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1. 发明申请

US20180207344A1 ARTIFICIAL LUNG 审中-公开
公开(公告)号：US20180207344A1
公开(公告)日：2018-07-26
申请号：US15919511
申请日：2018-03-13
申请人： TERUMO KABUSHIKI KAISHA
发明人： Kozo Hisamatsu , Eisuke Sasaki
IPC分类号： A61M1/16 , B01D63/02
CPC分类号： A61M1/1698 , A61M1/1629 , A61M2205/7536 , B01D63/02 , B01D69/02 , B01D2313/38 , B01D2325/04
摘要： An artificial lung 100 has a filling portion 110 that communicates with an inlet port 101 and an outlet port 102 for blood and is filled with blood, a heat exchange portion 160 that includes a bundle of a plurality of hollow fibers 163 for heat exchange and is provided inside the filling portion, a gas exchange portion 170 that includes a bundle of a plurality of hollow fibers 173 for gas exchange and is provided inside the filling portion to be adjacent to the heat exchange portion, and a porous member 180 that is disposed in a gap 190 between the heat exchange portion and the gas exchange portion. A volume within the housing occupied by a wall of the porous member correspondingly reduces a priming volume within the housing available for conveying the blood (i.e., a bulk volume of the porous member partially blocks or fills the gap.

2. 发明申请

US20170128621A1 HOLLOW FIBER MEMBRANE BUNDLE, ARTIFICIAL LUNG, AND METHOD OF MANUFACTURING HOLLOW FIBER MEMBRANE 审中-公开
公开(公告)号：US20170128621A1
公开(公告)日：2017-05-11
申请号：US15413765
申请日：2017-01-24
申请人： TERUMO KABUSHIKI KAISHA
发明人： Eisuke Sasaki
IPC分类号： A61L27/16 , D01F6/06 , A61M1/16 , A61L27/50
CPC分类号： A61L27/16 , A61L27/50 , A61L2400/12 , A61M1/1698 , A61M2205/75 , B01D63/021 , B01D63/025 , B01D63/043 , B01D2313/22 , B01D2319/06 , D01F6/06 , D10B2321/022 , D10B2509/00
摘要： A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter φd1 of the hollow fiber membrane 31 is equal to or smaller than 150 μm, a tilt angle θ with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60°, and a ratio φD1/L of an outer diameter φD1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.

3. 发明授权

US09839736B2 Production method for medical instrument and medical instrument 有权
公开(公告)号：US09839736B2
公开(公告)日：2017-12-12
申请号：US14495179
申请日：2014-09-24
申请人： Terumo Kabushiki Kaisha
发明人： Kazuhiko Takeuchi , Eisuke Sasaki
IPC分类号： A61M1/16 , B01D63/02 , F28D7/10 , B65H81/02 , F28D21/00
摘要： A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.

4. 发明授权

US10406258B2 Hollow fiber membrane bundle, artificial lung, and method of manufacturing hollow fiber membrane 有权
公开(公告)号：US10406258B2
公开(公告)日：2019-09-10
申请号：US15413765
申请日：2017-01-24
申请人： TERUMO KABUSHIKI KAISHA
发明人： Eisuke Sasaki
IPC分类号： A61M1/16 , A61L27/16 , A61L27/50 , D01F6/06 , B01D63/02 , B01D63/04
摘要： A hollow fiber membrane bundle configured to be used in an artificial lung and comprised of integrated hollow fiber membranes 31 has hollow portions through which a fluid passes. The hollow fiber membrane bundle is shaped as a cylinder body. In addition, the hollow fiber membrane 31 is tilted with respect to a central axis O of the cylinder body, is wound around the central axis O of the cylinder body, and satisfies the following conditions. An inner diameter ϕd1 of the hollow fiber membrane 31 is equal to or smaller than 150 μm, a tilt angle θ with respect to the central axis O of the cylinder body of the hollow fiber membrane 31 is equal to or smaller than 60°, and a ratio ϕD1/L of an outer diameter ϕD1 of the cylinder body to a length L of the cylinder body is equal to or greater than 0.4.

5. 发明授权

US09867919B2 Production method for medical instrument and medical instrument 有权
公开(公告)号：US09867919B2
公开(公告)日：2018-01-16
申请号：US14495179
申请日：2014-09-24
申请人： Terumo Kabushiki Kaisha
发明人： Kazuhiko Takeuchi , Eisuke Sasaki
IPC分类号： A61M1/16 , B01D63/02 , F28D7/10 , B65H81/02 , F28D21/00
CPC分类号： A61M1/1698 , B01D63/021 , B01D63/025 , B01D2313/38 , B01D2323/42 , B65H81/02 , F28D7/103 , F28D21/0015 , F28D2021/005
摘要： A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.

6. 发明申请

US20170173244A1 ARTIFICIAL LUNG AND ARTIFICIAL HEART-LUNG CIRCUIT DEVICE 审中-公开
公开(公告)号：US20170173244A1
公开(公告)日：2017-06-22
申请号：US15447502
申请日：2017-03-02
申请人： TERUMO KABUSHIKI KAISHA
发明人： Takashi Saito , Eisuke Sasaki
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/1621 , A61M1/1629 , A61M1/3606 , A61M1/3666 , A61M2205/3331 , A61M2205/3379 , A61M2207/00
摘要： An artificial lung has a gas exchanger portion with an external circulation-type gas exchanging hollow fiber membrane bundle and a heat exchanger portion with a heat exchanging element. Various design parameters of the gas exchanger and heat exchanger portions are configured to obtain a predetermined performance factor. in one embodiment, the design parameters are adjusted so that when a gas exchange performance, a heat exchange performance coefficient, a blood filling amount, and a blood side pressure loss are measured, they result in a performance factor between 1.5 and 2.5, wherein the performance factor is defined as (gas exchange performance×heat exchange performance coefficient)/(blood filling amount×blood side pressure loss).

7. 发明申请

US20150010433A1 PRODUCTION METHOD FOR MEDICAL INSTRUMENT AND MEDICAL INSTRUMENT 有权
标题翻译：医用仪器和医用仪器的生产方法
公开(公告)号：US20150010433A1
公开(公告)日：2015-01-08
申请号：US14495179
申请日：2014-09-24
申请人： Terumo Kabushiki Kaisha
发明人： Kazuhiko TAKEUCHI , Eisuke Sasaki
IPC分类号： A61M1/16 , B65H81/02
CPC分类号： A61M1/1698 , B01D63/021 , B01D63/025 , B01D2313/38 , B01D2323/42 , B65H81/02 , F28D7/103 , F28D21/0015 , F28D2021/005
摘要： A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.
摘要翻译：医疗器械的制造方法包括多个形成圆筒状体的基材的中空纤维膜。每个中空纤维膜依次通过设置在芯部件上的第一点，第二点，第三点，第四点和第五点。在从第二点朝向第三点的向外的路径中，中空纤维膜沿着芯构件的圆周方向被卷绕而以最短距离从第二点到达第三点。此外，在从第四点朝向第五点的回流路径中，中空纤维膜以最短距离从第四点到达第五点，同时沿与芯部件的相同方向缠绕在芯构件的圆周方向上外向路的情况。

8. 发明授权

US10758657B2 Artificial lung and method for manufacturing artificial lung 有权
公开(公告)号：US10758657B2
公开(公告)日：2020-09-01
申请号：US15699284
申请日：2017-09-08
申请人： TERUMO KABUSHIKI KAISHA
发明人： Takao Anzai , Eisuke Sasaki , Norikazu Ishida
IPC分类号： A61M1/16 , B01D67/00 , B01D69/02 , B01D63/02
摘要： An artificial lung is provided that includes a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I): wherein in Formula (I), R3 represents a hydrogen atom or a methyl group, R1 represents an alkylene group having 1 to 4 carbon atoms, and R2 represents an alkyl group having 1 to 4 carbon atoms.

9. 发明授权

US09867920B2 Medical instrument 有权
公开(公告)号：US09867920B2
公开(公告)日：2018-01-16
申请号：US14495269
申请日：2014-09-24
申请人： Terumo Kabushiki Kaisha
发明人： Kazuhiko Takeuchi , Eisuke Sasaki
IPC分类号： A61M1/16 , B01D63/02 , B65H81/00
CPC分类号： A61M1/1698 , A61M1/1623 , B01D63/021 , B01D63/025 , B01D2313/38 , B65H81/00 , F04C2270/041
摘要： An Oxygenator as a medical instrument includes at least one first hollow fiber membrane layer comprised of a plurality of integrated first hollow fiber membranes, and forms a shape of a cylindrical body as a whole, and at least one second hollow fiber membrane layer disposed at the outer circumferential side of the first hollow fiber membrane layer in a state of being concentric with the first hollow fiber membrane layer, has a plurality of integrated second hollow fiber membranes, and forms a shape of a cylindrical body as a whole. Moreover, each of the first hollow fiber membranes is wound around a central axis, and each of the second hollow fiber membranes is wound around a central axis. The number of times the second hollow fiber membranes are wound is smaller than the number of times the first hollow fiber membranes are wound.

10. 发明申请

US20170173245A1 ARTIFICIAL LUNG AND ARTIFICIAL HEART-LUNG CIRCUIT DEVICE 审中-公开
公开(公告)号：US20170173245A1
公开(公告)日：2017-06-22
申请号：US15447530
申请日：2017-03-02
申请人： TERUMO KABUSHIKI KAISHA
发明人： Takashi Saito , Eisuke Sasaki
IPC分类号： A61M1/16
摘要： An artificial lung has a gas exchanger portion with an external circulation-type gas exchanging hollow fiber membrane bundle and a heat exchanger portion with a heat exchanging element. Various design parameters of the gas exchanger and heat exchanger portions are configured to obtain a predetermined performance factor. In one embodiment, the design parameters are adjusted so that when a heat exchange performance coefficient of the artificial lung, a blood filling amount of the artificial lung, and a blood side pressure loss of the artificial lung are measured, they result in a performance factor equal to or greater than 1.5, wherein the performance factor is defined as heat exchange performance coefficient/(blood filling amount×blood side pressure loss).

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