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1. 发明授权

US11145497B2 Combined optical and mass spectral tissue identification probe 有权
公开(公告)号：US11145497B2
公开(公告)日：2021-10-12
申请号：US16308214
申请日：2017-06-06
申请人： Micromass UK Limited
发明人： Steven Pringle , Emrys Jones , Mike Morris , Keith Richardson , Zoltan Takats
IPC分类号： H01J49/00 , A61B5/00 , G01N21/71 , G01N27/622 , H01J49/16 , A61B1/313 , A61B18/00
摘要： A method of analysing a target is disclosed comprising ablating a portion of a target so as to cause an aerosol plume to be produced and light or other electromagnetic radiation to be emitted. The aerosol plume is analysed using mass spectrometry and/or ion mobility spectrometry and the emitted light or other electromagnetic radiation is analysed using optical spectroscopy in order to determine one or more regions of interest of the target and/or one or more margins or bounds of a region of interest of the target.

2. 发明授权

US11031221B2 Ionisation of gaseous samples 有权
公开(公告)号：US11031221B2
公开(公告)日：2021-06-08
申请号：US15555758
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： Emrys Jones , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Zoltan Takats
IPC分类号： H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145 , G06F19/00
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

3. 发明授权

US10777399B2 Capacitively coupled REIMS technique and optically transparent counter electrode 有权
公开(公告)号：US10777399B2
公开(公告)日：2020-09-15
申请号：US15764791
申请日：2016-09-22
申请人： Micromass UK Limited
发明人： Steven Derek Pringle , Lajos Godorhazy , Daniel Simon , Daniel Szalay , Zoltan Takats , Tamas Karancsi
IPC分类号： H01J49/04 , G01N33/483 , G01N21/31 , G01N21/65
摘要： A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.

4. 发明申请

US20150201913A1 SYSTEM AND METHOD FOR IDENTIFICATION OF BIOLOGICAL TISSUES 审中-公开
标题翻译：用于鉴定生物组织的系统和方法
公开(公告)号：US20150201913A1
公开(公告)日：2015-07-23
申请号：US14676720
申请日：2015-04-01
申请人： Micromass UK Limited
发明人： Zoltan Takats
IPC分类号： A61B10/02 , H01J49/16
CPC分类号： A61B10/02 , G01N1/02 , G01N27/62 , G01N2001/028 , G01N2001/045 , G01N2001/2886 , H01J49/04 , H01J49/165 , H01J49/168
摘要： The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyser, (c) using the analyser for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.
摘要翻译：本发明提供了用于分析，定位和/或识别组织类型的系统，方法和装置。该方法包括分析，定位和/或识别一个或多个组织样本，其特征在于，所述方法包括：（a）从所述一个或多个组织样品中的部位产生气体组织颗粒，（b）将气态组织颗粒从（c）使用分析器基于气体组织颗粒产生组织相关数据，以及（d）基于组织相关数据分析，定位和/或识别所述一个或多个组织样本。当一种或多种外科手术工具是电离的一体化部分时，本发明可以与外科手术紧密结合使用，或者作为用于分析一个或多个组织部分的单独的质谱探针。

5. 发明授权

US11367606B2 Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples 有权
公开(公告)号：US11367606B2
公开(公告)日：2022-06-21
申请号：US16544636
申请日：2019-08-19
申请人： Micromass UK Limited
发明人： Zoltan Takats , Emrys Jones , James Ian Langridge , Michael Raymond Morris , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Keith Richardson , Phillip Robert Bennett , David Alan MacIntyre , Pamela Pruski
IPC分类号： H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
摘要： A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

6. 发明授权

US11367605B2 Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue 有权
公开(公告)号：US11367605B2
公开(公告)日：2022-06-21
申请号：US15555818
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： Emrys Jones , Steven Derek Pringle , Zoltan Takats
IPC分类号： H01J49/04 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B18/00 , A61B18/04 , A61B18/14 , A61B18/18 , A61B18/20 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/68 , G01N33/92 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/24 , H01J49/26 , G16H10/40 , G16H15/00 , G16H50/20 , G16B20/00 , A61B1/00 , A61B1/31 , A61B5/145
摘要： A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

7. 发明授权

US11295941B2 Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue 有权
公开(公告)号：US11295941B2
公开(公告)日：2022-04-05
申请号：US15555818
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： Emrys Jones , Steven Derek Pringle , Zoltan Takats
IPC分类号： H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
摘要： A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

8. 发明授权

US11264223B2 Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples 有权
公开(公告)号：US11264223B2
公开(公告)日：2022-03-01
申请号：US16033447
申请日：2018-07-12
申请人： Micromass UK Limited
发明人： Zoltan Takats , Emrys Jones , James Ian Langridge , Michael Raymond Morris , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Keith Richardson , Phillip Robert Bennett , David Alan Macintyre , Pamela Pruski
IPC分类号： H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
摘要： A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

9. 发明授权

US11239066B2 Cell population analysis 有权
公开(公告)号：US11239066B2
公开(公告)日：2022-02-01
申请号：US15555694
申请日：2016-03-07
申请人： Micromass UK Limited
发明人： Emrys Jones , Steven Derek Pringle , Keith Richardson , James Ian Langridge , Zoltan Takats
IPC分类号： H01J49/04 , A61B10/02 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , G16B20/50 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , A61B17/32 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

10. 发明授权

US11133164B2 Capacitively coupled REIMS technique and optically transparent counter electrode 有权
公开(公告)号：US11133164B2
公开(公告)日：2021-09-28
申请号：US16778423
申请日：2020-01-31
申请人： Micromass UK Limited
发明人： Steven Derek Pringle , Lajos Godorhazy , Daniel Simon , Daniel Szalay , Zoltan Takats , Tamas Karancsi
IPC分类号： H01J49/04 , G01N33/483 , G01N21/31 , G01N21/65
摘要： A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.

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