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1. 发明公开

US20230293821A1 DOSE SETTING SENSOR ASSEMBLY WITH ALGORITHMIC AUTO CALIBRATION 审中-公开
公开(公告)号：US20230293821A1
公开(公告)日：2023-09-21
申请号：US18014566
申请日：2021-07-05
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Zeinab Mahmoudi
IPC分类号： A61M5/315
CPC分类号： A61M5/3155 , A61M5/31515 , A61M5/31556 , A61M2205/52
摘要： Drug delivery system comprising a dose setting member adapted to incrementally rotate in a first direction to set a dose, and incrementally rotate in an opposed second direction to reduce a set dose, the dose setting member having a rotational slack in each incremental rotational position. The system further comprises a rotary sensor adapted to detect the amount of rotation of the dose setting member during dose setting. Processor means is adapted to detect a first or second dose setting pattern when the final dose was set by rotating the setting member in the first respectively the second direction. When a first / second dose setting pattern is detected the detected amount of rotation is used to calculate a corrected amount of rotation using a first/ second algorithm compensating for a slack-induced error generated corresponding to the first/ second dose setting pattern.

2. 发明申请

US20230030751A1 NEEDLE UNIT WITH FLOATING NEEDLE HUB 有权
公开(公告)号：US20230030751A1
公开(公告)日：2023-02-02
申请号：US17961815
申请日：2022-10-07
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Vera Pinto Glenting , Kezia Ann Friis Praestmark , Bo Kvolsbjerg
IPC分类号： A61M5/32
摘要： The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

3. 发明申请

US20220339370A1 NEEDLE ASSEMBLY HAVING NEEDLE SHIELD AND PLUG 有权
公开(公告)号：US20220339370A1
公开(公告)日：2022-10-27
申请号：US17760565
申请日：2020-09-22
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson
IPC分类号： A61M5/32 , A61M5/20 , A61M5/24
摘要： The present invention provides a needle assembly (1) for a drug delivery device, comprising a needle hub (25) in which a needle (15) is fixedly mounted, the needle (15) extending along a reference axis and comprising a needle body with a lumen and a distal needle end portion adapted for insertion through a skin layer, a needle shield (12) axially displaceable relative to the needle hub (25) between an extended position in which the distal needle end portion is covered and a retracted position in which the distal needle end portion is exposed, the nee-dle shield (12) being biased towards the extended position, and an elastomeric plug member (10) fitted tightly around a portion of the needle (15), the plug member (10) comprising a self-sealing front section (10.4) and being axially displaceable along the needle body be-tween a proximal plug position in which the distal needle end portion is exposed and a distal plug position in which the distal needle end portion is covered and the lumen is sealed by the self-sealing front section (10.4), wherein the needle shield (12) and the plug member (10) comprise mutually interactable engagement members (12.1, 12.4, 10.5) configured to ensure displacement of the plug member (10) from the proximal plug position to the distal plug position in response to a displacement of the needle shield (12) from the retracted posi-tion to the extended position.

4. 发明申请

US20210290838A1 BIOSTATIC MULTI-USE NEEDLE ASSEMBLY FOR AN INJECTION DEVICE 有权
公开(公告)号：US20210290838A1
公开(公告)日：2021-09-23
申请号：US17266856
申请日：2019-07-11
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Vera Pinto Glenting , Kezia Ann Friis Praestmark
IPC分类号： A61M5/00 , A61M5/24 , A61M5/32
摘要： A multi-use needle assembly (200) for an injection device (50), wherein the injection device (50) comprises: a housing (52) and a cartridge (54) for storing a liquid drug for multiple injections, the multi-use needle assembly comprises: a support structure (201), needle cannula (210), a movable shield assembly comprising a movable shield (220) and an actuation member (222) fixed to the shield (220), and a cleaning assembly (230) adapted to change configuration by deformation. The shield (220) is adapted to be in a locked distal position, an unlocked distal position and an unlocked proximal position, and the cleaning assembly (230) is adapted to be configured in (i) an open configuration, wherein a gap is provided between an outer surface of the cannula (210) and the cleaning assembly (230) to allow adjustment of the relative axial position between the cleaning assembly and the cannula, (ii) a closed configuration, wherein the cleaning assembly (230) is configured to provide contact with the outer surface of the cannula to enable cleaning of the cannula. The actuation member (222) is adapted to deform and thereby operate the cleaning assembly (230) between the open and the closed configuration, in response to turning the shield between the unlocked and the locked configuration. The needle assembly (200) is adapted to enable cleaning of the cannula (210), when the shield (220) is in the locked distal position, and to allow exposure of the cannula (210), when the shield (220) is in the unlocked distal position.

5. 发明申请

US20210228818A1 Pre-Filled Disposable Injection Device 有权
公开(公告)号：US20210228818A1
公开(公告)日：2021-07-29
申请号：US17227531
申请日：2021-04-12
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Mads Schenstroem Stefansen , Lars Eilertsen , Henning Graaskov , Claus Moser , Thomas Bjarnsholt
IPC分类号： A61M5/32 , A61M5/00
摘要： The present invention relates to a pre-filled disposable injection device and a needle cannula in combination. The prefilled disposable injection device (1) is made from a housing (2) containing a non-exchangeable cartridge (10) for storing a liquid drug sufficient for a number of injections. The proximal end of the pre-filled injection device (1) carries the dose setting button (3) and the distal end carries the needle cannula (20) having a lumen (21) through which the settable dose is expelled. The distal end (23) of the needle cannula (20) is covered by a telescopic needle covering shield (30) which shield (30) can operate between a first position covering the tip (24) of the needle cannula (20) and a second retracted position allowing an injection to be performed. The shield (30) carries a cleaner (50) which cleans at least the tip (24) of the needle cannula (20) between successive injections such that the prefilled injection device can be used without changing the needle cannula (20) during its life cycle.

6. 发明申请

US20210030966A1 Flow Communication Unit With Unconnected and Connected Configuration 有权
公开(公告)号：US20210030966A1
公开(公告)日：2021-02-04
申请号：US17045708
申请日：2019-01-10
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Brian Jensen , Bo Kvolsbjerg
IPC分类号： A61M5/24 , A61M39/24
摘要： A flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) for establishing flow communication from a multi-use drug delivery device adapted for extended use, to a flow conducting device, wherein the drug delivery device comprises a reservoir comprising multiple doses of a liquid drug formulation, wherein the reservoir is adapted to pressurize the liquid drug formulation, wherein the flow conducting device (230) is adapted for conducting the drug to the subcutaneous tissue of a subject, wherein the flow communication unit is adapted for being in an unconnected and a connected configuration, whereby the flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) is adapted to enable the extended use of the multi-use drug delivery device.

7. 发明授权

US10335535B2 Injection device with a needle cannula 有权
公开(公告)号：US10335535B2
公开(公告)日：2019-07-02
申请号：US15032482
申请日：2014-10-10
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Lars Eilertsen , Casper Bo Jensen , Frederik Kaae Kirk
IPC分类号： A61M5/00 , A61M5/32 , A61M5/24 , A61M5/31
摘要： The present invention relates to an injection device for injecting a pharmaceutical liquid drug containing a preservative. The injection device comprises a housing (1) supporting a cartridge (20) having an interior chamber (21) holding the pharmaceutical preservative containing liquid drug to be injected, and a needle cannula (10) having a front part (11) and a back part (12), which back part (12) is adapted to be in liquid communication with the interior chamber (21) of the cartridge (20). The injection device is further provided with a telescopic needle covering shield (30) which distally is provided with a reservoir (31) which holds a liquid containing the same preservatives as in the pharmaceutical preservative containing liquid drug contained in the interior chamber of the cartridge. The telescopic needle covering shield (30) is telescopic movable in relation to the needle cannula (10) by a first resilient member between a first position and a second position. In the first position, the tip (13) of the front part (11) of the needle cannula (10) is maintained inside the reservoir (31), and in the second position, the tip (13) of the front part (11) of the needle cannula (10) is located outside the reservoir (31) and distally to the reservoir (31). The tip (13) of the needle cannula (10) is thus cleaned by the preservatives in the reservoir (31) between subsequent injections.

8. 发明申请

US20190198148A1 SYSTEMS AND METHODS FOR OPTIMIZATION OF BOLUS TIMING RELATIVE TO MEAL EVENTS 审中-公开
公开(公告)号：US20190198148A1
公开(公告)日：2019-06-27
申请号：US16323551
申请日：2017-08-14
申请人： Novo Nordisk A/S
发明人： Tinna Bjoerk Aradottir , Henrik Bengtsson , Pete Brockmeier , Jonas Kildegaard Pedersen
IPC分类号： G16H20/17 , G16H50/30 , G16H20/60 , A61K38/28 , A61M5/142
CPC分类号： G16H20/17 , A61B5/14532 , A61K38/28 , A61M5/14244 , A61M5/1723 , A61M2230/201 , G06F19/3456 , G16H10/60 , G16H20/60 , G16H50/20 , G16H50/30 , G16H50/70
摘要： Systems and methods are provided for optimizing short acting insulin medicament dosage timing relative to a meal event for a subject. Glucose measurements of the subject over a time course and the timing of the measurements are obtained. Meal events in the time course and information regarding when dosages were injected into the subject relative to the meal events is obtained. Bins, each for a different time range for when a dosage is injected relative to a meal event, are constructed. Each bin is assigned glucose measurements in one or more periods within the time course in which the subject injected the dosage within the time range associated with the bin. A glycaemic risk measure is determined for each bin with the assigned measurements and used to identify an optimal relative time range for the subject. This is communicated to a health care practitioner or to the subject.

9. 发明申请

US20190147999A1 BASAL TITRATION WITH ADAPTIVE TARGET GLUCOSE LEVEL 审中-公开
公开(公告)号：US20190147999A1
公开(公告)日：2019-05-16
申请号：US16316237
申请日：2017-06-23
申请人： Novo Nordisk A/S
发明人： Tinna Bjoerk Aradottir , Henrik Bengtsson , Pete Brockmeier
IPC分类号： G16H20/17 , A61M5/20 , G16H50/20
摘要： Systems and methods are provided for adjusting long acting insulin medicament dosages for a subject. A plurality of timestamped glucose measurements of the subject and insulin injection data is obtained. A first glycaemic risk measures is determined, where the first risk glycaemic risk measure is i) glucose level variability across the glucose measurements, (ii) a variability in fasting glucose levels calculated from the glucose measurements, (iii) a minimum observed glucose measurement in the plurality of glucose measurements (iv) rate of change in ISF, or (v) adherence values. A fasting blood glucose target function is computed based upon at least the first glycaemic risk measure thereby obtaining an updated target fasting blood glucose level that is between a minimum and maximum target fasting blood glucose level. The long acting insulin medicament dosage is adjusted based upon the updated target fasting blood glucose level.

10. 发明申请

US20180161506A1 Drug Delivery Device with Priming Mechanism 审中-公开
公开(公告)号：US20180161506A1
公开(公告)日：2018-06-14
申请号：US15736072
申请日：2016-07-01
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Anders Noerbygaard , Ronan Carroll , Emil Gram Spork
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/3146 , A61M5/31515 , A61M5/31551 , A61M2005/2444
摘要： The present invention relates to a drug delivery device for expelling a dose of drug from a held cartridge and that defines a distal drug outlet end and an opposite proximal end. The drug delivery device comprises: a distal housing component (110) holding a cartridge (113) comprising a liquid drug and a piston slideable arranged therein in an axial direction, and a proximal housing component (101) housing a dose setting and expelling mechanism comprising a piston rod for exerting a force on the piston of the cartridge (113) in a distal direction for expelling a dose. The distal housing component (110) and the proximal housing component (101) are displaceably arranged in axial direction relative to each other for reducing an axial distance between the piston rod (120) and the piston of the cartridge (113). One of the distal housing component (110) and the proximal housing component (101) comprises a threaded adjustment component (103) being held at an axial fixed location on said one of the distal housing component (110) and the proximal housing component (101) and defining a first thread (103b) being in threaded engagement with a second thread (110b) defined by the other of the distal housing component (110) and the proximal housing component (101). After displacement the threaded adjustment component (103) is rotatably fixated so that the adjustment component (103) cannot be rotated without the use of a tool.

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