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    • 4. 发明申请
    • Treating mouth sores caused by dental braces with blobs of hydrophilic gums
    • 治疗口腔溃疡由牙套和亲水性牙龈斑点引起
    • US20070098648A1
    • 2007-05-03
    • US11640147
    • 2006-12-14
    • Jeffrey Haley
    • Jeffrey Haley
    • A61K36/48A61K31/58A61K9/68
    • A61K31/58A61K9/006A61K36/484A61K2300/00
    • A method for treating mouth sores caused by abrasion of orthodontic braces by placing oral patch or blob on the brace or sore to speed healing and relieve pain. The oral patch or blob is placed either on the portion of the brace that comes into contact with the sore or onto the sore directly. If certain medications are applied to a mouth sore using an oral patch or blob that restricts local flow of saliva and delivers the medication for at least 30 minutes and the patch or blobs are used for at least two or more hours per day, the method reduces the healing time for mouth sores from typical 10-14 days to 1-5 days. The method can be used with various antimicrobials, glucocorticoids or anthihistamines incorporated into the patch or blob that reduce inflammation or speed the healing of mouth sores caused by braces.
    • 一种通过将口腔贴片或斑点放置在支架或疮上来治疗由正畸括号磨损引起的口疮的方法,以加速愈合和缓解疼痛。 将口腔贴片或斑块放置在与疼痛接触或直接暴露于酸痛的支架部分上。 如果使用限制唾液局部流动并将药物输送至少30分钟的口腔补片或斑块将某些药物施用于口腔炎,并且每天使用斑块或斑块至少两个或更多小时,则该方法减少 口疮从典型的10-14天到1-5天的愈合时间。 该方法可与各种抗微生物剂,糖皮质激素或结合到斑块或斑块中的硫代组胺一起使用,可减少炎症或加速由大括号引起的口腔溃疡愈合。
    • 9. 发明申请
    • Collagen troches for treating mouth lesions
    • 用于治疗口腔病变的胶原纤维
    • US20060134201A1
    • 2006-06-22
    • US11016474
    • 2004-12-16
    • Jeffrey Haley
    • Jeffrey Haley
    • A61K38/38A61K9/20
    • A61K9/0056A61K38/39
    • A soluble/erodable troche for delivering collagen in the mouth for treatment of mouth lesions. The collagen may be gelatin from animal skins. The structure of the troche may be formed with a porous network that remains solid at human mouth temperatures and slowly dissolves/erodes in saliva. In some embodiments, the network is elasto-plastic and in some cases it is hydrophilic. The collagen is located within pores of the network. The troche may be formed by mixing and hydrating the ingredients, bringing them to above an activation temperature below boiling, and cooling them to form a gel. The hot mixture may be poured into molds, including a flat sheet, and the mold may also serve as packaging for delivery. The packaging may comprise a germ barrier moisture passing film which allows the troche to dry out or become re-hydrated without growing mold.
    • 用于在口腔中输送胶原蛋白以治疗口腔损伤的可溶性/可侵蚀性的部分。 胶原蛋白可以是来自动物皮肤的明胶。 可以使用多孔网状物形成该组织的结构,该网状物在人口温度下保持固体,并在唾液中慢慢溶解/腐蚀。 在一些实施例中,网络是弹性塑料的,并且在一些情况下是亲水的。 胶原蛋白位于网络孔内。 可以通过将成分混合和水合,使它们达到低于沸点的活化温度并冷却它们以形成凝胶来形成该锭剂。 热混合物可以倒入包括平板的模具中,并且模具也可以用作输送的包装。 包装可以包含防菌湿透膜,其允许在不生长霉菌的情况下干燥或再水合。