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1. 发明申请

US20060165647A1 Immunosuppressive substance adsorbent, extracorporeal cicrulation column and method of treating cancer 审中-公开
标题翻译：免疫抑制物质吸附剂，体外培养柱和治疗癌症的方法
公开(公告)号：US20060165647A1
公开(公告)日：2006-07-27
申请号：US10516015
申请日：2003-04-03
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： A61K38/18 , A61K31/785
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.
摘要翻译：本发明的目的是提供一种用于免疫抑制物质的吸附剂，该吸附剂可以高效地和选择性地从体液中直接吸附过量的免疫抑制物质，可以安全地进行体外灌注，并可用于治疗癌症。这种过量的免疫抑制物质可能参与癌细胞的生长。本发明的免疫抑制物质的吸附剂包括水不溶性载体和固定在水不溶性载体上的亲水性氨基。本发明的体外灌注柱含有本发明的吸附剂。本发明的治疗癌症的方法使用本发明的体外灌注柱进行体外灌注。

2. 发明授权

US08932590B2 Method of adsorbing transforming growth factor β 有权
标题翻译：吸附转化生长因子的方法
公开(公告)号：US08932590B2
公开(公告)日：2015-01-13
申请号：US13067627
申请日：2011-06-15
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： A61K39/395 , B01J20/26 , B01J20/28 , B01J20/32 , B01J20/30 , A61M1/36
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要翻译：可以直接从体液吸附过量免疫抑制物质的免疫抑制物质吸附剂可以安全地进行体外灌注，可用于治疗癌症。过量的免疫抑制物质可能参与癌细胞的生长。用于免疫抑制物质的吸附剂包括固定在水不溶性载体上的水不溶性载体和亲水性氨基。体外灌注柱包含本发明的吸附剂。一种治疗癌症的方法使用体外灌注柱进行体外灌注。吸附转化生长因子的方法其与另一种蛋白质组合，包括吸收转化生长因子和bgr; 和含有每个氮原子上具有3〜18个碳原子的季铵基的水不溶性载体的吸附剂上的蛋白质，并且比表面积为0.1m 2以上。

3. 发明申请

US20110240560A1 Method of adsorbing transforming growth factor ß 审中-公开
标题翻译：吸附转化生长因子的方法
公开(公告)号：US20110240560A1
公开(公告)日：2011-10-06
申请号：US13067627
申请日：2011-06-15
申请人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
发明人： Kazuo Teramoto , Toshio Yoshioka , Masaaki Shimagaki , Takeo Matsunase , Koji Watanabe , Yuji Ueda , Yoshiki Yamamoto
IPC分类号： B01D15/00
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要翻译：可以直接从体液吸附过量免疫抑制物质的免疫抑制物质吸附剂可以安全地进行体外灌注，可用于治疗癌症。过量的免疫抑制物质可能参与癌细胞的生长。用于免疫抑制物质的吸附剂包括固定在水不溶性载体上的水不溶性载体和亲水性氨基。体外灌注柱包含本发明的吸附剂。一种治疗癌症的方法使用体外灌注柱进行体外灌注。吸附转化生长因子的方法其与另一种蛋白质组合，包括吸收转化生长因子和bgr; 和含有每个氮原子上具有3〜18个碳原子的季铵基的水不溶性载体的吸附剂上的蛋白质，并且比表面积为0.1m 2以上。

4. 发明申请

US20140017667A1 Immunosuppressive Cell-Capturing Material and Immunosuppressive Cell-Capturing Column 有权
标题翻译：免疫抑制细胞捕获材料和免疫抑制细胞捕获柱
公开(公告)号：US20140017667A1
公开(公告)日：2014-01-16
申请号：US14008538
申请日：2012-03-27
申请人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
发明人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/14 , A61M1/3679 , B01J20/26 , B01J20/264 , B01J20/28042
摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
摘要翻译：本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中氨基的含量为150mol / g以下。本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。

5. 发明授权

US09127250B2 Immunosuppressive cell-capturing material and immunosuppressive cell-capturing column 有权
标题翻译：免疫抑制细胞捕获材料和免疫抑制细胞捕获柱
公开(公告)号：US09127250B2
公开(公告)日：2015-09-08
申请号：US14008538
申请日：2012-03-27
申请人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
发明人： Kazumasa Ogasawara , Kazuo Teramoto , Yuji Ueda , Yasushi Itoh , Hirohito Ishigaki
IPC分类号： C12N5/078 , B01J20/26 , B01J20/28 , A61M1/36 , A61K35/14
CPC分类号： C12N5/0634 , A61K35/14 , A61M1/3679 , B01J20/26 , B01J20/264 , B01J20/28042
摘要： This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
摘要翻译：本发明公开了一种免疫抑制细胞捕获材料，其包含成型体，其包含：具有氨基的容易水解的缩聚物; 涂覆易水解的缩合聚合物的难溶于水的聚合物; 和配合物共轭的难以水解的聚合物，其涂覆不易水解的聚合物，其中配体是选自NH 2基，仲氨基，叔氨基，多胺残基，碱性环状多肽残基中的至少一种，氨基糖苷类化合物残基，氯喹，普氨氨酸，甲氟喹，咪喹莫特和制霉菌素，其中成型体中的氨基含量为150μmol/ g以下。本发明还公开了一种填充有捕获材料的免疫抑制细胞捕获柱。

6. 发明申请

US20110116192A1 HEAD-SLIDER INCLUDING THIN-FILM MAGNETIC-RECORDING HEAD HAVING REDUCED THERMAL PROTRUSION 有权
标题翻译：包括具有减少热导率的薄膜磁记录头的头部滑盖
公开(公告)号：US20110116192A1
公开(公告)日：2011-05-19
申请号：US12642739
申请日：2009-12-18
申请人： Shigeo FUJITA , Masahiko Soga , Hideaki Tanaka , Yuji Ueda , Tomohiro Okada , Takayoshi Ohtsu , Wataru Kimura , Yohji Maruyama
发明人： Shigeo FUJITA , Masahiko Soga , Hideaki Tanaka , Yuji Ueda , Tomohiro Okada , Takayoshi Ohtsu , Wataru Kimura , Yohji Maruyama
IPC分类号： G11B5/60
CPC分类号： G11B5/1278 , G11B5/3133 , G11B5/3136 , G11B5/3967 , G11B5/6005 , G11B5/6064 , G11B2005/0005
摘要： A head-slider. The head-slider includes a slider, and a thin-film magnetic-recording head. The thin-film magnetic-recording head includes: a read element; a write element; a non-magnetic insulating protective layer disposed around both read and write elements; a resist disposed at a position further away from an air-bearing surface than the read element; and, a hard-material member including a material selected from the group consisting of silicon carbide and tungsten, which is disposed at a position further away from the air-bearing surface than the read element and the write element. Both an end of the resist and an end of the hard-material member overlap the write element when viewed in a stacking direction. A ratio of a distance from the air-bearing surface to a deepest end of the hard-material member to a distance from the air-bearing surface to a deepest end of the resist is at least 0.9.
摘要翻译：头滑块。磁头滑动器包括滑块和薄膜磁记录头。薄膜磁记录头包括：读取元件; 写元素设置在读取和写入元件周围的非磁性绝缘保护层; 设置在远离所述读取元件的空气轴承表面的位置处的抗蚀剂; 以及包括选自碳化硅和钨的材料的硬质材料构件，其被设置在比读取元件和写入元件更远离空气轴承表面的位置处。当在堆叠方向上观察时，抗蚀剂的一端和硬质材料构件的一端与写入元件重叠。从空气轴承表面到硬质材料构件的最深端的距离与从空气轴承表面到抗蚀剂的最深端的距离的比率至少为0.9。

7. 发明授权

US6101068A MR composite-type thin-film magnetic head having an upper pole with a high saturation magnetic flux density and an intermediate pole with a high resistivity 有权
标题翻译： MR复合型薄膜磁头
公开(公告)号：US6101068A
公开(公告)日：2000-08-08
申请号：US157958
申请日：1998-09-22
申请人： Shigekazu Ohtomo , Shuji Sudo , Yuji Ueda , Kuniaki Yoshimura , Hideji Takahashi
发明人： Shigekazu Ohtomo , Shuji Sudo , Yuji Ueda , Kuniaki Yoshimura , Hideji Takahashi
IPC分类号： G11B5/31 , G11B5/39 , G11B5/21
CPC分类号： G11B5/3967 , G11B5/313 , G11B5/3146 , G11B5/3153 , G11B5/3103
摘要： A thin-film magnetic head includes an MR element serving as a reproducing element and a recording induction coil. The MR element is disposed between a lower magnetic pole and an intermediate magnetic pole. The recording induction coil is disposed between the intermediate magnetic pole and an upper magnetic pole. At least a portion of the upper magnetic pole in the vicinity of a recording gap is formed of a material having a high saturation magnetic flux density of 1.4 T or higher. The intermediate magnetic pole is formed of a material having a high resistivity of 80 .mu..OMEGA..multidot.cm or higher.
摘要翻译：薄膜磁头包括用作再现元件的MR元件和记录感应线圈。 MR元件设置在下磁极和中间磁极之间。记录感应线圈设置在中间磁极和上磁极之间。记录间隙附近的上磁极的至少一部分由具有1.4T以上的高饱和磁通密度的材料形成。中间磁极由具有80μm欧姆/厘米或更高的高电阻率的材料形成。

8. 发明授权

US5395727A Positive resist composition containing a novolak resin made from an aldehyde and dimer of isopropenyl phenol 失效
标题翻译：含有由醛形成的酚醛清漆树脂和异丙烯基苯酚二聚体的正性抗蚀剂组合物
公开(公告)号：US5395727A
公开(公告)日：1995-03-07
申请号：US158817
申请日：1993-11-29
申请人： Yasunori Uetani , Haruyoshi Osaki , Naoki Takeyama , Yuji Ueda , Hiromi Ueki , Takehiro Kusumoto
发明人： Yasunori Uetani , Haruyoshi Osaki , Naoki Takeyama , Yuji Ueda , Hiromi Ueki , Takehiro Kusumoto
IPC分类号： C08G8/08 , C08G8/20 , G03F7/023 , G03F7/30
CPC分类号： C08G8/08 , C08G8/20 , G03F7/0236
摘要： A novolak resin made from a carbonyl compound and a specific phenol compound, which resin has good properties, in particular, as a base resin of a photoresist.
摘要翻译：由羰基化合物和特定酚化合物制成的酚醛清漆树脂，该树脂具有良好的性能，特别是光致抗蚀剂的基础树脂。

9. 发明授权

US4021495A Purification of .beta.-naphthol 失效
标题翻译：纯化{62-萘酚
公开(公告)号：US4021495A
公开(公告)日：1977-05-03
申请号：US588117
申请日：1975-06-18
申请人： Hirokazu Hosaka , Kunihiko Tanaka , Yuji Ueda
发明人： Hirokazu Hosaka , Kunihiko Tanaka , Yuji Ueda
IPC分类号： C07C27/00 , C07C37/84 , C07C39/14 , C07C67/00
CPC分类号： C07C37/84
摘要： A process for purifying crude .beta.-naphthol obtained via an alkylnaphthalene hydroperoxide, comprising subjecting the crude .beta.-naphthol to a recrystallization treatment using (1) an aliphatic or alicyclic hydrocarbon solvent having 5 to 10 carbon atoms, or (2) a mixed solvent comprising the aliphatic or alicyclic hydrocarbon solvent and at least one other solvent selected from the group consisting of benzene, a benzene derivative, a ketone, an alcohol, an ether and an ester.
摘要翻译：一种纯化通过烷基萘氢过氧化物得到的粗β-萘酚的方法，包括使用（1）具有5至10个碳原子的脂族或脂环族烃溶剂对粗β-萘酚进行重结晶处理，或（2）包含脂族或脂环烃溶剂和选自苯，苯衍生物，酮，醇，醚和酯的至少一种其它溶剂。

10. 发明授权

US08419403B2 Conveyer of honeycomb formed article and conveying method thereof 有权
标题翻译：蜂窝成型体输送机及其输送方法
公开(公告)号：US08419403B2
公开(公告)日：2013-04-16
申请号：US12724672
申请日：2010-03-16
申请人： Yasumasa Fujioka , Yohei Takemori , Yuji Ueda , Kiyoshi Ishihara
发明人： Yasumasa Fujioka , Yohei Takemori , Yuji Ueda , Kiyoshi Ishihara
IPC分类号： B65G49/00
CPC分类号： B28B21/90 , B28B13/04 , B29C47/0028 , B29C47/34
摘要： There is disclosed a conveyer and a conveying method that enable conveying a lengthy honeycomb formed article extruded at a high speed with a simple apparatus without causing cracks and deformation. The conveyer of a honeycomb formed article includes a plurality of lengthy cradles that are sequentially supplied and then sequentially support and convey the honeycomb formed article, and a fixed support that is fixed so as to extend from the extruder to a supply position of the lengthy cradles, supports the honeycomb formed article just after being extruded, and conveys it to one of the lengthy cradles, and the fixed support is an air float having a supporting face and a plurality of air ejection pores formed on the supporting face that conveys the honeycomb formed article by feeding air from the air ejection pores.
摘要翻译：公开了一种输送机和输送方法，其能够以简单的装置输送长时间挤出的蜂窝成型制品而不引起裂纹和变形。蜂窝成型体的输送机包括依次供给的多个长的托架，然后顺序地支撑和输送蜂窝成型品，以及固定的支撑件，其从挤出机延伸到长的托架的供应位置在挤出后立即支撑蜂窝成型体，并将其输送到长条形托架中的一个，固定支撑件是具有支撑面的空气浮子和形成在支撑面上的多个空气喷射孔，其传送形成的蜂窝体通过从空气喷射孔输送空气的物品。

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