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1. 发明授权

US09585632B2 Estimation of a mechanical property of anatomy from medical scan data 有权
标题翻译：从医学扫描数据估计解剖学的力学性质
公开(公告)号：US09585632B2
公开(公告)日：2017-03-07
申请号：US14259801
申请日：2014-04-23
申请人： Jingjing Kanik , Puneet Sharma , Tommaso Mansi , Razvan Ionasec , Ali Kamen , Dorin Comaniciu , James S. Duncan
发明人： Jingjing Kanik , Puneet Sharma , Tommaso Mansi , Razvan Ionasec , Ali Kamen , Dorin Comaniciu , James S. Duncan
IPC分类号： A61B8/00 , A61B8/08
CPC分类号： A61B8/0883 , A61B8/5223 , A61B8/5276
摘要： A mechanical property of anatomy is estimated from a patient in vivo, such as estimating a patient-specific material property of a valve. A morphological model is used to determine anatomy dynamics. A biomechanical model, using the anatomy dynamics, predicts the dynamics, based, at least in part, on one or more material properties. Using an inverse solution based on comparison of dynamics predicted by the biomechanical model and the dynamics determined from the morphological model, values for the material properties are determined.
摘要翻译：从患者身体估计解剖学的机械性质，例如估计瓣膜的患者特异性材料性质。使用形态学模型来确定解剖动力学。使用解剖动力学的生物力学模型预测动力学，至少部分地基于一种或多种材料性质。使用基于生物力学模型预测的动力学与从形态学模型确定的动力学的比较的逆解决方案，确定材料性质的值。

2. 发明申请

US20150305706A1 ESTIMATION OF A MECHANICAL PROPERTY OF ANATOMY FROM MEDICAL SCAN DATA 有权
标题翻译：从医学扫描数据估计解剖学的机械性质
公开(公告)号：US20150305706A1
公开(公告)日：2015-10-29
申请号：US14259801
申请日：2014-04-23
申请人： Jingjing Kanik , Puneet Sharma , Tommaso Mansi , Razvan Ionasec , Ali Kamen , Dorin Comaniciu , James S. Duncan
发明人： Jingjing Kanik , Puneet Sharma , Tommaso Mansi , Razvan Ionasec , Ali Kamen , Dorin Comaniciu , James S. Duncan
IPC分类号： A61B8/08
CPC分类号： A61B8/0883 , A61B8/5223 , A61B8/5276
摘要： A mechanical property of anatomy is estimated from a patient in vivo, such as estimating a patient-specific material property of a valve. A morphological model is used to determine anatomy dynamics. A biomechanical model, using the anatomy dynamics, predicts the dynamics, based, at least in part, on one or more material properties. Using an inverse solution based on comparison of dynamics predicted by the biomechanical model and the dynamics determined from the morphological model, values for the material properties are determined.
摘要翻译：从患者身体估计解剖学的机械性质，例如估计瓣膜的患者特异性材料性质。使用形态学模型来确定解剖动力学。使用解剖动力学的生物力学模型预测动力学，至少部分地基于一种或多种材料性质。使用基于生物力学模型预测的动力学与从形态学模型确定的动力学的比较的逆解决方案，确定材料性质的值。

3. 发明申请

US20140136174A1 System and Method for Patient Specific Modeling of Liver Tumor Ablation 有权
标题翻译：肝脏肿瘤消融患者特异性建模的系统和方法
公开(公告)号：US20140136174A1
公开(公告)日：2014-05-15
申请号：US14071688
申请日：2013-11-05
申请人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
发明人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
IPC分类号： G06F19/12
CPC分类号： G16H50/50 , G06F19/00 , G06F19/3481 , G09B23/30
摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.
摘要翻译：公开了一种基于肝肿瘤消融的患者特异性模型的肿瘤消融计划和指导的方法和系统。根据患者的3D医学图像数据估计肝脏和肝脏循环系统的患者特异性解剖模型。根据患者特异性解剖模型模拟肝脏和肝脏循环系统的血流。基于虚拟消融探针位置和肝脏和肝脏静脉系统中的模拟血流模拟了消融引起的热扩散。基于模拟热扩散模拟肝脏细胞坏死。生成模拟坏死区域的可视化，并向用户显示决策和最佳治疗计划和指导。

4. 发明授权

US09846765B2 System and method for patient specific modeling of liver tumor ablation 有权
公开(公告)号：US09846765B2
公开(公告)日：2017-12-19
申请号：US14071688
申请日：2013-11-05
申请人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
发明人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
IPC分类号： G06F19/00 , G06F19/10 , G09B23/30
CPC分类号： G16H50/50 , G06F19/00 , G06F19/3481 , G09B23/30
摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.

5. 发明申请

US20140296842A1 Patient Specific Planning and Simulation of Ablative Procedures 有权
标题翻译：消融程序的患者具体规划和模拟
公开(公告)号：US20140296842A1
公开(公告)日：2014-10-02
申请号：US13854991
申请日：2013-04-02
申请人： Tommaso Mansi , Puneet Sharma , Viorel Mihalef , Ali Kamen , Saikiran Rapaka , Dorin Comaniciu
发明人： Tommaso Mansi , Puneet Sharma , Viorel Mihalef , Ali Kamen , Saikiran Rapaka , Dorin Comaniciu
IPC分类号： A61B19/00 , G06F17/50 , A61B18/12
CPC分类号： A61B19/50 , A61B18/1233 , A61B34/10 , A61B2018/00577 , A61B2034/104 , A61B2034/105
摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.
摘要翻译：模拟了器官中由于消融装置而导致的患者特异性温度分布。模拟消融的效果。建模是患者特异性的。从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。生成温度图以显示术前分析中消融的效果。可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。可能包括其他模型，例如消融期间的组织损伤。

6. 发明授权

US09259287B2 Patient specific planning and simulation of ablative procedures 有权
标题翻译：消融程序的患者具体规划和模拟
公开(公告)号：US09259287B2
公开(公告)日：2016-02-16
申请号：US13854991
申请日：2013-04-02
申请人： Tommaso Mansi , Puneet Sharma , Viorel Mihalef , Ali Kamen , Saikiran Rapaka , Dorin Comaniciu
发明人： Tommaso Mansi , Puneet Sharma , Viorel Mihalef , Ali Kamen , Saikiran Rapaka , Dorin Comaniciu
IPC分类号： A61B18/12 , A61B19/00 , A61B18/00
CPC分类号： A61B19/50 , A61B18/1233 , A61B34/10 , A61B2018/00577 , A61B2034/104 , A61B2034/105
摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.
摘要翻译：模拟了器官中由于消融装置而导致的患者特异性温度分布。模拟消融的效果。建模是患者特异性的。从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。生成温度图以显示术前分析中消融的效果。可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。可能包括其他模型，例如消融期间的组织损伤。

7. 发明授权

US09129053B2 Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model 有权
标题翻译：使用多物理流体 - 固体心脏模型的医学数据和图像进行高级测量计算和治疗计划的方法和系统
公开(公告)号：US09129053B2
公开(公告)日：2015-09-08
申请号：US13757517
申请日：2013-02-01
申请人： Tommaso Mansi , Viorel Mihalef , Xudong Zheng , Bogdan Georgescu , Saikiran Rapaka , Puneet Sharma , Ali Kamen , Dorin Comaniciu
发明人： Tommaso Mansi , Viorel Mihalef , Xudong Zheng , Bogdan Georgescu , Saikiran Rapaka , Puneet Sharma , Ali Kamen , Dorin Comaniciu
IPC分类号： G06F19/00 , G06T19/00
CPC分类号： G06F19/3437 , G06F19/00 , G06T19/00 , G06T2210/41 , G16H50/50
摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.
摘要翻译：用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。计算模型包括生物力学，电生理学和血液动力学。为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。估计的模型参数然后构成可用于决策的新的高级测量。

8. 发明申请

US20130197884A1 Method and System for Advanced Measurements Computation and Therapy Planning from Medical Data and Images Using a Multi-Physics Fluid-Solid Heart Model 有权
标题翻译：使用多物理流体固体心脏模型的医学数据和图像的高级测量计算和治疗计划的方法和系统
公开(公告)号：US20130197884A1
公开(公告)日：2013-08-01
申请号：US13757517
申请日：2013-02-01
申请人： Tommaso Mansi , Viorel Mihalef , Xudong Zheng , Bogdan Georgescu , Saikiran Rapaka , Puneet Sharma , Ali Kamen , Dorin Comaniciu
发明人： Tommaso Mansi , Viorel Mihalef , Xudong Zheng , Bogdan Georgescu , Saikiran Rapaka , Puneet Sharma , Ali Kamen , Dorin Comaniciu
IPC分类号： G06F19/00
CPC分类号： G06F19/3437 , G06F19/00 , G06T19/00 , G06T2210/41 , G16H50/50
摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.
摘要翻译：用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。计算模型包括生物力学，电生理学和血液动力学。为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。估计的模型参数然后构成可用于决策的新的高级测量。

9. 发明授权

US08682626B2 Method and system for comprehensive patient-specific modeling of the heart 有权
标题翻译：心脏综合患者特异性建模的方法和系统
公开(公告)号：US08682626B2
公开(公告)日：2014-03-25
申请号：US13091076
申请日：2011-04-20
申请人： Razvan Ioan Ionasec , Ingmar Voigt , Viorel Mihalef , Sasa Grbic , Dime Vitanovski , Yang Wang , Yefeng Zheng , Bogdan Georgescu , Dorin Comaniciu , Puneet Sharma , Tommaso Mansi
发明人： Razvan Ioan Ionasec , Ingmar Voigt , Viorel Mihalef , Sasa Grbic , Dime Vitanovski , Yang Wang , Yefeng Zheng , Bogdan Georgescu , Dorin Comaniciu , Puneet Sharma , Tommaso Mansi
IPC分类号： G06G7/48
CPC分类号： G06T13/20 , G06F19/321 , G06T2210/24 , G06T2210/41 , G16H50/50
摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.
摘要翻译：公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟血液流动在下一个时间步。代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

10. 发明授权

US09141763B2 Method and system for patient-specific computational modeling and simulation for coupled hemodynamic analysis of cerebral vessels 有权
标题翻译：用于患者特异性计算建模和模拟脑血管耦合血流动力学分析的方法和系统
公开(公告)号：US09141763B2
公开(公告)日：2015-09-22
申请号：US13366677
申请日：2012-02-06
申请人： Puneet Sharma , Tommaso Mansi , Viorel Mihalef , Jingdan Zhang , David Liu , Shaohua Kevin Zhou , Bogdan Georgescu , Dorin Comaniciu
发明人： Puneet Sharma , Tommaso Mansi , Viorel Mihalef , Jingdan Zhang , David Liu , Shaohua Kevin Zhou , Bogdan Georgescu , Dorin Comaniciu
IPC分类号： G06G7/48 , G06G7/50 , G06F19/00
CPC分类号： G06F19/3437 , G06F19/00 , G16H50/50
摘要： A method and system for patient-specific computational modeling and simulation for coupled hemodynamic analysis of cerebral vessels is disclosed. An anatomical model of a cerebral vessel is extracted from 3D medical image data. The anatomical model of the cerebral vessel includes an inner wall and an outer wall of the cerebral vessel. Blood flow in the cerebral vessel and deformation of the cerebral vessel wall are simulated using coupled computational fluid dynamics (CFD) and computational solid mechanics (CSM) simulations based on the anatomical model of the cerebral vessel.
摘要翻译：公开了一种用于脑血管耦合血流动力学分析的患者特异性计算建模和模拟方法及系统。从3D医学图像数据中提取脑血管的解剖模型。脑血管的解剖模型包括脑血管的内壁和外壁。基于脑血管解剖模型，使用耦合计算流体动力学（CFD）和计算固体力学（CSM）模拟模拟脑血管中的血流和脑血管壁的变形。

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