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1. 发明申请

US20080319494A1 System and method for preventing recurrence of atrial tachyarrhythmia 有权
标题翻译：用于预防房性快速性心律失常复发的系统和方法
公开(公告)号：US20080319494A1
公开(公告)日：2008-12-25
申请号：US12229563
申请日：2008-08-25
申请人： Victor T. Chen , Gary T. Seim , Milton M. Morris
发明人： Victor T. Chen , Gary T. Seim , Milton M. Morris
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.
摘要翻译：用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。起搏速率从初始值降低到检测到至少一个固有心脏收缩。在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。然后从至少一个固有心脏收缩确定固有心率。然后起搏速率增加并保持在高于（即大于）本征心率。

2. 发明授权

US08046061B2 System and method for preventing recurrence of atrial tachyarrhythmia 有权
标题翻译：用于预防房性快速性心律失常复发的系统和方法
公开(公告)号：US08046061B2
公开(公告)日：2011-10-25
申请号：US12229563
申请日：2008-08-25
申请人： Victor T. Chen , Gary T. Seim , Milton M. Morris
发明人： Victor T. Chen , Gary T. Seim , Milton M. Morris
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.
摘要翻译：用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。起搏速率从初始值降低到检测到至少一个固有心脏收缩。在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。然后从至少一个固有心脏收缩确定固有心率。然后起搏速率增加并保持在高于（即大于）本征心率。

3. 发明授权

US06829504B1 System and method for preventing recurrence of atrial tachyarrhythmia 有权
标题翻译：用于预防房性快速性心律失常复发的系统和方法
公开(公告)号：US06829504B1
公开(公告)日：2004-12-07
申请号：US09662091
申请日：2000-09-14
申请人： Victor T. Chen , Gary T. Seim , Milton M. Morris
发明人： Victor T. Chen , Gary T. Seim , Milton M. Morris
IPC分类号： A61N139
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.
摘要翻译：用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。起搏速率从初始值降低到检测到至少一个固有心脏收缩。在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。然后从至少一个固有心脏收缩确定固有心率。然后起搏速率增加并保持在高于（即大于）本征心率。

4. 发明授权

US07421294B2 System and method for preventing recurrence of atrial tachyarrhythmia 有权
公开(公告)号：US07421294B2
公开(公告)日：2008-09-02
申请号：US10975553
申请日：2004-10-28
申请人： Victor T. Chen , Gary T. Seim , Milton M. Morris
发明人： Victor T. Chen , Gary T. Seim , Milton M. Morris
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

5. 发明申请

US20100305639A1 METHOD AND APPARATUS FOR USING ATRIAL DISCRIMINATION ALGORITHMS TO DETERMINE OPTIMAL PACING THERAPY AND THERAPY TIMING 审中-公开
标题翻译：方法和装置用于确定最佳治疗方案和治疗时间的ATRIAL DISRIMINATION ALGORITHMS
公开(公告)号：US20100305639A1
公开(公告)日：2010-12-02
申请号：US12836784
申请日：2010-07-15
申请人： Victor T. Chen , David S. Wood , Milton M. Morris
发明人： Victor T. Chen , David S. Wood , Milton M. Morris
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/3622
摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing. Various embodiments are disclosed herein.
摘要翻译：一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中可能发生在患者身上。控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。本文公开了各种实施例。

6. 发明授权

US07764997B2 Method and apparatus for using atrial discrimination algorithms to determine optimal pacing therapy and therapy timing 有权
标题翻译：使用心房辨别算法确定最佳起搏治疗和治疗时机的方法和装置
公开(公告)号：US07764997B2
公开(公告)日：2010-07-27
申请号：US11266955
申请日：2005-11-04
申请人： Victor T. Chen , David S. Wood , Milton M. Morris
发明人： Victor T. Chen , David S. Wood , Milton M. Morris
IPC分类号： A61N1/00
CPC分类号： A61N1/3622
摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing. Various embodiments are disclosed herein.
摘要翻译：一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中可能发生在患者身上。控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。本文公开了各种实施例。

7. 发明授权

US06978177B1 Method and apparatus for using atrial discrimination algorithms to determine optimal pacing therapy and therapy timing 有权
标题翻译：使用心房辨别算法确定最佳起搏治疗和治疗时机的方法和装置
公开(公告)号：US06978177B1
公开(公告)日：2005-12-20
申请号：US09712600
申请日：2000-11-14
申请人： Victor T. Chen , David S. Wood , Milton M. Morris
发明人： Victor T. Chen , David S. Wood , Milton M. Morris
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622
摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. The invention may be implemented in a bradycardia pacemaker or other implantable cardiac device. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The discrimination criteria may be, for example, rate-based or morphology based. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. For example, antitachycardia pacing may be provided to the heart in response to the detection of a relatively lower rate supraventricular tachycardia/other atrial flutter, whereas another pacing control, e.g., ventricular pacing, such as ventricular rate regulation or Rate Smoothing, may be applied if a more rapid rate supraventricular tachycardia/fast atrial flutter is identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing.
摘要翻译：一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。本发明可以在心动过缓起搏器或其他可植入的心脏装置中实现。响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中可能发生在患者身上。歧视标准可以是例如基于速率或基于形态的。控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。例如，可以响应于检测相对较低的室上性心动过速/其他心房扑动而向心脏提供抗心动过速起搏，而可以应用另一起搏控制，例如心室起搏，例如心室速率调节或速率平滑如果确定更快速的室上性心动过速/快速心房扑动。可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。

8. 发明申请

US20180085593A1 DEVICES, SYSTEMS, AND METHODS FOR STIMULATION THERAPY 审中-公开
公开(公告)号：US20180085593A1
公开(公告)日：2018-03-29
申请号：US15830862
申请日：2017-12-04
申请人： Timothy A. Fayram , Alexander Yeh , Gary Shaw , Randolph Kerry Armstrong , Milton M. Morris , Elia Junco , Brad Holinski
发明人： Timothy A. Fayram , Alexander Yeh , Gary Shaw , Randolph Kerry Armstrong , Milton M. Morris , Elia Junco , Brad Holinski
IPC分类号： A61N1/372 , A61N1/378 , A61N1/375
CPC分类号： A61N1/36062 , A61B5/00 , A61N1/0551 , A61N1/0558 , A61N1/36185 , A61N1/37223 , A61N1/37229 , A61N1/37247 , A61N1/37252 , A61N1/37518 , A61N1/3756 , A61N1/3787 , H02J7/025 , H02J50/10 , H02J50/20 , H02J50/40 , H02J50/80 , H02J50/90
摘要： Generally discussed herein are systems, devices, and methods for providing a therapy (e.g., stimulation) and/or data signal using an implantable device. Systems, devices and methods for interacting with (e.g., communicating with, receiving power from) an external device are also provided.

9. 发明授权

US07894892B2 Therapy-selection methods for implantable heart monitors 有权
标题翻译：植入式心脏监护仪的治疗选择方法
公开(公告)号：US07894892B2
公开(公告)日：2011-02-22
申请号：US12254567
申请日：2008-10-20
申请人： Milton M. Morris
发明人： Milton M. Morris
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/3962
摘要： An implantable heart-monitoring device comprising one or more leads for sensing electrical signals of a patient's heart a therapy circuit for delivering pharmaceuticals to the patient; and a monitoring circuit coupled to the one or more leads and to the therapy circuit, the monitoring circuit for monitoring heart activity of the patient through one or more of the leads, the monitoring circuit operable to: determine a minimum interval from a set of two or more intervals based on sensed heart activity, determine a range parameter based on a difference between a first subset and second subset of the intervals, determine a dispersion parameter quantifying dispersion of a subset of the intervals, and to determine an assessment value for the set of intervals, based on the minimum interval, the range parameter, the dispersion index.
摘要翻译：一种可植入心脏监测装置，包括用于感测患者心脏的电信号的一个或多个引线，用于将药物输送给患者的治疗电路; 以及监测电路，其耦合到所述一个或多个引线和所述治疗电路，所述监测电路用于通过一个或多个引线监测患者的心脏活动，所述监测电路可操作以：从两组中的一组确定最小间隔基于感测到的心脏活动的更多间隔，基于间隔的第一子集和第二子集之间的差确定范围参数，确定量化间隔子集的色散的色散参数，并且确定该组的评估值基于最小间隔，范围参数，色散指数。

10. 发明授权

US08538519B2 Method and system for treatment of mechanical cardiac asynchrony 有权
标题翻译：用于治疗机械心脏不同步的方法和系统
公开(公告)号：US08538519B2
公开(公告)日：2013-09-17
申请号：US11113827
申请日：2005-04-25
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/365
CPC分类号： A61N1/36528 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A system and method for identifying patients with asynchronous ventricular contractions due to abnormal electro-mechanical coupling and computing optimal pacing parameters for restoring synchronous contractions is disclosed. Such patients may have normal intra-ventricular and inter-ventricular conduction and cannot be identified from intrinsic conduction data alone such as QRS width. Techniques for computing optimal resynchronization pacing in order to compensate for abnormal electro-mechanical coupling are also described.
摘要翻译：公开了一种用于识别异常心电耦合异常心室收缩患者的系统和方法，并且计算用于恢复同步收缩的最佳起搏参数。这样的患者可能具有正常的心室内和心室间传导，并且不能从内在传导数据单独识别，如QRS宽度。还描述了用于计算最佳再同步起搏以补偿异常机电耦合的技术。

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