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    • 8. 发明申请
    • UNCOUPLED COLLAGEN SYNTHESIS AND DEGRADATION ASSAYS
    • 解开胶原蛋白合成和降解测定
    • US20070292892A1
    • 2007-12-20
    • US11758471
    • 2007-06-05
    • Linda SandellPatrick Garnero
    • Linda SandellPatrick Garnero
    • G01N33/53
    • G01N33/564G01N33/6887G01N2800/10G01N2800/102G01N2800/105Y10S436/811
    • The invention relates to methods for determining the progression of cartilage degeneration diseases, such as osteoarthritis and rheumatoid arthritis, by quantitating collagen synthesis and degradation markers in patient samples. One can determine whether a cartilage degeneration condition is progressing, regressing, or remaining stable by quantitating collagen synthesis and degradation markers in patient samples and comparing the value obtained to a reference value. When a joint affected by cartilage degeneration in question expresses collagen synthesis and degradation markers, a change in this value is indicative of a change in the progression of the cartilage degeneration condition. The methods and apparatus of the invention allow accurate determination of the therapeutic effects certain cartilage degeneration drug treatments, including osteoarthritis and rheumatoid arthritis drug treatments, so are also useful for pharmaceutical efficacy studies in mammals.
    • 本发明涉及通过量化患者样品中的胶原合成和降解标记来测定软骨变性疾病如骨关节炎和类风湿性关节炎的进展的方法。 可以通过定量测定患者样品中的胶原合成和降解标记来确定软骨变性状态是否正在进行,回归或保持稳定,并将获得的值与参考值进行比较。 当受到软骨退化影响的关节表达胶原蛋白合成和降解标记物时,该值的变化表明软骨退化病情进展的变化。 本发明的方法和装置允许精确测定某些软骨变性药物治疗(包括骨关节炎和类风湿关节炎药物治疗)的治疗效果,因此也可用于哺乳动物的药物功效研究。