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1. 发明授权

US09352283B2 Tubular fiber membrane with nanoporous skin 有权
标题翻译：管状纤维膜与纳米多孔皮肤
公开(公告)号：US09352283B2
公开(公告)日：2016-05-31
申请号：US13881705
申请日：2010-10-25
申请人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
发明人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
IPC分类号： B01D63/02 , B01D63/06 , B01D71/68 , A61M1/16 , B01D67/00 , B01D69/08 , D01D5/06 , D01D5/247 , A61M1/36
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。表皮层中的孔可具有小于约7nm的平均孔径，并且管腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

2. 发明申请

US20130206673A1 TUBULAR FIBER MEMBRANE WITH NANOPOROUS SKIN 有权
标题翻译：管状纤维膜与纳米皮肤
公开(公告)号：US20130206673A1
公开(公告)日：2013-08-15
申请号：US13881705
申请日：2010-10-25
申请人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
发明人： Jackie Y. Ying , Rensheng Deng , Min Hu , Ming Ni
IPC分类号： B01D63/02 , D01D5/06 , D01D5/247
CPC分类号： B01D63/02 , A61M1/1621 , A61M1/1625 , A61M1/3689 , B01D63/06 , B01D67/0088 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2313/44 , D01D5/06 , D01D5/247
摘要： A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.
摘要翻译：提供了一种用于形成管状纤维膜的湿式纺丝方法。管状纤维膜具有纳米孔表皮层和微孔腔层。表皮层限定纤维膜的外表面，内腔层限定纤维膜的内表面。皮肤层中的孔可以具有小于约7nm的平均孔径，并且内腔层中的孔可具有约0.5至约3μm的平均孔径。纤维膜可以用于人造肾近端小管，人造肾，生物反应器或纤维筒。

3. 发明授权

US08834780B2 Hydrodynamic spinning of polymer fiber in coaxial laminar flows 有权
标题翻译：聚合物纤维在同轴层流中的流体动力学纺丝
公开(公告)号：US08834780B2
公开(公告)日：2014-09-16
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06 , D01D5/24 , A61L27/52 , D01D5/38 , D01D5/28
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

4. 发明申请

US20110006453A1 HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS 有权
标题翻译：聚合纤维在同轴层流中的水动力纺丝
公开(公告)号：US20110006453A1
公开(公告)日：2011-01-13
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

5. 发明申请

US20120196345A1 DOUBLE COATING PROCEDURE FOR THE MEMBRANES OF BIOARTIFICIAL KIDNEYS 有权
标题翻译：生物科学家膜的双重涂层程序
公开(公告)号：US20120196345A1
公开(公告)日：2012-08-02
申请号：US13019352
申请日：2011-02-02
申请人： Daniele Zink , Ming Ni , Jackie Y. Ying
发明人： Daniele Zink , Ming Ni , Jackie Y. Ying
IPC分类号： C12N11/08 , B01D61/28 , C12N11/06
CPC分类号： C12N11/06 , B01D67/0088
摘要： The present invention generally relates to modified substrates such as membranes for use in bioartificial organs, such as bioartificial kidneys, and other applications. Certain aspects are generally directed to a membrane or other substrate modified to facilitate the attachment of cells. In one set of embodiments, the substrate or membrane may be at least partially coated with an adhesive such as 3,4-dihydroxy-L-phenylalanine (DOPA), poly(dopamine), or other adhesive comprising a molecule having a catechol moiety, for example on one side of the membrane or substrate. On at least a portion of the adhesive coated portion of the substrate, a protein may be coated, such as an extracellular matrix protein (for example, a collagen), to which cells such as primary human renal proximal tubule cells may be adhered. Surprisingly, such a dual coating may be used to promote the attachment of such cells to a membrane or other substrate that otherwise may not promote cell adhesion. In certain embodiments, the coating may also facilitate or promote not only cell adhesion, but also cell proliferation and/or differentiation. Such membranes or other substrates may be useful, for example, in bioartificial organs such as bioartificial kidneys, hemodialysis cartridges, bioimplants, biosensors, bioreactors, etc. In certain embodiments, cells may be attached to a membrane or other substrate on only one side, while the other side may be kept free of attached cells.
摘要翻译：本发明一般涉及用于生物人造器官例如生物人造肾等的改性底物，例如膜。某些方面通常涉及修饰以便于细胞附着的膜或其他底物。在一组实施方案中，基底或膜可以至少部分地涂覆有粘合剂，例如3,4-二羟基-L-苯丙氨酸（DOPA），聚（多巴胺）或包含具有儿茶酚部分的分子的其它粘合剂，例如在膜或基底的一侧。在底物的粘合剂涂覆部分的至少一部分上，可以涂覆蛋白质，例如细胞外基质蛋白（例如胶原），细胞如原发性人肾近端小管细胞可以粘附到细胞上。令人惊奇的是，这种双重涂层可以用于促进这种细胞与膜或其它底物的连接，否则可能不促进细胞粘附。在某些实施方案中，该涂层还可促进或促进细胞粘附，但也促进细胞增殖和/或分化。这样的膜或其它底物可用于例如生物人造器官如生物人造肾，血液透析盒，生物移植物，生物传感器，生物反应器等中。在某些实施方案中，细胞可以仅在一侧附着于膜或其它底物，而另一侧可以保持没有附着的细胞。

6. 发明授权

US09447407B2 Double coating procedure for the membranes of bioartificial kidneys 有权
标题翻译：生物人造肾膜双重涂层程序
公开(公告)号：US09447407B2
公开(公告)日：2016-09-20
申请号：US13019352
申请日：2011-02-02
申请人： Daniele Zink , Ming Ni , Jackie Y. Ying
发明人： Daniele Zink , Ming Ni , Jackie Y. Ying
IPC分类号： C12N11/06 , B01D67/00
CPC分类号： C12N11/06 , B01D67/0088
摘要： The present invention generally relates to modified substrates such as membranes for use in bioartificial organs, such as bioartificial kidneys, and other applications. Certain aspects are generally directed to a membrane or other substrate modified to facilitate the attachment of cells. In one set of embodiments, the substrate or membrane may be at least partially coated with an adhesive such as 3,4-dihydroxy-L-phenylalanine (DOPA), poly(dopamine), or other adhesive comprising a molecule having a catechol moiety, for example on one side of the membrane or substrate. On at least a portion of the adhesive coated portion of the substrate, a protein may be coated, such as an extracellular matrix protein (for example, a collagen), to which cells such as primary human renal proximal tubule cells may be adhered. Surprisingly, such a dual coating may be used to promote the attachment of such cells to a membrane or other substrate that otherwise may not promote cell adhesion. In certain embodiments, the coating may also facilitate or promote not only cell adhesion, but also cell proliferation and/or differentiation. Such membranes or other substrates may be useful, for example, in bioartificial organs such as bioartificial kidneys, hemodialysis cartridges, bioimplants, biosensors, bioreactors, etc. In certain embodiments, cells may be attached to a membrane or other substrate on only one side, while the other side may be kept free of attached cells.
摘要翻译：本发明一般涉及用于生物人造器官例如生物人造肾等的改性底物，例如膜。某些方面通常涉及修饰以便于细胞附着的膜或其他底物。在一组实施方案中，基底或膜可以至少部分地涂覆有粘合剂，例如3,4-二羟基-L-苯丙氨酸（DOPA），聚（多巴胺）或包含具有儿茶酚部分的分子的其它粘合剂，例如在膜或基底的一侧。在底物的粘合剂涂覆部分的至少一部分上，可以涂覆蛋白质，例如细胞外基质蛋白（例如胶原），细胞如原发性人肾近端小管细胞可以粘附到细胞上。令人惊奇的是，这种双重涂层可以用于促进这种细胞与膜或其它底物的连接，否则可能不促进细胞粘附。在某些实施方案中，该涂层还可促进或促进细胞粘附，但也促进细胞增殖和/或分化。这样的膜或其它底物可用于例如生物人造器官如生物人造肾，血液透析盒，生物移植物，生物传感器，生物反应器等中。在某些实施方案中，细胞可以仅在一侧附着于膜或其它底物，而另一侧可以保持没有附着的细胞。

7. 发明授权

US09687464B2 Anti-cancer agent delivery vehicles capable of improved loading 有权
公开(公告)号：US09687464B2
公开(公告)日：2017-06-27
申请号：US13634036
申请日：2011-03-11
申请人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
发明人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
IPC分类号： A61K31/33 , A61K31/282 , A61K9/00 , A61K9/107 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00
摘要： There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.

8. 再颁专利

USRE44820E1 Nanocrystalline apatites and composites, prostheses incorporating them, and methods of their production 有权
标题翻译：纳米晶磷灰石和复合材料，并入其中的假体及其生产方法
公开(公告)号：USRE44820E1
公开(公告)日：2014-04-01
申请号：US13536924
申请日：2012-06-28
申请人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
发明人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
IPC分类号： A61F2/28 , C01B15/16
CPC分类号： A61L27/12 , A61F2/30767 , A61F2310/00239 , A61F2310/00293 , A61F2310/00796 , A61L27/32 , A61L2400/12 , B82Y30/00 , C01B25/32 , C03C4/0007 , C03C14/00 , C04B35/117 , C04B35/447 , C04B35/46 , C04B35/488 , C04B35/6262 , C04B35/62675 , C04B35/645 , C04B2235/3212 , C04B2235/3217 , C04B2235/3225 , C04B2235/3232 , C04B2235/3244 , C04B2235/3246 , C04B2235/5409 , C04B2235/5445 , C04B2235/5454 , C04B2235/549 , C04B2235/608 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/668 , C04B2235/77 , C04B2235/785 , C04B2235/80 , C04B2235/96 , C04B2235/9653 , F16C2240/64 , Y10S977/776
摘要： Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density.Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
摘要翻译：提出了纳米晶磷灰石的合成方法，以及一系列具体的反应参数，可以根据具体方式调整回收产物的特性。提供平均晶体尺寸小于150nm的颗粒状磷灰石组合物。产品还可以具有至少40m 2 / g的表面积，并且可以具有高密度。详细研究了羟基磷灰石材料。本发明的组合物可以用作假体植入物和用于假体植入物的涂层。

9. 发明申请

US20130295637A1 FIBROUS SUBSTRATES FOR CELL PROPAGATION AND DIFFERENTIATION 审中-公开
标题翻译：纤维基质用于细胞传播和分化
公开(公告)号：US20130295637A1
公开(公告)日：2013-11-07
申请号：US13814501
申请日：2011-08-05
申请人： Hongfang Lu , Andrew Chwee Aun Wan , Jackie Y. Ying , Karthikeyan Narayanan
发明人： Hongfang Lu , Andrew Chwee Aun Wan , Jackie Y. Ying , Karthikeyan Narayanan
IPC分类号： C12N11/04
CPC分类号： C12N11/04 , C12N5/0012 , C12N5/0606 , C12N2533/72 , C12N2533/74
摘要： The present invention relates to a method of releasably encapsulating pluripotent embryonic stem cells in a degradable continuous polyionic fiber for tissue culture, wherein the encapsulated embryonic stem cells are able to maintain a pluripotent phenotype in tissue culture; the method comprising (a) contacting an aqueous solution of a polyanion with an aqueous solution of a polycation to form an interface between the aqueous solution of polyanion and the aqueous solution of polycation, and wherein the aqueous solution of polyanion or the aqueous solution of polycation or both the aqueous solution of polyanion and the aqueous solution of polycation comprises a suspension of pluripotent embryonic stem cells; (b) drawing a continuous polyionic fiber which comprises encapsulated pluripotent embryonic stem cells from the interface; (c) passing the continuous polyionic fiber comprising encapsulated pluripotent embryonic stem cells in a continuous process through a solution which reduces secondary complexation of the components of the polyionic fiber.
摘要翻译：本发明涉及一种将多能胚胎干细胞可释放地包封在用于组织培养的可降解连续聚离子纤维中的方法，其中包封的胚胎干细胞能够在组织培养中保持多能表型; 该方法包括（a）将聚阴离子的水溶液与聚阳离子水溶液接触以形成聚阴离子水溶液与聚阳离子水溶液之间的界面，并且其中聚阴离子水溶液或聚阳离子水溶液或聚阴离子水溶液和聚阳离子水溶液两者均包含多能胚胎干细胞的悬浮液; （b）从界面绘制包含多能胚胎干细胞的连续聚离子纤维; （c）使包含多能胚胎干细胞的连续聚离子纤维在连续过程中通过减少聚离子纤维组分的次级络合的溶液。

10. 发明申请

US20130189604A1 NANOCOMPOSITES 有权
公开(公告)号：US20130189604A1
公开(公告)日：2013-07-25
申请号：US13522944
申请日：2011-03-30
申请人： Jackie Y. Ying , Jun Yang
发明人： Jackie Y. Ying , Jun Yang
IPC分类号： H01M4/92 , H01M4/88 , H01M4/96 , H01M4/86
CPC分类号： H01M4/921 , B01J23/50 , B01J27/045 , B01J35/002 , B01J35/004 , B01J35/006 , H01M4/8657 , H01M4/8842 , H01M4/926 , H01M4/96
摘要： The invention pertains to heterogenous noble metal nanostructures comprising silver salts and different noble metals, and methods for synthesis and use of various nanocomposite materials having silver salts and different noble metals.
摘要翻译：本发明涉及包含银盐和不同贵金属的异质贵金属纳米结构体，以及合成和使用具有银盐和不同贵金属的各种纳米复合材料的方法。

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