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1. 发明申请

US20060165647A1 Immunosuppressive substance adsorbent, extracorporeal cicrulation column and method of treating cancer 审中-公开
标题翻译：免疫抑制物质吸附剂，体外培养柱和治疗癌症的方法
公开(公告)号：US20060165647A1
公开(公告)日：2006-07-27
申请号：US10516015
申请日：2003-04-03
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： A61K38/18 , A61K31/785
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.
摘要翻译：本发明的目的是提供一种用于免疫抑制物质的吸附剂，该吸附剂可以高效地和选择性地从体液中直接吸附过量的免疫抑制物质，可以安全地进行体外灌注，并可用于治疗癌症。这种过量的免疫抑制物质可能参与癌细胞的生长。本发明的免疫抑制物质的吸附剂包括水不溶性载体和固定在水不溶性载体上的亲水性氨基。本发明的体外灌注柱含有本发明的吸附剂。本发明的治疗癌症的方法使用本发明的体外灌注柱进行体外灌注。

2. 发明授权

US08932590B2 Method of adsorbing transforming growth factor β 有权
标题翻译：吸附转化生长因子的方法
公开(公告)号：US08932590B2
公开(公告)日：2015-01-13
申请号：US13067627
申请日：2011-06-15
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： A61K39/395 , B01J20/26 , B01J20/28 , B01J20/32 , B01J20/30 , A61M1/36
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要翻译：可以直接从体液吸附过量免疫抑制物质的免疫抑制物质吸附剂可以安全地进行体外灌注，可用于治疗癌症。过量的免疫抑制物质可能参与癌细胞的生长。用于免疫抑制物质的吸附剂包括固定在水不溶性载体上的水不溶性载体和亲水性氨基。体外灌注柱包含本发明的吸附剂。一种治疗癌症的方法使用体外灌注柱进行体外灌注。吸附转化生长因子的方法其与另一种蛋白质组合，包括吸收转化生长因子和bgr; 和含有每个氮原子上具有3〜18个碳原子的季铵基的水不溶性载体的吸附剂上的蛋白质，并且比表面积为0.1m 2以上。

3. 发明申请

US20110240560A1 Method of adsorbing transforming growth factor ß 审中-公开
标题翻译：吸附转化生长因子的方法
公开(公告)号：US20110240560A1
公开(公告)日：2011-10-06
申请号：US13067627
申请日：2011-06-15
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： B01D15/00
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要翻译：可以直接从体液吸附过量免疫抑制物质的免疫抑制物质吸附剂可以安全地进行体外灌注，可用于治疗癌症。过量的免疫抑制物质可能参与癌细胞的生长。用于免疫抑制物质的吸附剂包括固定在水不溶性载体上的水不溶性载体和亲水性氨基。体外灌注柱包含本发明的吸附剂。一种治疗癌症的方法使用体外灌注柱进行体外灌注。吸附转化生长因子的方法其与另一种蛋白质组合，包括吸收转化生长因子和bgr; 和含有每个氮原子上具有3〜18个碳原子的季铵基的水不溶性载体的吸附剂上的蛋白质，并且比表面积为0.1m 2以上。

4. 发明申请

US20070196401A1 Nano-Fiber Compound Solutions, Emulsions And Gels, Production Method Thereof, Nano-Fiber Synthetic Papers, And Production Method Thereof 有权
标题翻译：纳米纤维复合溶液，乳液和凝胶，其制备方法，纳米纤维合成纸及其制备方法
公开(公告)号：US20070196401A1
公开(公告)日：2007-08-23
申请号：US10589411
申请日：2005-02-16
申请人： Yoshihiro Naruse , Takeo Matsunase , Takashi Ochi , Kakuji Murakami , Shuichi Nonaka
发明人： Yoshihiro Naruse , Takeo Matsunase , Takashi Ochi , Kakuji Murakami , Shuichi Nonaka
IPC分类号： A61K9/70 , A61K8/02 , D21H17/00 , B01D29/00
CPC分类号： A61K8/88 , A61K8/027 , A61K8/86 , A61Q1/02 , A61Q19/00 , D01F6/44 , D01F6/88 , D21H13/10 , D21H15/02 , Y10T442/60 , Y10T442/608 , Y10T442/64 , Y10T442/68
摘要： This invention provides compound solutions, emulsions and gels excellent in homogeneous dispersibility and long-term dispersion stability and also excellent in the properties as cosmetics, using disarranged nanofibers not limited in either form or polymer, widely applicable and small in the irregularity of single fiber diameter. This invention also provides a method for producing them. Furthermore, this invention provides synthetic papers composed of fibers, small in pore area and uniform in pore size, using disarranged nanofibers, and also provides a method for producing them. This invention provides compound solutions, emulsions, gels and synthetic papers containing disarranged nanofibers of 1 to 500 nm in number average diameter and 60% or more in the sum Pa of single fiber ratios.
摘要翻译：本发明提供了均匀分散性和长期分散稳定性优异的化合物溶液，乳液和凝胶，并且在化妆品的性能方面也优异，使用不限于形式或聚合物的不均匀的纳米纤维，广泛适用且单纤维直径不规则。本发明还提供了一种制造它们的方法。此外，本发明提供了由纤维构成的合成纸，其孔径小，孔径均匀，使用不均匀的纳米纤维，并且还提供了制造它们的方法。本发明提供了在单纤维比率的总和Pa中含有数均粒径为1〜500nm的不均匀纳米纤维和60％以上的复合溶液，乳液，凝胶和合成纸。

5. 发明申请

US20070218279A1 Abrasive Cloth and Method for Producing Nanofiber Structure 有权
标题翻译：磨料布和生产纳米纤维结构的方法
公开(公告)号：US20070218279A1
公开(公告)日：2007-09-20
申请号：US11578926
申请日：2005-04-20
申请人： Shuichi Nonaka , Yoshihiro Naruse , Takashi Ochi , Takeo Matsunase
发明人： Shuichi Nonaka , Yoshihiro Naruse , Takashi Ochi , Takeo Matsunase
IPC分类号： B24B37/00 , D04H1/42
CPC分类号： B24B37/24 , D04H1/42 , D04H1/4358 , D04H1/4382 , Y10T428/2915 , Y10T442/2008 , Y10T442/2861 , Y10T442/2893 , Y10T442/608 , Y10T442/614 , Y10T442/626 , Y10T442/659
摘要： An abrasive cloth which comprises an article in a sheet form having, in at least a part thereof, nanofibers comprising a thermoplastic polymer and having a number average single fiber fineness of 1×10−8 to 2×10−4 dtex wherein the sum of single fiber fineness percentages (which is defined in the specification) of a single fiber fineness of 1×10−8 to 2×10−4 dtex is the range of 60% or more, and exhibits a stress at 10% elongation in a longitudinal direction of 5 to 200 N/cm-width; and a method for preparing a nanofiber structure, which comprises providing a nanofiber dispersion having a dispersant and, dispersed therein, nanofibers comprising a thermoplastic polymer and having a number average diameter of 1 to 500 nm, attaching the dispersion to a support, and then removing said dispersant. The above abrasive cloth is excellent in texturing characteristics, and the above method allows the preparation of a nanofiber structure wherein nanofibers form a composite with the support.
摘要翻译：一种研磨布，其包括片状制品，其至少一部分具有包含热塑性聚合物的纳米纤维，并且具有1×10 -8至2×10 -6的平均单纤维细度， 4tex，其中单纤维细度为1×10 -8至2×10 -4分特的单纤维细度百分比（在说明书中定义）之和为60％以上的范围，在长度方向的10％伸长率的应力为5〜200N / cm宽; 以及纳米纤维结构体的制造方法，其特征在于，提供具有分散剂的纳米纤维分散体，分散在其中的纳米纤维，所述纳米纤维包含热塑性聚合物，数均粒径为1〜500nm，将所述分散体附着到载体上，所述分散剂。上述研磨布的纹理特性优异，上述方法可以制备其中纳米纤维与载体形成复合材料的纳米纤维结构。

6. 发明授权

US08895458B2 Abrasive cloth and method for producing nanofiber structure 有权
标题翻译：磨料布及其制造方法
公开(公告)号：US08895458B2
公开(公告)日：2014-11-25
申请号：US11578926
申请日：2005-04-20
申请人： Shuichi Nonaka , Yoshihiro Naruse , Takashi Ochi , Takeo Matsunase
发明人： Shuichi Nonaka , Yoshihiro Naruse , Takashi Ochi , Takeo Matsunase
IPC分类号： D04H1/00 , B24B37/24 , D04H1/42
CPC分类号： B24B37/24 , D04H1/42 , D04H1/4358 , D04H1/4382 , Y10T428/2915 , Y10T442/2008 , Y10T442/2861 , Y10T442/2893 , Y10T442/608 , Y10T442/614 , Y10T442/626 , Y10T442/659
摘要： An abrasive cloth which comprises an article in a sheet form having, in at least a part thereof, nanofibers comprising a thermoplastic polymer and having a number average single fiber fineness of 1×10−8 to 2×10−4 dtex wherein the sum of single fiber fineness percentages (which is defined in the specification) of a single fiber fineness of 1×10−8 to 2×10−4 dtex is the range of 60% or more, and exhibits a stress at 10% elongation in a longitudinal direction of 5 to 200 N/cm-width; and a method for preparing a nanofiber structure, which comprises providing a nanofiber dispersion having a dispersant and, dispersed therein, nanofibers comprising a thermoplastic polymer and having a number average diameter of 1 to 500 nm, attaching the dispersion to a support, and then removing said dispersant. The above abrasive cloth is excellent in texturing characteristics, and the above method allows the preparation of a nanofiber structure wherein nanofibers form a composite with the support.
摘要翻译：一种研磨布，其包括片状制品，其至少一部分具有包含热塑性聚合物并且具有1×10-8至2×10-4dtex的数均单纤维细度的纳米纤维，其中， 1×10-8〜2×10-4dtex的单纤维纤度的单纤维纤度百分比（在规范中定义）为60％以上的范围，纵向呈现10％伸长应力方向为5〜200N / cm宽; 以及纳米纤维结构体的制造方法，其特征在于，提供具有分散剂的纳米纤维分散体，分散在其中的纳米纤维，所述纳米纤维包含热塑性聚合物，数均粒径为1〜500nm，将所述分散体附着到载体上，所述分散剂。上述研磨布的纹理特性优异，上述方法可以制备其中纳米纤维与载体形成复合材料的纳米纤维结构。

7. 发明授权

US08501642B2 Nano-fiber compound solutions, emulsions and gels, production method thereof, Nano-fiber synthetic papers, and production method thereof 有权
标题翻译：纳米纤维复合溶液，乳液和凝胶，其制备方法，纳米纤维合成纸及其制备方法
公开(公告)号：US08501642B2
公开(公告)日：2013-08-06
申请号：US10589411
申请日：2005-02-16
申请人： Yoshihiro Naruse , Takeo Matsunase , Takashi Ochi , Kakuji Murakami , Shuichi Nonaka
发明人： Yoshihiro Naruse , Takeo Matsunase , Takashi Ochi , Kakuji Murakami , Shuichi Nonaka
IPC分类号： D04H1/00 , B01D24/00
CPC分类号： A61K8/88 , A61K8/027 , A61K8/86 , A61Q1/02 , A61Q19/00 , D01F6/44 , D01F6/88 , D21H13/10 , D21H15/02 , Y10T442/60 , Y10T442/608 , Y10T442/64 , Y10T442/68
摘要： This invention provides compound solutions, emulsions and gels excellent in homogeneous dispersibility and long-term dispersion stability and also excellent in the properties as cosmetics, using disarranged nanofibers not limited in either form or polymer, widely applicable and small in the irregularity of single fiber diameter. This invention also provides a method for producing them. Furthermore, this invention provides synthetic papers composed of fibers, small in pore area and uniform in pore size, using disarranged nanofibers, and also provides a method for producing them. This invention provides compound solutions, emulsions, gels and synthetic papers containing disarranged nanofibers of 1 to 500 nm in number average diameter and 60% or more in the sum Pa of single fiber ratios.
摘要翻译：本发明提供了均匀分散性和长期分散稳定性优异的化合物溶液，乳液和凝胶，并且在化妆品的性能方面也优异，使用不限于形式或聚合物的不均匀的纳米纤维，广泛适用且单纤维直径不规则。本发明还提供了一种制造它们的方法。此外，本发明提供了由纤维构成的合成纸，其孔径小，孔径均匀，使用不均匀的纳米纤维，并且还提供了制造它们的方法。本发明提供了在单纤维比率的总和Pa中含有数均粒径为1〜500nm的不均匀纳米纤维和60％以上的复合溶液，乳液，凝胶和合成纸。

8. 发明授权

US5502090A High tenacity and high toughness acrylic sulfide fibers, a process for production thereof, and composite materials prepared by using it 失效
标题翻译：高韧性和高韧性的丙烯酸硫化物纤维，其制备方法和使用它制备的复合材料
公开(公告)号：US5502090A
公开(公告)日：1996-03-26
申请号：US412563
申请日：1989-09-25
申请人： Takeo Matsunase , Takashi Takada
发明人： Takeo Matsunase , Takashi Takada
IPC分类号： C04B16/06 , D01F6/18 , D06M11/57 , C08J7/12 , C08J5/14
CPC分类号： C04B16/06 , D01F6/18 , D06M11/57 , Y10T428/31699
摘要： The present invention relates to acrylic sulfide fibers whose tensile strength is at least 3.5 g/d, toughness expressed by TE.sup.1/2 product of tensile strength (T g/d) and a square root of tensile elongation (E %), is higher than 10 and sulfur content is higher than 0.5 weight %, a process for producing acrylic sulfide fibers characterized by heating acrylic fibers whose tensile strength is at least higher than 7 g/d in sulfur-containing atmosphere, and composite materials being reinforced with above described acrylic sulfide fibers.Acrylic sulfide fibers obtained have high tenacity and high toughness as well as excellent heat resistance, anti-flammability and alkali resistance.Therefore, above described acrylic sulfide fibers are useful for such applications as heat resistant and flame resistant spun-woven products, reinforcing cement cured in an autoclave and abrasive materials as asbestos substituting fibers.
摘要翻译：本发明涉及拉伸强度至少为3.5g / d，TE1 / 2产品拉伸强度（T g / d）和拉伸伸长率平方根（E％）的韧性的丙烯酸类硫化物纤维，高于 10，硫含量高于0.5重量％，制备丙烯酸硫化纤维的方法，其特征在于在含硫气氛中加热抗拉强度至少高于7g / d的丙烯酸纤维，以及用上述丙烯酸硫化纤维。得到的丙烯酸硫化纤维具有高韧性和高韧性以及优异的耐热性，抗燃性和耐碱性。因此，上述丙烯酸硫化物纤维可用于耐热和阻燃纺织产品，在高压釜中固化的增强水泥和作为石棉替代纤维的研磨材料。

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