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1. 发明授权

US09795775B2 Microneedles with improved open channel cross-sectional geometries 有权
公开(公告)号：US09795775B2
公开(公告)日：2017-10-24
申请号：US14787044
申请日：2014-05-20
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Andrew Baker , Russell F. Ross , Sridhar Ranganathan
IPC分类号： A61M5/00 , A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0038
摘要： In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid-to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.

2. 发明申请

US20170246439A9 Increased Bioavailability of Transdermally Delivered Agents 审中-公开
公开(公告)号：US20170246439A9
公开(公告)日：2017-08-31
申请号：US13658864
申请日：2012-10-24
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Russell F. Ross
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/0061
摘要： A method for delivering a bioactive agent to the cardiovascular system is described. The method delivers the agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. For instance, little or none of the bioactive agent will be sequestered in lymph tissue and prevented from circulation in the cardiovascular system. The method includes utilization of a transdermal delivery device including microneedles with structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes.

3. 发明授权

US11285239B2 Absorbent articles containing a multifunctional gel 有权
公开(公告)号：US11285239B2
公开(公告)日：2022-03-29
申请号：US16007447
申请日：2018-06-13
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Ali Yahiaoui , Candace Dyan Krautkramer , Margaret G. Latimer , Jack Nelson Lindon , Russell F. Ross , Melissa Jean Jacobs , Garry Roland Woltman
IPC分类号： A61F13/53 , A61L15/58 , A61L15/60 , A61F13/82 , A61F13/15
摘要： Improved skin-adhesive compositions for bonding a substrate, such as an absorbent article, to skin are disclosed. More particularly, the skin-adhesive composition has an improved, yet gentle, adhesion to the skin of a user, while maintaining strong, effective bonding to various inanimate, non-skin substrates. In one embodiment, the skin-adhesive composition can provide one or more skin benefit agents to the user. The skin-adhesive composition may be applied to an absorbent article, such as a panty-liner, sanitary napkin, or an incontinence article, for directly adhering the article to the skin of a user.

4. 发明申请

US20190143090A1 MICRONEEDLE ARRAY ASSEMBLY, DRUG DELIVERY DEVICE AND METHOD FOR ADMINISTERING LIQUID ACROSS A BROAD AREA AT LOW PRESSURE 审中-公开
公开(公告)号：US20190143090A1
公开(公告)日：2019-05-16
申请号：US16095210
申请日：2017-04-17
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Andrew T. Baker , Russell F. Ross , Elizabeth Deibler Gadsby , Luke Hagan
IPC分类号： A61M37/00
摘要： A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.

5. 发明授权

US09861801B2 Drug delivery device 有权
公开(公告)号：US09861801B2
公开(公告)日：2018-01-09
申请号：US14762534
申请日：2014-02-28
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Andrew Baker , Russell F. Ross , Luke Hagan
IPC分类号： A61M5/00 , A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0061 , A61M2210/04
摘要： A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.

6. 发明申请

US20170043148A1 RECEPTACLE PORTION OF TRANSDERMAL DRUG DELIVERY APPARATUS AND METHODS 审中-公开
标题翻译：转运药物递送装置和方法的接收部分
公开(公告)号：US20170043148A1
公开(公告)日：2017-02-16
申请号：US15305206
申请日：2015-04-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Andrew T. Baker , Elizabeth Deibler Gadsby , Russell F. Ross , Luke Hagan
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A receptacle, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a housing for being fastened to the user, a force provider that is elastic, at least one deformable component, and a microneedle assembly movably mounted to the housing for moving inwardly and outwardly relative to the housing. The force provider may be positioned between the housing and the microneedle assembly for forcing the microneedle assembly outwardly relative to the housing and against the skin of the user. The at least one deformable component may be connected between the microneedle assembly and the housing for both allowing relative movement between the microneedle assembly and the housing, and at least partially restricting the microneedle assembly from falling away from the housing. An arresting member may be positioned between the housing and the microneedle assembly for restricting any movement of at least tips of microneedles of the microneedle assembly into an interior of the housing.
摘要翻译：适合用作透皮药物输送装置的一部分的容器可以包括用于紧固到使用者的壳体，弹性的力提供者，至少一个可变形部件和可移动地安装到所述壳体相对于所述壳体向内和向外移动。力提供者可以定位在壳体和微针组件之间，用于迫使微针组件相对于壳体向外并抵靠使用者的皮肤。所述至少一个可变形部件可以连接在微针组件和壳体之间，用于允许微针组件和壳体之间的相对移动，并且至少部分地限制微针组件从壳体脱落。止动构件可以定位在壳体和微针组件之间，用于限制微针组件的至少尖端的至少尖端的任何运动进入壳体的内部。

7. 发明申请

US20170043146A1 CONTROLLER PORTION OF TRANSDERMAL DRUG DELIVERY APPARATUS AND METHODS 审中-公开
标题翻译：超导药物输送装置和方法的控制部分
公开(公告)号：US20170043146A1
公开(公告)日：2017-02-16
申请号：US15305201
申请日：2015-04-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Andrew T. Baker , Elizabeth Deibler Gadsby , Russell F. Ross , Luke Hagan
IPC分类号： A61M37/00
CPC分类号： A61M37/00 , A61M2037/0023
摘要： A controller, which may be used in a transdermal drug delivery apparatus, includes a housing, a pushing mechanism mounted for moving relative to the housing, a force provider positioned between the housing and the pushing mechanism for moving the pushing mechanism relative to the housing, and a latching mechanism for selectively restricting and allowing relative movement between the housing and the pushing mechanism. The pushing mechanism may be configured for pushing against a reservoir of the transdermal drug delivery apparatus. The latching mechanism may include flexible arms extending between the opposite ends of the latching mechanism, and the latching mechanism may be configured so that the arms release the pushing mechanism in response to the opposite ends being forced toward one another.
摘要翻译：可用于透皮药物输送装置的控制器包括壳体，安装成相对于壳体移动的推动机构，位于壳体和推动机构之间的力提供件，用于相对于壳体移动推动机构，以及用于选择性地限制和允许壳体和推动机构之间的相对运动的闭锁机构。推动机构可以被配置为推动透皮药物递送装置的储存器。闩锁机构可以包括在闩锁机构的相对端部之间延伸的柔性臂，并且闩锁机构可以被构造成使得臂相对于相对的端部被迫朝向彼此而释放推动机构。

8. 发明申请

US20170035652A1 CARTRIDGE PORTION OF TRANSDERMAL DRUG DELIVERY APPARATUS AND METHODS 审中-公开
标题翻译：转运药物递送装置的方法和方法
公开(公告)号：US20170035652A1
公开(公告)日：2017-02-09
申请号：US14914306
申请日：2015-04-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Andrew T. Baker , Elizabeth Deibler Gadsby , Russell F. Ross , Luke Hagan
IPC分类号： A61J1/06 , A61J1/14 , A61M37/00
CPC分类号： A61J1/06 , A61J1/1406 , A61M1/1037 , A61M5/14224 , A61M5/14586 , A61M37/00 , A61M37/0015 , A61M2037/0023
摘要： A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.
摘要翻译：适合用作透皮药物输送装置的一部分的药筒可以包括至少部分地限定用于容纳由透皮药物递送装置输送的流体的内部的本体。主体还可以至少部分地限定到主体内部的第一和第二开口，其中第一和第二开口分别靠近主体的第一和第二端。盒还可以包括至少部分地封闭第一开口的自密封构件和至少部分地封闭第二开口的可移动构件，其中可移动构件的至少一部分被推动进入身体的内部身体内部压力增加。

9. 发明申请

US20140112921A1 Increased Bioavailability of Transdermally Delivered Agents 审中-公开
标题翻译：增加经皮递送药剂的生物利用度
公开(公告)号：US20140112921A1
公开(公告)日：2014-04-24
申请号：US13658864
申请日：2012-10-24
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Russell F. Ross
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/0061
摘要： A method for delivering a bioactive agent to the cardiovascular system is described. The method delivers the agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. For instance, little or none of the bioactive agent will be sequestered in lymph tissue and prevented from circulation in the cardiovascular system. The method includes utilization of a transdermal delivery device including microneedles with structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes.
摘要翻译：描述了将生物活性剂递送至心血管系统的方法。该方法以高生物利用度递送药剂，并且将药剂的损失少于身体的自然防御机制。例如，很少或没有一种生物活性剂将被隔离在淋巴组织中并且阻止在心血管系统中循环。该方法包括利用包含微针的透皮递送装置，该微针具有在微针的表面上制造的结构以形成纳米形貌。可以制造随机或非随机的结构图案，例如包括不同尺寸和/或形状的结构的复杂图案。

10. 发明申请

US20170100521A1 PATTERNED SURFACES 审中-公开
公开(公告)号：US20170100521A1
公开(公告)日：2017-04-13
申请号：US15316979
申请日：2015-06-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Russell F. Ross
IPC分类号： A61L27/50 , A61L27/26 , A61L27/34
CPC分类号： A61L27/50 , A61L27/26 , A61L27/34 , A61L27/58 , A61L2400/18 , A61L2420/02 , C08L23/12
摘要： The present disclosure provides patterned materials that may be useful in reducing certain negative effects associated with damaged tissue in vivo. The patterned materials can modify the healing process, and may minimize the formation of scar tissue. Such effects can provide inhibition of adhesion between tissues and/or reduction of fibrotic encapsulation around implanted medical devices.

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