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1. 发明授权

US10852523B2 Real-time autofocus scanning 有权
公开(公告)号：US10852523B2
公开(公告)日：2020-12-01
申请号：US16674742
申请日：2019-11-05
申请人： Leica Biosystems Imaging, Inc.
发明人： Leng-Chun Chen , Allen Olson , Yunlu Zou , Peyman Najmabadi , Greg Crandall
IPC分类号： G02B21/24 , G02B21/00 , G06T7/50 , H04N5/372
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

2. 发明授权

US08923597B2 Creating and viewing three dimensional virtual slides 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US08923597B2
公开(公告)日：2014-12-30
申请号：US14060496
申请日：2013-10-22
申请人： Leica Biosystems Imaging, Inc.
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00 , G02B27/22 , G02B21/36 , H04N13/04
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维数字幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。这些二维数字幻灯片图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像，并且选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

3. 发明授权

US11422350B2 Real-time focusing in line scan imaging 有权
公开(公告)号：US11422350B2
公开(公告)日：2022-08-23
申请号：US16818916
申请日：2020-03-13
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Yunlu Zou , Allen Olson , Kiran Saligrama , Ruby Chen , Peyman Najmabadi , Greg Crandall
IPC分类号： G02B21/24 , G03B13/36 , G02B7/38 , H04N5/232 , G02B21/36 , G02B21/34 , G02B21/26 , G02B21/18 , G02B21/02
摘要： System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.

4. 发明授权

US10591710B2 Real-time focusing in line scan imaging 有权
公开(公告)号：US10591710B2
公开(公告)日：2020-03-17
申请号：US15763061
申请日：2016-09-23
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Yunlu Zou , Allen Olson , Kiran Saligrama , Ruby Chen , Peyman Najmabadi , Greg Crandall
IPC分类号： G02B21/24 , G02B21/36 , G02B21/02 , G02B21/18 , G02B21/26 , G02B21/34 , H04N5/232
摘要： System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.

5. 发明授权

US10585273B2 Two pass macro image 有权
公开(公告)号：US10585273B2
公开(公告)日：2020-03-10
申请号：US16146991
申请日：2018-09-28
申请人： Leica Biosystems Imaging, Inc.
发明人： Leng-Chun Chen , Yunlu Zou , Allen Olson , Peyman Najmabadi , Greg Crandall , Nicholas Newberg , Aaron Stearrett
IPC分类号： G02B21/00 , H04N5/369 , H04N5/217 , H04N5/225
摘要： Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.

6. 发明申请

US20150015578A1 CREATING AND VIEWING THREE DIMENSIONAL VIRTUAL SLIDES 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US20150015578A1
公开(公告)日：2015-01-15
申请号：US14499583
申请日：2014-09-29
申请人： Leica Biosystems Imaging, Inc.
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G02B27/22 , G02B21/36 , H04N13/04 , G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维数字幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。这些二维数字幻灯片图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像，并且选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

7. 发明申请

US20140044346A1 Creating and Viewing Three Dimensional Virtual Slides 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US20140044346A1
公开(公告)日：2014-02-13
申请号：US14060496
申请日：2013-10-22
申请人： Leica Biosystems Imaging, Inc.
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维数字幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。这些二维数字幻灯片图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像，并且选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

8. 发明授权

US11422351B2 Real-time autofocus scanning 有权
公开(公告)号：US11422351B2
公开(公告)日：2022-08-23
申请号：US17105251
申请日：2020-11-25
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Leng-Chun Chen , Allen Olson , Yunlu Zou , Peyman Najmabadi , Greg Crandall
IPC分类号： G02B21/00 , G02B21/24 , G06T7/50 , H04N5/372
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

9. 发明授权

US10955650B2 Two pass macro image 有权
公开(公告)号：US10955650B2
公开(公告)日：2021-03-23
申请号：US16812010
申请日：2020-03-06
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Leng-Chun Chen , Yunlu Zou , Allen Olson , Peyman Najmabadi , Greg Crandall , Nicholas Newberg , Aaron Stearrett
IPC分类号： G02B21/00 , H04N5/217 , H04N5/225 , H04N5/369
摘要： Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.

10. 发明授权

US10481377B2 Real-time autofocus scanning 有权
公开(公告)号：US10481377B2
公开(公告)日：2019-11-19
申请号：US16147465
申请日：2018-09-28
申请人： Leica Biosystems Imaging, Inc.
发明人： Leng-Chun Chen , Allen Olson , Yunlu Zou , Peyman Najmabadi , Greg Crandall
IPC分类号： G02B21/24 , G02B21/00 , G06T7/50 , H04N5/372
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

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