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1. 发明申请

US20070276230A1 Lymph Node Detecting Apparatus 有权
标题翻译：淋巴结检测装置
公开(公告)号：US20070276230A1
公开(公告)日：2007-11-29
申请号：US10580007
申请日：2004-11-16
申请人： Mitsuharu Miwa , Takahiro Shikayama , Toshiyuki Kitai
发明人： Mitsuharu Miwa , Takahiro Shikayama , Toshiyuki Kitai
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , A61B5/0059 , A61B5/415 , A61B5/418 , G01N21/6428
摘要： A sentinel lymph node detecting apparatus 1 includes: an excitation light source unit 2 that illuminates an excitation light 10 onto a living body observation portion 20 including a sentinel lymph node 21 near a tumor into which a fluorescent dye that emits fluorescence is injected; an optical filter 3 that transmits a fluorescence image 11; an image pickup device 4 that is integral with excitation light source unit 2 and picks up fluorescence image 11 transmitted through optical filter 3; an adjusting device 5 that adjusts the picked-up observation image; and an image displaying device 6 that displays the adjusted observation image. Adjusting device 5 adjusts at least one of a luminance and a contrast of the observation image. A lymph node detecting apparatus that is simple in apparatus arrangement, is easy to handle, and enables good images to be obtained is thereby realized.
摘要翻译：前哨淋巴结检测装置1包括：激发光源单元2，其将激发光10照射到包括发射荧光的荧光染料的肿瘤附近的前哨淋巴结21的生物体观察部20上; 透过荧光图像11的滤光器3; 与激发光源单元2成一体并拾取通过滤光器3透射的荧光图像11的摄像装置4; 调整装置5，其调整拍摄观察图像; 以及显示调整后的观察图像的图像显示装置6。调整装置5调整观察图像的亮度和对比度中的至少一个。因此，能够容易地进行装置配置的淋巴结检测装置的实现，能够获得良好的图像。

2. 发明授权

US08190231B2 Lymph node detecting apparatus 有权
标题翻译：淋巴结检测装置
公开(公告)号：US08190231B2
公开(公告)日：2012-05-29
申请号：US10580007
申请日：2004-11-16
申请人： Mitsuharu Miwa , Takahiro Shikayama , Toshiyuki Kitai
发明人： Mitsuharu Miwa , Takahiro Shikayama , Toshiyuki Kitai
IPC分类号： A61B5/05
CPC分类号： G01N21/6456 , A61B5/0059 , A61B5/415 , A61B5/418 , G01N21/6428
摘要： A sentinel lymph node detecting apparatus 1 includes: an excitation light source unit 2 that illuminates an excitation light 10 onto a living body observation portion 20 including a sentinel lymph node 21 near a tumor into which a fluorescent dye that emits fluorescence is injected; an optical filter 3 that transmits a fluorescence image 11; an image pickup device 4 that is integral with excitation light source unit 2 and picks up fluorescence image 11 transmitted through optical filter 3; an adjusting device 5 that adjusts the picked-up observation image; and an image displaying device 6 that displays the adjusted observation image. Adjusting device 5 adjusts at least one of a luminance and a contrast of the observation image. A lymph node detecting apparatus that is simple in apparatus arrangement, is easy to handle, and enables good images to be obtained is thereby realized.
摘要翻译：前哨淋巴结检测装置1包括：激发光源单元2，其将激发光10照射到包括发射荧光的荧光染料的肿瘤附近的前哨淋巴结21的生物体观察部20上; 透过荧光图像11的滤光器3; 与激发光源单元2成一体并拾取通过滤光器3透射的荧光图像11的摄像装置4; 调整装置5，其调整拍摄观察图像; 以及显示调整后的观察图像的图像显示装置6。调整装置5调整观察图像的亮度和对比度中的至少一个。因此，能够容易地进行装置配置的淋巴结检测装置的实现，能够获得良好的图像。

3. 发明授权

US08956591B2 Method for detecting cancer using ICG fluorescence method 有权
标题翻译：使用ICG荧光法检测癌症的方法
公开(公告)号：US08956591B2
公开(公告)日：2015-02-17
申请号：US12466085
申请日：2009-05-14
申请人： Osamu Ishikawa , Terumasa Yamada , Kunihito Gotoh , Mitsuharu Miwa , Takahiro Shikayama
发明人： Osamu Ishikawa , Terumasa Yamada , Kunihito Gotoh , Mitsuharu Miwa , Takahiro Shikayama
IPC分类号： A61B5/00 , A61K49/00 , G01N21/64
CPC分类号： A61K49/0034 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4244 , A61B5/445 , A61B6/12 , A61B8/085 , G01N21/6428 , G01N21/6456 , G06F19/00
摘要： A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.
摘要翻译：一种检测附属癌症病变的方法，其特征在于，其中向活体施用吲哚青绿的给药步骤，其中手术暴露疑似患有癌症的靶器官并用吲哚青绿的激发光照射的照射步骤，其中获得来自目标器官中激发的吲哚菁绿的近红外荧光强度分布图像，以及识别步骤，其中在强度分布图像中具有近红外荧光的区域，不包括术前检查或术中宏观观察中检测到的区域，被鉴定为附属癌症病变。

4. 发明授权

US08046055B2 Lymph node detector 有权
标题翻译：淋巴结检测器
公开(公告)号：US08046055B2
公开(公告)日：2011-10-25
申请号：US11629471
申请日：2005-05-25
申请人： Mitsuharu Miwa , Takahiro Shikayama
发明人： Mitsuharu Miwa , Takahiro Shikayama
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/06 , A61B5/415 , A61B5/418 , A61B2562/0233 , A61B2562/043
摘要： A sentinel lymph node detecting apparatus 1 according to an embodiment of the present invention includes: a light source unit 2, illuminating an excitation light 10 and an illumination light 11 onto a biological observation location 20 that includes a sentinel lymph node 21 near a tumor, into which a fluorescent dye that emits fluorescence is injected; an optical filter 3, transmitting a fluorescence image 11 and a normal image 13; an image pickup device 5, disposed integral to the light source unit 2 and picking up the fluorescence image 11 and the normal image 13 transmitted through the optical filter 3; and an image display device 7, displaying the observation images that have been picked up. The wavelength of the illumination light 11 is set to a value close to the wavelength of the fluorescence emitted from the fluorescent dye.
摘要翻译：根据本发明实施例的前哨淋巴结检测装置1包括：光源单元2，将激发光10和照明光11照射到包括肿瘤附近的前哨淋巴结21的生物学观察位置20上，注射发出荧光的荧光染料; 透射荧光图像11和正常图像13的滤光器3; 图像拾取装置5，与光源单元2集成并拾取透过滤光器3的荧光图像11和正常图像13; 以及显示已经被拾取的观察图像的图像显示装置7。照明光11的波长被设定为接近从荧光染料发出的荧光的波长的值。

5. 发明申请

US20080097198A1 Lymph Node Detector 有权
标题翻译：淋巴结检测器
公开(公告)号：US20080097198A1
公开(公告)日：2008-04-24
申请号：US11629471
申请日：2005-05-25
申请人： Mitsuharu Miwa , Takahiro Shikayama
发明人： Mitsuharu Miwa , Takahiro Shikayama
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/06 , A61B5/415 , A61B5/418 , A61B2562/0233 , A61B2562/043
摘要： A sentinel lymph node detecting apparatus 1 according to an embodiment of the present invention includes: a light source unit 2, illuminating an excitation light 10 and an illumination light 11 onto a biological observation location 20 that includes a sentinel lymph node 21 near a tumor, into which a fluorescent dye that emits fluorescence is injected; an optical filter 3, transmitting a fluorescence image 11 and a normal image 13; an image pickup device 5, disposed integral to the light source unit 2 and picking up the fluorescence image 11 and the normal image 13 transmitted through the optical filter 3; and an image display device 7, displaying the observation images that have been picked up. The wavelength of the illumination light 11 is set to a value close to the wavelength of the fluorescence emitted from the fluorescent dye.
摘要翻译：根据本发明实施例的前哨淋巴结检测装置1包括：光源单元2，将激发光10和照明光11照射到包括肿瘤附近的前哨淋巴结21的生物学观察位置20上，注射发出荧光的荧光染料; 透射荧光图像11和正常图像13的滤光器3; 图像拾取装置5，与光源单元2集成并拾取透过滤光器3的荧光图像11和正常图像13; 以及显示已经被拾取的观察图像的图像显示装置7。照明光11的波长被设定为接近从荧光染料发出的荧光的波长的值。

6. 发明授权

US5774223A Optical measuring method and an optical measuring apparatus for determining the internal structure of an object 失效
标题翻译：光学测量方法和用于确定物体的内部结构的光学测量装置
公开(公告)号：US5774223A
公开(公告)日：1998-06-30
申请号：US703766
申请日：1996-08-27
申请人： Tsuneyuki Urakami , Mitsuharu Miwa , Yutaka Yamashita , Yutaka Tsuchiya
发明人： Tsuneyuki Urakami , Mitsuharu Miwa , Yutaka Yamashita , Yutaka Tsuchiya
IPC分类号： G01N21/27 , A61B5/00 , G01J1/42 , G01B11/00 , G01N33/48
CPC分类号： A61B5/0059
摘要： An optical measuring method and an optical measuring apparatus are capable of obtaining the true mean time delay of a light waveform within a short time for the purpose of obtaining information on the internal structure of an object. Calculations include a first mean time delay when the light path includes the object, a second mean time delay when the light path does not include the object, and a subtraction of the second mean time delay from the first mean time delay to obtain a true mean time delay.
摘要翻译：光学测量方法和光学测量装置能够在短时间内获得光波形的真实平均时间延迟，以获得关于对象的内部结构的信息。计算包括当光路包括物体时的第一平均时间延迟，当光路不包括物体时的第二平均时间延迟，以及从第一平均时间延迟减去第二平均时间延迟以获得真实平均值时间延迟

7. 发明授权

US07725170B2 Breast carcinoma detector 有权
标题翻译：乳腺癌检测器
公开(公告)号：US07725170B2
公开(公告)日：2010-05-25
申请号：US10471015
申请日：2002-03-13
申请人： Mitsuharu Miwa
发明人： Mitsuharu Miwa
IPC分类号： A61B6/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B10/0041
摘要： The breast cancer detector of the invention comprising a transparent breast pressing member 1 having a pressing face 4 which is pressed to a breast of a subject that makes it possible to observe the breast pressed to the body from the opposite face to the pressing face 4, a light source means 2 for irradiating light of a designated wavelength with respect to the breast in an area to which the pressing face 4 is pressed and an image pickup means 3 sensitive to light from the breast derived from irradiated light of the light source means 2 and obtaining the breast image through the breast pressing member 1, wherein breast cancer is detected from the breast image obtained by the image pickup means. Therefore, the breast is pressed to the body by using the breast pressing member 1 to keep the breast thin, thus making it possible to irradiate uniformly the light emitted from the light source 2 to an area of the breast to which the pressing face 4 is pressed. The light from the breast derived from the irradiated light is obtained from the image pickup means 3 to detect breast cancer in the breast from the thus-obtained image.
摘要翻译：本发明的乳腺癌检测器包括：透明乳房按压构件1，其具有按压面4，按压面4被按压到被检体的乳房，使得可以从与按压面4相反的面观察被按压到身体的乳房; 光源装置2，用于在按压面4的区域中照射相对于乳房的指定波长的光;以及摄像装置3，其对来自源自照射光的光源装置2的来自乳房的光敏感; 并且通过乳房按压部件1获得乳房图像，其中从由图像拾取装置获得的乳房图像中检测乳腺癌。因此，通过使用乳房按压部件1将乳房按压到身体，以保持乳房变薄，从而可以将从光源2发射的光均匀地照射到按压面4为乳房的区域按下。来自照射光的来自乳房的光从图像拾取装置3获得，以从如此获得的图像中检测乳房中的乳腺癌。

8. 发明授权

US5772588A Apparatus and method for measuring a scattering medium 失效
标题翻译：用于测量散射介质的装置和方法
公开(公告)号：US5772588A
公开(公告)日：1998-06-30
申请号：US704124
申请日：1996-08-28
申请人： Mitsuharu Miwa , Yutaka Tsuchiya
发明人： Mitsuharu Miwa , Yutaka Tsuchiya
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1455 , G01N21/49 , G01N21/75 , G01N33/72 , A61B3/00
CPC分类号： G01N21/49
摘要： An apparatus and method are provided for measuring a scattering medium containing a light absorbing substance. The apparatus includes a light source; a photodetector; a gate voltage applying circuit for applying gate voltage pulses to the photodetector at a plurality of detection timings in order to generate the photodetector output light detection signals corresponding to the intensity of the light during periods of application of the pulses; and a signal processing unit for obtaining signal intensities during the periods and calculating internal information of the scattering medium based on the signal intensities.
摘要翻译：提供了一种用于测量含有光吸收物质的散射介质的装置和方法。该装置包括光源; 光检测器; 栅极电压施加电路，用于在多个检测定时向光电检测器施加栅极电压脉冲，以便在施加脉冲期间产生对应于光强度的光电检测器输出光检测信号; 以及信号处理单元，用于在这些周期期间获得信号强度，并且基于信号强度来计算散射介质的内部信息。

9. 发明授权

US5676142A Method and apparatus for measuring scattering property and absorption property in scattering medium 失效
标题翻译：用于测量散射介质中散射特性和吸收性能的方法和装置
公开(公告)号：US5676142A
公开(公告)日：1997-10-14
申请号：US551746
申请日：1995-11-07
申请人： Mitsuharu Miwa , Yutaka Tsuchiya , Yukio Ueda
发明人： Mitsuharu Miwa , Yutaka Tsuchiya , Yukio Ueda
IPC分类号： G01N21/27 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/49
CPC分类号： A61B5/14553 , A61B5/0091 , A61B5/4312 , G01N21/49 , A61B2562/0242
摘要： Measuring scattering and absorption properties of a scattering medium according to the following: (a) causing pulsed measuring light having a predetermined wavelength to enter the scattering medium; (b) performing time-resolved measurement of the measuring light having diffusively propagated in the scattering medium at light detection positions corresponding to a plurality of combinations, each comprising a light incidence position on the scattering medium in the first step and a light detection position on the scattering medium where the measuring light entered the scattering medium in the first step and a light detection position on the scattering medium where the measuring light is detected, having different incidence-detection distances between the light incidence position and the light detection position; (c) calculating a plurality of mean optical pathlengths of the measuring light corresponding to the plurality of incidence-detection distances, based on results of the time-resolved measurement measured in the second step; and (d) calculating a scattering coefficient and an absorption coefficient in the scattering medium, based on a plurality of simultaneous relations consisting of calculation values of the plurality of mean optical pathlengths corresponding to the incidence-detection distances, calculated in the third step, and a theoretical equation of the mean optical pathlengths derived in correspondence to light diffusion properties comprising a scattering property and an absorption property in diffusive propagation paths in the scattering medium.
摘要翻译：测量散射介质的散射和吸收性能：（a）使具有预定波长的脉冲测量光进入散射介质; （b）在对应于多个组合的光检测位置对散射介质进行扩散传播的测量光进行时间分辨测量，每个组合包括在第一步骤中的散射介质上的光入射位置和在第一步骤中测量光进入散射介质的散射介质和在检测光的散射介质上的光检测位置，其具有在入射位置和光检测位置之间不同的入射检测距离; （c）基于在第二步骤中测量的时间分辨测量结果，计算与多个入射检测距离对应的测量光的多个平均光程长度; 和（d）基于由第三步计算的与入射检测距离对应的多个平均光程长度的计算值构成的多个同时关系，计算散射介质中的散射系数和吸收系数，以及与散射介质中漫射传播路径中散射特性和吸收特性相对应的光散射特性导出的平均光程长度的理论方程。

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