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1. 发明授权

US07662866B2 Polymeric support having novel pore structures 失效
标题翻译：具有新颖孔结构的聚合物载体
公开(公告)号：US07662866B2
公开(公告)日：2010-02-16
申请号：US10517226
申请日：2003-06-17
申请人： Philippe Busson , Ronnie Palmgren , Michael Morrison
发明人： Philippe Busson , Ronnie Palmgren , Michael Morrison
IPC分类号： C08J9/26
CPC分类号： B01J20/28092 , B01J20/26 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/28042 , B01J20/28057 , B01J20/28061 , B01J20/28097 , B01J20/285 , B01J20/3064 , B01J2220/82 , C08F2/18 , C08J9/26
摘要： The invention is a method of producing a cross-linked polymeric support having a multimodal pore structure, which comprises providing a degradable initiator molecule; providing an organic phase comprising said initiator molecule, radically polymerizable monomers and a porogen in a solvent; providing an aqueous phase comprising a transition metal catalyst; suspension polymerization of the organic phase by adding a ligand, co-ordinating to the transition metal in the aqueous phase to produce a cross-linked polymeric support having a primary pore structure and comprising initiator molecule; and subjecting the support obtained to degrading conditions to remove the initiator molecule from within the support to produce a cross-linked polymeric support having a secondary pore structure in addition to the primary pore structure.
摘要翻译：本发明是一种生产具有多峰孔结构的交联聚合物载体的方法，其包括提供可降解的引发剂分子; 提供包含所述引发剂分子，可自由基聚合的单体和在溶剂中的致孔剂的有机相; 提供包含过渡金属催化剂的水相; 通过添加配体来悬浮聚合有机相，与水相中的过渡金属配位以产生具有一次孔结构并包含引发剂分子的交联聚合物载体; 并使获得的载体降解条件从支持体内除去引发剂分子，以产生除主孔结构之外具有二次孔结构的交联聚合物载体。

2. 发明申请

US20050245624A1 Polymeric support having novel pore structures 失效
标题翻译：具有新颖孔结构的聚合物载体
公开(公告)号：US20050245624A1
公开(公告)日：2005-11-03
申请号：US10517226
申请日：2003-06-17
申请人： Philippe Busson , Ronnie Palmgren , Michael Morrison
发明人： Philippe Busson , Ronnie Palmgren , Michael Morrison
IPC分类号： B01J20/281 , B01J20/26 , B01J20/285 , C08F2/18 , C08F4/00 , C08F4/40 , C08F12/08 , C08F12/36 , C08J9/26 , C08J9/00
CPC分类号： B01J20/28092 , B01J20/26 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/28042 , B01J20/28057 , B01J20/28061 , B01J20/28097 , B01J20/285 , B01J20/3064 , B01J2220/82 , C08F2/18 , C08J9/26
摘要： The invention is a method of producing a cross-linked polymeric support having a multimodal pore structure, which comprises providing a degradable initiator molecule; providing an organic phase comprising said initiator molecule, radically polymerisable monomers and a porogen in a solvent; providing an aqueous phase comprising a transition metal catalyst; suspension polymerisation of the organic phase by adding a ligand, co-ordinating to the transition metal in the aqueous phase to produce a cross-linked polymeric support having a primary pore structure and comprising initiator molecule; and subjecting the support obtained to degrading conditions to remove the initiator molecule from within the support to produce a cross-linked polymeric support having a secondary pore structure in addition to the primary pore structure.
摘要翻译：本发明是一种生产具有多峰孔结构的交联聚合物载体的方法，其包括提供可降解的引发剂分子; 提供包含所述引发剂分子，可自由基聚合的单体和在溶剂中的致孔剂的有机相; 提供包含过渡金属催化剂的水相; 通过添加配体来悬浮聚合有机相，与水相中的过渡金属配位以产生具有一次孔结构并包含引发剂分子的交联聚合物载体; 并使获得的载体降解条件从支持体内除去引发剂分子，以产生除主孔结构之外具有二次孔结构的交联聚合物载体。

3. 发明授权

US09797871B2 Method for storage and stabilization of a target substance 有权
公开(公告)号：US09797871B2
公开(公告)日：2017-10-24
申请号：US13813800
申请日：2011-04-28
申请人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
发明人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
IPC分类号： C07K16/00 , G01N30/56 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , B01D15/20 , B01D15/22 , G01N30/60
CPC分类号： G01N30/56 , B01D15/206 , B01D15/22 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , G01N30/6069 , G01N2030/562
摘要： The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about −20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance.

4. 发明申请

US20130131323A1 METHOD FOR STORAGE AND STABILIZATION OF A TARGET SUBSTANCE 有权
标题翻译：目标物质的储存和稳定化方法
公开(公告)号：US20130131323A1
公开(公告)日：2013-05-23
申请号：US13813800
申请日：2011-04-28
申请人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
发明人： James Van Alstine , Johan Ohman , Philippe Busson , Ronnie Palmgren , Klas Allmer , John Daicic
IPC分类号： C07K1/22
CPC分类号： G01N30/56 , B01D15/206 , B01D15/22 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , G01N30/6069 , G01N2030/562
摘要： The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about −20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance.
摘要翻译：本发明涉及用于在某些捕获介质上以结合形式稳定储存敏感的生物或化学目标物质的系统和方法。该方法包括在合适的缓冲液中提供含有目标物质的样品; 将样品与捕获介质结合以实现目标物质与捕获介质的可逆结合; 并将目标物质的捕获介质储存在约-20至20℃之间; 并从捕获介质中回收目标物质。回收的目标物质保持所需的活性。还提供了减少敏感生物或化学物质中的聚集体的方法。

5. 发明授权

US09567039B2 Fairlead for guiding an anchoring chain and intended to be provided to anchoring equipment on the floor of a floating platform 有权
标题翻译：导轨用于引导锚链，并且旨在提供给浮动平台地板上的锚固设备
公开(公告)号：US09567039B2
公开(公告)日：2017-02-14
申请号：US14362653
申请日：2012-12-13
申请人： Philippe Busson
发明人： Philippe Busson
IPC分类号： B63B21/10 , B63B21/18 , B63B21/50
CPC分类号： B63B21/10 , B63B21/18 , B63B21/50
摘要： A fairlead for guiding an anchor chain, intended to equip a ground anchor system for a floating platform, includes a bending structure for guiding a direction change of the associated anchor chain, and a locking structure that includes a grip jaw consisting of two jaws associated with operating elements for rotatably moving the jaws in opposite directions. The operating elements include: (a) an inert mass, referred to as “counterweight”, which is movably coupled to the jaws and which is height-adjustable between a low position and a high position corresponding to an active position and an inactive position of the jaws, respectively, so as to operate and tend to maintain the jaws in the active position, and (b) an actuator driven by control elements, for operating the jaws from the active position to the inactive position and for operating the counterweight from the low position to the high position.
摘要翻译：用于引导锚链的导轨，用于装备用于浮动平台的地面锚固系统，包括用于引导相关锚链的方向改变的弯曲结构，以及锁定结构，该锁定结构包括由两个相关联的两个钳口用于沿相反方向可旋转地移动钳口的操作元件。操作元件包括：（a）被称为“配重”的惰性物质，其可移动地联接到钳口，并且在对应于活动位置的低位置和高位置之间是高度可调节的，颚爪分别操作并且倾向于将夹爪保持在主动位置，以及（b）由控制元件驱动的致动器，用于将夹爪从主动位置操作到非活动位置，并且用于将配重从低位到高位。

6. 发明申请

US20080154031A1 Method of Preparing a Separation Matrix 有权
标题翻译：准备分离矩阵的方法
公开(公告)号：US20080154031A1
公开(公告)日：2008-06-26
申请号：US11913236
申请日：2006-06-28
申请人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
IPC分类号： C07H3/00
CPC分类号： B01J20/291 , B01J20/24 , B01J20/262 , B01J20/267 , B01J20/28033 , B01J20/28042 , B01J20/285 , B01J20/3206 , B01J20/3244 , B01J20/3274 , B01J20/3282 , B01J2220/54 , C08B37/0039 , C08J3/24 , C08J2301/00
摘要： The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.
摘要翻译：本发明涉及一种制备不溶性分离基质的方法，该方法包括多糖凝胶的盐处理，然后交联多糖聚合物。在一个实施方案中，该方法包括提供可胶凝天然多糖的水溶液; 将多糖溶液的温度降低到低于其凝胶点的值; 通过向所得多糖中加入至少一种盐进行盐处理; 并交联盐处理的多糖。多糖可以例如制备。成颗粒，膜或整料。

7. 发明授权

US07208093B2 Chromatographic two-layer particles 有权
标题翻译：色谱双层颗粒
公开(公告)号：US07208093B2
公开(公告)日：2007-04-24
申请号：US10526088
申请日：2003-08-18
申请人： Hans Berg , Philippe Busson , Mats Carlsson
发明人： Hans Berg , Philippe Busson , Mats Carlsson
IPC分类号： B01D15/08
CPC分类号： B01D15/363 , B01D15/1807 , B01J20/285 , B01J20/286 , B01J20/3285 , B01J20/3293 , B01J39/26 , B01J41/20
摘要： The present invention is a method of producing a chromatographic separation matrix, wherein porous polymeric particles comprised of two layers with different properties are prepared in a two-phase system by (a) providing porous polymeric particles with reactive groups on their surfaces; (b) washing said particles with a first solvent and draining the particles to enclose a first phase; (c) wetting the outer layer of the particles by adding a second solvent, which is essentially insoluble in the first solvent; (d) reacting the reactive groups in the outer layer by adding a reagent, which is essentially non-reactive in the first solvent; and (e) coupling of chromatographic binding groups to the reactive groups in the inner layer. The invention also encompasses a porous polymer particle suitable for use as a chromatographic separation matrix and a process of separation, wherein a matrix according to the invention is used.
摘要翻译：本发明是一种制备色谱分离基质的方法，其中通过（a）在其表面上提供具有反应性基团的多孔聚合物颗粒，在两相体系中制备由具有不同性质的两层组成的多孔聚合物颗粒。（b）用第一溶剂洗涤所述颗粒并排出颗粒以包围第一相; （c）通过加入基本不溶于第一溶剂的第二溶剂润湿颗粒外层; （d）通过添加在第一溶剂中基本上不反应的试剂使外层中的反应性基团反应; 和（e）色谱结合基团与内层中的反应性基团的偶合。本发明还包括适合用作色谱分离基质的多孔聚合物颗粒和分离方法，其中使用根据本发明的基质。

8. 发明申请

US20140339485A1 FAIRLEAD FOR GUIDING AN ANCHORING CHAIN AND INTENDED TO BE PROVIDED TO ANCHORING EQUIPMENT ON THE FLOOR OF A FLOATING PLATFORM 有权
标题翻译：用于指导锚链的意图和意图提供给浮动平台地板上的设备的锚固装置
公开(公告)号：US20140339485A1
公开(公告)日：2014-11-20
申请号：US14362653
申请日：2012-12-13
申请人： Philippe Busson
发明人： Philippe Busson
IPC分类号： B63B21/10 , B63B21/50
CPC分类号： B63B21/10 , B63B21/18 , B63B21/50
摘要： A fairlead for guiding an anchor chain, intended to equip a ground anchor system for a floating platform, includes a bending structure for guiding a direction change of the associated anchor chain, and a locking structure that includes a grip jaw consisting of two jaws associated with operating elements for rotatably moving the jaws in opposite directions. The operating elements include: (a) an inert mass, referred to as “counterweight”, which is movably coupled to the jaws and which is height-adjustable between a low position and a high position corresponding to an active position and an inactive position of the jaws, respectively, so as to operate and tend to maintain the jaws in the active position, and (b) an actuator driven by control elements, for operating the jaws from the active position to the inactive position and for operating the counterweight from the low position to the high position.
摘要翻译：用于引导锚链的导轨，用于装备用于浮动平台的地面锚固系统，包括用于引导相关锚链的方向改变的弯曲结构，以及锁定结构，该锁定结构包括由两个相关联的两个钳口用于沿相反方向可旋转地移动钳口的操作元件。操作元件包括：（a）被称为“配重”的惰性物质，其可移动地联接到钳口，并且在对应于活动位置的低位置和高位置之间是高度可调节的，颚爪分别操作并且倾向于将夹爪保持在主动位置，以及（b）由控制元件驱动的致动器，用于将夹爪从主动位置操作到非活动位置，并且用于将配重从低位到高位。

9. 发明授权

US08309709B2 Method of preparing a separation matrix 有权
标题翻译：制备分离基质的方法
公开(公告)号：US08309709B2
公开(公告)日：2012-11-13
申请号：US11913236
申请日：2006-06-28
申请人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
IPC分类号： C07H1/00 , A61K31/715 , A01N43/04
CPC分类号： B01J20/291 , B01J20/24 , B01J20/262 , B01J20/267 , B01J20/28033 , B01J20/28042 , B01J20/285 , B01J20/3206 , B01J20/3244 , B01J20/3274 , B01J20/3282 , B01J2220/54 , C08B37/0039 , C08J3/24 , C08J2301/00
摘要： The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.
摘要翻译：本发明涉及一种制备不溶性分离基质的方法，该方法包括多糖凝胶的盐处理，然后交联多糖聚合物。在一个实施方案中，该方法包括提供可胶凝天然多糖的水溶液; 将多糖溶液的温度降低到低于其凝胶点的值; 通过向所得多糖中加入至少一种盐进行盐处理; 并交联盐处理的多糖。多糖可以例如制备。成颗粒，膜或整料。

10. 发明授权

US07148264B2 Method of producing macroporous cross-linked polymer particles 有权
标题翻译：生产大孔交联聚合物颗粒的方法
公开(公告)号：US07148264B2
公开(公告)日：2006-12-12
申请号：US10915290
申请日：2004-08-09
申请人： Tobias Söderman , Anders Larsson , Philippe Busson
发明人： Tobias Söderman , Anders Larsson , Philippe Busson
IPC分类号： C08F16/32
CPC分类号： G01N30/482 , B01D15/325 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/285 , B01J20/287 , B01J20/30 , B01J2220/54 , C08F283/06 , C08F216/125
摘要： The present invention relates to a method of producing one or more macroporous cross-linked polymer particles, which comprises polymerization and cross-linking of divinyl ether monomers in an inert solvent, in which method the polymerization is free radical initiated. The invention also relates to particles so produced, which are useful as separation medium e.g. in RPC or, after suitable derivatization, in other chromatographic methods.
摘要翻译：本发明涉及一种制备一种或多种大孔交联聚合物颗粒的方法，其包括在惰性溶剂中聚合和交联二乙烯基醚单体，其中聚合是自由基引发的。本发明还涉及如此制备的颗粒，其可用作分离介质，例如在RPC中，或在适当的衍生化后，在其他色谱方法中。

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