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1. 发明申请

US20150192510A1 IMAGING OR MEASUREMENT METHODS AND SYSTEMS 审中-公开
标题翻译：成像或测量方法和系统
公开(公告)号：US20150192510A1
公开(公告)日：2015-07-09
申请号：US14409397
申请日：2013-06-24
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： Rafael Piestun , Anurag Agrawal , Sean Quirin , Anthony Barsic , Ginni Grover
IPC分类号： G01N15/14 , G01B21/16 , G01B11/00 , G01B11/14
CPC分类号： G01N15/1429 , G01B11/002 , G01B11/14 , G01B21/16 , G01N15/1456 , G01N21/6458 , G01N2015/0038 , G01N2015/1445
摘要： Imaging or measurement methods and systems including methods and systems for finding the three-dimensional orientation and position of multiple dipole-like particles and single molecules, methods and systems for generating helical beams and helical spread functions, and methods and systems for super-resolution and super-localization of dense arrays of emitters.
摘要翻译：成像或测量方法和系统，包括用于发现多个偶极子颗粒和单分子的三维取向和位置的方法和系统，用于产生螺旋波束和螺旋扩散函数的方法和系统，以及用于超分辨率和密集阵列发射体的超定位。

2. 发明申请

US20150035946A1 METHODS AND SYSTEMS FOR THREE DIMENSIONAL OPTICAL IMAGING, SENSING, PARTICLE LOCALIZATION AND MANIPULATION 有权
标题翻译：用于三维光学成像，感测，粒子定位和操作的方法和系统
公开(公告)号：US20150035946A1
公开(公告)日：2015-02-05
申请号：US14465543
申请日：2014-08-21
申请人： The Regents of the University of Colorado, a body corporate
发明人： Rafael Piestun , Sean Albert Quirin
IPC分类号： H04N13/02 , G06T7/00
CPC分类号： H04N13/204 , G06T7/77 , G06T2207/10056 , G06T2207/10064
摘要： Embodiments include methods, systems, and/or devices that may be used to image, obtain three-dimensional information from a scene, and/or locate multiple small particles and/or objects in three dimensions. A point spread function (PSF) with a predefined three dimensional shape may be implemented to obtain high Fisher information in 3D. The PSF may be generated via a phase mask, an amplitude mask, a hologram, or a diffractive optical element. The small particles may be imaged using the 3D PSF. The images may be used to find the precise location of the object using an estimation algorithm such as maximum likelihood estimation (MLE), expectation maximization, or Bayesian methods, for example. Calibration measurements can be used to improve the theoretical model of the optical system. Fiduciary particles/targets can also be used to compensate for drift and other type of movement of the sample relative to the detector.
摘要翻译：实施例包括可以用于图像，从场景获取三维信息和/或定位三维中的多个小粒子和/或对象的方法，系统和/或设备。可以实现具有预定三维形状的点扩散函数（PSF）以获得3D中的高Fisher信息。 PSF可以通过相位掩模，幅度掩模，全息图或衍射光学元件生成。可以使用3D PSF对小颗粒进行成像。例如，图像可以用于使用诸如最大似然估计（MLE），期望最大化或贝叶斯方法的估计算法来找到对象的精确位置。校准测量可用于改善光学系统的理论模型。受信颗粒/目标也可用于补偿样品相对于检测器的漂移和其他类型的运动。

3. 发明授权

US10955331B2 Imaging or measurement methods and systems 有权
公开(公告)号：US10955331B2
公开(公告)日：2021-03-23
申请号：US14409397
申请日：2013-06-24
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： Rafael Piestun , Anurag Agrawal , Sean Quirin , Anthony Barsic , Ginni Grover
IPC分类号： G01N15/14 , G01B11/00 , G01B11/14 , G01B21/16 , G01N21/64 , G01N15/00
摘要： Imaging or measurement methods and systems including methods and systems for finding the three-dimensional orientation and position of multiple dipole-like particles and single molecules, methods and systems for generating helical beams and helical spread functions, and methods and systems for super-resolution and super-localization of dense arrays of emitters.

4. 发明授权

US10657346B2 3-D localization and imaging of dense arrays of particles 有权
公开(公告)号：US10657346B2
公开(公告)日：2020-05-19
申请号：US15856539
申请日：2017-12-28
申请人： The Regents of the University of Colorado, a body corporate
发明人： Rafael Piestun , Anthony Barsic
IPC分类号： G06K9/00 , G06T7/73 , G02B21/36 , G06K9/68 , G01N21/64 , G02B21/14
摘要： Systems, methods, and computer program products are disclosed to localize and/or image a dense array of particles. In some embodiments, a plurality of particles may be imaged using an imaging device. A plurality of point spread function dictionary coefficients of the image may be estimated using a point spread function dictionary; where the point spread function dictionary can include a plurality of spread function responses corresponding to different particle positions. From the point spread function dictionary coefficients the number of particles in the image can be determined. Moreover location of each particle in the image can be determined from the point spread function dictionary coefficients.

5. 发明授权

US10215975B2 Method and/or system for stabilization, tracking, and/or control of microscopic systems 有权
公开(公告)号：US10215975B2
公开(公告)日：2019-02-26
申请号：US15018684
申请日：2016-02-08
申请人： The Regents of the University of Colorado, a body corporate
发明人： Rafael Piestun , Wyatt Mohrman , Ginni Grover
IPC分类号： G02B21/16 , G02B21/36 , G02B21/12 , G02B21/24
摘要： Some embodiments of the invention include a system comprising a positioning device configured to a hold a sample and adjust a position of a sample in response to receiving a drift compensation signal; a first light source disposed to transilluminate the sample; a second light source disposed to epi-illuminate the sample; an optical system configured to receive light from the sample and generate a three-dimensional point spread function from the light from the sample; an image sensor disposed relative to the optical system that produces an image from the light collected from the sample via the optical system; and logic electrically coupled with the image detector and the positioning device, the logic configured to determine one or more drift compensation values from images imaged by the image detector, and configured to send one or more drift compensation signals to the positioning device.

6. 发明申请

US20160356746A1 IMAGING THROUGH SCATTERING MEDIA WITH HIGH SIGNAL TO NOISE RATIO AND RESOLUTION 审中-公开
标题翻译：通过具有高信号噪声比和分辨率的散射介质成像
公开(公告)号：US20160356746A1
公开(公告)日：2016-12-08
申请号：US14913958
申请日：2014-08-26
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： Rafael Piestun , Hengyi Ju , Jacob Dove , Antonio Miguel Caravacca-Aguirre , Todd Murray , Donald Conkey
IPC分类号： G01N29/24 , G01N29/06
CPC分类号： G01N29/2418 , A61B5/0095 , G01N21/1702 , G01N29/0654 , G01N2021/1706 , G01N2201/0675
摘要： Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Embodiments of the invention can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.
摘要翻译：公开了系统和方法来增强散射材料后面，通过或内部的三维光声成像。本发明的实施例可以在散射体之前使用波前整形来增加超声波换能器焦点中的光能密度和/或增强光强度。由放置在散射介质后面的物体引起的光声信号可以用作反馈以优化波前，使光声振幅能够提高一个数量级。使用增强的光强度，可以在二维扫描物体和/或可以在对数据进行后处理以重构图像之前重新优化波阵面来扫描点。时间光声信号提供重建第三维信息的信息。

7. 发明公开

US20240134179A1 Methods And Systems For High-Resolution And High Signal-To-Noise Ratio Imaging Through Generalized Media 审中-公开
公开(公告)号：US20240134179A1
公开(公告)日：2024-04-25
申请号：US18546996
申请日：2022-02-18
申请人： The Regents of the University of Colorado, a body corporate
发明人： Rafael Piestun , Sakshi Singh , Simon Labouesse
IPC分类号： G02B21/16 , A61B5/00 , G02B23/24 , G02B23/26
CPC分类号： G02B21/16 , A61B5/0068 , A61B5/0071 , G02B23/2469 , G02B23/26
摘要： Technology is disclosed herein that enhances imaging, sensing, and property detection of objects. In an implementation, a wave radiation source transmits waves through a complex medium towards an object. The complex medium may be engineered or naturally occurring. Wave modulators modulate the waves transmitted through the complex medium. The wave modulators may comprise spatial or temporal modulators. Secondary waves propagate back though the complex medium in response interaction between the waves and the object. Detectors detect wave properties from the secondary waves. A digital processor reconstructs data based on the secondary wave properties.

8. 发明申请

US20210080484A1 Methods And Systems For Scanning Probe Sample Property Measurement And Imaging 有权
公开(公告)号：US20210080484A1
公开(公告)日：2021-03-18
申请号：US17105475
申请日：2020-11-25
申请人： The Regents of the University of Colorado, a body corporate
发明人： Rafael Piestun , Simon Labouesse , Markus B. Raschke , Eric Muller , Samuel Johnson
IPC分类号： G01Q60/22 , G01Q60/06 , G01Q10/06 , G01Q30/04 , G01J3/44 , G01J3/45 , G01J3/10 , G01J3/02 , G01J3/28
摘要： Infrared (IR) vibrational scattering scanning near-field optical microscopy (s-SNOM) has advanced to become a powerful nanoimaging and spectroscopy technique with applications ranging from biological to quantum materials. However, full spatiospectral s-SNOM continues to be challenged by long measurement times and drift during the acquisition of large associated datasets. Various embodiments provide for a novel approach of computational spatiospectral s-SNOM by transforming the basis from the stationary frame into the rotating frame of the IR carrier frequency. Some embodiments see acceleration of IR s-SNOM data collection by a factor of 10 or more in combination with prior knowledge of the electronic or vibrational resonances to be probed, the IR source excitation spectrum, and other general sample characteristics.

9. 发明授权

US10514586B2 Methods and systems for control of nonlinear light transmission 有权
公开(公告)号：US10514586B2
公开(公告)日：2019-12-24
申请号：US16039156
申请日：2018-07-18
申请人： The Regents of the University of Colorado, a body corporate
发明人： Omer Tzang , Rafael Piestun , Antonio Miguel Caravaca-Aguirre , Kelvin Wagner
IPC分类号： G02F1/365 , G02F1/35
摘要： Recent remarkable progress in wave-front shaping has enabled control of light propagation inside linear media to focus and image through scattering objects. In particular, light propagation in multimode fibers comprises complex intermodal interactions and rich spatiotemporal dynamics. Control of physical phenomena in multimode fibers and its applications is in its infancy, opening opportunities to take advantage of complex mode interactions. Various embodiments of the present technology provide wave-front shaping for controlling nonlinear phenomena in multimode fibers. Using a spatial light modulator at the fiber's input and a genetic algorithm optimization, some embodiments control a highly nonlinear stimulated Raman scattering cascade and its interplay with four wave mixing via a flexible implicit control on the superposition of modes that are coupled into the fiber.

10. 发明授权

US09967541B2 3D imaging, ranging, and/or tracking using active illumination and point spread function engineering 有权
公开(公告)号：US09967541B2
公开(公告)日：2018-05-08
申请号：US14934031
申请日：2015-11-05
申请人： The Regents of the University of Colorado, a body corporate
发明人： Rafael Piestun
IPC分类号： H04N13/00 , H04N13/02
CPC分类号： H04N13/204 , G06T2200/04 , H04N5/23212 , H04N13/254
摘要： Imaging systems and imaging methods are disclosed to estimate a three-dimensional position of an object at a scene and/or generate a three-dimensional image of the scene. The imaging system may include, for example, one or many light sources; an optical system configured to direct light from the one or more light sources into a pattern onto the scene; a mask; a detector array disposed to receive light from the scene through the mask; and at least one processor communicatively coupled with the detector and configured to estimate a depth of a particle within the scene.

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