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1. 发明授权

US08951302B2 Biomimetic vascular network and devices using the same 有权
标题翻译：生物模拟血管网和使用该装置的装置
公开(公告)号：US08951302B2
公开(公告)日：2015-02-10
申请号：US12576826
申请日：2009-10-09
申请人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/04 , A61F2/06 , G01N33/50
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

2. 发明授权

US10327885B2 Biomimetic vascular network and devices using the same 有权
公开(公告)号：US10327885B2
公开(公告)日：2019-06-25
申请号：US14615646
申请日：2015-02-06
申请人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/06 , A61F2/04 , A61F2/02 , G01N33/50
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

3. 发明申请

US20100234678A1 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 有权
标题翻译：生物体血管网络及使用该装置的装置
公开(公告)号：US20100234678A1
公开(公告)日：2010-09-16
申请号：US12576826
申请日：2009-10-09
申请人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/06 , C12N5/02
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

4. 发明申请

US20150366651A1 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 审中-公开
标题翻译：生物体血管网络及使用该装置的装置
公开(公告)号：US20150366651A1
公开(公告)日：2015-12-24
申请号：US14615646
申请日：2015-02-06
申请人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Howard I. Pryor , Ira Spool , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/06 , A61F2/02
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

5. 发明授权

US08591597B2 Biomimetic vascular network and devices using the same 有权
公开(公告)号：US08591597B2
公开(公告)日：2013-11-26
申请号：US12728557
申请日：2010-03-22
申请人： David M. Hoganson , Joseph P. Vacanti , Howard I. Pryor
发明人： David M. Hoganson , Joseph P. Vacanti , Howard I. Pryor
IPC分类号： A61F2/04
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

6. 发明申请

US20110091930A1 WELL-BASED FLOW SYSTEM FOR CELL CULTURE 审中-公开
标题翻译：用于细胞培养的基于细胞的流动系统
公开(公告)号：US20110091930A1
公开(公告)日：2011-04-21
申请号：US12866970
申请日：2009-02-13
申请人： Joseph P. Vacanti , Howard I. Pryor , Craig M. Neville , Ira Spool
发明人： Joseph P. Vacanti , Howard I. Pryor , Craig M. Neville , Ira Spool
IPC分类号： C12Q1/20 , C12M3/00 , C12N5/071
CPC分类号： G01N33/5014 , C12M25/04 , C12M35/08 , G01N33/5067
摘要： A well-based flow system for cell culture is described which provides for flow of culture containing compounds for drug screening to be exposed to cells seeded on a membrane. The flow of medium may be planar or radial and means are provided for the removal of waste media through fluid outlets in fluid communication with the assay well plates through conduits. Methods of using the system for cell culture and drug toxicity screening are also provided including coculturing cells such as hepatocytes, stem cells, fibroblasts and smooth muscle cells and selectively exposing cells to test compounds.
摘要翻译：描述了用于细胞培养的基于基础的流动系统，其提供含有用于药物筛选的化合物的培养物流，以暴露于接种在膜上的细胞。介质的流动可以是平面的或径向的，并且提供了用于通过导管与测定孔板流体连通的流体出口去除废弃介质的装置。还提供了使用该系统用于细胞培养和药物毒性筛选的方法，包括共培养细胞如肝细胞，干细胞，成纤维细胞和平滑肌细胞，并选择性地将细胞暴露于测试化合物。

7. 发明授权

US10670585B2 System and method for in vitro blood vessel modeling 审中-公开
公开(公告)号：US10670585B2
公开(公告)日：2020-06-02
申请号：US15440888
申请日：2017-02-23
申请人： David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： G01N33/50 , A61L27/18 , A61L27/38 , A61L27/50 , A61L27/56 , C12M3/00 , C12M1/12 , C12M1/42 , C12M1/00 , G09B23/28 , B01L3/00
摘要： The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.

8. 发明申请

US20170241991A1 SYSTEM AND METHOD FOR IN VITRO BLOOD VESSEL MODELING 审中-公开
公开(公告)号：US20170241991A1
公开(公告)日：2017-08-24
申请号：US15440888
申请日：2017-02-23
申请人： David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： G01N33/50 , B01L3/00
CPC分类号： G01N33/5088 , A61L27/18 , A61L27/38 , A61L27/507 , A61L27/56 , B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0681 , C12M21/08 , C12M23/34 , C12M25/02 , C12M35/08 , G09B23/28 , C08L69/00
摘要： The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.

9. 发明授权

US09595206B2 System and method for in vitro blood vessel modeling 有权
标题翻译：用于体外血管建模的系统和方法
公开(公告)号：US09595206B2
公开(公告)日：2017-03-14
申请号：US12866968
申请日：2009-02-11
申请人： David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： C12Q1/02 , G09B23/28 , A61L27/18 , A61L27/38 , A61L27/50 , A61L27/56 , C12M3/00 , C12M1/12 , C12M1/42 , C12M1/00 , B01L3/00
CPC分类号： G01N33/5088 , A61L27/18 , A61L27/38 , A61L27/507 , A61L27/56 , B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0681 , C12M21/08 , C12M23/34 , C12M25/02 , C12M35/08 , G09B23/28 , C08L69/00
摘要： The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.
摘要翻译：本发明提供了用于研究药物诱导的血管损伤和其它血管病变的体外血管模型。体外血管模型提供了由多孔膜分离的两个通道，其通过内皮细胞层在一侧被涂覆并且被另一侧涂覆在平滑肌细胞层上，其中所述模型易于血液外渗由于药物引起的血管损伤，穿过所述多孔膜的细胞。

10. 发明申请

US20100274353A1 BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 有权
公开(公告)号：US20100274353A1
公开(公告)日：2010-10-28
申请号：US12728557
申请日：2010-03-22
申请人： Howard I. Pryor , David M. Hoganson , Joseph P. Vacanti
发明人： Howard I. Pryor , David M. Hoganson , Joseph P. Vacanti
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

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