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1. 发明申请

US20210302371A1 DETECTION AND ANALYSIS OF OLEFINS IN PETROLEUM BY ELECTROSPRAY IONIZATION MASS SPECTROMETRY 有权
公开(公告)号：US20210302371A1
公开(公告)日：2021-09-30
申请号：US17205528
申请日：2021-03-18
申请人： ExxonMobil Research and Engineering Company
发明人： Ashley M. Wittrig , Kuangnan Qian , Thomas R. Fredriksen
IPC分类号： G01N27/626 , H01J49/16 , G01N1/38 , H01J49/38
摘要： A method for detecting and analyzing olefins in petroleum by electrospray ionization mass spectrometry can include obtaining a hydrocarbon sample comprising at least about 90 wt % of saturate compounds; producing a solution comprising the hydrocarbon sample and a metal salt, the metal salt comprising a metal ion; forming olefin-metal ion complexes by electrospray ionization; and detecting the olefin-metal ion complexes using mass spectrometry.

2. 发明申请

US20200335321A1 Mass Spectrometry 审中-公开
公开(公告)号：US20200335321A1
公开(公告)日：2020-10-22
申请号：US16332570
申请日：2017-09-12
申请人： THE UNIVERSITY OF WARWICK
发明人： Peter O'Connor , Maria A. Van Agthoven
IPC分类号： H01J49/42 , H01J49/00 , H01J49/38
摘要： A method of carrying out mass spectrometry, comprising: using an electrostatic or electrodynamic ion trap to contain a plurality of ions, each ion having a mass to charge ratio, the ions having a first plurality of mass to charge ratios, each ion following a path within the electrostatic or electrodynamic ion trap having a radius; and for each of a second plurality of the mass to charge ratios: modulating the radii of the ions in a mass to charge ratio-dependent fashion dependent upon the mass to charge ratio; fragmenting the ions thus modulated in a radius-dependent fashion; and determining a mass spectrum of the ions.

3. 发明授权

US10755907B2 Method of producing a mass spectrum 有权
公开(公告)号：US10755907B2
公开(公告)日：2020-08-25
申请号：US15131300
申请日：2016-04-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Konstantin Aizikov , Dmitry Grinfeld , Alexander Makarov
IPC分类号： H01J49/00 , H01J49/10 , H01J49/38 , H01J49/42
摘要： A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a Fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.

4. 发明授权

US10302624B2 Methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging 有权
公开(公告)号：US10302624B2
公开(公告)日：2019-05-28
申请号：US15143064
申请日：2016-04-29
申请人： Med-Life Discoveries LP
发明人： Dayan Goodenowe
IPC分类号： G01N33/92 , G01N33/49 , G01N33/574 , G01N33/68 , H01J49/00 , H01J49/38
摘要： The present invention relates to methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging. The present invention describes the relationship between plasmalogen biosynthesis dysfunction and the biochemical and clinical manifestations of age related disorders. Specifically the present invention describes an increased prevalence of colon cancer, prostate cancer, lung cancer, breast cancer, ovary cancer, kidney cancer, cognitive impairment and dementia in subjects suffering from adult onset plasmalogen biosynthesis disorder (AO-PBD).

5. 发明申请

US20180226238A1 Method and Apparatus for Isotope Ratio Mass Spectrometry 审中-公开
公开(公告)号：US20180226238A1
公开(公告)日：2018-08-09
申请号：US15887520
申请日：2018-02-02
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jens GRIEP-RAMING
IPC分类号： H01J49/00 , G01N30/72 , H01J49/04 , H01J49/40 , H01J49/28 , H01J49/38
CPC分类号： H01J49/0031 , G01N30/7233 , G01N30/8658 , G01N2030/324 , H01J49/0036 , H01J49/0459 , H01J49/282 , H01J49/38 , H01J49/40
摘要： A method of isotope ratio mass spectrometry comprising: flowing a liquid mobile phase through a separation device; reducing the flow rate of the mobile phase through the separation device for at least a portion of time that at least one molecular species is emerging from the separation device to achieve a desired isotope ratio precision, wherein the flow rate is reduced from a first rate to a second rate corresponding to a higher theoretical plate height of the separation device; and mass analyzing the molecular species that has emerged from the separation device at least while the flow rate is reduced; and determining at least one isotope ratio from the intensities of mass peaks of at least two isotopologues, wherein the mass analysis is performed with mass resolving power high enough to resolve the two most abundant mass peaks at the nominal mass of at least one of the isotopologues.

6. 发明授权

US09741551B2 Ion detection 有权
公开(公告)号：US09741551B2
公开(公告)日：2017-08-22
申请号：US15332734
申请日：2016-10-24
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/00 , H01J49/28 , H01J49/02 , H01J49/38 , H01J49/42 , H01J49/08
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

7. 发明授权

US09698002B2 Method and apparatus for mass analysis utilizing ion charge feedback 有权
公开(公告)号：US09698002B2
公开(公告)日：2017-07-04
申请号：US15131117
申请日：2016-04-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jan-Peter Hauschild , Oliver Lange , Ulf Fröhlich , Andreas Wieghaus , Alexander Kholomeev , Alexander Makarov
IPC分类号： H01J49/04 , H01J49/00 , H01J49/38 , H01J49/42
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/027 , H01J49/04 , H01J49/38 , H01J49/4245 , H01J49/425
摘要： A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.

8. 发明授权

US09659761B2 Dynamically harmonized FT-ICR cell with specially shaped electrodes for compensation of inhomogeneity of the magnetic field 有权
公开(公告)号：US09659761B2
公开(公告)日：2017-05-23
申请号：US14024419
申请日：2013-09-11
申请人： Bruker Daltonik GmbH
发明人： Yury Kostyukevich , Evgeny Nikolaev , Gleb Vladimirov
IPC分类号： H01J49/38 , H01J49/34 , H01J49/00
CPC分类号： H01J49/38 , H01J49/0027 , H01J49/34
摘要： A method and apparatus of compensating a magnetic field inhomogeneity in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell, the extra electrodes being shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field on the cycling ions.

9. 发明授权

US09620349B2 ICR cell operating with a duplexer 有权
公开(公告)号：US09620349B2
公开(公告)日：2017-04-11
申请号：US14961908
申请日：2015-12-08
申请人： Bruker BioSpin AG
发明人： Walter Roeck , Christoph Martin Gosteli , Arthur Schwilch
IPC分类号： H01J49/00 , H01J49/38 , H01J49/02
CPC分类号： H01J49/38 , H01J49/0027 , H01J49/022
摘要： An ICR cell (01) operates with a duplexer (08), which is an integral part of a transmission and receiving device (09) of an FT-ICR mass spectrometry device. The device transmits a transmitter (03) voltage to at least one electrode (11) of the ICR cell during an ion excitation phase and protects a preamplifier (04) from overvoltage. An ion received signal passes through a reception path (12) to the preamplifier during an ion detection phase. The duplexer has at least one active serial switch (07) with two switchable states, each with different series impedances, which is inserted in the reception path (12). As a result, a duplexer for an ICR cell of an FT-ICR mass spectrometry device is provided in which at least one electrode can be used for both ion excitation and for subsequent ion detection.

10. 发明申请

US20160268114A1 Ion Trap Mass Spectrometers 审中-公开
标题翻译：离子阱质谱仪
公开(公告)号：US20160268114A1
公开(公告)日：2016-09-15
申请号：US15035952
申请日：2014-11-11
申请人： MICROMASS UK LIMITED
发明人： Kevin Giles , Martin Raymond Green , Keith Richardson , Jason Lee Wildgoose
IPC分类号： H01J49/06 , H01J49/38 , G01N27/62
CPC分类号： H01J49/06 , G01N27/622 , H01J49/004
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region. The method further comprises accumulating the target ions within the ion storage region during an ion accumulation period.
摘要翻译：公开了一种质谱法或离子迁移光谱法，其包括：向离子存储区提供离子; 在任何给定时间选择期望存储在离子存储区域内的目标最大电荷; 并且减少通过离子存储区域的离子电流，使得进入离子存储区域的离子不会使存储区域内的总电荷升高到高于目标最大电荷。降低通过离子存储区域的离子电流的步骤包括：在离子迁移率分离器中根据其离子迁移率暂时分离离子; 并根据质量与质量过滤器的质荷比质量过滤离子。分离和质量过滤离子的所述步骤基本上仅导致具有选择的离子迁移率和质荷比的组合的目标离子被传输到离子存储区域。该方法还包括在离子累积期间在离子存储区内积聚目标离子。

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