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1. 发明授权

US09797886B2 Agglutination enhancer 有权
公开(公告)号：US09797886B2
公开(公告)日：2017-10-24
申请号：US14123899
申请日：2012-06-04
申请人： Naoyuki Yamamoto , Tsutomu Masuda
发明人： Naoyuki Yamamoto , Tsutomu Masuda
IPC分类号： G01N33/53 , C08F220/36 , C08F220/60 , G01N33/542
CPC分类号： G01N33/5306 , C08F220/36 , C08F220/60 , G01N33/542
摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

2. 发明申请

US20140113311A1 AGGLUTINATION ENHANCER 有权
公开(公告)号：US20140113311A1
公开(公告)日：2014-04-24
申请号：US14123899
申请日：2012-06-04
申请人： Naoyuki Yamamoto , Tsutomu Masuda
发明人： Naoyuki Yamamoto , Tsutomu Masuda
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , C08F220/36 , C08F220/60 , G01N33/542
摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.
摘要翻译：本发明的目的是提供一种与常规免疫凝集增强剂相比具有优异的凝集增强作用的凝集增强剂，本发明涉及用于免疫凝集测定方法的凝集增强剂，其包含具有单体单元以下通式[1]表示：（其中R1表示氢原子或甲基; R2和R3分别独立地表示甲基或乙基; X表示-NH-或氧原子; n表示1的整数）至6; m表示1〜3的整数），以及免疫凝集测定方法，其中在上述用于免疫凝集测定法的凝集增强剂的共存下，将分析物的抗体或分析物的抗原进入与分析物接触以引起抗原 - 抗体反应。

3. 发明申请

US20120277238A1 PHARMACEUTICAL COMPOSITION CONTAINING FUSED HETERO-RING DERIVATIVE 审中-公开
标题翻译：含有金属杂环衍生物的药物组合物
公开(公告)号：US20120277238A1
公开(公告)日：2012-11-01
申请号：US13388296
申请日：2010-07-29
申请人： Yuuki Tachibana , Masayoshi Miyagawa , Tsutomu Masuda , Tsuyoshi Hasegawa
发明人： Yuuki Tachibana , Masayoshi Miyagawa , Tsutomu Masuda , Tsuyoshi Hasegawa
IPC分类号： A61K31/496 , C07D471/04 , C07D491/052 , C07D487/04 , A61K31/4985 , A61K31/404 , A61K31/437 , A61P11/06 , A61P37/08 , A61P11/00 , A61P29/00 , A61P17/06 , A61P1/00 , A61P9/10 , A61P25/00 , C07D403/06
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/1652 , A61K9/2054 , A61K9/4866 , A61K31/496 , A61K31/4985 , C07C2601/02 , C07D207/34 , C07D209/42 , C07D209/52 , C07D235/24 , C07D401/06 , C07D403/06 , C07D471/04 , C07D487/04 , C07D491/052
摘要： The present invention provides a compound which indicates a histamine H4 receptor modulating activity.A compound represented by a formula (I): wherein A ring is a ring represented by the following formula: wherein R1 is substituted or unsubstituted alkyl, etc., W is —O—, etc., n is an integer of 0 to 6; X is —N(R7)— or —O—; R7 is hydrogen, substituted or unsubstituted alkyl, etc.; Y is —C(R8)═ or —N═; R8 is hydrogen, substituted or unsubstituted alkyl, etc.; Z is ═O, ═S, etc.; B ring is a ring represented by the following formula: wherein R10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino; R11, R12a and R12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.; p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：本发明提供了表示组胺H 4受体调节活性的化合物。由式（I）表示的化合物：其中A环是由下式表示的环：其中R1是取代或未取代的烷基等，W是-O-等，n是0-6的整数 ; X是-N（R 7） - 或-O-; R7是氢，取代或未取代的烷基等; Y是-C（R8）=或-N =; R8是氢，取代或未取代的烷基等; Z是═O，═S等; B环是由下式表示的环：其中R 10各自独立地是取代或未取代的烷基，卤素，羟基，取代或未取代的烷氧基，取代或未取代的氨基; R11，R12a和R12b各自独立地为氢或取代或未取代的烷基等; p为0〜4的整数，或其药学上可接受的盐或其溶剂合物。

4. 发明授权

US08173841B2 Tetrahydro-naphthalene derivatives 失效
标题翻译：四氢萘衍生物
公开(公告)号：US08173841B2
公开(公告)日：2012-05-08
申请号：US13052482
申请日：2011-03-21
申请人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
发明人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
IPC分类号： C07C273/00 , A61K31/17
CPC分类号： C07D295/088 , C07C233/29 , C07C233/75 , C07C235/42 , C07C237/40 , C07C275/32 , C07C275/38 , C07C275/40 , C07C275/42 , C07C317/32 , C07C323/44 , C07C2602/10 , C07D207/27 , C07D211/22 , C07D211/46 , C07D211/62 , C07D295/135
摘要： This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢萘衍生物及其盐。本发明的四氢萘衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁，膀胱过度活动症，急迫性尿失禁，慢性疼痛，神经性疼痛，手术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，炎症性疾病，哮喘和COPD。

5. 发明申请

US20090298811A1 BENZIMIDAZOLONE DERIVATIVES 审中-公开
公开(公告)号：US20090298811A1
公开(公告)日：2009-12-03
申请号：US12440646
申请日：2007-09-03
申请人： Kazuo Ando , Ingrid Price Buchler , Shridhar Gajanan Hedge , Makoto Kawai , Tsutomu Masuda , Hirofumi Omura
发明人： Kazuo Ando , Ingrid Price Buchler , Shridhar Gajanan Hedge , Makoto Kawai , Tsutomu Masuda , Hirofumi Omura
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/4965 , A61K31/437 , A61K31/4245 , A61K31/4184 , C07D405/14 , C07D413/06 , C07D403/08 , C07D471/04 , C07D413/12 , C07D235/24
CPC分类号： C07D413/06 , A61K31/16 , C07D235/26 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12 , C07D413/14 , C07D471/04
摘要： This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of the compound of formula (I) or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein. These compounds are useful in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, spasticity, epilepsy, Tourette's syndrome, Parkinson's disease, neuroprotection, anxiety, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, cachexia, nausea, emesis, chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasodialation, hypertension, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis and bronchitis.

6. 发明授权

US07435743B2 Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US07435743B2
公开(公告)日：2008-10-14
申请号：US11240867
申请日：2005-09-30
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshiro , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuiyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshiro , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuiyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K31/4418 , A61K31/444 , A61K31/4436 , C07D213/22 , C07D409/04 , C07D213/73
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents hydrogen, —CR31R32R33; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译：其中R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1 -C 6烷基， 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基，（C 1-6烷基）氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯基磺酰基氨基，C 1 -C 6烷基氨基，，或-O-（CH 2）n - n - R 111; R 2表示氢或卤素; R 3表示氢，-CR 31，32，32，33， R 4是氢，氨基甲酰基，CN，羧基等; R 5是氨基，C 1-6烷基氨基，C 1-6烷基氨基等，或其盐。该化合物具有优异的抗炎活性和其他生物活性。

7. 发明申请

US20060166989A1 2-naphthamide derivatives 审中-公开
标题翻译： 2-萘甲酰胺衍生物
公开(公告)号：US20060166989A1
公开(公告)日：2006-07-27
申请号：US10517677
申请日：2003-05-30
申请人： Makoto Shimazaki , Osamu Sakurai , Toshiki Murata , Klaus Urbahns , Noriyuki Yamamoto , Satoru Yoshikawa , Masaomi Umeda , Masaomi Tajimi , Tsutomu Masuda , Takuya Shintani , Haruka Shimizu
发明人： Makoto Shimazaki , Osamu Sakurai , Toshiki Murata , Klaus Urbahns , Noriyuki Yamamoto , Satoru Yoshikawa , Masaomi Umeda , Masaomi Tajimi , Tsutomu Masuda , Takuya Shintani , Haruka Shimizu
IPC分类号： A61K31/537 , A61K31/44 , A61K31/195 , C07D213/55 , C07D265/30 , C07C237/40
CPC分类号： C07C235/66
摘要： The present invention relates to 2-naphthamides, which are useful as an active ingredient of pharmaceutical preparations. The 2-naphthamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benign prostatic hypertrophy (BPH), pro-statitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the disease is also alleviated by treatment with an IP receptor antagonist.
摘要翻译：本发明涉及可用作药物制剂活性成分的2-萘甲酰胺。本发明的2-萘甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体活性相关的疾病。这些疾病包括尿路疾病或病症如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大），pro-statitis，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺增生症，膀胱炎或自发性膀胱过敏反应。本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压血友病和出血; 和炎症，因为该疾病也通过用IP受体拮抗剂治疗而缓解。

8. 发明授权

US06984649B1 Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US06984649B1
公开(公告)日：2006-01-10
申请号：US10402500
申请日：2003-03-28
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K31/4545 , C07D409/14 , C07D211/68 , C07D213/73
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents 1.2.3.6-tetrahydro-pyridine, or —CR31R32R33 wherein R31 represents H or C1-6 alkyl and R32 and R33 are joined to form a 5-8 membered saturated ring optionally containing up to three heteroatoms; R4 is carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译：吡啶化合物，其通式如下：其中R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基，（C 1-6烷基）氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯基磺酰基氨基，C 1 -C 6烷基氨基，，或-O-（CH 2）n - n - R 111; R 2表示氢或卤素; R 3表示1.2.3.6-四氢 - 吡啶或-CR 31，其中R 1，R 2，R 3， SUP> 31表示H或C 1-6烷基，R 32和R 33连接形成5-8 任选地含有至多三个杂原子的饱和环; R 4是氨基甲酰基，CN，羧基等; R 5是氨基，C 1-6烷基氨基，C 1-6烷基氨基等，或其盐。该化合物具有优异的抗炎活性和其他生物活性。

9. 发明授权

US4348478A Method for preparation of a recombinant DNA phage 失效
标题翻译：重组DNA噬菌体的制备方法
公开(公告)号：US4348478A
公开(公告)日：1982-09-07
申请号：US87167
申请日：1979-10-22
申请人： Eiichi Nakano , Tsutomu Masuda , Narimasa Saito , Danji Fukushima
发明人： Eiichi Nakano , Tsutomu Masuda , Narimasa Saito , Danji Fukushima
IPC分类号： C12N15/09 , C12N15/00 , C12P19/34 , C12R1/91
CPC分类号： C12N15/00
摘要： A method for the preparation of a novel recombinant DNA, which comprises (1) cleaving with an endonuclease a temperate phage DNA having an endonuclease-sensitive region not in the DNA segment participating in the replication of phage DNA and the integration of phage DNA into a host chromosome but at least in the DNA segment carrying genetic information for the coat protein production and another DNA carrying intended genetic information, (2) adding DNA-ligase to the mixture of both cleft DNA's, and (3) recovering from the mixture a phage DNA having its coat protein producing ability deleted by the replacement of the DNA segments carrying genetic information for the coat protein production with a DNA fragment carrying the intended information.
摘要翻译：一种制备新的重组DNA的方法，其包括（1）用核酸内切酶切割温和的噬菌体DNA，所述温带噬菌体DNA具有参与噬菌体DNA复制的DNA片段中不具有内切核酸酶敏感区域，并将噬菌体DNA整合到宿主染色体，但至少在DNA片段中携带外壳蛋白生产的遗传信息和携带预期遗传信息的另一个DNA，（2）向裂解DNA的混合物中加入DNA连接酶，和（3）从混合物中回收噬菌体通过用携带预期信息的DNA片段替代携带用于外壳蛋白生产的遗传信息的DNA片段，缺失其外壳蛋白产生能力的DNA。

10. 发明授权

US07842799B2 Recombinant vector capable of increasing secretion of Koji mold protease 失效
标题翻译：能增加Koji模型蛋白酶分泌的重组载体
公开(公告)号：US07842799B2
公开(公告)日：2010-11-30
申请号：US11990926
申请日：2006-09-19
申请人： Osamu Hatamoto , Genryou Umitsüki , Masayuki Machida , Motoaki Sano , Akimitsu Tanaka , Chitoshi Oka , Hiroshi Maeda , Hitoshi Tainaka , Touru Ito , Tomomi Uchikawa , Tsutomu Masuda , Kenichiro Matsushima
发明人： Osamu Hatamoto , Genryou Umitsüki , Masayuki Machida , Motoaki Sano , Akimitsu Tanaka , Chitoshi Oka , Hiroshi Maeda , Hitoshi Tainaka , Touru Ito , Tomomi Uchikawa , Tsutomu Masuda , Kenichiro Matsushima
IPC分类号： C12N15/31 , C12N15/79 , C12N15/80
CPC分类号： C12N15/80 , A23L11/09 , A23L27/24 , A23L27/50 , C07K14/38 , C12N9/62 , C12P21/02
摘要： To improve the activity of a Koji mold protease in a solid or liquid culture medium in the production of foods (e.g., a seasoning), pharmaceuticals (e.g., a digestive agent), protease for use in a detergent and the like.Disclosed are a recombinant vector having capability of increasing the secretion of the Koji mold protease, a Koji mold which is transformed with the vector and has an increased expression of a gene for a protease or an increase secretion of the same, a method for the production of a protease by using the transformed Koji mold, and the like.
摘要翻译：改善在固体或液体培养基中生产食品（例如调味品），药物（例如消化剂），用于洗涤剂等的蛋白酶中的Koji模具蛋白酶的活性。公开了具有增加Koji模型蛋白酶的分泌能力的重组载体，用载体转化并具有增加的蛋白酶基因表达或其增加分泌的Koji模型，生产方法的蛋白酶通过使用转化的Koji模具等。

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