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1. 发明授权

US11573232B2 Method for capturing specific cells 有权
公开(公告)号：US11573232B2
公开(公告)日：2023-02-07
申请号：US16249454
申请日：2019-01-16
申请人： SUMITOMO RUBBER INDUSTRIES, LTD. , YAMAGATA UNIVERSITY
发明人： Yasuhisa Minagawa , Masaru Tanaka , Takashi Hoshiba , Haruka Emura
IPC分类号： G01N33/574 , B01D21/26 , G01N33/50 , G01N33/539 , G01N33/537 , G01N35/00
摘要： The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM), and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: agglutinating blood cells in sampled blood or biological fluid; centrifuging the resulting blood or biological fluid; and then capturing specific cells therefrom onto a hydrophilic polymer layer.

2. 发明授权

US10556040B2 Surface-modified metal and method for modifying metal surface 有权
公开(公告)号：US10556040B2
公开(公告)日：2020-02-11
申请号：US15223965
申请日：2016-07-29
申请人： SUMITOMO RUBBER INDUSTRIES, LTD.
发明人： Yasuhisa Minagawa
IPC分类号： C08F2/46 , C08G61/04 , A61L31/10 , A61L31/14 , A61L31/02 , C08F292/00
摘要： Provided are surface-modified metals and methods for modifying a metal surface, which involve a lubricating surface layer chemically fixed to the metal surface to provide excellent lubricity and excellent lubricant durability, and further which have good productivity and good economic efficiency. Included is a surface-modified metal whose surface is at least partially provided with a treatment layer having a thickness of 50 to 800 nm, the treatment layer being formed by treating a surface of a metal with a silane coupling agent, followed by adsorbing a hydrogen abstraction type photopolymerization initiator onto the surface and then polymerizing a monomer.

3. 发明申请

US20190233555A1 HYDROPHILIC SUBSTRATE 审中-公开
公开(公告)号：US20190233555A1
公开(公告)日：2019-08-01
申请号：US16237923
申请日：2019-01-02
申请人： SUMITOMO RUBBER INDUSTRIES, LTD.
发明人： Yasuhisa Minagawa , Mitsuko Takii
IPC分类号： C08F20/28 , C08K5/315 , C09D133/14
CPC分类号： C08F20/28 , C08F120/28 , C08F2500/01 , C08J7/045 , C08J2333/14 , C08J2333/16 , C08K5/315 , C09D133/14
摘要： The present invention provides a hydrophilic substrate including a hydrophilic polymer layer having a smooth surface and formed of a special polymer (hydrophilic polymer). Included is a hydrophilic substrate including on its surface a hydrophilic polymer layer formed of a hydrophilic polymer having a number average molecular weight of 40,000 or more.

4. 发明授权

US09981073B2 Surface-modified metal and method for modifying metal surface 有权
公开(公告)号：US09981073B2
公开(公告)日：2018-05-29
申请号：US15201963
申请日：2016-07-05
申请人： SUMITOMO RUBBER INDUSTRIES, LTD.
发明人： Shunsuke Kosaka , Yasuhisa Minagawa
IPC分类号： C08F2/46 , C08F2/50 , C08G61/04 , A61L31/10 , A61L29/08 , A61L29/14 , A61L31/14 , A61L31/02 , C08F220/34 , C08F220/38 , C08F220/56 , C23C26/00
CPC分类号： A61L31/10 , A61L29/085 , A61L29/14 , A61L31/022 , A61L31/14 , A61L2400/10 , A61L2420/00 , A61L2420/02 , C08F220/34 , C08F220/38 , C08F220/56 , C23C26/00 , C08L33/08 , C08L33/10
摘要： Provided are surface-modified metals such as metal medical devices, e.g. guide wires, syringe needles, and metal tubes in medical devices or equipment, and methods for modifying a metal surface, wherein a lubricant layer is firmly bonded to the metal surface to impart lubricity to the metal surface and further to improve the durability of the lubricant layer on the metal surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified metal at least partially having a treated surface, the treated surface being obtained by treating a surface of a metal with a silane coupling agent, followed by adsorbing a hydrogen abstraction type photopolymerization initiator onto the surface and then polymerizing a monomer in the presence of an alkali metal salt.

5. 发明授权

US09540493B2 Surface modification method and surface-modified elastic body 有权
标题翻译：表面改性法和表面改性弹性体
公开(公告)号：US09540493B2
公开(公告)日：2017-01-10
申请号：US14107746
申请日：2013-12-16
申请人： SUMITOMO RUBBER INDUSTRIES, LTD.
发明人： Yasuhisa Minagawa
IPC分类号： C08J7/18 , C08F2/50 , C08F291/00
CPC分类号： C08J7/18 , C08F2/50 , C08F291/00 , C08J2311/00
摘要： The present invention aims to provide a method for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, which is capable of cost-effectively imparting a variety of functions, such as sliding properties and biocompatibility, according to the applications. The present invention relates to a surface modification method for surface-modifying an object of a rubber vulcanizate or a thermoplastic elastomer, the method including: step 1 of forming polymerization initiation points A on a surface of the object; step 2 of radically polymerizing a non-functional monomer, starting from the polymerization initiation points A, to grow non-functional polymer chains; step 3 of forming polymerization initiation points B on the surface of the object where the non-functional polymer chains are formed; and step 4 of radically polymerizing a functional monomer, starting from the polymerization initiation points B, to grow functional polymer chains.
摘要翻译：本发明的目的在于提供一种橡胶硫化橡胶或热塑性弹性体的表面改性方法，其能够根据应用成本有效地赋予各种功能，如滑动性能和生物相容性。本发明涉及一种表面改性橡胶硫化橡胶或热塑性弹性体物体表面改性方法，该方法包括：在物体表面上形成聚合起始点A的步骤1; 从聚合引发点A开始自由基聚合非官能单体的步骤2，生长非功能性聚合物链; 在形成非功能性聚合物链的物体的表面上形成聚合引发点B的步骤3; 以及从聚合引发点B开始自由基聚合官能单体的步骤4，以生长功能性聚合物链。

6. 发明授权

US09488707B2 Method for predicting resistance to heat deterioration of isoprene rubber 有权
标题翻译：预测异戊二烯橡胶耐热劣化性的方法
公开(公告)号：US09488707B2
公开(公告)日：2016-11-08
申请号：US13829595
申请日：2013-03-14
申请人： SUMITOMO RUBBER INDUSTRIES, LTD.
发明人： Masatoshi Kobayashi , Yasuhisa Minagawa
IPC分类号： G01R33/46 , G01N24/08
CPC分类号： G01R33/46 , G01N24/08
摘要： A method for predicting the resistance to heat deterioration of a sulfur-vulcanized isoprene rubber is disclosed. The nuclear magnetic resonance spectrum of the isoprene rubber is obtained by the use of a solid state nuclear magnetic resonance method employing magic angle spinning. The spectrum of a cross-linked structure α and the spectrum of a cross-linked structure β in the nuclear magnetic resonance spectrum are identified. The percentage of the cross-linked structure α and the percentage of the cross-linked structure β in the overall cross-linked structures of the sulfur are computed from the spectrum. From the computed percentages, the resistance to heat deterioration of the isoprene rubber is predicted.
摘要翻译：公开了一种用于预测硫硫化异戊二烯橡胶的耐热劣化性的方法。异戊二烯橡胶的核磁共振谱通过使用魔角旋转的固态核磁共振法获得。确定交联结构α的光谱和核磁共振谱中交联结构β的光谱。从光谱计算交联结构α的百分比和交联结构β在硫的整体交联结构中的百分比。从计算出的百分比，预测异戊二烯橡胶的耐热劣化性。

7. 发明授权

US09394391B2 Surface modification method, surface-modified elastic body, gasket for injector, injector, and tire 有权
公开(公告)号：US09394391B2
公开(公告)日：2016-07-19
申请号：US14730024
申请日：2015-06-03
申请人： SUMITOMO RUBBER INDUSTRIES, LTD. , KYUSHU UNIVERSITY
发明人： Yasuhisa Minagawa , Yasuhiko Kondo , Tetsuo Mizoguchi , Atsushi Takahara , Motoyasu Kobayashi
IPC分类号： C08J3/28 , C08F2/46 , C08G61/04 , C08F136/18 , C08F2/38 , A61M5/315 , C08F8/34 , A61M5/31 , B60C1/00 , F16J9/26 , F16J9/28 , C08F293/00
CPC分类号： C08F136/18 , A61M5/3129 , A61M5/31511 , A61M5/31513 , A61M2005/3131 , B60C1/0016 , C08F2/38 , C08F8/34 , C08F293/005 , C08F2438/01 , C08J3/28 , C08J2315/02 , F16J9/26 , F16J9/28
摘要： Provided are: surface modification method for imparting slidability to surface of elastic body such as vulcanized rubber or thermoplastic elastomer without using expensive self-lubricating resin; surface-modified elastic body with polymer brush formed on its surface; and gasket for injector and injector formed of surface-modified elastic body. The surface modification method applies to surface of thermoplastic elastomer or vulcanized rubber. The surface modification method comprises the step of forming hydroxyl group on surface of to-be-modified object such as rubber so that water contact angle of the surface becomes 8 to 50 degrees smaller than original water contact angle in unmodified condition, the step of forming polymerization initiation site by subjecting the hydroxyl group to action of secondary or tertiary organic halide, and the step of growing polymer brush on the surface of to-be-modified object by subjecting monomer to radical polymerization at the polymerization initiation site acting as a point of initiation.

8. 发明申请

US20150203612A1 SURFACE MODIFICATION METHOD AND SURFACE-MODIFIED ELASTIC BODY 审中-公开
标题翻译：表面改性方法和表面改性弹性体
公开(公告)号：US20150203612A1
公开(公告)日：2015-07-23
申请号：US14421319
申请日：2013-09-09
申请人： SUMITOMO RUBBER INDUSTRIES LTD.
发明人： Yasuhisa Minagawa
IPC分类号： C08F36/18 , B60C1/00
CPC分类号： C08F36/18 , A61M5/31513 , A61M2207/00 , B60C1/0016 , B60C1/0025 , B60C11/1346 , B60C13/04 , C08F2/50 , C08J7/18 , C08J2319/00 , C08J2323/22
摘要： The present invention aims to provide methods for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, which can cost-effectively impart a variety of functions, such as sliding properties or biocompatibility, according to the application. The present invention relates to a method for surface-modifying an object of a rubber vulcanizate or a thermoplastic elastomer, the method including: step 1 of forming polymerization initiation points A on the surface of the object; and step 2 of radically polymerizing a non-functional monomer, starting from the polymerization initiation points A, to grow non-functional polymer chains, and further radically polymerizing a fluorine-containing functional monomer to grow fluorine-containing functional polymer chains.
摘要翻译：本发明的目的是提供一种橡胶硫化橡胶或热塑性弹性体的表面改性方法，其可根据应用成本有效地赋予各种功能，如滑动性能或生物相容性。本发明涉及橡胶硫化橡胶或热塑性弹性体的表面改性方法，该方法包括：步骤1，在物体的表面上形成聚合起始点A. 以及从聚合引发点A开始自由基聚合非官能单体的步骤2，生长非官能聚合物链，并进一步自由基聚合含氟官能单体生长含氟官能聚合物链。

9. 发明授权

US11226330B2 Method for capturing specific cells 有权
公开(公告)号：US11226330B2
公开(公告)日：2022-01-18
申请号：US16249527
申请日：2019-01-16
申请人： SUMITOMO RUBBER INDUSTRIES, LTD. , YAMAGATA UNIVERSITY , OSAKA UNIVERSITY
发明人： Yasuhisa Minagawa , Masaru Tanaka , Takashi Hoshiba , Haruka Emura , Masaki Mori , Hirofumi Yamamoto , Naotsugu Haraguchi
IPC分类号： G01N33/50 , B01D21/26 , G01N33/574 , G01N33/543
摘要： The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: subjecting sampled blood or biological fluid to enrichment; and capturing specific cells therefrom onto a hydrophilic polymer layer in a flow field.

10. 发明授权

US10954352B2 Surface modification method and surface-modified elastic body 有权
公开(公告)号：US10954352B2
公开(公告)日：2021-03-23
申请号：US16370205
申请日：2019-03-29
申请人： Sumitomo Rubber Industries, Ltd.
发明人： Yasuhisa Minagawa
IPC分类号： C08J7/16 , C08F279/02 , A61M5/315 , C08F2/48 , C08F8/20 , C08F236/10 , C08L15/02 , C08C19/25
摘要： Provided are methods for surface-modifying a rubber vulcanizate and surface-modified elastic bodies, which can cost-effectively provide a variety of functions, including sliding properties, liquid leakage resistance, and protein adsorption resistance. Included is a method for surface-modifying a rubber vulcanizate as a modification target, the method including: step 1 of forming polymerization initiation points A on the surface of the modification target; step 2 of radically polymerizing a monomer starting from the polymerization initiation points A to grow polymer chains; and step 3 of adding a silane compound to the surfaces of the polymer chains, followed by reaction with at least a fluoroalkyl group-containing silane compound to form modified polymer chains.

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