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1. 发明申请

US20140378661A1 MOLDED REGENERATED SILK GEOMETRIES USING TEMPERATURE CONTROL AND MECHANICAL PROCESSING 审中-公开
标题翻译：使用温度控制和机械加工的模制再生丝绸几何
公开(公告)号：US20140378661A1
公开(公告)日：2014-12-25
申请号：US14112637
申请日：2012-04-20
申请人： Tim Jia-Ching Lo , Gary G. Leisk , Lei Li , David L. Kaplan
发明人： Tim Jia-Ching Lo , Gary G. Leisk , Lei Li , David L. Kaplan
IPC分类号： D01F4/02 , B05D7/24 , B05D3/00 , B29C39/00
CPC分类号： D01F4/02 , B05D3/007 , B05D7/24 , B29C39/003 , B29K2089/00 , B29K2105/04 , B29K2105/25 , B29K2883/00 , B29L2001/005 , B29L2001/007 , B29L2007/008 , B29L2031/7132 , D01F1/10 , D10B2211/22
摘要： The present disclosure provides methods for fabricating various regenerated silk geometries using temperature control. In addition to temperature control, mechanical processing can be used to enhance properties of the fabricated article. The present disclosure also provides silk foam and paper-like materials molded using freezer processing.
摘要翻译：本公开提供了使用温度控制来制造各种再生丝几何形状的方法。除了温度控制之外，还可以使用机械加工来增强制造物品的性能。本公开还提供了使用冷冻机加工模制的丝绸泡沫和纸状材料。

2. 发明申请

US20120244143A1 DRAWN SILK EGEL FIBERS AND METHODS OF MAKING SAME 有权
标题翻译：拉丝丝织物及其制造方法
公开(公告)号：US20120244143A1
公开(公告)日：2012-09-27
申请号：US13498722
申请日：2010-09-28
申请人： Tim Jia-Ching Lo , Gary G. Leisk , David L. Kaplan
发明人： Tim Jia-Ching Lo , Gary G. Leisk , David L. Kaplan
IPC分类号： C07K14/435 , C08L89/00 , A61K39/395
CPC分类号： D01F4/02 , D01D1/02 , D01D5/00 , G02B6/02033
摘要： The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.
摘要翻译：本发明涉及丝绒丝素纤维的组合物和方法。所得到的纤维可以透射光，因此可以用作光纤。丝素蛋白纤维通过包括向溶解的丝素蛋白溶液施加电场以产生丝素蛋白凝胶的方法产生; 将丝素蛋白凝胶转化为粘稠的丝液; 并从粘性丝液中抽出丝纤维。本发明的丝纤维可以用于纺织品，医用缝合线和组织材料等材料，并且可以赋予这些材料光学特性。

3. 发明授权

US09074302B2 Methods of making drawn silk fibers 有权
标题翻译：制作拉丝丝纤维的方法
公开(公告)号：US09074302B2
公开(公告)日：2015-07-07
申请号：US13498722
申请日：2010-09-28
申请人： Tim Jia-Ching Lo , Gary G. Leisk , David L. Kaplan
发明人： Tim Jia-Ching Lo , Gary G. Leisk , David L. Kaplan
IPC分类号： C08L89/00 , D01D5/40 , D01F4/00 , D01F4/02 , D01D1/02 , D01D5/00 , G02B6/02
CPC分类号： D01F4/02 , D01D1/02 , D01D5/00 , G02B6/02033
摘要： The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.
摘要翻译：本发明涉及丝绒丝素纤维的组合物和方法。所得到的纤维可以透射光，因此可以用作光纤。丝素蛋白纤维通过包括向溶解的丝素蛋白溶液施加电场以产生丝素蛋白凝胶的方法产生; 将丝素蛋白凝胶转化为粘稠的丝液; 并从粘性丝液中抽出丝纤维。本发明的丝纤维可以用于纺织品，医用缝合线和组织材料等材料，并且可以赋予这些材料光学特性。

4. 发明授权

US08501172B2 pH-induced silk gels and uses thereof 有权
标题翻译： pH诱导的丝凝胶及其用途
公开(公告)号：US08501172B2
公开(公告)日：2013-08-06
申请号：US12974796
申请日：2010-12-21
申请人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
发明人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
IPC分类号： A61K39/395
CPC分类号： A61K47/42 , A61K9/10 , A61K41/00 , A61L26/0047 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/38 , A61L27/52 , H01L41/193 , C08L89/00
摘要： This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
摘要翻译：本发明提供了在称为电凝胶的方法中，使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物，方法和装置。丝素蛋白凝胶可以通过施加反向电压而可逆地转化为液体形式，或者可以通过施加剪切力或其它处理而进一步转化成β-折叠结构。电致凝胶丝可以用作提取的体积凝胶，喷雾或凝胶流加工成材料或装置，或者可以用作设备的丝凝胶涂层。活性剂可以嵌入丝绸凝胶中用于各种医疗应用。本发明还提供了制备粘性丝pH凝胶的方法和组合物。例如，该方法包括降低丝素蛋白溶液的pH值以增加丝素蛋白溶液的体积或局部质子浓度，由此形成粘性丝凝胶。

5. 发明申请

US20110171239A1 pH INDUCED SILK GELS AND USES THEREOF 有权
标题翻译： pH诱导丝光凝胶及其用途
公开(公告)号：US20110171239A1
公开(公告)日：2011-07-14
申请号：US12974796
申请日：2010-12-21
申请人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
发明人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
IPC分类号： A61K39/395 , C07K14/00 , A61K47/42 , A61K35/12 , A61K38/00 , A61K31/7088 , A61K39/00 , A61K38/22 , A61K38/18 , A61K38/43 , A61K35/76 , A61P17/02 , C25B3/00
CPC分类号： A61K47/42 , A61K9/10 , A61K41/00 , A61L26/0047 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/38 , A61L27/52 , H01L41/193 , C08L89/00
摘要： This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
摘要翻译：本发明提供了在称为电凝胶的方法中，使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物，方法和装置。丝素蛋白凝胶可以通过施加反向电压而可逆地转化回液体形式，或者可以通过施加剪切力或其它处理而进一步转化为“薄片”结构。电致凝胶丝可以用作提取的体积凝胶，喷雾或凝胶流加工成材料或装置，或者可以用作设备的丝凝胶涂层。活性剂可以嵌入丝绸凝胶中用于各种医疗应用。本发明还提供了制备粘性丝pH凝胶的方法和组合物。例如，该方法包括降低丝素蛋白溶液的pH值以增加丝素蛋白溶液的体积或局部质子浓度，由此形成粘性丝凝胶。

6. 发明授权

US10335519B2 Dynamic silk coatings for implantable devices 有权
公开(公告)号：US10335519B2
公开(公告)日：2019-07-02
申请号：US14112078
申请日：2012-04-20
申请人： David L. Kaplan , Lee W. Tien , Gary G. Leisk , Tim Jia-Ching Lo , Cinzia Metallo , Fiorenzo Omenetto
发明人： David L. Kaplan , Lee W. Tien , Gary G. Leisk , Tim Jia-Ching Lo , Cinzia Metallo , Fiorenzo Omenetto
IPC分类号： A61L31/10 , A61B5/0478 , A61B5/00 , A61L27/22 , A61L27/36 , A61L31/04 , A61L31/14 , A61N1/05 , A61L31/16 , A61N1/375
摘要： Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.

7. 发明申请

US20150202351A1 DYNAMIC SILK COATINGS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入设备的动态丝绸涂料
公开(公告)号：US20150202351A1
公开(公告)日：2015-07-23
申请号：US14112078
申请日：2012-04-20
申请人： David L. Kaplan , Lee W. Tien , Gary G. Leisk , Tim Jia-Ching Lo , Cinzia Metallo , Fiorenzo Omenetto
发明人： David L. Kaplan , Lee W. Tien , Gary G. Leisk , Tim Jia-Ching Lo , Cinzia Metallo , Fiorenzo Omenetto
IPC分类号： A61L31/10 , A61L31/16 , A61N1/05
CPC分类号： A61L31/10 , A61B5/0478 , A61B5/4088 , A61B5/4094 , A61B5/686 , A61B5/6868 , A61B5/6877 , A61B2562/125 , A61L27/227 , A61L27/3604 , A61L27/3675 , A61L31/047 , A61L31/14 , A61L31/16 , A61L2400/18 , A61L2420/06 , A61N1/05 , A61N1/0529 , A61N1/0541 , A61N1/375
摘要： Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
摘要翻译：本文涉及具有动态丝涂层的可植入装置和系统。在一些实施方案中，动态丝涂层可以原位或体内形成。

8. 发明授权

US08187616B2 Method for silk fibroin gelation using sonication 有权
标题翻译：使用超声处理丝素蛋白凝胶化方法
公开(公告)号：US08187616B2
公开(公告)日：2012-05-29
申请号：US12601845
申请日：2008-05-29
申请人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
发明人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
IPC分类号： A61K9/00 , A61K38/17
CPC分类号： A61K47/42 , A61K9/06 , A61K9/5052 , A61K9/5063 , A61K9/5089 , A61K35/28 , A61K2035/124 , C07K14/43586
摘要： This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
摘要翻译：本发明提供了通过超声波快速形成丝素蛋白凝胶化的方法。在适当的条件下，超声波处理后两小时即可控制凝胶化。包括活细胞或治疗剂在内的生物材料可以包封在由该方法形成的水凝胶中并用作输送载体。

9. 发明授权

US08722067B2 Method for silk fibroin gelation using sonication 有权
标题翻译：使用超声处理丝素蛋白凝胶化方法
公开(公告)号：US08722067B2
公开(公告)日：2014-05-13
申请号：US13457705
申请日：2012-04-27
申请人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
发明人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
IPC分类号： A61K9/00 , A61K38/17
CPC分类号： A61K47/42 , A61K9/06 , A61K9/5052 , A61K9/5063 , A61K9/5089 , A61K35/28 , A61K2035/124 , C07K14/43586
摘要： This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
摘要翻译：本发明提供了通过超声波快速形成丝素蛋白凝胶化的方法。在适当的条件下，超声波处理后两小时即可控制凝胶化。包括活细胞或治疗剂在内的生物材料可以包封在由该方法形成的水凝胶中并用作输送载体。

10. 发明申请

US20100178304A1 METHOD FOR SILK FIBROIN GELATION USING SONICATION 有权
标题翻译：使用声音的丝光纤凝胶的方法
公开(公告)号：US20100178304A1
公开(公告)日：2010-07-15
申请号：US12601845
申请日：2008-05-29
申请人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
发明人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
IPC分类号： A61K9/00 , C07K14/435 , A61K45/00 , A61K35/12 , A61K38/16 , A61K38/00 , A61K39/395 , A61K38/43 , A61K31/7088 , A61P43/00
CPC分类号： A61K47/42 , A61K9/06 , A61K9/5052 , A61K9/5063 , A61K9/5089 , A61K35/28 , A61K2035/124 , C07K14/43586
摘要： This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
摘要翻译：本发明提供了通过超声波快速形成丝素蛋白凝胶化的方法。在适当的条件下，超声波处理后两小时即可控制凝胶化。包括活细胞或治疗剂在内的生物材料可以包封在由该方法形成的水凝胶中并用作输送载体。

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