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1. 发明授权

US09721326B2 Method and system for improving resolution in laser imaging microscopy 有权
公开(公告)号：US09721326B2
公开(公告)日：2017-08-01
申请号：US14356555
申请日：2012-11-08
申请人： UNIVERSITÉ LAVAL
发明人： Michel Piché , Harold Dehez , Yves De Koninck
IPC分类号： G06K9/00 , G06T3/40 , G02B21/00 , G02B21/16 , G02B21/36 , G01N21/64
CPC分类号： G06T3/4053 , G01N21/6458 , G02B21/002 , G02B21/16 , G02B21/367 , G02B2207/113 , G06T2207/20224
摘要： A method and a system for obtaining a high-resolution image of a volume of a sample using laser imaging are provided. The method includes a step of probing the volume of the sample with a first excitation beam having an intensity profile of maximum intensity at a center thereof, thereby obtaining a positive image of the volume. The method also includes a step of probing the volume of the sample with a second excitation beam having an intensity profile of minimum intensity at a center thereof and defining a peripheral region of maximum intensity around the center, thereby obtaining a negative image of the volume. The method finally includes a step of subtracting the negative image from the positive image, thereby obtaining the high-resolution image of the volume of the sample. Advantageously, embodiments of the invention can be probe- and fluorescence-independent, and be conveniently retrofitted into existing laser imaging systems.

2. 发明申请

US20140321772A1 METHOD AND SYSTEM FOR IMPROVING RESOLUTION IN LASER IMAGING MICROSCOPY 有权
标题翻译：用于改善激光成像显微镜中分辨率的方法和系统
公开(公告)号：US20140321772A1
公开(公告)日：2014-10-30
申请号：US14356555
申请日：2012-11-08
申请人： UNIVERSITÉ LAVAL
发明人： Michel Piché , Harold Dehez , Yves De Koninck
IPC分类号： G06T3/40
CPC分类号： G06T3/4053 , G01N21/6458 , G02B21/002 , G02B21/16 , G02B21/367 , G02B2207/113 , G06T2207/20224
摘要： A method and a system for obtaining a high-resolution image of a volume of a sample using laser imaging are provided. The method includes a step of probing the volume of the sample with a first excitation beam having an intensity profile of maximum intensity at a center thereof, thereby obtaining a positive image of the volume. The method also includes a step of probing the volume of the sample with a second excitation beam having an intensity profile of minimum intensity at a center thereof and defining a peripheral region of maximum intensity around the center, thereby obtaining a negative image of the volume. The method finally includes a step of subtracting the negative image from the positive image, thereby obtaining the high-resolution image of the volume of the sample. Advantageously, embodiments of the invention can be probe- and fluorescence-independent, and be conveniently retrofitted into existing laser imaging systems.
摘要翻译：提供了一种使用激光成像获得样品体积的高分辨率图像的方法和系统。该方法包括利用在其中心处具有最大强度的强度分布的第一激发光束来探测样品的体积的步骤，从而获得体积的正图像。该方法还包括用中心具有最小强度强度分布的第二激发光束探测样品的体积的步骤，并且围绕中心限定最大强度的周边区域，由此获得体积的负像。该方法最终包括从正像减去负像的步骤，从而获得样品体积的高分辨率图像。有利地，本发明的实施方案可以是探针和荧光无关的，并且可以方便地加装到现有的激光成像系统中。

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