专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20230131302A1 Method for Correcting Mass Spectral Data 有权
公开(公告)号：US20230131302A1
公开(公告)日：2023-04-27
申请号：US18049314
申请日：2022-10-25
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Hamish STEWART , Bernd HAGEDORN , Dmitry GRINFELD
IPC分类号： H01J49/40 , H01J49/00 , H01J49/42
摘要： A method for correcting mass spectral data obtained for a sample is described, where the mass spectral data is a time-of-flight mass spectral data. The method includes receiving mass spectral data obtained from a sample, the mass spectral data being indicative of an ion abundance. The method further includes applying a correction function to the mass spectral data based on the ion abundance indicated by the mass spectral data and on one or more trapping parameters associated with the mass spectral data. The correction function defines correction values for the mass spectral data for a range of ion abundances and for a range of trapping parameters.

2. 发明申请

US20220319828A1 ION TRAP 有权
公开(公告)号：US20220319828A1
公开(公告)日：2022-10-06
申请号：US17693999
申请日：2022-03-14
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Hamish STEWART , Dmitry GRINFELD , Alexander WAGNER
IPC分类号： H01J49/42 , H01J29/84
摘要： The ion trap comprises a multipole electrode assembly, a first confining electrode, and a second confining electrode. The multipole electrode assembly is configured to confine ions of the first polarity to an ion channel extending in an axial direction of the multipole electrode assembly. The first confining electrode is provided adjacent to the multipole electrode assembly and extends in the axial direction of the multipole electrode assembly. The second confining electrode is provided adjacent to the multipole electrode assembly and extends in the axial direction of the multipole electrode assembly aligned with the first confining electrode. The first and second confining electrodes are spaced apart in the axial direction in order to define an ion confining region of the ion channel between the first and second confining electrodes. The first and second confining electrodes are configured to receive a DC potential of the first polarity to further confine ions within the ion channel in the ion confining region.

3. 发明申请

US20160005585A1 MULTI-REFLECTION MASS SPECTROMETER 有权
公开(公告)号：US20160005585A1
公开(公告)日：2016-01-07
申请号：US14852466
申请日：2015-09-11
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Dmitry GRINFELD , Alexander MAKAROV
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/406 , H01J49/0027 , H01J49/004 , H01J49/061
摘要： A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction, the X direction being orthogonal to Y, characterized in that the mirrors are not a constant distance from each other in the X direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer. The motion of ions along the drift direction is opposed by an electric field resulting from the non-constant distance of the mirrors from each other along at least a portion of their lengths in the drift direction that causes the ions to reverse their direction.

4. 发明申请

US20160314951A1 Method of Producing a Mass Spectrum 审中-公开
标题翻译：产生质谱的方法
公开(公告)号：US20160314951A1
公开(公告)日：2016-10-27
申请号：US15131300
申请日：2016-04-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Konstantin AIZIKOV , Dmitry GRINFELD , Alexander MAKAROV
IPC分类号： H01J49/00 , H01J49/42 , H01J49/38 , H01J49/10
摘要： A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a Fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.
摘要翻译：一种从在质谱仪中检测的时变瞬态信号产生质谱的方法，所述方法包括：执行所述瞬态信号的傅里叶变换以产生第一组复振幅，其中每个复振幅对应于相应的第一组频率的频率; 产生第二组复振幅，其中每个复振幅对应于具有小于瞬态信号的持续时间的倒数的最小间隔的第二组频率的相应频率; 优化第二组复振幅以产生改进的第二组; 从所述改进的第二组复振幅中的至少一些产生质谱; 其中优化所述第二组复幅度以产生改进的第二组复幅度是基于经受一些相位约束的目标函数。

5. 发明申请

US20160225603A1 ION EJECTION FROM A QUADRUPOLE ION TRAP 有权
标题翻译：离子离子由四倍子离子捕获
公开(公告)号：US20160225603A1
公开(公告)日：2016-08-04
申请号：US15093152
申请日：2016-04-07
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Christian Albrecht HOCK , Dmitry GRINFELD , Richard HEMING
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/427 , H01J49/0031 , H01J49/0481 , H01J49/063 , H01J49/282 , H01J49/40 , H01J49/4225 , H01J49/424 , H01J49/4245
摘要： A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.
摘要翻译：从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

6. 发明申请

US20220238321A1 ION INJECTION TO AN ELECTROSTATIC TRAP 有权
公开(公告)号：US20220238321A1
公开(公告)日：2022-07-28
申请号：US17724219
申请日：2022-04-19
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Mikhail BELOV , Eduard DENISOV , Gregor QUIRING , Dmitry GRINFELD
IPC分类号： H01J49/42 , H01J49/06
摘要： Ions are injected into an orbital electrostatic trap. An ejection potential is applied to an ion storage device, to cause ions stored in the ion storage device to be ejected towards the orbital electrostatic trap. Synchronous injection potentials are applied to a central electrode of the orbital electrostatic trap and a deflector electrode associated with the orbital electrostatic trap, to cause the ions ejected from the ion storage device to be captured by the electrostatic trap such that they orbit the central electrode. Application of the ejection potential and application of the synchronous injection potentials are each started at respective different times, the difference in times being selected based on desired values of mass-to-charge ratios of ions to be captured by the orbital electrostatic trap.

7. 发明申请

US20170278692A1 MULTI-REFLECTION MASS SPECTROMETER 审中-公开
公开(公告)号：US20170278692A1
公开(公告)日：2017-09-28
申请号：US15620255
申请日：2017-06-12
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Dmitry GRINFELD , Alexander MAKAROV
IPC分类号： H01J49/40 , H01J49/06 , H01J49/00
CPC分类号： H01J49/406 , H01J49/0027 , H01J49/004 , H01J49/061
摘要： A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction, the X direction being orthogonal to Y, characterized in that the mirrors are not a constant distance from each other in the X direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer. The motion of ions along the drift direction is opposed by an electric field resulting from the non-constant distance of the mirrors from each other along at least a portion of their lengths in the drift direction that causes the ions to reverse their direction.

8. 发明申请

US20160005580A1 MULTI-REFLECTION MASS SPECTROMETER 有权
公开(公告)号：US20160005580A1
公开(公告)日：2016-01-07
申请号：US14853892
申请日：2015-09-14
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Dmitry GRINFELD , Alexander MAKAROV
IPC分类号： H01J49/06 , H01J49/42 , H01J49/00
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/005 , H01J49/406 , H01J49/4245
摘要： A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction and having a space therebetween, the X direction being orthogonal to Y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the X direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length.

9. 发明申请

US20220392759A1 Voltage supply for a mass analyser 有权
公开(公告)号：US20220392759A1
公开(公告)日：2022-12-08
申请号：US17661331
申请日：2022-04-29
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Hamish Stewart , Dmitry GRINFELD , Philipp COCHEMS
IPC分类号： H01J49/40 , H01J49/06
摘要： A voltage supply for a mass analyser is provided. The voltage supply comprises a voltage source, a first voltage output, a second voltage output, and a voltage divider network. The first voltage output is configured to provide a first voltage to a first electrode of the mass analyser, wherein the first electrode of the mass analyser has a first mass shift per volt perturbation. The second voltage output is configured to provide a second voltage to a second electrode of the mass analyser, wherein the second electrode of the mass analyser has a second mass shift per volt perturbation. The second mass shift per volt perturbation opposes the first mass shift per volt perturbation. The voltage divider network comprises a first resistor and a second resistor. The first resistor is configured to define the first voltage, the first resistor having a first temperature coefficient. The second resistor is configured to define the second voltage, the second resistor having a second temperature coefficient. The second temperature coefficient is selected based on the first and second mass shift per volt perturbations and the first temperature coefficient such that a first mass shift associated with the first electrode is compensated by a second mass shift associated with the second electrode.

10. 发明申请

US20180366312A1 MASS SPECTROMETER AND METHOD FOR TIME-OF-FLIGHT MASS SPECTROMETRY 审中-公开
公开(公告)号：US20180366312A1
公开(公告)日：2018-12-20
申请号：US16011464
申请日：2018-06-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Stewart HAMISH , Dmitry GRINFELD , Alexander MAKAROV
IPC分类号： H01J49/40 , H01J49/42
摘要： A mass spectrometer comprising: a pulsed ion source for generating pulses of ions having a range of masses; a time-of-flight mass analyzer for receiving and mass analyzing the pulses of ions from the ion source; and an energy controlling electrode assembly located between the pulsed ion source and the time-of-flight mass analyzer configured to receive the pulses of ions from the pulsed ion source and apply a time-dependent potential to the ions thereby to control the energy of the ions depending on their m/z before they reach the time-of-flight mass analyzer. Mass dependent differences in average energy of ions can be reduced for injection into a time-of-flight mass analyzer, which can improve ion transmission and/or instrument resolving power.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式