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1. 发明申请

US20090045333A1 Electrospray emitter and method of using same 失效
标题翻译：电喷发射体及其使用方法
公开(公告)号：US20090045333A1
公开(公告)日：2009-02-19
申请号：US12155114
申请日：2008-05-29
申请人： Paul Rudolph Chiarot , Sergey I. Gubarenko , Ridha Ben Mrad , Pierre Edward Sullivan
发明人： Paul Rudolph Chiarot , Sergey I. Gubarenko , Ridha Ben Mrad , Pierre Edward Sullivan
IPC分类号： B01D59/44 , H01J27/02
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/5027 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , H01J27/26
摘要： The present invention relates to electrospray emitters that have a rigid substrate layer, a second layer, a channel formed in one of the rigid substrate layer and an exit orifice in flow communication with the channel. The second layer is attached to the first layer. The exit orifice is capable of holding an electric charge. The electrospray emitter may be used with such devices as a mass spectrometer, a colloidal thruster or an ion mobility device. Additionally, it may be used to coat a surface.
摘要翻译：本发明涉及具有刚性衬底层，第二层，形成在刚性衬底层之一中的通道和与沟道流动连通的出口孔的电喷射发射器。第二层连接到第一层。出口孔能够保持电荷。电喷射发射器可以与诸如质谱仪，胶体推进器或离子迁移率装置的装置一起使用。另外，它可以用于涂覆表面。

2. 发明授权

US07829847B2 Electrospray emitter and method of using same 失效
标题翻译：电喷发射体及其使用方法
公开(公告)号：US07829847B2
公开(公告)日：2010-11-09
申请号：US12155114
申请日：2008-05-29
申请人： Paul Rudolph Chiarot , Sergey I. Gubarenko , Ridha Ben Mrad , Pierre Edward Sullivan
发明人： Paul Rudolph Chiarot , Sergey I. Gubarenko , Ridha Ben Mrad , Pierre Edward Sullivan
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/5027 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , H01J27/26
摘要： The present invention relates to electrospray emitters that have a rigid substrate layer, a second layer, a channel formed in one of the rigid substrate layer and an exit orifice in flow communication with the channel. The second layer is attached to the first layer. The exit orifice is capable of holding an electric charge. The electrospray emitter may be used with such devices as a mass spectrometer, a colloidal thruster or an ion mobility device. Additionally, it may be used to coat a surface.
摘要翻译：本发明涉及具有刚性衬底层，第二层，形成在刚性衬底层之一中的通道和与沟道流动连通的出口孔的电喷射发射器。第二层连接到第一层。出口孔能够保持电荷。电喷射发射器可以与诸如质谱仪，胶体推进器或离子迁移率装置的装置一起使用。另外，它可以用于涂覆表面。

3. 发明申请

US20120298205A1 Method and apparatus for the mechanical filtration of particles in discrete flow microfluidic devices 审中-公开
标题翻译：离散流微流体装置中颗粒机械过滤的方法和装置
公开(公告)号：US20120298205A1
公开(公告)日：2012-11-29
申请号：US13305507
申请日：2011-11-28
申请人： Michael John Schertzer , Ridha Ben Mrad , Pierre Edward Sullivan
发明人： Michael John Schertzer , Ridha Ben Mrad , Pierre Edward Sullivan
IPC分类号： B81B1/00 , B01L3/00
CPC分类号： B01L3/502707 , B01L3/502792 , B01L2200/0647 , B01L2200/0673 , B01L2300/0681 , B01L2300/0816 , B01L2400/0415 , B01L2400/0436 , B01L2400/0487 , B01L2400/086 , Y10T137/0318
摘要： A method and apparatus for moving droplets passed a porous obstructions in microfluidic devices is presented. The invention describes the process of using of an enabling droplet to allow a droplet to pass an obstruction. The enabling droplet and the unfiltered droplet approach the obstruction from opposite sides, merge together within the obstruction, and the interface on the enabling side of the droplet is actuated to pull fluid through the obstruction. This technique was successful for filters with pore sizes between 2 μm and 72 without the use of surfactants. This invention can (1) move droplets past physical obstructions, (2) allow fluid within a particle to pass an obstruction while limiting the motion of man-made or biological particles within the droplet, (3) sort particles based on size in droplet-based microfluidic devices, or (4) provide an interface between continuous and discrete flow regions on a microfluidic device.
摘要翻译：提出了用于移动液滴的方法和装置通过微流体装置中的多孔障碍物。本发明描述了使用能量液滴以允许液滴通过障碍物的过程。启动液滴和未过滤的液滴从相对侧接近障碍物，在障碍物内合并在一起，并且启动液滴的使能侧上的界面以拉动流体通过阻塞物。这种技术对于孔径在2μm和72之间的过滤器无需使用表面活性剂。本发明可以（1）将液滴移动穿过物理障碍物，（2）允许颗粒内的流体通过阻塞物，同时限制液滴内人造或生物颗粒的运动，（3）基于液滴中的尺寸对颗粒进行分类，或（4）在微流体装置上提供连续和离散流动区域之间的界面。

4. 发明申请

US20130068622A1 Method and apparatus for real-time monitoring of droplet composition in microfluidic devices 审中-公开
标题翻译：在微流体装置中实时监测液滴组成的方法和装置
公开(公告)号：US20130068622A1
公开(公告)日：2013-03-21
申请号：US13300754
申请日：2011-11-21
申请人： Michael John Schertzer , Ridha Ben Mrad , Pierre Edward Sullivan
发明人： Michael John Schertzer , Ridha Ben Mrad , Pierre Edward Sullivan
IPC分类号： G01N27/04
CPC分类号： G01N27/04 , G01N27/07
摘要： A device for real time monitoring of fluid composition in microfluidic devices. The invention can be integrated into any microfluidic device where fluid moves along a pathway with a measurement region consisting of at least two measurement electrodes. The fluidic pathway can contain an unbound droplet, a droplet confined in at least one aspect, or a continuous flow. The device also includes control circuitry connected to measurement electrodes that allows for the determination of the droplet composition by measuring at least one of capacitance, resistance, or impedance between said electrodes. This invention can (1) measure droplet composition, (2) compare composition against a known sample, (3) monitor droplet mixing, (4) control mixing to achieve specific mixing ratios, (5) measure the particle concentration within a droplet, (6) determine the position of particles in a droplet, and (7) monitor chemical reactions. These functions call all be performed in real time.
摘要翻译：用于实时监测微流体装置中流体组成的装置。本发明可以集成到任何微流体装置中，其中流体沿着具有由至少两个测量电极组成的测量区域的路径移动。流体通道可包含未结合的液滴，限制在至少一个方面的液滴或连续流。该装置还包括连接到测量电极的控制电路，其允许通过测量所述电极之间的电容，电阻或阻抗中的至少一个来确定液滴组成。本发明可以（1）测量液滴组成，（2）比较组合与已知样品，（3）监测液滴混合，（4）控制混合以达到比混合比，（5）测量液滴内的颗粒浓度， 6）确定液滴中颗粒的位置，（7）监测化学反应。这些功能调用全部被实时执行。

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