的颜色。应用灰度平衡算法来校正不均匀照明，然后应用颜色校准算法来校准人类受试者数据。该系统已应用于具有不同仪器的多个临床部位。

6. 发明申请

US20050111758A1 Systems and methods for registering reflectance and fluorescence hyperspectral imagery 失效
标题翻译：用于记录反射率和荧光高光谱图像的系统和方法
公开(公告)号：US20050111758A1
公开(公告)日：2005-05-26
申请号：US10895440
申请日：2003-08-15
申请人： Holger Lange , Ulf Gustafsson
发明人： Holger Lange , Ulf Gustafsson
IPC分类号： G06K9/00 , G06K9/32 , G06T7/00
CPC分类号： G06T7/33 , G06T2207/30004
摘要： The image registration systems and methods according to this invention register reflectance and fluorescence hyperspectral imagery and provide the spatial image transformation between the reflectance and fluorescence hyperspectral imagery. A reflectance image is embedded into the fluorescence hyperspectral imagery and thereby resolves the resemblance problem of reflectance and fluorescence hyperspectral imagery. The reflectance image is embedded into the fluorescence hyperspectral imagery using (1) light from a narrow-band source embedded in Ultraviolet (UV) excitation light, (2) second order diffracted light, and/or (3) Ultraviolet (UV) excitation light reflectance. Resembling reflectance images are calculated from the reflectance hyperspectral imagery and the embedded reflectance image in the fluorescence hyperspectral imagery. The two respective reflectance images are pre-processed to maximize the resemblance between them. Image registration algorithms use the two pre-processed reflectance images and calculate the spatial image transformation that allows to map the spatial coordinates from the reflectance to the fluorescence hyperspectral imagery (and vice versa).
摘要翻译：根据本发明的图像配准系统和方法记录反射率和荧光高光谱图像，并提供反射率和荧光高光谱图像之间的空间图像转换。反射图像被嵌入到荧光高光谱图像中，从而解决了反射和荧光高光谱图像的相似问题。使用（1）来自嵌入紫外（UV）激发光的窄带光源，（2）二次衍射光和/或（3）紫外（UV）激发光）的光，将反射率图像嵌入到荧光高光谱图像中反射率。从反射高光谱图和荧光高光谱图像中嵌入的反射率图像计算反射率图像。两个相应的反射率图像被预处理以最大化它们之间的相似性。图像配准算法使用两个预处理的反射图像，并计算允许将反射率的空间坐标映射到荧光高光谱图像（反之亦然）的空间图像变换。

7. 发明授权

US07302602B2 Control unit 失效
标题翻译：控制单元
公开(公告)号：US07302602B2
公开(公告)日：2007-11-27
申请号：US10575314
申请日：2004-07-22
申请人： Bernhard Mattes , Siegfried Malicki , Holger Lange , Klaus Ott
发明人： Bernhard Mattes , Siegfried Malicki , Holger Lange , Klaus Ott
IPC分类号： G06F1/04 , H03B1/00
CPC分类号： G05B19/0428 , G05B2219/24047 , G05B2219/24125 , G05B2219/2637
摘要： A control unit having an oscillator for a processor is described, the control unit storing a temporary absence of oscillation of the oscillator in a first error memory, if oscillation begins again after the absence.
摘要翻译：描述具有用于处理器的振荡器的控制单元，如果在不存在之后再次振荡，则控制单元在第一错误存储器中存储振荡器的暂时的振荡。

8. 发明授权

US6089197A Electromagnetic actuator for an engine valve, including an integrated valve slack adjuster 失效
标题翻译：用于发动机气门的电磁致动器，包括一个集成的阀门松弛调节器
公开(公告)号：US6089197A
公开(公告)日：2000-07-18
申请号：US440091
申请日：1999-11-15
申请人： Holger Lange , Michael Schebitz
发明人： Holger Lange , Michael Schebitz
IPC分类号： H01F7/16 , F01L1/24 , F01L1/25 , F01L9/04
CPC分类号： F01L1/25 , F01L9/04
摘要： An electromagnetic actuator includes a housing; two spaced electromagnets disposed in the housing and having respective pole faces oriented toward one another; an armature movable between the pole faces; an opening spring and a closing spring exerting oppositely directed forces to the armature; a supply arrangement for delivering hydraulic oil under pressure; and an armature stem affixed to the armature and having a free end oriented toward a free end of a valve stem of an engine valve of an internal-combustion engine. The valve stem and the armature stem are urged toward one another by the opening and closing springs. The armature stem is provided with a channel adapted to be supplied with hydraulic oil from the supply arrangement. Further, a guide is provided for supporting and guiding the armature stem in displacements thereof. A piston-and-cylinder unit, including a cylinder chamber, is disposed between the free and of the armature stem and the free end of the valve stem for transmitting displacement forces from the armature stem to the valve stem by the piston-and-cylinder unit. A valve assembly is provided which has a first state in which hydraulic communication is maintained between the supply arrangement and the cylinder chamber via the channel in the armature stem and a second state in which hydraulic communication is blocked between the supply arrangement and the cylinder chamber.
摘要翻译：电磁致动器包括壳体; 两个间隔开的电磁铁设置在壳体中并具有相互朝向彼此的相对的极面; 电极之间可移动的电枢; 打开弹簧和向电枢施加相反方向的力的闭合弹簧; 用于在压力下输送液压油的供应装置; 以及固定在电枢上的电枢杆，并具有朝向内燃机的发动机气门的阀杆自由端的自由端。阀杆和电枢杆通过打开和关闭弹簧彼此推动。电枢杆设置有适于从供应装置供应液压油的通道。此外，提供了用于在其位移中支撑和引导电枢杆的引导件。包括气缸室的活塞和气缸单元设置在自由和电枢杆与阀杆的自由端之间，用于通过活塞和气缸将活塞力从电枢杆传递到阀杆单元。提供了一种阀组件，其具有第一状态，其中通过电枢杆中的通道在供应装置和气缸室之间保持液压连通，以及在供应装置和气缸室之间液压连通被阻塞的第二状态。

9. 发明授权

US08027533B2 Method of automated image color calibration 失效
标题翻译：自动图像色彩校准方法
公开(公告)号：US08027533B2
公开(公告)日：2011-09-27
申请号：US12077659
申请日：2008-03-19
申请人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
发明人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
IPC分类号： G06K9/00
CPC分类号： H04N1/6033 , H04N1/00045 , H04N1/401 , H04N1/6086
摘要： A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.
摘要翻译：一种自动图像校准方法，用于校正不均匀照明并校准简单，快速，自动，准确和可靠的颜色。应用灰度平衡算法来校正不均匀照明，然后应用颜色校准算法来校准人类受试者数据。该系统已应用于具有不同仪器的多个临床部位。

10. 发明申请

US20090046905A1 Uterine cervical cancer computer-aided-diagnosis (CAD) 失效
标题翻译：子宫颈癌计算机辅助诊断（CAD）
公开(公告)号：US20090046905A1
公开(公告)日：2009-02-19
申请号：US11184046
申请日：2005-02-03
申请人： Holger Lange , Rolf Holger Wolters
发明人： Holger Lange , Rolf Holger Wolters
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/053 , A61B5/7264 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/3481 , G06T7/0012 , G06T7/30 , G06T2207/10016 , G06T2207/10024 , G06T2207/30004
摘要： Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.
摘要翻译：根据本发明的子宫颈癌计算机辅助诊断（CAD）包括一个核心处理系统，其自动分析从子宫颈获得的数据，并提供组织和患者诊断以及检查的充分性。数据可以包括但不限于彩色静止图像或视频，反射率和荧光多光谱或超光谱图像，相干光学断层摄影图像和阻抗测量，在使用和不使用造影剂如3- 5％乙酸，Lugol碘或5-氨基乙酰丙酸。核心处理系统基于开放，模块化和基于特征的架构，专为多数据，多传感器和多功能融合而设计。核心处理系统可以嵌入到不同的CAD系统实现中。例如：用于宫颈癌筛查的CAD系统可以在非常简单的版本中由手持装置组成，其仅在施加3-5％乙酸后才获得子宫颈的一个数字RGB图像，并自动提供患者诊断。用作阴道镜附件的CAD系统可以提供与阴道镜相关的所有功能，并且可以由计算机提供从临床工作流程自动化到自动化患者诊断和治疗推荐的所有功能。

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