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1. 发明公开

US20240261480A1 OXYGENATOR OF ORGANIC FLUIDS 审中-公开
公开(公告)号：US20240261480A1
公开(公告)日：2024-08-08
申请号：US18034540
申请日：2021-10-28
申请人： QURA S.R.L.
发明人： Daniele GALAVOTTI
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/1625 , A61M2202/0007 , A61M2202/0014 , A61M2202/0021 , A61M2202/0208 , A61M2202/0225 , A61M2206/20 , A61M2207/10
摘要： The oxygenator (10) of organic fluids comprises a container body (20); a first aperture (21) for the entry of oxygen and a second aperture (22) for the exit of an exhausted gas; a third aperture (23) for the entry of an organic fluid to be oxygenated and a fourth aperture (24) for the exit of an oxygenated organic fluid; an oxygenation chamber (30) to oxygenate the organic fluid to be oxygenated, defined inside the container body (20); and a mass (31) of capillary fibers (32) which are impermeable to liquids and porous to gases, disposed so as to be lapped by the organic fluid inside the oxygenation chamber (30), parallel to each other in a first direction (X).

2. 发明申请

US20180353673A9 EXTRACORPOREAL AMBULATORY ASSIST LUNG 审中-公开
公开(公告)号：US20180353673A9
公开(公告)日：2018-12-13
申请号：US15738406
申请日：2016-06-23
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人： Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
IPC分类号： A61M1/36 , A61M1/10 , A61M1/16
CPC分类号： A61M1/3667 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1036 , A61M1/1625 , A61M1/1698 , A61M1/3666 , A61M2205/7536
摘要： An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.

3. 发明申请

US20090180924A1 Hollow fiber membrane-type artificial lung 失效
标题翻译：中空纤维膜型人造肺
公开(公告)号：US20090180924A1
公开(公告)日：2009-07-16
申请号：US11990566
申请日：2006-10-20
申请人： Tomokazu Niitsuma
发明人： Tomokazu Niitsuma
IPC分类号： A61M1/36
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D53/22 , B01D63/02 , B01D2313/22 , B01D2313/38 , B01D2317/04
摘要： A hollow fiber bundle that is formed by arranging a plurality of porous hollow fiber membranes 8 in one direction; a heat exchange pipe bundle that is formed by arranging and laminating a plurality of heat exchange pipes 9 in one direction crossing the hollow fiber membranes and is apposed with the hollow fiber bundle; and a potting material 10 that is filled in a region including both end parts of the hollow fiber membranes and the heat exchange pipes and forms a blood channel extending across the hollow fiber membranes and the heat exchange pipes are provided. The housing includes: blood ports 3a, 3b that face both ends of the blood channel; gas headers 4a, 4b that form gas ports 5a, 5b facing both ends of the hollow fiber bundle; and heat exchange headers 6a, 6b that form heat exchange liquid ports 7a, 7b facing both ends of the heat exchange pipe bundle. The blood flows through the blood channel and an oxygen-containing gas flows through a bore of the hollow fiber membrane so as to perform the gas exchange, and the heat exchange liquid flows through a bore of the heat exchange pipe so as to perform the heat exchange. A hollow fiber membrane-type artificial lung, in which the heat exchange part is apposed with the gas exchange part without unnecessarily increasing a priming volume, can be structured.
摘要翻译：中空纤维束，其通过在一个方向上排列多个多孔中空丝膜8而形成; 通过在与中空纤维膜交叉的一个方向上配置多个热交换管9并配置中空纤维束而形成的热交换管束，以及填充在包括中空纤维膜的两个端部的区域和热交换管中的灌封材料10，并且形成横跨中空纤维膜和热交换管延伸的血液通道。壳体包括：血液通道3a，3b，其面向血液通道的两端; 气体集管4a，4b，其形成面对中空纤维束两端的气体口5a，5b; 以及形成面对热交换管束的两端的热交换液体口7a，7b的热交换头6a，6b。血液流过血液通道，含氧气体流过中空纤维膜的孔，进行气体交换，热交换液体流过热交换管的孔，从而进行热量交换。可以构造中空纤维膜型人造肺，其中热交换部分配置有气体交换部分而不必增加启动体积。

4. 发明申请

US20070102340A1 BLOOD TREATMENT FILTER AND METHOD OF MANUFACTURING 审中-公开
标题翻译：血液处理过滤器及其制造方法
公开(公告)号：US20070102340A1
公开(公告)日：2007-05-10
申请号：US11553148
申请日：2006-10-26
申请人： Martin Stillig , Jeffrey Burbank , Goetz Friederichs , James Brugger
发明人： Martin Stillig , Jeffrey Burbank , Goetz Friederichs , James Brugger
IPC分类号： B01D63/00
CPC分类号： B01D63/021 , A61M1/1625 , B01D63/02 , B01D2313/20
摘要： A configuration of a blood microtubular filter/dializer used in many kinds of renal replacement therapy systems is disclosed which may allow a straight thin-walled tube to be used for a majority of the structure of the housing and other benefits disclosed.
摘要翻译：公开了用于许多种类的肾脏置换治疗系统中的血液微管过滤器/拨号器的结构，其可以允许将直的薄壁管用于壳体的大部分结构和所公开的其它益处。

5. 发明申请

US20050281705A1 Methods, apparatuses, and applications for compliant membrane blood gas exchangers 有权
公开(公告)号：US20050281705A1
公开(公告)日：2005-12-22
申请号：US11211115
申请日：2005-08-24
申请人： J.D. Mortensen , Robert Schaap , Barry Bagley
发明人： J.D. Mortensen , Robert Schaap , Barry Bagley
IPC分类号： A61M1/16 , A61M1/14
CPC分类号： A61M1/16 , A61M1/1625 , A61M1/1698 , Y10S128/03 , Y10S261/28
摘要： A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.

6. 发明申请

US20050232811A1 Intravenous oxygenator 有权
标题翻译：静脉给药
公开(公告)号：US20050232811A1
公开(公告)日：2005-10-20
申请号：US10522331
申请日：2003-07-22
申请人： Rudiger Autschbach , Gjorgio Cattaneo , Helmut Reul
发明人： Rudiger Autschbach , Gjorgio Cattaneo , Helmut Reul
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1678 , A61M1/262
摘要： An intravenous oxygenator for enriching blood with oxygen, said oxygenator having a bundle of fibers, said fibers being each connected to a gas supply means through a first connection and to a gas evacuation means through a second connection, with the fiber bundle being twisted during operation by relative rotation of the first connections of the fibers relative to the second connections of the fibers about a longitudinal axis of the oxygenator. Further, an intravenous oxygenator for insertion into a vein, the connections being respectively connected to a first and to a second fiber holder and being displaceable along a longitudinal axis of the oxygenator, with the fiber holders being mounted so as to be rotatable relative to one another about the longitudinal axis of the oxygenator. Such a constellation permits particularly efficient gas exchange.
摘要翻译：一种用氧气富集血液的静脉给药器，所述充氧器具有一束纤维，所述纤维各自通过第一连接与气体供给装置连接，并通过第二连接与气体排出装置相连，纤维束在操作期间被扭曲通过纤维的第一连接相对于纤维围绕氧合器纵轴的相对旋转。此外，用于插入静脉的静脉内氧合器，所述连接分别连接到第一和第二纤维保持器，并且可沿着所述充氧器的纵向轴线移动，其中所述纤维保持器被安装成可相对于一个另一个关于氧合器的纵向轴线。这样的星座允许特别有效的气体交换。

7. 发明授权

US06508983B1 Exchanger apparatus and method of manufacture 失效
标题翻译：交换器和制造方法
公开(公告)号：US06508983B1
公开(公告)日：2003-01-21
申请号：US09356762
申请日：1999-07-19
申请人： Laura L. McBurney , Tom L. Clark , Randy E. Livingston
发明人： Laura L. McBurney , Tom L. Clark , Randy E. Livingston
IPC分类号： A61M114
CPC分类号： B01D63/025 , A61M1/1625 , A61M1/1698 , B01D63/02 , B01D63/022 , B01D65/00
摘要： An exchanger and method for manufacturing the same are disclosed. In one embodiment, the exchanger crimps a hollow fiber bundle along a length of a cylindrical case in at least two radial positions. At least one crimp is between an inlet port and an outlet port of a blood conduit. Preferably, the cylindrical case has two portions with different radii so that when the two portions are mated to enclose the hollow fiber bundle, crimping is achieved. In this way, shunting of blood is avoided by being forced to pass a crimped position between the inlet and outlet ports to more evenly distribute the blood among the fibers of the bundle. In another embodiment, a method for making an exchanger includes filling a chamber, integral to the exchanger, with uncured potting material. The exchanger is spun to distribute the uncured potting material about open ends of an encasement. After curing, a portion of the potting material and the hollow fiber bundle are trimmed away. Preferably, the cured potting material includes an annular relief.
摘要翻译：公开了一种交换器及其制造方法。在一个实施例中，交换器在至少两个径向位置沿着圆柱形壳体的长度卷曲中空纤维束。至少一个卷曲位于血液导管的入口和出口之间。优选地，圆筒形壳体具有两个具有不同半径的部分，使得当两个部分配合以包围中空纤维束时，实现卷曲。以这种方式，通过被迫通过入口和出口之间的卷曲位置来避免血液分流，以使血液在束的纤维之间更均匀地分布。在另一个实施例中，制造交换器的方法包括用未固化的灌封材料填充与交换器成一体的室。将交换器旋转以将未固化的灌封材料围绕包装的开放端分布。固化后，将一部分灌封材料和中空纤维束修剪掉。优选地，固化的灌封材料包括环形浮雕。

8. 发明授权

US5762868A Blood oxygenator and heat exchanger 失效
标题翻译：血液充氧器和换热器
公开(公告)号：US5762868A
公开(公告)日：1998-06-09
申请号：US565438
申请日：1995-11-30
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/14 , A61M1/16 , A61M1/18 , A61M1/36 , B01D63/02 , A61M1/34
CPC分类号： B01D63/026 , A61M1/1625 , A61M1/1629 , A61M1/1698 , B01D63/02 , B01D2313/38 , Y10T428/2927
摘要： An integral blood oxygenator and heat exchanger device for oxygenating and heating or cooling a patient's blood during heart bypass surgery. The device preferably includes a pleated blood filter disposed within a gap formed between the opposite ends of the blood oxygenating medium. A blood inlet manifold closely receives a tubular heat exchanging barrier and directs blood flow around the barrier to a blood outlet slot. The blood oxygenating medium covers the blood outlet slot so that blood must flow through the blood oxygenating medium before reaching the blood filter. A vent port and bypass port may be provided in the gap formed by the opposite ends of the blood oxygenating medium upstream of the blood filter.
摘要翻译：用于在心脏旁路手术期间对患者血液进行氧化和加热或冷却的整体式血氧机和热交换器装置。该装置优选地包括设置在形成在血液充氧介质的相对端之间的间隙内的褶式血液过滤器。血液入口歧管紧密地接收管状热交换屏障，并将血液围绕屏障引导到血液出口狭槽。血液充氧介质覆盖血液出口狭缝，使血液在到达血液过滤器之前必须流经血液充氧介质。可以在由血液过滤器上游的血液充氧介质的相对端形成的间隙中设置排气口和旁通口。

9. 发明授权

US5747138A Multilayer hollow-fiber body and method of making 失效
标题翻译：多层中空纤维体及其制造方法
公开(公告)号：US5747138A
公开(公告)日：1998-05-05
申请号：US822523
申请日：1997-04-16
申请人： Ronald J. Leonard
发明人： Ronald J. Leonard
IPC分类号： A61M1/18 , A61M1/16 , B01D63/02 , B32B5/12
CPC分类号： B01D63/026 , A61M1/1625 , B01D63/02 , B01D63/021 , A61M1/1698 , B01D2313/025 , Y10T428/24124 , Y10T428/24215 , Y10T428/24231
摘要： A multilayer hollow fiber body useful, for example, in a blood oxygenator. The multilayer hollow fiber body comprises a single hollow fiber mat arranged in the form of a body comprising a plurality of hollow fiber plies. The mat comprises a plurality of generally parallel hollow fibers disposed at regular intervals, and a plurality of connecting fibers holding the connecting fibers. The mat is repeatedly folded over on itself along fold lines, each of which is at an oblique angle to the hollow fibers, to form a multilayer hollow fiber body in which the hollow fibers of any ply of the multilayer hollow fiber body are disposed so as to cross the hollow fibers of an adjacent successive ply of the multilayer hollow fiber body. Also disclosed is a method of making the multilayer hollow fiber body.
摘要翻译：可用于例如在血液充氧器中的多层中空纤维体。多层中空纤维体包括以包括多个中空纤维层的主体的形式布置的单个中空纤维垫。垫包括以规则间隔布置的多个大致平行的中空纤维，以及多个连接纤维，其保持连接纤维。该折叠线沿着与中空纤维成倾斜角的折叠线重复折叠，形成多层中空纤维体，多层中空纤维体的任何层的中空纤维被设置为以交叉多层中空纤维体的相邻连续层的中空纤维。还公开了制造多层中空纤维体的方法。

10. 发明授权

US5578267A Cylindrical blood heater/oxygenator 失效
公开(公告)号：US5578267A
公开(公告)日：1996-11-26
申请号：US511287
申请日：1995-08-04
申请人： Louis C. Cosentino , Jeffrey A. Lee , Daniel A. Baker
发明人： Louis C. Cosentino , Jeffrey A. Lee , Daniel A. Baker
IPC分类号： A61M1/16 , B01D63/02 , B01D63/04 , A61M1/14
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , B01D63/025 , B01D63/04 , B01D2313/38 , Y10S261/28
摘要： A combination heat exchanger and oxygenator device is provided. The device includes a generally cylindrical housing having first and second compartments with hollow heat exchange tubes and hollow gas exchange tubes disposed therein, a blood inlet, a blood outlet, a heat exchanges medium inlet, a heat exchange medium outlet, an oxygenating fluid inlet and an oxygenating fluid outlet. The housing has a central axis with the second compartment being concentric thereto. The blood flow passage is defined by blood entering the device generally axially through a path extending along the central axis of the housing and flows generally radially through the second, oxygenating compartment.

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