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1. 发明申请

US20200240095A1 INTEGRATED ARROW BOARD AND LIGHT TOWER 审中-公开
公开(公告)号：US20200240095A1
公开(公告)日：2020-07-30
申请号：US16747753
申请日：2020-01-21
申请人： Vincenzo Rizzo , Valentino Rizzo
发明人： Vincenzo Rizzo , Valentino Rizzo
IPC分类号： E01F9/615 , E01F9/692 , E01F9/608 , G08G1/0955 , G08G1/054 , E01F9/646
摘要： A system includes a directional sign having a plurality of lights capable of indicating an intended traffic direction, a telescoping central mast coupled to the sign, a base coupled to the central mast, the base having wheels, and at least one light in communication with at least one power source, the at least one light being disposed on the telescoping central mast.

2. 发明申请

US20050059156A1 Method for detecting contaminants in pharmaceutical products 审中-公开
标题翻译：检测药品中污染物的方法
公开(公告)号：US20050059156A1
公开(公告)日：2005-03-17
申请号：US10912318
申请日：2004-08-05
申请人： Vincenzo Rizzo , Mario Arangio , Giuseppe Razzano , Maristella Colombo , Federico Sirtori
发明人： Vincenzo Rizzo , Mario Arangio , Giuseppe Razzano , Maristella Colombo , Federico Sirtori
IPC分类号： B01D59/44 , C12P19/56 , C12P29/00 , C12Q1/68 , G01N33/00 , G01N33/15
CPC分类号： G01N30/00 , G01N30/7233 , G01N33/15 , G01N2030/8872 , Y10T436/143333
摘要： The present invention relates to a quantitative, highly sensitive analytical procedure capable to control at part per billion (ppb) detection level the possible presence of undesired chemical contaminants, especially β-lactam antibiotics, in anthracycline products.
摘要翻译：本发明涉及一种能够以十亿分之一（ppb）检测水平控制在蒽环类产品中可能存在不期望的化学污染物，特别是β-内酰胺抗生素的定量，高度灵敏的分析方法。

3. 发明授权

US5585372A Tricyclic cefem sulphones 失效
标题翻译：三环头孢磺酸钠
公开(公告)号：US5585372A
公开(公告)日：1996-12-17
申请号：US367319
申请日：1995-01-20
申请人： Marco Alpegiani , Pierluigi Bissolino , Ettore Perrone , Vincenzo Rizzo
发明人： Marco Alpegiani , Pierluigi Bissolino , Ettore Perrone , Vincenzo Rizzo
IPC分类号： A61K31/545 , A61K31/546 , A61P11/00 , A61P25/04 , A61P29/00 , C07D501/00 , C07D501/62
CPC分类号： C07D501/00
摘要： The present invention provides compounds of formula (I) and pharmaceutically or veterinarily salts thereof; ##STR1## wherein R.sub.1 is hydrogen or halogen or an organic group; R.sub.2 is hydrogen or an optionally substituted C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.6 -C.sub.10 aryl or C.sub.7 -C.sub.14 aralkyl group;R.sub.3 is hydrogen or halogen, or an organic groupR.sub.4 is hydrogen or a group defined as R.sub.2 above or R.sub.4 taken together with R.sub.3 constitutes a C.sub.2 -C.sub.6 alkanediyl or an alkanediyl radical optionally substituted by methyl or phenyland X is either oxygen or sulphur or NR.sub.6, wherein R.sub.6 is either hydrogen or a group as defined for R.sub.2. A process for their preparation by cyclization of appropriate intermediates is also described.The compounds of formula I and the pharmaceutically and veterinarily acceptable salts thereof are elastase inhibitors.
摘要翻译： PCT No.PCT / EP94 / 01643 Sec。 371 1995年1月20日第 102（e）1995年1月20日PCT PCT 1994年5月17日PCT公布。 WO94 / 28003 PCT出版物日期：1994年12月8日本发明提供式（I）化合物及其药学上或兽用盐; （I）其中R1是氢或卤素或有机基团; R 2是氢或任选取代的C 1 -C 6烷基，C 3 -C 6环烷基，C 6 -C 10芳基或C 7 -C 14芳烷基; R3是氢或卤素，或有机基团R4是氢或被定义为R2上面的R2或与R4一起构成的基团构成任选被甲基或苯基取代的C 2 -C 6烷二基或烷二基，X是氧或硫或 NR 6，其中R 6是氢或根据R 2定义的基团。还描述了通过合适的中间体的环化制备其方法。式I化合物及其药学上和兽医学上可接受的盐是弹性蛋白酶抑制剂。

4. 发明授权

US5580865A 2,2-disubstituted cephem sulphones 失效
标题翻译： 2,2-二取代的头孢烯砜
公开(公告)号：US5580865A
公开(公告)日：1996-12-03
申请号：US43023
申请日：1993-04-05
申请人： Marco Alpegiani , Pierluigi Bissolino , Ettore Perrone , Vincenzo Rizzo
发明人： Marco Alpegiani , Pierluigi Bissolino , Ettore Perrone , Vincenzo Rizzo
IPC分类号： A61K31/545 , A61K31/546 , A61P11/00 , A61P17/00 , A61P19/06 , A61P29/00 , C07D501/00 , C07D501/04 , C07D501/16 , C07D501/20 , C07D501/36 , C07D501/22 , C07D501/24
CPC分类号： C07D501/00
摘要： The present invention provides cephalosporin sulphones or formula (I), and pharmaceutically or veterinarily acceptable salts thereof; ##STR1## wherein n is zero, one or two; R.sub.1 is hydrogen, halogen or an optionally substituted C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or C.sub.1 -C.sub.4 carboxamido group;R.sub.2 is hydrogen or an optionally substituted C.sub.1 -C.sub.8 alkyl, C.sub.6 -C.sub.10 aryl, C.sub.2 -C.sub.5 alkenyl or C.sub.3 -C.sub.6 cycloalkyl group;R.sub.3 is hydrogen or acetoxymethyl, methoxymethyl, methyl or an optionally substituted heterocyclylthiomethyl group;R.sub.4 is an optionally substituted C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.6 alkenyl, aryl(C.sub.1 -C.sub.8)alkyl or heterocyclyl(C.sub.1 -C.sub.8)alkyl group; andR.sub.5 is an optionally substituted C.sub.6 -C.sub.10 aryl or a heterocyclyl group.The compounds of formula I and the pharmaceutically and veterinarily acceptable salts thereof are elastase inhibitors.
摘要翻译：本发明提供头孢菌素砜或式（I）化合物及其药学或兽医学上可接受的盐; （I）其中n为0，1或2; R 1是氢，卤素或任选取代的C 1 -C 4烷基，C 2 -C 4烯基，C 1 -C 4烷氧基，C 1 -C 4烷硫基或C 1 -C 4甲酰氨基; R 2是氢或任选取代的C 1 -C 8烷基，C 6 -C 10芳基，C 2 -C 5烯基或C 3 -C 6环烷基; R3是氢或乙酰氧基甲基，甲氧基甲基，甲基或任意取代的杂环硫基甲基; R4是任选取代的C 1 -C 8烷基，C 2 -C 6烯基，芳基（C 1 -C 8）烷基或杂环基（C 1 -C 8）烷基; 并且R 5是任选取代的C 6 -C 10芳基或杂环基。式I化合物及其药学上和兽医学上可接受的盐是弹性蛋白酶抑制剂。

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