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1. 发明申请

US20060253261A1 Digitizing biology 审中-公开
标题翻译：数字化生物学
公开(公告)号：US20060253261A1
公开(公告)日：2006-11-09
申请号：US11484040
申请日：2006-07-11
申请人： John Maier , Patrick Treado , Jeffrey Cohen , Jason Neiss
发明人： John Maier , Patrick Treado , Jeffrey Cohen , Jason Neiss
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G01N21/65
摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
摘要翻译：用于确定疾病进展的方法和装置。确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。用光照射含有至少一个电池的样品。收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。在多个预定向量空间中分析变换点的分布。根据分析，对样本的疾病状况进行分类。

2. 发明申请

US20060209301A1 Method and apparatus for compact spectrometer for fiber array spectral translator 有权
标题翻译：用于光纤阵列光谱转换器的紧凑型光谱仪的方法和装置
公开(公告)号：US20060209301A1
公开(公告)日：2006-09-21
申请号：US11366531
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

3. 发明申请

US20060001867A1 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US20060001867A1
公开(公告)日：2006-01-05
申请号：US10879632
申请日：2004-06-30
申请人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
发明人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

4. 发明申请

US20060268266A1 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
公开(公告)号：US20060268266A1
公开(公告)日：2006-11-30
申请号：US11366660
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

5. 发明申请

US20060203238A1 Method and apparatus for compact spectrometer for detecting hazardous agents 有权
标题翻译：用于检测危险物质的紧凑型光谱仪的方法和装置
公开(公告)号：US20060203238A1
公开(公告)日：2006-09-14
申请号：US11366532
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01J3/45
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
摘要： The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

6. 发明申请

US20100217537A1 Method and Apparatus for Multimodal Detection 有权
标题翻译：多模态检测方法与装置
公开(公告)号：US20100217537A1
公开(公告)日：2010-08-26
申请号：US12718362
申请日：2010-03-05
申请人： Jason Neiss , Patrick Treado , Robert C. Schweitzer
发明人： Jason Neiss , Patrick Treado , Robert C. Schweitzer
IPC分类号： G01J3/44 , G06F19/00
CPC分类号： G01J3/28
摘要： System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.
摘要翻译：用于评估包含多个实体的样品中未知物质的发生的系统和方法。提供了包括代表至少一种已知物质的多个参考数据集的参考文库。评估实体的第一特征，其中第一特征是未知物质的特征。选择感兴趣区域，其中感兴趣区域包括展示第一特征的至少一个实体。获得空间精确的波长分辨拉曼图像，其中图像中的每个像素是相应位置处样品的拉曼光谱。评估空间上准确的波长分辨图像，从而识别未知物质。

7. 发明申请

US20120134582A1 System and Method for Multimodal Detection of Unknown Substances Including Explosives 审中-公开
标题翻译：包括爆炸物在内的未知物质的多模态检测系统和方法
公开(公告)号：US20120134582A1
公开(公告)日：2012-05-31
申请号：US13193860
申请日：2011-07-29
申请人： Patrick Treado , Robert Schewitzer , Jason Neiss
发明人： Patrick Treado , Robert Schewitzer , Jason Neiss
IPC分类号： G06K9/00
CPC分类号： G01J3/28
摘要： A system and method for identifying an unknown substance in a sample comprising multiple entities. A method may comprise generating a RGB image representative of a sample and assessing said RGB image to identify at least one region of interest. This region of interest may he assessed to generate a spatially accurate wavelength resolved image, which may be a hyperspectral image. This spatially accurate wavelength resolved image may comprise a fluorescence, Raman, near infrared, short wave infrared, mid wave infrared and/or long wave infrared image. This spatially accurate wavelength resolved image may be assessed to identify said unknown substance. A system may comprise: a reference database, a first detector for generating an RGB image, a second detector for generating a spatially accurate wavelength resolved image, and a means for assessing said RGB image and said spatially accurate wavelength resolved image.
摘要翻译：一种用于识别包含多个实体的样品中的未知物质的系统和方法。方法可以包括生成代表样本的RGB图像并评估所述RGB图像以识别至少一个感兴趣的区域。他可以评估该感兴趣的区域以产生空间准确的波长分辨图像，其可以是高光谱图像。该空间准确的波长分辨图像可以包括荧光，拉曼，近红外，短波红外，中波红外和/或长波红外图像。可以评估该空间上准确的波长分辨图像以识别所述未知物质。系统可以包括：参考数据库，用于产生RGB图像的第一检测器，用于产生空间上精确的波长分辨图像的第二检测器，以及用于评估所述RGB图像和所述空间上精确的波长分辨图像的装置。

8. 发明授权

US07532320B2 Multimodal method for identifying hazardous agents 有权
标题翻译：用于识别危险物质的多模态方法
公开(公告)号：US07532320B2
公开(公告)日：2009-05-12
申请号：US11000841
申请日：2004-11-30
申请人： Jason Neiss , Matthew P. Nelson , Patrick Treado , Robert Schweitzer
发明人： Jason Neiss , Matthew P. Nelson , Patrick Treado , Robert Schweitzer
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/4406 , G01N21/6458
摘要： The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.
摘要翻译：本发明涉及通过对样品进行多峰频谱分析来评估样品中危险剂的发生的装置和方法。公开了对具有特征性危险物质的一种或多种光学特性的样品中的实体采用拉曼光谱的方法。还公开了适于执行这些方法的装置和系统。

9. 发明申请

US20080192246A1 MULTIMODAL METHOD FOR IDENTIFYING HAZARDOUS AGENTS 有权
标题翻译：用于识别危险剂的多模式方法
公开(公告)号：US20080192246A1
公开(公告)日：2008-08-14
申请号：US11000841
申请日：2004-11-30
申请人： Jason Neiss , Matthew P. Nelson , Patrick Treado , Robert Schweitzer
发明人： Jason Neiss , Matthew P. Nelson , Patrick Treado , Robert Schweitzer
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/4406 , G01N21/6458
摘要： The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.
摘要翻译：本发明涉及通过对样品进行多峰频谱分析来评估样品中危险剂的发生的装置和方法。公开了对具有特征性危险物质的一种或多种光学特性的样品中的实体采用拉曼光谱的方法。还公开了适于执行这些方法的装置和系统。

10. 发明授权

US07990532B2 Method and apparatus for multimodal detection 有权
标题翻译：多模态检测方法和装置
公开(公告)号：US07990532B2
公开(公告)日：2011-08-02
申请号：US12718362
申请日：2010-03-05
申请人： Jason Neiss , Patrick Treado , Robert C. Schweitzer
发明人： Jason Neiss , Patrick Treado , Robert C. Schweitzer
IPC分类号： G01J3/44
CPC分类号： G01J3/28
摘要： System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.
摘要翻译：用于评估包含多个实体的样品中未知物质的发生的系统和方法。提供了包括代表至少一种已知物质的多个参考数据集的参考文库。评估实体的第一特征，其中第一特征是未知物质的特征。选择感兴趣区域，其中感兴趣区域包括展示第一特征的至少一个实体。获得空间精确的波长分辨拉曼图像，其中图像中的每个像素是相应位置处样品的拉曼光谱。评估空间上准确的波长分辨图像，从而识别未知物质。

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