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1. 发明申请

US20190186050A1 COMPOSITE MOLDING COMPOSITION INCLUDING FIBROIN-LIKE PROTEIN, AND METHOD FOR PRODUCING COMPOSITE MOLDING COMPOSITION 审中-公开
公开(公告)号：US20190186050A1
公开(公告)日：2019-06-20
申请号：US16326081
申请日：2017-07-24
申请人： RIKEN , SPIBER INC.
发明人： Keiji NUMATA , Kousuke TSUCHIYA , Junichi SUGAHARA , Takaoki ISHII , Hongfang CHI
IPC分类号： D01F4/02 , D01F1/10 , D01D5/16
CPC分类号： D01F4/00 , D01F4/02
摘要： Provided are a composite molding composition such as a composite film and a composite fiber that have properties such as an improved tensile strength, strain and toughness as a result of blending a peptide or polyamino acid having a β-sheet structure with a natural or artificially modified fibroin-derived protein; a method for producing such composite molding composition; and a method for improving the physical properties of a composite molding composition containing a fibroin-derived protein.

2. 发明授权

US09993527B2 Silk fibroin materials and use thereof 有权
公开(公告)号：US09993527B2
公开(公告)日：2018-06-12
申请号：US13680570
申请日：2012-11-19
申请人： Trustees of Tufts College , Massachusetts Institute of Technology
发明人： David L. Kaplan , Rina Sears , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： A61K38/18 , A61K47/42 , A61L27/38 , A61L27/56 , A61L27/22 , A61L27/26 , A61L27/36 , D01D5/00 , D01F4/02 , C12N5/00 , C12N5/079
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.

3. 发明申请

US20160281266A1 PEPTIDE-BASED NANOFIBRILLAR MATERIALS 审中-公开
标题翻译：基于肽的NANOFIBRILLAR材料
公开(公告)号：US20160281266A1
公开(公告)日：2016-09-29
申请号：US15034983
申请日：2014-11-07
申请人： TURFTS UNIVERSITY
发明人： Fiorenzo OMENETTO , David KAPLAN , Benedetto MARELLI , Alexander Nicholas MITROPOULOS
IPC分类号： D01F4/02 , C12Q1/26 , C12Q1/28
CPC分类号： D01F4/02 , A61L27/227 , A61L27/3604 , A61L27/56 , A61L2400/12 , B82Y30/00 , B82Y40/00 , C07K14/78 , C08J9/28 , C08J2205/022 , C08J2207/10 , C08J2389/02 , C12Q1/26 , C12Q1/28 , D01F4/00
摘要： Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.
摘要翻译：本文公开了纳米原纤维材料和由纳米原纤维组成的气凝胶状材料，以及制造这种材料的方法。

4. 发明授权

US09068282B2 System and method for making biomaterial structures 有权
标题翻译：制造生物材料结构的系统和方法
公开(公告)号：US09068282B2
公开(公告)日：2015-06-30
申请号：US12934666
申请日：2009-04-08
申请人： Christopher Cannizzaro , Michael L. Lovett , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Christopher Cannizzaro , Michael L. Lovett , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： D01D10/00 , D01F4/02 , D01D5/06 , D01D5/18 , D01D7/00 , D01D5/04
CPC分类号： D01F4/02 , D01D5/04 , D01D5/06 , D01D5/18 , D01D7/00
摘要： A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
摘要翻译：用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。控制器引起支撑结构和至少一个施加器之间的相对运动，并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。通过适当选择材料加工，卷绕策略和后卷绕处理，可以控制生物材料装置的性能。

5. 发明申请

US20150141618A1 SOLUTION-DYED PROTEIN FIBER AND METHOD FOR PRODUCING SAME 有权
标题翻译：溶液型蛋白纤维及其制造方法
公开(公告)号：US20150141618A1
公开(公告)日：2015-05-21
申请号：US14405101
申请日：2013-04-26
申请人： SPIBER INC.
发明人： Mizuki Ishikawa , Kazuhide Sekiyama
IPC分类号： D01F4/02 , D01D1/02 , D01D5/06 , C07K14/435 , D01D5/04
CPC分类号： D01F4/02 , C07K14/43518 , D01D1/02 , D01D5/04 , D01D5/06 , D01F1/06 , D01F4/00
摘要： A solution-dyed protein fiber of the present invention includes 0-100 mass % of silk fibroin and 100-0 mass % of a polypeptide derived from spider silk proteins when the protein fiber is assumed to be 100 mass %, wherein the solution-dyed protein fiber contains a solution-dyeing colorant. The fiber is obtained by: dissolving or dispersing a solution-dyeing colorant in a solvent used for a spinning solution or in dimethyl sulfoxide, thereby preparing a coloring liquid; adding a solvent to the coloring liquid in an amount necessary for a spinning solution; adding and dissolving protein powder into the solvent, thereby preparing a spinning solution; and subjecting the spinning solution to wet spinning or dry-wet spinning. Thereby, the present invention provides a low-cost solution-dyed protein fiber in which a solution-dyeing colorant is dispersed uniformly and that can exhibit bright color tone, and a method for producing the same.
摘要翻译：当蛋白质纤维假定为100质量％时，本发明的溶液染色蛋白质纤维包含0-100质量％的丝素蛋白和100-0质量％的衍生自蜘蛛丝蛋白的多肽，其中溶液染色蛋白质纤维含有溶液染色剂。纤维通过以下方法获得：将溶染染色剂溶解或分散在用于纺丝溶液或二甲基亚砜的溶剂中，从而制备着色液体; 以纺丝溶液所需的量向着色液中加入溶剂; 将蛋白粉加入溶解溶剂中，制备纺丝溶液; 并对纺丝溶液进行湿纺或干湿纺丝。因此，本发明提供了一种低成本的溶染染色蛋白质纤维，其中染色着色剂均匀分散并且可以表现出明亮的色调，及其制备方法。

6. 发明授权

US08721991B2 Microfluidic device for controlled aggregation of spider silk 有权
标题翻译：微流控装置用于蜘蛛丝的控制聚集
公开(公告)号：US08721991B2
公开(公告)日：2014-05-13
申请号：US12227498
申请日：2007-05-21
申请人： Thomas Scheibel , Daniel Huemmerich , Sebastian Remmensee , Christian Freudiger , Andreas Bausch
发明人： Thomas Scheibel , Daniel Huemmerich , Sebastian Remmensee , Christian Freudiger , Andreas Bausch
IPC分类号： B01L3/00
CPC分类号： C07K14/43518 , D01D5/02 , D01D5/06 , D01F4/02
摘要： The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.
摘要翻译：本发明涉及一种控制两种或多种蜘蛛丝蛋白的一种或两种或更多种蜘蛛丝蛋白的相分离的装置和方法，导致将所述丝蛋白定义和可控地组装到限定的形态，例如球形，纳米原纤维，丝线等

7. 发明申请

US20140094410A1 SILK FIBROIN MATERIALS AND USE THEREOF 有权
标题翻译：丝绸纤维材料及其用途
公开(公告)号：US20140094410A1
公开(公告)日：2014-04-03
申请号：US13680570
申请日：2012-11-19
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： A61K47/42 , A61K38/18
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译：本发明提供生产多孔丝素蛋白支架材料的方法。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。因此，用于三维组织工程的方法，例如，还提供使用丝素蛋白骨架材料的骨和软骨。

8. 发明授权

US08361617B2 Silk fibroin materials and use thereof 有权
标题翻译：丝素蛋白材料及其用途
公开(公告)号：US08361617B2
公开(公告)日：2013-01-29
申请号：US12836692
申请日：2010-07-15
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： B32B9/02 , A23J7/00 , A61K38/08 , A61K38/39
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present application provides a composition comprising porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffold described herein can be adjusted to mimic the gradient of densities found in natural tissue.
摘要翻译：本申请提供了包含多孔丝素蛋白支架材料的组合物。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率，以模拟在天然组织中发现的密度梯度。

9. 发明授权

US08348974B2 Spinning solution composition, process for producing regenerated silk fiber using the composition, and regenerated silk fiber produced by the process 有权
标题翻译：旋转溶液组合物，使用该组合物生产再生丝纤维的方法，以及通过该方法生产的再生丝纤维
公开(公告)号：US08348974B2
公开(公告)日：2013-01-08
申请号：US12307208
申请日：2007-03-01
申请人： Tetsuo Asakura
发明人： Tetsuo Asakura
IPC分类号： A61B17/04 , A61L17/00 , C09K3/00 , A61K47/00 , D01F4/00
CPC分类号： C08H1/00 , A61L17/08 , C08K5/05 , D01D1/02 , D01F1/10 , D01F4/02
摘要： A spinning solution composition which provides regenerated silk fiber that exhibits a strength and elongation close to those of natural silk fiber, is rapidly degradable in vivo, and can be caused to have ability to gradually release a drug to prevent inflammation; a process for producing such regenerated silk fiber by use of the composition; and regenerated silk fiber obtained through the process.
摘要翻译：提供显示强度和伸长率与天然丝纤维接近的再生丝纤维的纺丝溶液组合物在体内迅速降解，并且可以使其具有逐渐释放药物以防止炎症的能力; 使用该组合物生产这种再生丝纤维的方法; 并通过该方法获得再生丝纤维。

10. 发明授权

US08195021B2 Biopolymer optical waveguide and method of manufacturing the same 有权
标题翻译：生物聚合物光波导及其制造方法
公开(公告)号：US08195021B2
公开(公告)日：2012-06-05
申请号：US12513387
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb
IPC分类号： G02B6/10 , G02B1/12 , A61N5/06 , A61B6/00
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.
摘要翻译：制造生物聚合物光波导的方法包括提供生物聚合物，逐渐解卷生物聚合物以提取单个生物聚合物纤维，以及将展开的纤维置于张力下。然后将张紧的纤维浇铸在不同的聚合物中以形成由于生物聚合物和不同聚合物之间的折射率差异而引导光的生物聚合物光波导。光纤可以用于生物医学应用，并且可以作为透射介质插入体内。印刷技术可用于制造生物聚合物光波导。

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