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1. 发明授权

US07902530B1 Multiple medical accelerators and a kV-CT incorporated radiation therapy device and semi-automated custom reshapeable blocks for all field synchronous image guided 3-D-conformal-intensity modulated radiation therapy 失效
标题翻译：多个医疗加速器和一个kV-CT并入放射治疗装置和半自动定制可重构块，用于所有场同步图像引导的3-D保形强度调制放射治疗
公开(公告)号：US07902530B1
公开(公告)日：2011-03-08
申请号：US11974876
申请日：2007-10-15
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1045 , A61N5/1084 , A61N2005/1061 , A61N2005/1096
摘要： S-band, C-band or X-band microwave powered linear accelerators capable of delivering therapeutic photon and electron beams are mounted to a gantry with extensions to hold multiple accelerators and are combined with a kV CT for 3-D conformal—IMRT and IGRT to treat a patient by SSD or SAD methods and in a full circle. The invention's tertiary collimator system consists of semi-automated reusable custom field shaping with tungsten powder or melted Cerrobend blocks. The beam's intensity modulation is by means of simultaneous but independently operating multiple accelerators. This system's multiple accelerators enable to avoid interrupted subfractionated radiation therapy to each treatment fields. Hence its effective dose rate at the tumor site is high. The improved radiobiology reduces the total radiation dose to treat a tumor, reducing the incidence of developing second primary tumors is also minimized.
摘要翻译：能够提供治疗光子和电子束的S波段，C波段或X波段微波功率线性加速器安装到具有扩展部的机架，以保持多个加速器，并与用于3-D保形IMRT和IGRT的kV CT组合通过SSD或SAD方法治疗患者，并在一个完整的环节。本发明的三次准直仪系统由半自动可重复使用的定制场地成型与钨粉或熔化的Cerrobend块组成。光束的强度调制是通过同时但独立运行的多个加速器来实现的。该系统的多个加速器能够避免每个治疗领域的中断次分级放射治疗。因此，其在肿瘤部位的有效剂量率高。改善的放射生物学减少治疗肿瘤的总辐射剂量，减少发展中的第二原发性肿瘤的发生率也被最小化。

2. 发明授权

US09555264B1 MEMS based parallel microbeam radiosurgery without adaptive resistance to radiation 有权
标题翻译：基于MEMS的平行微束放射外科手术，无适应性抗辐射
公开(公告)号：US09555264B1
公开(公告)日：2017-01-31
申请号：US14325355
申请日：2014-07-07
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/01 , A61N5/10
CPC分类号： A61N5/1007 , A61B10/0233 , A61N5/1027 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/1052 , A61N2005/1054 , A61N2005/1055 , A61N2005/1091
摘要： This invention relates to MEMS X-ray sources based on carbon nanotube coated with metal oxides and metal oxide crystals and insulated with parylene for parallel microbeam intraoperative 100 to 1,000 Gy radiation therapies with minimal toxicity to normal tissue. It sterilizes cancer stem cells that cause tumor recurrence and metastasis. It generates high brightness, 10,000 to 20,000 Gy/s radiations that is closer to synchrotron radiation's dose rate.The parallel microbeam generating X-ray sources are microfabricated with CNT and its variant herringbone, stacked carbon nanotube. They are implantable or contact therapy X-ray sources. Each microfocus carbon nanotube based X-ray source is capable of switching a series of parallel microbeam simultaneously or in sequence. The 100-1,000 Gy single fraction radiosurgery exposes tumor antigens that induce local and systemic tumor immunity. It avoids adaptive resistance to radiation therapy as with 2 Gy daily fractionated radiation therapies that lasts several weeks.
摘要翻译：产生X射线源的平行微束与CNT及其变体人字形堆叠碳纳米管进行微制造。它们是植入式或接触治疗X射线源。每个微焦碳纳米管的X射线源能够同时或按顺序切换一系列平行微束。 100-1,000 Gy单级放射外科手术暴露了诱导局部和全身肿瘤免疫的肿瘤抗原。它避免了对放射治疗的适应性抵抗，就像持续数周的2 Gy每日分级放射治疗一样。

3. 发明授权

US5842987A Simulated patient setup for medical imaging with increased patient throughput 失效
标题翻译：用于医疗成像的模拟患者设置，增加患者吞吐量
公开(公告)号：US5842987A
公开(公告)日：1998-12-01
申请号：US858963
申请日：1997-05-20
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61B5/055 , A61B6/00 , A61B6/04 , A61N5/10 , A61B5/05
CPC分类号： A61B6/04 , A61B6/00 , A61N2005/1063 , A61N5/10
摘要： A preliminary simulated patient setup is done with a x-ray unit (14) or an ultrasound unit (16) with patient on a flat table top insert (68) on preliminary imaging tables (12) in preliminary imaging support rooms (10). Patient is transported from tables to table by sliding the flat table top insert (68) on these tables' cradle. If surgery is to be done, before or after surgery, patient is transferred to flat table top insert (68). Multiple preliminary imaging tables (12) are connected to patient transport room (26). It also connects to CT or MRI imaging room (32). A patient transport table (28), in patient transport room (26) makes connection with preliminary imaging tables (12), a mobile surgical table (22) and CT or MRI-table (36). After imaging, patient is unloaded to a patient unloading room (66). For use of a single CT or MRI for CT or MRI combined radiation therapy, patient is transported from CT or MRI scanning table (36) to patient handling table on rail (40) on rails (42) in accelerators' anteroom (38) and to accelerators' table (48) in accelerator room (44). Delivery of a required radiation dose to the CT or MRI verified treatment field generally takes only about a minute. With this system configuration, a continuous flow of patients can be imaged and or treated with a single CT or MRI (FIG. 1). For still further increased patient throughput, more than one CT or MRI and accelerator is used as in FIG. 5 and 6.
摘要翻译：用初步成像支持室（10）中的初步成像台（12）上的平板台面插入物（68）上的患者进行X射线单元（14）或超声单元（16）的初步模拟患者设置。将平台顶部插入物（68）滑入这些桌子的摇篮上，将患者从桌子运送到桌子。如果要进行手术，手术前或手术后，将患者转移到平台顶部插入物（68）。多个初步成像台（12）连接到患者运输室（26）。它还连接到CT或MRI成像室（32）。患者运输室（26）中的患者运输台（28）与初步成像台（12），移动手术台（22）和CT或MRI表（36）连接。成像后，病人卸载到患者卸药室（66）。为了使用单个CT或MRI进行CT或MRI联合放射治疗，将患者从CT或MRI扫描台（36）运送到加速器前厅（38）的轨道（42）上的轨道（40）上的患者手术台，到加速器室（44）中的加速器台（48）。向CT或MRI验证的治疗区域递送所需的辐射剂量通常只需要一分钟。利用该系统配置，患者的连续流动可以用单个CT或MRI进行成像和/或治疗（图1）。为了进一步增加患者吞吐量，如图1所示使用多于一个CT或MRI和加速器。 5和6。

4. 发明授权

US09636525B1 Method of image guided intraoperative simultaneous several ports microbeam radiation therapy with microfocus X-ray tubes 有权
公开(公告)号：US09636525B1
公开(公告)日：2017-05-02
申请号：US14450245
申请日：2014-08-03
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/00 , A61N5/10 , A61B10/02
CPC分类号： A61N5/1077 , A61B10/02 , A61B10/0233 , A61N5/1001 , A61N5/1027 , A61N5/1039 , A61N5/1084 , A61N2005/1022 , A61N2005/1052 , A61N2005/1054 , A61N2005/1055 , A61N2005/1091
摘要： This invention pertains to a method of low-cost intraoperative all field simultaneous parallel microbeam single fraction few seconds duration 100 to 1,000 Gy and higher dose radiosurgery with micro-electro-mechanical systems (MEMS)-carbon nanotube based microaccelerators. It ablates cancer cells including the mesenchymal epithelial transformation associated cancer stem cells. Microbeam brachy-therapeutic radiosurgery is performed. Microaccelerators are configured for simultaneous parallel microbeam emission from varying angels to an isocentric tumor. Their additive dose rate at the isocentric tumor is in the range of 10,000 to 20,000 Gy/s. It eliminates most tumor recurrence and metastasis which enhances cancer cure rates. It also exposes cancer antigens which induces cancer immunity. Stereotactic breast core biopsy is combined with, positron emission tomography and computerized tomography and phase-contrast imaging. Parallel microbeam brachytherapy preserves normal breast appearance. Migration of normal stem cells from unirradiated valley regions heals the radiation damage to the normal tissue.

5. 发明授权

US09155910B1 Device and methods for adaptive resistance inhibiting inverse compton scattering microbeam and nanobeam radiosurgery 有权
标题翻译：用于自适应电阻抑制逆柯顿散射微束和纳米射线放射外科的装置和方法
公开(公告)号：US09155910B1
公开(公告)日：2015-10-13
申请号：US13743297
申请日：2013-01-16
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/10 , H05H7/06 , H01S4/00 , H05G2/00 , H01S3/09
CPC分类号： A61N5/1077 , A61N5/1084 , A61N2005/1085 , H01S3/09 , H01S4/00 , H05G2/00 , H05H7/06 , H05H15/00
摘要： This invention relates to adaptive resistance inhibiting 100 to 1,000 Gy, single fraction radiosurgery with inverse Compton scattering gamma ray microbeam and nanobeam. The distance from two adjacent microbeams or the nanobeam generate peak and valley dose. Proliferation of normal tissue's clonogenic cells from low or no dose valley region to peak dose regions makes the normal tissue tolerance to to 100 to 1,000 Gy. The collilinear electron beam and gamma ray microbeam and nanobeam are generated in microfocus carbon tubes in a tissue equivalent primary collimator. Electron beam is absorbed by the tissue equivalent primary collimator. Focusing anode and magnets and multiwalled carbon nanotubes channels the microbeam and nanobeam as focused beams. Methods of spread out or spot scanned or raster scanned collilinear gamma ray microbeam and nanobeam radiosurgery are implemented. Adaptive resistance to cancer treatment is inhibited by inactivation of cancer cell's repair capabilities.
摘要翻译：本发明涉及抑制100-1000Gy，具有反康普顿散射γ射线微束和nanobeam的单分数放射外科的适应性阻力。距离两个相邻的微束或nanobeam的距离产生峰谷剂量。从低或无剂量谷区到峰值剂量区域的正常组织的克隆形成细胞的增殖使正常组织耐受性达到100至1,000Gy。在组织等效初级准直仪中的微焦碳管中产生共线电子束和γ射线微束和nanobeam。电子束被组织等效初级准直器吸收。聚焦阳极和磁体和多壁碳纳米管通过微束和纳米束体作为聚焦光束。实施扩散或斑点扫描或光栅扫描的单线γ射线微束和nanobeam放射外科手术。通过灭活癌细胞的修复能力来抑制对癌症治疗的适应性抗性。

6. 发明授权

US07741624B1 Single session interactive ultra-short duration super-high biological dose rate radiation therapy and radiosurgery 失效
标题翻译：单次交互超短期超高生物剂量率放射治疗和放射外科手术
公开(公告)号：US07741624B1
公开(公告)日：2010-06-22
申请号：US12151014
申请日：2008-05-03
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/06 , G01J5/02
CPC分类号： G01R33/4808 , A61N5/1081 , A61N5/1084 , A61N2005/1055 , G01R33/4806 , G01R33/485 , G01T1/00
摘要： A medical accelerator system consisting of coplanar and non-coplanar beams, on line magnetic resonance anatomic and functional imaging and cone beam computed tomographic imaging for single session image guided all field simultaneous radiation therapy and radiosurgery is provided. This system enables single session simulation, field-shaping block making, treatment planning, dose calculations and treatment of tumors. The radiation exposure time to the tumor and the normal tissue is reduced to a few seconds to less than a minute. In filed intensity modulated radiation is rendered by combined divergent and pencil beam, multiple smaller fields within a larger field, selectively varying beam's energy, dose rate and beam weight. Since all the treatment fields are treated simultaneously the dose rate at the tumor site is the sum of each of the converging beam's dose rate at depth. This super-high biological dose rate impairs the lethal and sublethal damage repair.
摘要翻译：提供由共面和非共面光束组成的医疗加速器系统，在线磁共振解剖和功能成像以及用于单次会话图像引导的全场同步放射治疗和放射外科的锥束计算机断层成像。该系统可实现单次会话模拟，现场整形模块制作，治疗计划，剂量计算和肿瘤治疗。对肿瘤和正常组织的放射线暴露时间减少到几秒到不到一分钟。在场强度调制辐射通过组合的发散和笔形束，较大场中的多个较小的场，选择性地改变束的能量，剂量率和束重量来呈现。由于所有治疗领域同时治疗，肿瘤部位的剂量率是每个会聚束的深度剂量率的总和。这种超高的生物剂量率损害了致死和亚致死的损伤修复。

7. 发明申请

US20180154183A1 Normal Tissue Toxicity Reducing Microbeam-Broadbeam Radiotherapy, Skin's Radio-Response Immunotherapy and Mutated Molecular Apheresis Combined Cancer Treatments 审中-公开
公开(公告)号：US20180154183A1
公开(公告)日：2018-06-07
申请号：US15846208
申请日：2017-12-19
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/10 , A61M1/34 , A61M1/36
CPC分类号： A61N5/1084 , A61M1/3496 , A61M1/3615 , A61M1/3693 , A61N5/1045 , A61N5/1067 , A61N5/1081 , A61N2005/1088 , A61N2005/1089 , A61N2005/109 , A61N2005/1094
摘要： Normal tissue complications limit curative broadbeam radiotherapy to tumors including lung cancer. Radiation retinitis causing blindness limits quality of life and long term survival for patients with ocular melanoma. This invention pertains to alternative, normal tissue sparing 100 to 1,000 Gy microbeam radiations with least normal tissue complications and concomitant radio-immunotherapy by innate immune response of epidermis and dermis to low dose radiation with 50 kV X-rays. Total body skin radiation with former airport passenger screening machines with 50 kV X-ray is disclosed. Microbeams are generated without contaminating scatter and neutron radiations from collinear gamma ray and electron beam produced by inverse Compton interaction with high energy laser and electron beam and from proton and carbon ion beams in tissue equivalent cylindrical collimators. Extracorporeal immunotherapy and chemotherapy and apheresis of mutated subcellular particles released into circulation in response to cancer-therapies are by clinical continuous flow ultracentrifugation combined chromatography.

8. 发明授权

US08139714B1 Few seconds beam on time, breathing synchronized image guided all fields simultaneous radiation therapy combined with hyperthermia 失效
标题翻译：几秒钟光束按时，呼吸同步图像引导所有领域同时放射治疗结合热疗
公开(公告)号：US08139714B1
公开(公告)日：2012-03-20
申请号：US12459120
申请日：2009-06-25
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/10 , G01N23/04
CPC分类号： A61N5/1065 , A61N5/025 , A61N5/1084 , A61N2005/1055
摘要： This invention relates to single session image guided all field simultaneous radiation therapy combined with hyperthermia. Hyperthermia renders the radiation resistant cells as more radiation sensitive cells. The high and super-high dose rate radiation greatly improves the RBE of the photon radiation. It also minimizes photon radiation therapy's OER and cell cycle dependent tumor cell kill by minimizing the repair capacity of cell after photon radiation. Single session hyperthermia and radiation therapy overcomes the thermotolerance-associated inefficiency of hyperthermia treatment as it is when hyperthermia is combined with fractionated, lower dose rate radiation. The synergetic effects of sublethal damage repair inhibiting single session hyperthermia-combined with high dose and dose rate single session radiation therapy, and combined chemotherapy brings the photon radiation therapy's tumor cure and control capabilities closer to high LET radiation therapy.
摘要翻译：本发明涉及单次会话图像引导全场同时放疗与高热联合。热疗使耐辐射细胞成为更多的辐射敏感细胞。高和超高剂量率辐射大大提高了光子辐射的RBE。它还通过最小化光子辐射后细胞的修复能力，最大限度地减少光子辐射治疗的OER和依赖细胞周期的肿瘤细胞。单次会话热疗和放射治疗克服了热疗相关的低热治疗低效率，因为当热疗与分级，较低剂量率的辐射组合时。亚临床损伤修复抑制单次会话热疗与高剂量和单剂量单次会议放射治疗联合化疗的协同效应使光子放射治疗的肿瘤治愈和控制能力更接近高LET放射治疗。

9. 发明授权

US5851182A Megavoltage radiation therapy machine combined to diagnostic imaging devices for cost efficient conventional and 3D conformal radiation therapy with on-line Isodose port and diagnostic radiology 失效
标题翻译： Megavoltage放射治疗机联合诊断成像装置，用于在线等剂量端口和诊断放射学方面具有成本效益的常规和3D适形放射治疗
公开(公告)号：US5851182A
公开(公告)日：1998-12-22
申请号：US712623
申请日：1996-09-11
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/10 , A61B5/05
CPC分类号： A61N5/1049 , A61N2005/1063
摘要： A patient setup and treatment verification system for radiation therapy having diagnostic imaging devices connected to a room containing a megavoltage radiation therapy machine. The diagnostic rooms and the megavoltage therapy room are connected to each other by openings in the shared secondary wall of the accelerator or through an anteroom to the megavoltage therapy room. Daily patient setup for routine and three-dimensional conformal radiation therapy and on-line treatment port verification with superimposed isodose are done with the patient on a diagnostic-imaging table. The patients are transferred from the diagnostic table to the treatment table without changing the verified treatment position. Sliding or rotating shield or maze walled anteroom are used for radiation protection. A patient setup with multiple diagnostic devices in separate chambers allows rapid turnover of patients in the megavoltage treatment room with patients spending much less time in the treatment room. When the diagnostic device is not in use with the megavoltage therapy machine for radiation therapy of patients in a radiation oncology department, it can be used as a routine diagnostic device for a diagnostic radiology department.
摘要翻译：一种用于放射治疗的患者设置和治疗验证系统，其具有连接到包含兆伏级放射治疗机的房间的诊断成像装置。诊断室和兆伏治疗室通过加速器的共享次级壁中的开口或通过前室到达兆伏治疗室彼此连接。患者在诊断成像台上进行常规和三维适形放射治疗的每日患者设置和叠加等剂量的在线治疗口验证。将患者从诊断台转移到治疗台，而不改变验证的治疗位置。滑动或旋转屏蔽或迷宫围墙前端用于辐射防护。具有多个诊断设备的患者设置在不同的房间中可以让患者在万伏治疗室中快速更换，患者在治疗室花费的时间少得多。当诊断装置不与放射治疗部门的患者放射治疗用的兆伏治疗机一起使用时，可以用作诊断放射科的常规诊断装置。

10. 发明授权

US4321208A Preparation of directly iodinated steroid hormones and related compounds 失效
标题翻译：直接碘化类固醇激素及相关化合物的制备
公开(公告)号：US4321208A
公开(公告)日：1982-03-23
申请号：US727284
申请日：1976-09-27
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： C07B39/00 , A61K51/00 , A61K51/04 , C07B31/00 , C07C67/00 , C07J1/00 , C07J5/00 , C07J9/00 , G01N33/74
CPC分类号： A61K51/0493 , G01N33/743 , A61K2123/00
摘要： A process for the direct iodination of steroids and steroid hormones in the presence of hydrogen peroxide or chloramine-T is disclosed. The antigenicity and the specific receptor binding of directly iodinated estradiol 17-beta is identical to tritiated estradiol 17-beta.
摘要翻译：公开了在过氧化氢或氯胺T的存在下直接碘化类固醇和类固醇激素的方法。直接碘化雌二醇17-β的抗原性和特异性受体结合与氚化雌二醇17-β相同。

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