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1. 发明授权

US09737660B2 Drug infusion device with controllable valve 有权
公开(公告)号：US09737660B2
公开(公告)日：2017-08-22
申请号：US13217981
申请日：2011-08-25
申请人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
发明人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
IPC分类号： A61M5/168 , A61M39/22 , A61M5/142
CPC分类号： A61M5/16827 , A61M5/14276 , A61M5/1684 , A61M39/223 , A61M2205/3523 , A61M2205/3569 , A61M2210/1003
摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the valve to open and close the first fluid pathway and to open and close the second fluid pathway.

2. 发明申请

US20120053514A1 DRUG INFUSION DEVICE WITH CONTROLLABLE VALVE 有权
标题翻译：具有可控阀的药物输注装置
公开(公告)号：US20120053514A1
公开(公告)日：2012-03-01
申请号：US13217981
申请日：2011-08-25
申请人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
发明人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
IPC分类号： A61M5/168 , A61M5/158 , A61M39/22
CPC分类号： A61M5/16827 , A61M5/14276 , A61M5/1684 , A61M39/223 , A61M2205/3523 , A61M2205/3569 , A61M2210/1003
摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the value to open and close the first fluid pathway and to open and close the second fluid pathway.
摘要翻译：通常描述包括至少一个可控阀的治疗流体输送装置。在一个示例中，可植入治疗流体递送系统包括构造成输送第一治疗流体的第一流体通路和构造成输送第二治疗流体的第二流体通路，第二流体通路与第一流体通路分离。治疗流体递送系统包括连接到第一流体通路和第二流体通路的阀，以及配置成控制该值的致动以打开和关闭第一流体通路并打开和关闭第二流体通路的处理器。

3. 发明申请

US20080103543A1 Implantable medical device with titanium alloy housing 审中-公开
标题翻译：带钛合金外壳的植入式医疗器械
公开(公告)号：US20080103543A1
公开(公告)日：2008-05-01
申请号：US11590678
申请日：2006-10-31
申请人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh , John E. Kast , Keith A. Miesel , Darren A. Janzig , Gerald G. Lindner
发明人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh , John E. Kast , Keith A. Miesel , Darren A. Janzig , Gerald G. Lindner
IPC分类号： A61N1/375
CPC分类号： C22C14/00 , A61L31/022 , A61N1/375
摘要： An implantable medical device includes a housing comprising a titanium alloy selected from the group consisting of Ti-4.5Al-3V-2Fe-2Mo-0.15O, Ti-4Al-2.5V-1.5Fe-0.25O, Ti-6Al-2Sn-4Zr-2Mo, Ti-3Al-2.5V, and combinations thereof
摘要翻译：一种可植入医疗装置，包括：外壳，其包含选自Ti-4.5Al-3V-2Fe-2Mo-0.15O，Ti-4Al-2.5V-1.5Fe-0.25O，Ti-6Al-2Sn- 4Zr-2Mo，Ti-3Al-2.5V及其组合

4. 发明授权

US09724784B2 Optical feedthrough for medical devices 有权
公开(公告)号：US09724784B2
公开(公告)日：2017-08-08
申请号：US12401239
申请日：2009-03-10
申请人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
发明人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
IPC分类号： B23K26/00 , B23K26/20 , B23K26/21 , A61N1/375 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/00 , B29C35/08 , G02B6/38 , G02B6/42
CPC分类号： B23K26/206 , A61N1/375 , B23K26/21 , B29C65/14 , B29C65/1406 , B29C65/16 , B29C65/4845 , B29C66/54 , B29C2035/0827 , G02B6/3897 , G02B6/4248
摘要： In general, the disclosure is directed toward transmitting radiant energy across a boundary of a medical device via an optical feedthrough. A system for transmitting radiant energy across a boundary of a medical device includes a first functional module of a medical device, a second functional module of the medical device, an optical feedthrough assembly coupled to the first functional module, and a radiant energy source that emits a beam through the optical feedthrough assembly to perform a manufacturing process on the first functional module and the second functional module.

5. 发明授权

US08192418B2 Releasing a material within a medical device via an optical feedthrough 有权
标题翻译：通过光学馈通在医疗装置内释放材料
公开(公告)号：US08192418B2
公开(公告)日：2012-06-05
申请号：US12401267
申请日：2009-03-10
申请人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
发明人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
IPC分类号： A61M5/32
CPC分类号： A61M5/14276 , A61M5/1407 , A61M39/04 , A61M2205/368
摘要： In general, the disclosure is directed toward releasing material within a medical device via an optical feedthrough. A system for releasing material with a medical device comprises a cup that holds a material, wherein the cup includes a discharge port, a seal disc that seals the material within the cup, an optical feedthrough assembly coupled to the cup, a shell that defines a chamber within a medical device, wherein the optical feedthrough assembly is coupled to the shell, and a radiant energy source that shines a beam through the optical feedthrough assembly to puncture the seal disc to allow the material to enter the chamber via the discharge port.
摘要翻译：通常，本公开涉及经由光学馈通释放医疗装置内的材料。用于使用医疗装置释放材料的系统包括保持材料的杯，其中杯包括排出口，密封杯内的材料的密封盘，耦合到杯的光学馈通组件，其中所述光学馈通组件耦合到所述壳体，以及辐射能源，其将光束照射通过所述光学馈通组件以刺穿所述密封盘以允许所述材料经由所述排出口进入所述腔室。

6. 发明授权

US08401648B2 Housing for implantable medical device 有权
标题翻译：可植入医疗器械的外壳
公开(公告)号：US08401648B2
公开(公告)日：2013-03-19
申请号：US12186855
申请日：2008-08-06
申请人： John E. Kast , Reginald D. Robinson , Randy S. Roles , Bernard Q. Li
发明人： John E. Kast , Reginald D. Robinson , Randy S. Roles , Bernard Q. Li
IPC分类号： A61N1/375
CPC分类号： A61L31/022 , A61N1/375
摘要： An implantable medical device includes a housing having frame with one or more openings. The openings of the frame are covered with a thin metallic foil that is welded to the frame to provide a hermetic seal. Non-conductive members may be placed in or about the openings to provide a backing or structural support for the metallic foil. By decreasing the mass of conductive material capable of forming eddy currents, improved recharge or telemetry performance may be realized.
摘要翻译：可植入医疗装置包括具有一个或多个开口的框架的外壳。框架的开口被薄的金属箔覆盖，金属箔被焊接到框架以提供气密密封。非导电构件可以放置在开口中或周围，以为金属箔提供背衬或结构支撑。通过降低能够形成涡流的导电材料的质量，可以实现提高的再充电或遥测性能。

7. 发明申请

US20100234825A1 RELEASING A MATERIAL WITHIN A MEDICAL DEVICE VIA AN OPTICAL FEEDTHROUGH 有权
标题翻译：通过光学发送在医疗设备中释放材料
公开(公告)号：US20100234825A1
公开(公告)日：2010-09-16
申请号：US12401267
申请日：2009-03-10
申请人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Linder , Brad C. Tischendorf , Andrew J. Thom
发明人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Linder , Brad C. Tischendorf , Andrew J. Thom
IPC分类号： A61B19/00
CPC分类号： A61M5/14276 , A61M5/1407 , A61M39/04 , A61M2205/368
摘要： In general, the disclosure is directed toward releasing material within a medical device via an optical feedthrough. A system for releasing material with a medical device comprises a cup that holds a material, wherein the cup includes a discharge port, a seal disc that seals the material within the cup, an optical feedthrough assembly coupled to the cup, a shell that defines a chamber within a medical device, wherein the optical feedthrough assembly is coupled to the shell, and a radiant energy source that shines a beam through the optical feedthrough assembly to puncture the seal disc to allow the material to enter the chamber via the discharge port.
摘要翻译：通常，本公开涉及经由光学馈通释放医疗装置内的材料。用于使用医疗装置释放材料的系统包括保持材料的杯，其中杯包括排出口，密封杯内的材料的密封盘，耦合到杯的光学馈通组件，其中所述光学馈通组件耦合到所述壳体，以及辐射能源，其将光束照射通过所述光学馈通组件以刺穿所述密封盘以允许所述材料经由所述排出口进入所述腔室。

8. 发明申请

US20100230392A1 OPTICAL FEEDTHROUGH FOR MEDICAL DEVICES 有权
标题翻译：用于医疗设备的光学
公开(公告)号：US20100230392A1
公开(公告)日：2010-09-16
申请号：US12401239
申请日：2009-03-10
申请人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
发明人： Reginald D. Robinson , David D. Differding , James A. Johnson , Bernard Q. Li , Gerald G. Lindner , Brad C. Tischendorf , Andrew J. Thom
IPC分类号： B23K26/00
CPC分类号： B23K26/206 , A61N1/375 , B23K26/21 , B29C65/14 , B29C65/1406 , B29C65/16 , B29C65/4845 , B29C66/54 , B29C2035/0827 , G02B6/3897 , G02B6/4248
摘要： In general, the disclosure is directed toward transmitting radiant energy across a boundary of a medical device via an optical feedthrough. A system for transmitting radiant energy across a boundary of a medical device includes a first functional module of a medical device, a second functional module of the medical device, an optical feedthrough assembly coupled to the first functional module, and a radiant energy source that emits a beam through the optical feedthrough assembly to perform a manufacturing process on the first functional module and the second functional module.
摘要翻译：通常，本公开涉及经由光学馈通穿过医疗装置的边界发射辐射能。用于在医疗装置的边界上传送辐射能的系统包括医疗装置的第一功能模块，医疗装置的第二功能模块，耦合到第一功能模块的光学馈通组件和发射的辐射能源通过光学馈通组件的光束，以对第一功能模块和第二功能模块执行制造过程。

9. 发明申请

US20080294207A1 HOUSING FOR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：可植入医疗器械的住房
公开(公告)号：US20080294207A1
公开(公告)日：2008-11-27
申请号：US12186855
申请日：2008-08-06
申请人： John E. Kast , Reginald D. Robinson , Randy S. Roles , Bernard Q. Li
发明人： John E. Kast , Reginald D. Robinson , Randy S. Roles , Bernard Q. Li
IPC分类号： A61N1/00
CPC分类号： A61L31/022 , A61N1/375
摘要： An implantable medical device includes a housing having frame with one or more openings. The openings of the frame are covered with a thin metallic foil that is welded to the frame to provide a hermetic seal. Non-conductive members may be placed in or about the openings to provide a backing or structural support for the metallic foil. By decreasing the mass of conductive material capable of forming eddy currents, improved recharge or telemetry performance may be realized.
摘要翻译：可植入医疗装置包括具有一个或多个开口的框架的外壳。框架的开口被薄的金属箔覆盖，金属箔被焊接到框架以提供气密密封。非导电构件可以放置在开口中或周围，以为金属箔提供背衬或结构支撑。通过降低能够形成涡流的导电材料的质量，可以实现提高的再充电或遥测性能。

10. 发明授权

US08639352B2 Wire configuration and method of making for an implantable medical apparatus 有权
标题翻译：电线配置和可植入医疗器械的制造方法
公开(公告)号：US08639352B2
公开(公告)日：2014-01-28
申请号：US12419082
申请日：2009-04-06
申请人： Ling Wang , Bernard Q. Li
发明人： Ling Wang , Bernard Q. Li
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/0472 , A61N1/0488 , A61N1/0551 , Y10T29/49002
摘要： A filar includes an inner conductive core that is formed of a low-resistivity material such as silver having a resistivity of less than 20 μΩ per centimeter. A conductive coil is provided around the core to form a filar. This coil is formed of a biocompatible alloy or super alloy having an ultimate tensile strength (UTS) of between 150 kilo pounds per square inch (ksi) and 280 ksi at room temperature. Examples of such alloys include CoCrMo, CoFeCrMo, and CoFeNiCrMo. In one specific embodiment, the alloy is MP35N (CoNiCrMo), which may be low-titanium (“low-ti”) MP35N. One or more such filars may be included within a wire. This wire may be carried by an implantable medical apparatus such as a lead, lead extension, or catheter. The wire may electrically couple elements such as connector electrodes to conducting electrodes or sensors.
摘要翻译：丝状物包括由诸如银的低电阻率材料形成的内导电芯，其电阻率小于每平方厘米20微米。在芯周围设置导电线圈以形成丝状体。该线圈由在室温下具有150千磅/平方英寸（ksi）和280ksi之间的极限拉伸强度（UTS）的生物相容性合金或超级合金形成。这种合金的实例包括CoCrMo，CoFeCrMo和CoFeNiCrMo。在一个具体实施方案中，合金是MP35N（CoNiCrMo），其可以是低钛（“低钛”）MP35N。一根或多根这样的丝状物可以包括在线内。该线可以由诸如铅，引线延伸或导管的可植入医疗设备携带。导线可以将诸如连接器电极的元件电耦合到导电电极或传感器。

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