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1. 发明申请

US20060253261A1 Digitizing biology 审中-公开
标题翻译：数字化生物学
公开(公告)号：US20060253261A1
公开(公告)日：2006-11-09
申请号：US11484040
申请日：2006-07-11
申请人： John Maier , Patrick Treado , Jeffrey Cohen , Jason Neiss
发明人： John Maier , Patrick Treado , Jeffrey Cohen , Jason Neiss
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G01N21/65
摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
摘要翻译：用于确定疾病进展的方法和装置。确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。用光照射含有至少一个电池的样品。收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。在多个预定向量空间中分析变换点的分布。根据分析，对样本的疾病状况进行分类。

2. 发明申请

US20060276697A1 Non-invasive biochemical analysis 有权
标题翻译：非侵入性生化分析
公开(公告)号：US20060276697A1
公开(公告)日：2006-12-07
申请号：US11146458
申请日：2005-06-07
申请人： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
发明人： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418
摘要： The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.
摘要翻译：本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估的血液成分用于表现出血液光学特性的一个或多个区域。

3. 发明申请

US20120078524A1 System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
标题翻译：使用荧光和拉曼技术诊断组织样本的系统和方法
公开(公告)号：US20120078524A1
公开(公告)日：2012-03-29
申请号：US13136366
申请日：2011-07-29
申请人： Shona Stewart , Jeffrey Cohen , Amy Drauch , John Maier
发明人： Shona Stewart , Jeffrey Cohen , Amy Drauch , John Maier
IPC分类号： G01N33/48 , G01N21/64 , G01J3/44
CPC分类号： A61B5/0059 , A61B5/417 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/10 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/6458 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/16 , G02B21/365 , G06F19/325 , G16H50/70
摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.
摘要翻译：用于确定测试生物样品的诊断的系统和方法。一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。可以评估该拉曼数据集以确定样品的诊断。诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

4. 发明授权

US07956996B2 Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging 有权
标题翻译：使用拉曼分子成像区分浸润性导管癌和浸润性小叶癌
公开(公告)号：US07956996B2
公开(公告)日：2011-06-07
申请号：US12206500
申请日：2008-09-08
申请人： John Maier , Jeffrey Cohen , Shona Stewart
发明人： John Maier , Jeffrey Cohen , Shona Stewart
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , A61B5/0059 , A61B5/417 , G01J3/0291 , G01J3/0294 , G01J3/28 , G01J3/2823 , G01J3/36 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N33/57415 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , Y02A90/26
摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
摘要翻译：一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。用基本上单色的光照射测试乳样品以产生散射的光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

5. 发明申请

US20090033930A1 Spectral Imaging of Biofilms 有权
标题翻译：生物膜的光谱成像
公开(公告)号：US20090033930A1
公开(公告)日：2009-02-05
申请号：US12248344
申请日：2008-10-09
申请人： John Maier , Jeffrey Cohen
发明人： John Maier , Jeffrey Cohen
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N2021/656 , G01N2201/129
摘要： A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.
摘要翻译：鉴定微生物生物膜的光谱方法和系统。用基本上单色的辐射照射含有样品微生物的样品。基于从照射样品散射的辐射获得拉曼数据集。根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知无形形式相关联。基于通过搜索识别的已知拉曼数据集来鉴定样品微生物的固定形式。

6. 发明申请

US20070109535A1 Spectral imaging of biofilms 有权
标题翻译：生物膜的光谱成像
公开(公告)号：US20070109535A1
公开(公告)日：2007-05-17
申请号：US11598245
申请日：2006-11-09
申请人： John Maier , Jeffrey Cohen
发明人： John Maier , Jeffrey Cohen
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N2021/656 , G01N2201/129
摘要： A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.
摘要翻译：鉴定微生物生物膜的光谱方法和系统。用基本上单色的辐射照射含有样品微生物的样品。基于从照射样品散射的辐射获得拉曼数据集。根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知无形形式相关联。基于通过搜索识别的已知拉曼数据集来鉴定样品微生物的固定形式。

7. 发明申请

US20130003044A1 System and Method for Raman Based Chronic Exposure Detection 审中-公开
标题翻译：基于拉曼的慢性暴露检测系统和方法
公开(公告)号：US20130003044A1
公开(公告)日：2013-01-03
申请号：US13541171
申请日：2012-07-03
申请人： John Maier , Jeffrey Cohen , Ryan Priore
发明人： John Maier , Jeffrey Cohen , Ryan Priore
IPC分类号： G01J3/28 , G01J3/44
CPC分类号： G01N21/84 , G01J3/0208 , G01J3/021 , G01J3/0224 , G01J3/0248 , G01J3/027 , G01J3/0291 , G01J3/10 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J5/0846 , G01J2005/0077 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/65 , G01N21/658 , G01N2201/129 , G02B21/0092 , G02B21/14 , G02B21/16
摘要： The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.
摘要翻译：本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。可以照射生物样品，从而产生一个或多个相互作用的光子。可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。可以将生成的光谱数据集与至少一个参考数据集进行比较。每个参考数据集可以与已知分析物的已知暴露相关联。本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

8. 发明授权

US08289503B2 System and method for classifying a disease state using representative data sets 有权
标题翻译：使用代表性数据集分类疾病状态的系统和方法
公开(公告)号：US08289503B2
公开(公告)日：2012-10-16
申请号：US12762609
申请日：2010-04-19
申请人： Jeffrey Cohen , John Maier
发明人： Jeffrey Cohen , John Maier
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： System and method for determining a disease state of a sample. A sample is positioned in a field of view and a first spectroscopic data set is obtained. The positional information is stored and the sample is treated with a contrast enhancing agent. The sample is repositioned in the field of view and a digital image is obtained. The spectroscopic data is linked with the digital image and a database comprising representative spectroscopic data sets is searched to classify the disease state of the sample. The disclosure also provides for the step of obtaining a processed derivative image and searching a database comprising representative processed derivative images to classify a disease state of the sample.
摘要翻译：用于确定样品的疾病状态的系统和方法。将样品放置在视场中，并获得第一光谱数据组。存储位置信息，并用对比度增强剂处理样品。样本在视野中重新定位，并获得数字图像。光谱数据与数字图像相关联，并且搜索包含代表性光谱数据集的数据库以分类样品的疾病状态。本公开还提供了获得经处理的衍生图像并搜索包括代表性处理的衍生图像的数据库以分类样本的疾病状态的步骤。

9. 发明授权

US07990533B2 System and method for analyzing biological samples using Raman molecular imaging 有权
标题翻译：使用拉曼分子成像分析生物样品的系统和方法
公开(公告)号：US07990533B2
公开(公告)日：2011-08-02
申请号：US12834370
申请日：2010-07-12
申请人： John Maier , Shona Stewart , Jeffrey Cohen
发明人： John Maier , Shona Stewart , Jeffrey Cohen
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
摘要： A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
摘要翻译：用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。

10. 发明申请

US20100280762A1 System and Method for Analyzing Biological Samples Using Raman Molecular Imaging 有权
标题翻译：使用拉曼分子成像分析生物样品的系统和方法
公开(公告)号：US20100280762A1
公开(公告)日：2010-11-04
申请号：US12834370
申请日：2010-07-12
申请人： John Maier , Shona Stewart , Jeffrey Cohen
发明人： John Maier , Shona Stewart , Jeffrey Cohen
IPC分类号： G01J3/44 , G06F19/00 , G01N33/48
CPC分类号： G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
摘要： A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
摘要翻译：用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。

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