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1. 发明授权

US08951302B2 Biomimetic vascular network and devices using the same 有权
标题翻译：生物模拟血管网和使用该装置的装置
公开(公告)号：US08951302B2
公开(公告)日：2015-02-10
申请号：US12576826
申请日：2009-10-09
申请人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/04 , A61F2/06 , G01N33/50
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

2. 发明申请

US20150366651A1 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 审中-公开
标题翻译：生物体血管网络及使用该装置的装置
公开(公告)号：US20150366651A1
公开(公告)日：2015-12-24
申请号：US14615646
申请日：2015-02-06
申请人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/06 , A61F2/02
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

3. 发明申请

US20100234678A1 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 有权
标题翻译：生物体血管网络及使用该装置的装置
公开(公告)号：US20100234678A1
公开(公告)日：2010-09-16
申请号：US12576826
申请日：2009-10-09
申请人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/06 , C12N5/02
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

4. 发明授权

US10327885B2 Biomimetic vascular network and devices using the same 有权
公开(公告)号：US10327885B2
公开(公告)日：2019-06-25
申请号：US14615646
申请日：2015-02-06
申请人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/06 , A61F2/04 , A61F2/02 , G01N33/50
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

5. 发明申请

US20110091930A1 WELL-BASED FLOW SYSTEM FOR CELL CULTURE 审中-公开
标题翻译：用于细胞培养的基于细胞的流动系统
公开(公告)号：US20110091930A1
公开(公告)日：2011-04-21
申请号：US12866970
申请日：2009-02-13
申请人： Joseph P. Vacanti , Howard I. Pryor , Craig M. Neville , Ira Spool
发明人： Joseph P. Vacanti , Howard I. Pryor , Craig M. Neville , Ira Spool
IPC分类号： C12Q1/20 , C12M3/00 , C12N5/071
CPC分类号： G01N33/5014 , C12M25/04 , C12M35/08 , G01N33/5067
摘要： A well-based flow system for cell culture is described which provides for flow of culture containing compounds for drug screening to be exposed to cells seeded on a membrane. The flow of medium may be planar or radial and means are provided for the removal of waste media through fluid outlets in fluid communication with the assay well plates through conduits. Methods of using the system for cell culture and drug toxicity screening are also provided including coculturing cells such as hepatocytes, stem cells, fibroblasts and smooth muscle cells and selectively exposing cells to test compounds.
摘要翻译：描述了用于细胞培养的基于基础的流动系统，其提供含有用于药物筛选的化合物的培养物流，以暴露于接种在膜上的细胞。介质的流动可以是平面的或径向的，并且提供了用于通过导管与测定孔板流体连通的流体出口去除废弃介质的装置。还提供了使用该系统用于细胞培养和药物毒性筛选的方法，包括共培养细胞如肝细胞，干细胞，成纤维细胞和平滑肌细胞，并选择性地将细胞暴露于测试化合物。

6. 发明授权

US09408980B2 Dual-chambered drug delivery device for high pressure injections 有权
标题翻译：用于高压注射的双室药物输送装置
公开(公告)号：US09408980B2
公开(公告)日：2016-08-09
申请号：US12998853
申请日：2009-12-08
申请人： Michel Bruehwiler , Melissa Rosen , Ryan Schoonmaker , Ira Spool
发明人： Michel Bruehwiler , Melissa Rosen , Ryan Schoonmaker , Ira Spool
IPC分类号： A61M5/315 , A61M5/19 , A61M5/20 , A61M5/48 , A61M5/31
CPC分类号： A61M5/31553 , A61M5/19 , A61M5/204 , A61M5/31511 , A61M5/484 , A61M2005/3128
摘要： A dual-chambered drug delivery device (201) includes a first chamber (205) in which a medicament is stored. A dose setting member (213) is rotated to set a medicament dose. The dose setting member (213) being rotatable to set the medicament dose. The dose setting member (213) is not axially moveable. A second chamber (221) is in fluid communication with the first chamber (205). The medicament dose is transferred to the second chamber (221) from the first chamber (205) prior to injecting the medicament dose. A needle (203) communicates with the second chamber (221) to inject the medicament dose into an injection site.
摘要翻译：双室药物输送装置（201）包括其中储存药物的第一腔室（205）。旋转剂量设定构件（213）以设定药物剂量。剂量设定构件（213）可旋转以设定药物剂量。剂量设定构件（213）不能轴向移动。第二室（221）与第一室（205）流体连通。在注射药物剂量之前，药物剂量从第一腔室（205）转移到第二腔室（221）。针（203）与第二腔（221）连通以将药剂剂量注入注射部位。

7. 发明授权

US07651458B2 Adaptive intracavitary brachytherapy applicator 失效
标题翻译：适应性腔内近距离放射治疗仪
公开(公告)号：US07651458B2
公开(公告)日：2010-01-26
申请号：US11495027
申请日：2006-07-28
申请人： Firas Mourtada , John Horton , Patricia Eifel , Anuja Jhingran , Ira Spool
发明人： Firas Mourtada , John Horton , Patricia Eifel , Anuja Jhingran , Ira Spool
IPC分类号： A61M36/10
CPC分类号： A61N5/1007
摘要： The invention is a novel adaptive CT-friendly brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.
摘要翻译：本发明是一种新型适应性CT适应性近距离放射治疗仪，具有远程控制的径向和纵向运动的放射源管腔屏蔽，可以由放射肿瘤学家操纵，以优化对近距离放射治疗程序的靶标和正常组织结构的剂量分布。

8. 发明申请

US20120041390A1 Needle Dispensing And Storing Apparatus For Medicament Delivery Device 有权
标题翻译：用于药物输送装置的针头分配和储存装置
公开(公告)号：US20120041390A1
公开(公告)日：2012-02-16
申请号：US13204632
申请日：2011-08-05
申请人： Ira Spool , Cole Constantineau , Ryan Schoonmaker , Sean P. Sullivan , Abhijitsinh Raj , Michel Bruehwiler
发明人： Ira Spool , Cole Constantineau , Ryan Schoonmaker , Sean P. Sullivan , Abhijitsinh Raj , Michel Bruehwiler
IPC分类号： A61M5/32 , A61M5/34
CPC分类号： A61M5/002 , A61M5/003 , A61M5/008 , A61M5/24 , A61M5/3202 , A61M5/3205
摘要： A flip-open multi-pack assembly is provided which can contain a plurality of new pen needles, such as through the provision of a rectangular or tube-shaped shaped, hinged shell housing, wherein new pen needles can be stored in a plurality of user accessible openings each having a sterility barrier formed, for example, by covers that cover the non-patient end of the openings in which the new pen needles are contained. Used pen needles can be returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell can be provided with a slidable internal holder within the device and are configured to releasably secure the inner shield of the new pen needle, and to then be pulled forward when the new pen needle is removed and lock at a forward position, and thereby create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored.
摘要翻译：提供了一种翻转多组件组件，其可以包含多个新的笔针，例如通过设置矩形或管状形状的铰接壳体壳体，其中新的笔针可以存储在多个用户中可接近的开口各自具有例如通过覆盖其中容纳有新的笔针的开口的非患者端的覆盖物形成的无菌屏障。可以将二手笔针返回并储存在可旋转打开壳体外壳的开口中。壳体壳体的第一和第二相对端内的一个或多个开口可以在该装置内设置有可滑动的内部保持器，并且构造成可释放地固定新笔针的内护罩，然后在新的笔针被移除并锁定在前部位置，从而形成内部空间，当打开铰接的外壳时，可以从相对端接近，以便插入和存储用过的笔针。

9. 发明申请

US20100318167A1 NEUROSTIMULATION ELECTRODE ARRAY AND METHOD OF MANUFACTURE 审中-公开
标题翻译：神经网络电极阵列及其制造方法
公开(公告)号：US20100318167A1
公开(公告)日：2010-12-16
申请号：US12762540
申请日：2010-04-19
申请人： Brian M. Conn , James R. Easter , Farid Moumane , Michel Bruhwiler , Ira Spool , Melissa Rosen
发明人： Brian M. Conn , James R. Easter , Farid Moumane , Michel Bruhwiler , Ira Spool , Melissa Rosen
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , A61N1/0529 , Y10T29/49208
摘要： An implantable neurostimulation electrode array may include a flexible, electrically non-conductive carrier, and a plurality of electrodes supportably interconnected to and spaced along a length of a carrier. In various embodiments, different ones of at least some of the plurality of electrodes may comprise corresponding contact surfaces having different areas. The different surface areas may be achieved by defining a different area per unit length of the carrier and/or by defining a different total length (e.g. as measured along a length of the carrier). In some embodiments, insulator portions having different corresponding lengths may be disposed between different adjacent ones of the electrodes. The insulated portions may be integrally defined with the carrier. Electrical connection lines may be embedded within the carrier. In a manufacturing method, a plurality of electrodes may be supportably interconnected to a first side of a sacrificial substrate and a carrier may be interconnected to the electrodes. In turn, at least a portion of the substrate may be removed from the electrodes to yield at least a partially completed electrode array. The substrate may be configured into a predetermined configuration wherein the carrier material may be formed within an internal volume thereof to define at least a portion of the configuration of the carrier of the electrode array.
摘要翻译：可植入神经刺激电极阵列可以包括柔性的非导电载体，以及多个电极，其可被支撑地互连到载体的长度上并沿其间隔开。在各种实施例中，多个电极中的至少一些电极中的不同的电极可以包括具有不同区域的对应的接触表面。可以通过限定载体的每单位长度的不同面积和/或通过限定不同的总长度（例如沿着载体的长度测量）来实现不同的表面积。在一些实施例中，具有不同对应长度的绝缘体部分可以设置在不同的相邻电极之间。绝缘部分可以与载体一体地限定。电连接线可以嵌入在载体内。在制造方法中，多个电极可以可支撑地互连到牺牲衬底的第一侧，并且载体可以互连到电极。反过来，衬底的至少一部分可以从电极去除以产生至少部分完成的电极阵列。衬底可以被配置成预定的构造，其中载体材料可以形成在其内部体积内以限定电极阵列的载体的构造的至少一部分。

10. 再颁专利

USRE39286E1 Multi-blade cutting device 有权
公开(公告)号：USRE39286E1
公开(公告)日：2006-09-19
申请号：US10408308
申请日：2003-04-08
申请人： Michael I. Silver , Wendy L. Silver , Eric Chan , Rama Chorpash , Ira Spool
发明人： Michael I. Silver , Wendy L. Silver , Eric Chan , Rama Chorpash , Ira Spool
IPC分类号： B26B13/06
CPC分类号： B26B13/00
摘要： A cutting device especially designed for cutting up salad greens includes two blades, a rib and handles. The two blades are inter-secured to rotate together about a common axis, but are spaced apart from each other along the common axis. The rib is pivotably secured to the two blades so as to rotate about the common axis, and is curved in a direction of rotation so as to have a concave surface. The handles are integrated with the two blades and the rib to control the two blades and the rib to rotate simultaneously between open and closed positions. The concave surface of the rib is the lead surface when moving from the open position to the closed position, and the cutting edges of the two blades cross edges of the concave surface when moving from the open position to the closed position, so as to perform a cutting action.

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