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1. 发明授权

US09075423B2 Generating a regulated signal from another regulated signal 有权
标题翻译：从另一个调节信号产生调节信号
公开(公告)号：US09075423B2
公开(公告)日：2015-07-07
申请号：US12859478
申请日：2010-08-19
申请人： Liang Zhu , Jun Liu , Hai Bo Zhang
发明人： Liang Zhu , Jun Liu , Hai Bo Zhang
IPC分类号： G05F1/577 , G05F1/575 , H02M3/145
CPC分类号： G05F1/575
摘要： An embodiment of a method includes generating a regulated output signal from a regulated intermediate signal in response to a reference signal and the regulated output signal, and generating the regulated intermediate signal from an input signal in response to the regulated output signal and the regulated intermediate signal. By generating one regulated signal (e.g., a regulated output voltage) from another regulated signal (e.g., a regulated intermediate voltage), the magnitude of the ripple component of the one regulated signal may be reduced. Furthermore, by generating the regulated intermediate signal in response to the regulated output signal, the efficiency of the regulation may be increased.
摘要翻译：一种方法的实施例包括响应于参考信号和调节的输出信号从调节的中间信号产生调节的输出信号，以及响应于调节的输出信号和调节的中间信号从输入信号产生调节的中间信号。通过从另一调节信号（例如，调节中间电压）产生一个调节信号（例如，调节输出电压），可以减小一个调节信号的纹波分量的幅度。此外，通过响应于调节的输出信号产生调节的中间信号，可以提高调节的效率。

2. 发明授权

US08946216B2 Indazole derivatives useful as ERK inhibitors 有权
标题翻译：用作ERK抑制剂的吲唑衍生物
公开(公告)号：US08946216B2
公开(公告)日：2015-02-03
申请号：US13819366
申请日：2011-08-29
申请人： Yonqi Deng , Gerald W. Shipps, Jr. , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Kiran Muppalla
发明人： Yonqi Deng , Gerald W. Shipps, Jr. , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Kiran Muppalla
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K45/06 , C07D417/12 , C07D491/113
CPC分类号： A61K31/541 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/113
摘要： The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供式I化合物：式I或其药学上可接受的盐，溶剂合物或酯，其中R，R 1，R 2，R 3，R 4，X，m和n如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

3. 发明申请

US20140329799A1 AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS 有权
标题翻译：作为白介素受体相关激酶抑制剂的氨基酰亚胺
公开(公告)号：US20140329799A1
公开(公告)日：2014-11-06
申请号：US14355353
申请日：2012-10-26
申请人： W. Michael Seganish , Stephanie Nicole Brumfield , Jongwon Lim , Julius J. Matasi , William T. Mcelroy , Deen B. Tulshian , Brian J. Lavey , Michael D. Altman , Criag R. Gibeau , John William Lampe , Joey Methot , Liang Zhu
发明人： W. Michael Seganish , Stephanie Nicole Brumfield , Jongwon Lim , Julius J. Matasi , William T. Mcelroy , Deen B. Tulshian , Brian J. Lavey , Michael D. Altman , Criag R. Gibeau , John William Lampe , Joey Methot , Liang Zhu
IPC分类号： C07D417/04 , A61K45/06 , C07D417/14 , C07D513/04 , C07D487/10 , C07D401/04 , A61K31/5377 , A61K31/513 , C07D491/107
CPC分类号： C07D417/04 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/08 , C07D487/10 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/08 , C07D513/04
摘要： This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.
摘要翻译：本发明涉及作为白介素受体相关激酶抑制剂，特别是IRAK-4的式（I）的氨基嘧啶酮化合物，可用于治疗或预防炎性疾病，包括类风湿性关节炎和炎症性肠病。

4. 发明授权

US08716483B2 Compounds that are ERK inhibitors 有权
标题翻译： ERK抑制剂的化合物
公开(公告)号：US08716483B2
公开(公告)日：2014-05-06
申请号：US12918099
申请日：2009-02-19
申请人： Alan B. Cooper , Yang Nan , Yongqi Deng , Gerald W. Shipps, Jr. , Neng-Yang Shih , Hugh Y. Zhu , Jagdish A. Desai , James J-S Wang , Sunil Paliwal , Hon-Chung Tsui , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Ahmed Samatar
发明人： Alan B. Cooper , Yang Nan , Yongqi Deng , Gerald W. Shipps, Jr. , Neng-Yang Shih , Hugh Y. Zhu , Jagdish A. Desai , James J-S Wang , Sunil Paliwal , Hon-Chung Tsui , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Ahmed Samatar
IPC分类号： C07D401/04 , A61K31/444
CPC分类号： C07D403/14
摘要： Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, and solvates thereof. Q is a tetrahydropyridinyl ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂及其药学上可接受的盐和溶剂化物。 Q是四氢吡啶环。所有其他取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

5. 发明授权

US08693565B2 Method and device for transmitting and receiving signal in wireless communication system 有权
标题翻译：无线通信系统中发送和接收信号的方法和装置
公开(公告)号：US08693565B2
公开(公告)日：2014-04-08
申请号：US13223620
申请日：2011-09-01
申请人： Ning Ge , Liang Zhu , Yukui Pei
发明人： Ning Ge , Liang Zhu , Yukui Pei
IPC分类号： H04B7/02
CPC分类号： H04L25/03343
摘要： A method and device for transmitting and receiving a signal in a wireless communication system. The method for transmitting a signal in a wireless communication system includes: receiving an original data block to be transmitted, the length of the original data block being M, wherein M is an integer; disordering the original data block for one or more times, whereby M data symbols in the original data block are rearranged in each of the one or more times of the disordering, so as to obtain one or more disordered data blocks with length of M; cascading the original data block and the one or more disordered data blocks with a cyclic prefix, to form an equalized signal of frequency domain diversity with time-frequency interleaving; and transmitting the equalized signal of frequency domain diversity through a single carrier.
摘要翻译：一种用于在无线通信系统中发送和接收信号的方法和装置。在无线通信系统中发送信号的方法包括：接收要发送的原始数据块，原始数据块的长度为M，其中M为整数; 原始数据块一次或多次失调，由此原始数据块中的M个数据符号在一次或多次无序中的每一个中重新排列，以便获得长度为M的一个或多个无序数据块; 以循环前缀级联原始数据块和一个或多个无序数据块，以形成具有时频交织的频域分集的均衡信号; 并通过单载波传输频域分集的均衡信号。

6. 发明授权

US08999957B2 Heterocyclic compounds as ERK inhibitors 有权
标题翻译：杂环化合物作为ERK抑制剂
公开(公告)号：US08999957B2
公开(公告)日：2015-04-07
申请号：US13703250
申请日：2011-06-22
申请人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
发明人： Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
IPC分类号： C07D401/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D401/14 , C07D405/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07F7/18
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供了式I化合物：（式I应在此插入）或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2和R 3如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

7. 发明授权

US08979614B2 Deburring machine 有权
标题翻译：去毛刺机
公开(公告)号：US08979614B2
公开(公告)日：2015-03-17
申请号：US13480713
申请日：2012-05-25
申请人： Ming-Lu Yang , Liang Zhu , Zhong-Wei Yang
发明人： Ming-Lu Yang , Liang Zhu , Zhong-Wei Yang
IPC分类号： B24B9/00
CPC分类号： B24B9/005
摘要： A deburring machine for removing burrs from workpieces includes a framework, a deburring mechanism and a transport mechanism. The deburring mechanism mounted on the framework, includes deburring units positioned on the framework. The transport mechanism is positioned on the framework adjacent to the deburring units. The transport mechanism includes a base, multi-station rotating plate and a first driver. The base is positioned on the framework. The multi-station rotating plate is rotatably positioned on the base. The first driver is positioned on the framework and connects with the base. The first driver is capable of driving the multi-station rotating plate to transport the workpieces to the plurality of deburring units, the plurality of deburring units are capable of removing the burrs of the workpieces.
摘要翻译：用于从工件去除毛刺的去毛刺机器包括框架，去毛刺机构和输送机构。安装在框架上的去毛刺机构包括位于框架上的去毛刺单元。运输机构位于与去毛刺单元相邻的框架上。输送机构包括基座，多工位旋转板和第一驱动器。基座位于框架上。多工位旋转板可旋转地定位在基座上。第一个驱动器位于框架上并与基座连接。第一驱动器能够驱动多工位旋转板将工件运送到多个去毛刺单元，多个去毛刺单元能够去除工件的毛刺。

8. 发明授权

US08546404B2 Compounds that are ERK inhibitors 有权
标题翻译： ERK抑制剂的化合物
公开(公告)号：US08546404B2
公开(公告)日：2013-10-01
申请号：US11810282
申请日：2007-06-05
申请人： Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr. , Neng-Yang Shih , Hugh Y. Zhu , Robert Sun , Joseph M. Kelly , Ronald J. Doll , Yang Nan , Tong Wang , Jagdish A. Desai , James J-S Wang , Youhao Dong , Vincent S. Madison , Li Xiao , Alan W. Hruza , M. Arshad Siddiqui , Ahmed A. Samatar , Sunil Paliwal , Hon-Chung Tsui , Azim Alan Celebi , Yiji Wu , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Mehul Patel
发明人： Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr. , Neng-Yang Shih , Hugh Y. Zhu , Robert Sun , Joseph M. Kelly , Ronald J. Doll , Yang Nan , Tong Wang , Jagdish A. Desai , James J-S Wang , Youhao Dong , Vincent S. Madison , Li Xiao , Alan W. Hruza , M. Arshad Siddiqui , Ahmed A. Samatar , Sunil Paliwal , Hon-Chung Tsui , Azim Alan Celebi , Yiji Wu , Sobhana Babu Boga , Abdul-Basit Alhassan , Xiaolei Gao , Liang Zhu , Mehul Patel
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了式1.0的ERK抑制剂及其药学上可接受的盐，酯和溶剂化物。 Q是可以具有桥或稠合环的哌啶或哌嗪环。哌啶环可以在环中具有双键。所有其他取代基如本文所定义。还公开了使用式1.0化合物治疗癌症的方法。

9. 发明授权

US08114982B2 Multi-microRNA methods and compositions 失效
标题翻译：多微RNA方法和组合物
公开(公告)号：US08114982B2
公开(公告)日：2012-02-14
申请号：US12312616
申请日：2007-11-28
申请人： Liang Zhu , Daqian Sun
发明人： Liang Zhu , Daqian Sun
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2320/10
摘要： Provided are DNAs comprising a polynucleotide that encodes at least a first modified miR-30 precursor and a second modified miR-30 precursor. Also provided are vectors comprising the the DNAs, where the vector can replicate in a host cell. Additionally, specific lentiviral vectors comprising the above-described DNA are provided, as are methods of inhibiting expression of a target gene in a eukaryotic cell.
摘要翻译：提供了包含编码至少第一修饰的miR-30前体和第二修饰的miR-30前体的多核苷酸的DNA。还提供了包含DNA的载体，其中载体可以在宿主细胞中复制。此外，提供了包含上述DNA的特定慢病毒载体，以及抑制靶基因在真核细胞中的表达的方法。

10. 发明授权

US09169260B2 Amidopyrazole inhibitors of interleukin receptor-associated kinases 有权
标题翻译：白介素受体相关激酶的吡咯唑抑制剂
公开(公告)号：US09169260B2
公开(公告)日：2015-10-27
申请号：US14006565
申请日：2012-03-21
申请人： William T. McElroy , Guoqing Li , Ginny Dai Ho , Zheng Tan , Sunil Paliwal , William Michael Seganish , Deen Tulshian , John Lampe , Joey L. Methot , Hua Zhou , Michael D. Altman , Liang Zhu
发明人： William T. McElroy , Guoqing Li , Ginny Dai Ho , Zheng Tan , Sunil Paliwal , William Michael Seganish , Deen Tulshian , John Lampe , Joey L. Methot , Hua Zhou , Michael D. Altman , Liang Zhu
IPC分类号： C07D487/04 , A61K31/519 , A61K31/4162
CPC分类号： C07D487/04 , A61K31/4162
摘要： This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.
摘要翻译：本发明涉及作为白介素受体相关激酶抑制剂，特别是IRAK-4的氨基吡唑化合物，可用于治疗细胞增殖性疾病，例如癌症，增生，再狭窄，心脏肥大，免疫疾病和炎症。

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