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1. 发明申请

US20220205960A1 CONTAINERS FOR CHROMATOGRAPHY MEDIA 有权
公开(公告)号：US20220205960A1
公开(公告)日：2022-06-30
申请号：US17690975
申请日：2022-03-09
申请人： Cytiva Sweden AB
发明人： Klaus Gebauer
IPC分类号： G01N30/56 , C07K1/14 , C07K1/18 , C07K1/20 , C07K1/22 , B01D15/20 , B01D15/22 , G01N30/60
摘要： The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for

2. 发明申请

US20220089716A1 TRANSITION ANALYSIS METHOD FOR CHROMATOGRAPHY COLUMN QUALIFICATION 有权
公开(公告)号：US20220089716A1
公开(公告)日：2022-03-24
申请号：US17545128
申请日：2021-12-08
申请人： Janssen Biotech, Inc.
发明人： Paul Randolph
IPC分类号： C07K16/24 , G01N30/56 , G01N30/86 , B01D15/20 , B01D15/36 , B01D15/38 , C07K1/18 , C07K1/22 , B01D15/16 , G01N35/00
摘要： The present disclosure is directed to a method of operating a chromatography column. This method involves collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during operation of the chromatography column comprising column packing. A model gamma cumulative distribution curve is determined based on the collected column outlet signal and accumulated flow parameters for the at least one mobile phase transition front. The height equivalent theoretical plate (HETP) value is calculated for the at least one mobile phase transition front using parameters of the model gamma cumulative distribution curve and the quality of the chromatography column packing is assessed based on the calculated HETP value. If during routine column monitoring, an adverse trend in HETP is observed or the control limits are exceeded, the eluate product quality, column process performance, and/or impurity removal data should be evaluated to ensure product quality for the identified batch. Should any of the product quality or column performance fail the criteria set, appropriate corrective action, such as conditioning, repacking or replacing the column, and qualification should be performed prior to release for further use.

3. 发明申请

US20210170303A1 Packing of Chromatography Columns 有权
公开(公告)号：US20210170303A1
公开(公告)日：2021-06-10
申请号：US17169699
申请日：2021-02-08
申请人： Cytiva BioProcess R&D AB
发明人： Klaus Gebauer
IPC分类号： B01D15/10 , B01D15/18 , G01N30/46 , B01D15/20 , G01N30/60 , G01N30/02 , G01N30/56
摘要： Disclosed herein is a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.

4. 发明申请

US20210101131A1 COLUMN PACKING MATERIAL FOR SUPERCRITICAL FLUID CHROMATOGRAPHY, COLUMN FOR SUPERCRITICAL FLUID CHROMATOGRAPHY AND PREPARATION METHOD THEREFOR 有权
公开(公告)号：US20210101131A1
公开(公告)日：2021-04-08
申请号：US16590435
申请日：2019-10-02
申请人： SHIMADZU CORPORATION
发明人： Risa ISHII , Michio BUTSUGAN , Keita SAKURAI , Yuka FUJITO
IPC分类号： B01J20/26 , B01D15/20 , B01D15/40 , G01N30/56 , B01J20/28 , B01J20/281 , B01J20/30 , C08F20/14
摘要： A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.

5. 发明授权

US10814319B2 Functionalized polyolefin capillaries for open tubular ion chromatography 有权
公开(公告)号：US10814319B2
公开(公告)日：2020-10-27
申请号：US15395202
申请日：2016-12-30
申请人： Purnendu K. Dasgupta , Weixiong Huang
发明人： Purnendu K. Dasgupta , Weixiong Huang
IPC分类号： B01D15/20 , B01D15/22 , B01D15/36 , B01J20/286 , B01J20/32 , B01J39/26 , B01J41/20 , B01J47/02 , G01N30/60 , G01N30/96 , G01N30/56
摘要： Open tubular capillary columns for liquid and ion chromatography, based upon an ionically impermeable polyolefin capillary having a bore with a sulfonate-group- or amine-group-functionalized internal surface. The capillary columns may include a coating of ion exchanging nanoparticles electrostatically bound to the functionalized internal surface. The capillary columns may be made by exposing the interior surface to a sulfonating reagent comprising chlorosulfonic acid (ClSO3H), preferably from 85 wt % to 95 wt % chlorosulfonic acid at a process temperature of 20 to 25° C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.

6. 发明授权

US10767259B2 Components with an atomic layer deposition coating and methods of producing the same 有权
公开(公告)号：US10767259B2
公开(公告)日：2020-09-08
申请号：US14597159
申请日：2015-01-14
申请人： Agilent Technologies, Inc.
发明人： Elizabeth Carr , Kevin P. Killeen
IPC分类号： A61N1/05 , B32B3/26 , C23C16/44 , B01D15/22 , C23C16/04 , B01D15/20 , C23C16/455 , G01N30/60 , G01N30/56
摘要： Liquid chromatography and gas chromatography components with a conformal protective coating on internal surfaces thereof and methods for producing the same are provided. The conformal protective coating is formed via an atomic layer deposition (ALD) process. The components and methods of the present disclosure find use in providing protective coatings for liquid chromatography and gas chromatography components that are compatible with bioanalytical separations and sensitive trace analyses.

7. 发明申请

US20200030719A1 SINGLE USE SLURRYING AND CHROMATOGRAPHY SYSTEMS 审中-公开
公开(公告)号：US20200030719A1
公开(公告)日：2020-01-30
申请号：US16589759
申请日：2019-10-01
申请人： GE HEALTHCARE BIO-SCIENCES CORP.
发明人： JOHN J. VICALVI , JOSEPH MAKOWIECKI , JOSEPH D. CROWELL , PARRISH M. GALLIHER
IPC分类号： B01D15/22 , G01N30/56 , B01F13/02 , B01F13/08 , B01F7/22 , B01F15/00 , B01F7/16 , B01F7/00 , B01F13/06
摘要： Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

8. 发明申请

US20190204278A1 LIQUID CHROMATOGRAPHY PACKING MATERIAL 审中-公开
公开(公告)号：US20190204278A1
公开(公告)日：2019-07-04
申请号：US16302253
申请日：2017-05-25
申请人： SHOWA DENKO K.K.
发明人： Hideyuki KONDO , Junya KATO , Naoko MARUOKA
IPC分类号： B01J20/281 , G01N30/56 , G01N30/32
CPC分类号： G01N30/482 , G01N30/26 , G01N30/32 , G01N30/56 , G01N30/88 , G01N2030/027 , G01N2030/324 , G01N2030/484 , G01N2030/562
摘要： A liquid chromatography packing material employing crosslinked polymer particles, wherein the volume average particle size of the crosslinked polymer particles is at least 2 μm but not more than 10 μm, the amount of fine particles having a particle size of 1 μm or less among the crosslinked polymer particles is less than 1% by volume, and the identity coefficient in the particle size distribution is not more than 1.15.

9. 发明授权

US10195541B2 Method for transferring slurry 有权
公开(公告)号：US10195541B2
公开(公告)日：2019-02-05
申请号：US15023972
申请日：2014-09-26
申请人： GE Healthcare Bio-Sciences AB
发明人： Mikael Bjorling , Bengt Niklas Edblad , Per Karlberg , Jonas Karlsson , Joakim Lundkvist
IPC分类号： B01D15/10 , B01D15/20 , G01N30/56
摘要： A method and a slurry tank system for transferring chromatography media slurry from a slurry tank (3) to a chromatography column (9), said method comprising monitoring the content of slurry in the slurry tank (3) during the transferring and controlling the transferring of the slurry to the column (9) in dependence of the content of slurry in the slurry tank (3).

10. 发明授权

US09555394B2 Method of making ionic liquid mediated sol-gel sorbents 有权
标题翻译：制备离子液体介导的溶胶 - 凝胶吸附剂的方法
公开(公告)号：US09555394B2
公开(公告)日：2017-01-31
申请号：US14046302
申请日：2013-10-04
申请人： Abdul Malik , Anne M. Shearrow
发明人： Abdul Malik , Anne M. Shearrow
IPC分类号： G01N30/60 , B01J20/291 , B01J20/26 , B01J20/32 , G01N30/00 , G01N30/56
CPC分类号： B01J20/291 , B01J20/26 , B01J20/3217 , B01J20/3225 , B01J20/3272 , B01J2220/52 , B01J2220/86 , G01N30/6078 , G01N2030/009 , G01N2030/567
摘要： Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. A method was developed which provides phosphonium-based, pyridinium-based, and imidazolium-based IL-mediated advanced sol-gel organic-inorganic hybrid materials for capillary microextraction. Scanning electron microscopy results demonstrate that ILs can serve as porogenic agents in sol-gel reactions. IL-mediated sol-gel coatings prepared with silanol-terminated polymers provided up to 28 times higher extractions compared to analogous sol-gel coatings prepared without any IL in the sol solution. This study shows that IL-generated porous morphology alone is not enough to provide effective extraction media: careful choice of the organic polymer and the precursor with close sol-gel reactivity must be made to ensure effective chemical bonding of the organic polymer to the created sol-gel material to be able to provide the desired sorbent characteristics.
摘要翻译：离子液体（IL）介导的溶胶 - 凝胶杂化有机 - 无机材料在分析微萃取中有巨大的潜力。实现这一前景的一个障碍来自于高粘度的ILs显着减慢溶胶 - 凝胶反应。开发了一种提供用于毛细管微萃取的基于鏻，吡啶鎓和咪唑鎓的IL介导的高级溶胶 - 凝胶有机 - 无机杂化材料的方法。扫描电子显微镜结果表明，ILs可作为溶胶 - 凝胶反应中的致孔剂。与溶胶溶液中没有任何IL制备的类似溶胶 - 凝胶涂层相比，用硅烷醇封端的聚合物制备的IL介导的溶胶 - 凝胶涂层提供高达28倍的提取量。这项研究表明，单独的IL产生的多孔形态不足以提供有效的提取介质：必须仔细选择有机聚合物和具有近似溶胶 - 凝胶反应性的前体，以确保有机聚合物与所产生的溶胶的有效化学键合凝胶材料能够提供所需的吸附剂特性。

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