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1. 发明授权

US09353217B2 Biodegradable particles, vascular occlusion material, and method for producing biodegradable particles 有权
标题翻译：可生物降解颗粒，血管闭塞材料和生产可生物降解颗粒的方法
公开(公告)号：US09353217B2
公开(公告)日：2016-05-31
申请号：US13991495
申请日：2011-12-09
申请人： Kazuhiro Tanahashi , Megumi Nakanishi , Yasufumi Yamamura , Masaki Fujita
发明人： Kazuhiro Tanahashi , Megumi Nakanishi , Yasufumi Yamamura , Masaki Fujita
IPC分类号： C08G65/332 , C08G65/00 , A61L31/14 , C08J3/12 , C08J3/24 , A61L24/00 , A61L24/04
CPC分类号： C08G65/00 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L31/14 , A61L31/148 , A61L2300/60 , A61L2430/36 , C08G65/332 , C08G65/3322 , C08G2650/30 , C08J3/12 , C08J3/24 , C08J2300/16
摘要： Spherical biodegradable particles have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like. The biodegradable particles include a synthetic polymer chemically cross-linked to a polyvalent carboxylic acid, the biodegradable particles having a water content of 20 to 90% in a water-saturated state.
摘要翻译：球形可生物降解的颗粒具有改善的柔性，导致颗粒之间的聚集较少，并且在通过导管等之后具有改善的颗粒形状恢复能力。可生物降解的颗粒包括与多价羧酸化学交联的合成聚合物，在水饱和状态下，生物降解性颗粒的水含量为20-90％。

2. 发明申请

US20140018505A1 BIODEGRADABLE PARTICLE, VASCULAR EMBOLIZATION MATERIAL AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES 有权
标题翻译：生物可降解颗粒，生物可降解颗粒的血管形成材料和方法
公开(公告)号：US20140018505A1
公开(公告)日：2014-01-16
申请号：US14008194
申请日：2012-03-29
申请人： Masaki Fujita , Megumi Nakanishi , Yoshitake Takahashi , Yasufumi Yamamura , Kazuhiro Tanahashi
发明人： Masaki Fujita , Megumi Nakanishi , Yoshitake Takahashi , Yasufumi Yamamura , Kazuhiro Tanahashi
IPC分类号： A61L24/04 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0042 , A61L31/06 , A61L31/148 , A61L2430/36 , C08G63/08 , C08G63/664 , C08J3/28 , C08J2367/04 , C08L67/04
摘要： A biodegradable particle including a block copolymer produced by copolymerization of a biodegradable copolymer having a structure composed of hydroxycarboxylic acid a1, whose homopolymer produced by homopolymerization has a glass transition point of not less than 40° C. and hydroxycarboxylic acid a2, whose homopolymer produced by homopolymerization has a glass transition point of not more than −40° C.; a water-soluble polymer comprising a functional group selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group at each of both ends; and a polyvalent compound comprising 2 or more functional groups each selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group; wherein a ratio of mass of said structure composed of hydroxycarboxylic acid a2 to mass of said biodegradable copolymer is 30 to 90% by mass.
摘要翻译：包含由具有由均聚产生的均聚物的羟基羧酸a1构成的结构的生物降解性共聚物的共聚制得的嵌段共聚物的玻璃化转变温度为40℃以上的生物降解性粒子和羟基羧酸a2，其均聚物由均聚反应玻璃化转变温度不高于-40℃。在两端各自包含选自羟基，氨基和羧酸基的官能团的水溶性聚合物; 和包含2个以上选自羟基，氨基和羧酸基的官能团的多价化合物; 其中由羟基羧酸a2构成的所述结构的质量与所述生物降解性共聚物的质量之比为30〜90质量％。

3. 发明申请

US20120156302A1 BIODEGRADABLE PARTICLE AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：生物可降解颗粒及其生产方法
公开(公告)号：US20120156302A1
公开(公告)日：2012-06-21
申请号：US13402851
申请日：2012-02-22
申请人： Kazuhiro TANAHASHI , Megumi Nakanishi
发明人： Kazuhiro TANAHASHI , Megumi Nakanishi
IPC分类号： A61K9/14 , A61K47/34
CPC分类号： A61L31/148 , A61K9/0019 , A61K9/14 , A61L24/0042 , A61L24/046 , A61L31/06 , A61L2430/36 , C08J3/12 , C08J2367/04 , C08L67/04 , C08L71/02 , C08L2666/22
摘要： The present invention aims to provide a biodegradable particle capable of being molded without an aggregation or cohesion of the particles, capable of being carried or injected without clogging by an aggregation in a micro diameter tube such as of a catheter, needle or syringe mainly used in pharmaceutical and medical applications of which inner diameter is smaller than the particle size or in a blood vessel and capable of being smoothly degraded in a specified period of time so that degraded component can finally be absorbed or discharged in vitro. As means for solving the problem, the present invention provides a biodegradable particle characterized in that a compressive modulus of the particle in water saturated state is 10 MPa or less.
摘要翻译：本发明的目的在于提供一种可生物降解的颗粒，其能够在没有颗粒聚集或内聚的情况下模制，能够被携带或注入，而不会在主要用于其内径小于粒径或在血管中的能够在规定时间内顺利降解的药物和医疗应用，使得降解的成分最终能够在体外被吸收或排出。作为解决问题的手段，本发明提供一种生物降解性粒子，其特征在于，水饱和状态下的粒子的压缩弹性模量为10MPa以下。

4. 发明申请

US20060069168A1 Vascular embolization material 审中-公开
标题翻译：血管栓塞材料
公开(公告)号：US20060069168A1
公开(公告)日：2006-03-30
申请号：US10533090
申请日：2003-10-28
申请人： Norikazu Tabata , Kazuhiro Tanahashi , Megumi Nakanishi
发明人： Norikazu Tabata , Kazuhiro Tanahashi , Megumi Nakanishi
IPC分类号： A61K47/32
CPC分类号： A61L31/148 , A61L24/046 , A61L31/06 , A61L2430/36 , C08L71/02
摘要： This invention provides an embolization material used for blocking a blood vessel in vivo for stopping the blood flow. The most suitable embolization material has a water swelling ratio of 30% or more, is degradable in a phosphate buffered saline, is formed as virtually spherical particles, and is preferably composed of a water insoluble poly(ethylene glycol) copolymer, wherein when the film formed from said polymer is saturated with water, it has an elastic modulus in tension of 1500 MPa or less. The embolization material of this invention can reliably block a blood vessel at an intended site without causing cohesion or clogging in a catheter or in the blood vessel at other than the intended site. Thereafter, the blocked site concerned can be liberated from the embolized state by degradation, and the degraded components can be metabolized or excreted outside the body.
摘要翻译：本发明提供一种用于阻断体内血管以阻止血流的栓塞材料。最合适的栓塞材料的水溶胀比为30％以上，在磷酸盐缓冲盐水中可降解，形成为实际上为球形的颗粒，优选由水不溶性聚（乙二醇）共聚物组成，其中当膜由所述聚合物形成的水被水饱和，其拉伸弹性模量为1500MPa以下。本发明的栓塞材料可以可靠地阻止预期部位的血管，而不会导致导管或血管内的凝结或堵塞，而不是预期的部位。此后，有关的阻塞部位可以通过降解从栓塞状态释放，并且降解的成分可以在体外代谢或排泄。

5. 发明授权

US09408948B2 Biodegradable particles for medical treatment and vascular embolization material 有权
标题翻译：用于医疗和血管栓塞材料的生物降解颗粒
公开(公告)号：US09408948B2
公开(公告)日：2016-08-09
申请号：US13995294
申请日：2011-12-19
申请人： Yasufumi Yamamura , Kazuhiro Tanahashi , Megumi Nakanishi , Masaki Fujita
发明人： Yasufumi Yamamura , Kazuhiro Tanahashi , Megumi Nakanishi , Masaki Fujita
IPC分类号： A61L31/06 , C08G63/664 , A61L24/00 , A61L24/04
CPC分类号： A61L31/06 , A61L24/0042 , A61L24/046 , A61L2430/36 , C08G63/664 , Y10T428/2982 , C08L67/04
摘要： Biodegradable particles for medical use and a vascular embolization material have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like. The biodegradable particles for medical use are composed of an A1-B-A2 type triblock copolymer, wherein A1 and A2 are each a block of biodegradable copolymer constituted of monomers including glycolic acid, lactic acid and 6-hydroxycaproic acid, and B is a block of water-soluble polymer.
摘要翻译：用于医疗用途的生物降解性颗粒和血管栓塞材料具有改善的柔性，导致颗粒之间的聚集较少，并且在通过导管等之后具有改善的颗粒形状恢复能力。用于医疗用途的生物降解性颗粒由A1-B-A2型三嵌段共聚物组成，其中A1和A2各自是由包含乙醇酸，乳酸和6-羟基己酸的单体构成的生物可降解共聚物的嵌段，B是嵌段的水溶性聚合物。

6. 发明申请

US20130273372A1 BIODEGRADABLE PARTICLES FOR MEDICAL TREATMENT AND VASCULAR EMBOLIZATION MATERIAL 有权
标题翻译：用于医疗治疗和血管扩张材料的生物可降解颗粒
公开(公告)号：US20130273372A1
公开(公告)日：2013-10-17
申请号：US13995294
申请日：2011-12-19
申请人： Yasufumi Yamamura , Kazuhiro Tanahashi , Megumi Nakanishi , Masaki Fujita
发明人： Yasufumi Yamamura , Kazuhiro Tanahashi , Megumi Nakanishi , Masaki Fujita
IPC分类号： A61L31/06
CPC分类号： A61L31/06 , A61L24/0042 , A61L24/046 , A61L2430/36 , C08G63/664 , Y10T428/2982 , C08L67/04
摘要： Biodegradable particles for medical use and a vascular embolization material have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like. The biodegradable particles for medical use are composed of an A1-B-A2 type triblock copolymer, wherein A1 and A2 are each a block of biodegradable copolymer constituted of monomers including glycolic acid, lactic acid and 6-hydroxycaproic acid, and B is a block of water-soluble polymer.
摘要翻译：用于医疗用途的生物降解性颗粒和血管栓塞材料具有改善的柔性，导致颗粒之间的聚集较少，并且在通过导管等之后具有改善的颗粒形状恢复能力。用于医疗用途的生物降解性颗粒由A1-B-A2型三嵌段共聚物组成，其中A1和A2分别是由包括乙醇酸，乳酸和6-羟基己酸的单体构成的可生物降解的共聚物嵌段，B是嵌段的水溶性聚合物。

7. 发明申请

US20130253136A1 BIODEGRADABLE PARTICLES, VASCULAR OCCLUSION MATERIAL, AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES 有权
标题翻译：生物可降解颗粒，血管填充材料和生产可生物降解颗粒的方法
公开(公告)号：US20130253136A1
公开(公告)日：2013-09-26
申请号：US13991495
申请日：2011-12-09
申请人： Kazuhiro Tanahashi , Megumi Nakanishi , Yasufumi Yamamura , Masaki Fujita
发明人： Kazuhiro Tanahashi , Megumi Nakanishi , Yasufumi Yamamura , Masaki Fujita
IPC分类号： C08G65/00
CPC分类号： C08G65/00 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L31/14 , A61L31/148 , A61L2300/60 , A61L2430/36 , C08G65/332 , C08G65/3322 , C08G2650/30 , C08J3/12 , C08J3/24 , C08J2300/16
摘要： Spherical biodegradable particles have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like. The biodegradable particles include a synthetic polymer chemically cross-linked to a polyvalent carboxylic acid, the biodegradable particles having a water content of 20 to 90% in a water-saturated state.
摘要翻译：球形可生物降解的颗粒具有改善的柔性，导致颗粒之间的聚集较少，并且在通过导管等之后具有改善的颗粒形状恢复能力。可生物降解的颗粒包括与多价羧酸化学交联的合成聚合物，在水饱和状态下，生物降解性颗粒的水含量为20-90％。

8. 发明授权

US09226997B2 Biodegradable particle and method for producing the same 有权
标题翻译：生物降解颗粒及其制备方法
公开(公告)号：US09226997B2
公开(公告)日：2016-01-05
申请号：US13402851
申请日：2012-02-22
申请人： Kazuhiro Tanahashi , Megumi Nakanishi
发明人： Kazuhiro Tanahashi , Megumi Nakanishi
IPC分类号： A61K9/14 , A61L31/14 , A61K9/00 , A61L24/00 , A61L24/04 , A61L31/06 , C08J3/12 , C08L67/04 , C08L71/02
CPC分类号： A61L31/148 , A61K9/0019 , A61K9/14 , A61L24/0042 , A61L24/046 , A61L31/06 , A61L2430/36 , C08J3/12 , C08J2367/04 , C08L67/04 , C08L71/02 , C08L2666/22
摘要： The present invention aims to provide a biodegradable particle capable of being molded without an aggregation or cohesion of the particles, capable of being carried or injected without clogging by an aggregation in a micro diameter tube such as of a catheter, needle or syringe mainly used in pharmaceutical and medical applications of which inner diameter is smaller than the particle size or in a blood vessel and capable of being smoothly degraded in a specified period of time so that degraded component can finally be absorbed or discharged in vitro. As means for solving the problem, the present invention provides a biodegradable particle characterized in that a compressive modulus of the particle in water saturated state is 10 MPa or less.
摘要翻译：本发明的目的在于提供一种可生物降解的颗粒，其能够在没有颗粒聚集或内聚的情况下模制，能够被携带或注入，而不会在主要用于其内径小于粒径或在血管中的能够在规定时间内顺利降解的药物和医疗应用，使得降解的成分最终能够在体外被吸收或排出。作为解决问题的手段，本发明提供一种生物降解性粒子，其特征在于，水饱和状态下的粒子的压缩弹性模量为10MPa以下。

9. 发明授权

US08871873B2 Biodegradable particle, vascular embolization material and method for producing biodegradable particles 有权
标题翻译：生物降解颗粒，血管栓塞材料及生物降解颗粒的生产方法
公开(公告)号：US08871873B2
公开(公告)日：2014-10-28
申请号：US14008194
申请日：2012-03-29
申请人： Masaki Fujita , Megumi Nakanishi , Yoshitake Takahashi , Yasufumi Yamamura , Kazuhiro Tanahashi
发明人： Masaki Fujita , Megumi Nakanishi , Yoshitake Takahashi , Yasufumi Yamamura , Kazuhiro Tanahashi
IPC分类号： A61L24/04 , A61L24/00 , C08J3/28 , C08G63/664 , C08G63/08 , A61L31/06 , A61L31/14 , C08G65/32
CPC分类号： A61L24/046 , A61L24/0042 , A61L31/06 , A61L31/148 , A61L2430/36 , C08G63/08 , C08G63/664 , C08J3/28 , C08J2367/04 , C08L67/04
摘要： A biodegradable particle including a block copolymer produced by copolymerization of a biodegradable copolymer having a structure composed of hydroxycarboxylic acid a1, whose homopolymer produced by homopolymerization has a glass transition point of not less than 40° C., and hydroxycarboxylic acid a2, whose homopolymer produced by homopolymerization has a glass transition point of not more than −40° C.; a water-soluble polymer comprising a functional group selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group at each of both ends; and a polyvalent compound comprising 2 or more functional groups each selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group; wherein a ratio of mass of said structure composed of hydroxycarboxylic acid a2 to mass of said biodegradable copolymer is 30 to 90% by mass.
摘要翻译：包含由具有由均聚产生的均聚物的羟基羧酸a1构成的具有玻璃化转变温度为40℃以上的结构的生物降解性共聚物和其均聚物生成的羟基羧酸a2共聚而成的生物降解性粒子通过均聚反应的玻璃化转变温度不高于-40℃。在两端各自包含选自羟基，氨基和羧酸基的官能团的水溶性聚合物; 和包含2个以上选自羟基，氨基和羧酸基的官能团的多价化合物; 其中由羟基羧酸a2构成的所述结构的质量与所述生物降解性共聚物的质量之比为30〜90质量％。

10. 发明申请

US20090311337A1 BIODEGRADABLE PARTICLE AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：生物可降解颗粒及其生产方法
公开(公告)号：US20090311337A1
公开(公告)日：2009-12-17
申请号：US12084102
申请日：2006-10-26
申请人： Kazuhiro Tanahashi , Megumi Nakanishi
发明人： Kazuhiro Tanahashi , Megumi Nakanishi
IPC分类号： A61K9/14 , A61K47/30
CPC分类号： A61L31/148 , A61K9/0019 , A61K9/14 , A61L24/0042 , A61L24/046 , A61L31/06 , A61L2430/36 , C08J3/12 , C08J2367/04 , C08L67/04 , C08L71/02 , C08L2666/22
摘要： The present invention aims to provide a biodegradable particle capable of being molded without an aggregation or cohesion of the particles, capable of being carried or injected without clogging by an aggregation in a micro diameter tube such as of a catheter, needle or syringe mainly used in pharmaceutical and medical applications of which inner diameter is smaller than the particle size or in a blood vessel and capable of being smoothly degraded in a specified period of time so that degraded component can finally be absorbed or discharged in vitro. As means for solving the problem, the present invention provides a biodegradable particle characterized in that a compressive modulus of the particle in water saturated state is 10 MPa or less.
摘要翻译：本发明的目的在于提供一种可生物降解的颗粒，其能够在没有颗粒聚集或内聚的情况下模制，能够被携带或注入，而不会在主要用于其内径小于粒径或在血管中的能够在规定时间内顺利降解的药物和医疗应用，使得降解的成分最终能够在体外被吸收或排出。作为解决问题的手段，本发明提供一种生物降解性粒子，其特征在于，水饱和状态下的粒子的压缩弹性模量为10MPa以下。

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