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1. 发明授权

US08825163B2 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分的系统和方法以实现选择性生理反应
公开(公告)号：US08825163B2
公开(公告)日：2014-09-02
申请号：US12579581
申请日：2009-10-15
申请人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
发明人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。系统和方法使用放置在阴部神经上，旁边或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

2. 发明授权

US06907293B2 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分的系统和方法以实现选择性生理反应
公开(公告)号：US06907293B2
公开(公告)日：2005-06-14
申请号：US10113828
申请日：2002-03-29
申请人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
发明人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
IPC分类号： A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。这些系统和方法使用放置在阴部神经中，外侧或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

3. 发明授权

US5324322A Thin film implantable electrode and method of manufacture 失效
标题翻译：薄膜可植入电极及其制造方法
公开(公告)号：US5324322A
公开(公告)日：1994-06-28
申请号：US871352
申请日：1992-04-20
申请人： Warren M. Grill, Jr. , Graham H. Creasey , David A. Ksienski , Claude S. Veraart , J. Thomas Mortimer
发明人： Warren M. Grill, Jr. , Graham H. Creasey , David A. Ksienski , Claude S. Veraart , J. Thomas Mortimer
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/05 , A61N1/0556
摘要： A sheet (30) of polymeric material defines a cuff portion (A), a contact portion (B), and an interconnecting elongated lead portion (C). Using physical vapor deposition (PVD), chemical vapor deposition (CVD), or other thin film deposition techniques, a plurality of electrodes (12), contact pads (16), and interconnecting leads (14) are deposited on the base layer. An elastomer covering layer (18) is laminated to the base layer. The elastomeric covering layer is stretched along direction (24) before lamination, such that at least the cuff portion is elastomerically biased to curl into a spiral. Windows (20) are defined in the elastomeric portion to provide for electrical conduction between the electrodes (12) and nerve tissue about which the cuff electrode is wrapped. The electrodes are arced (FIG. 6) such that they are more recessed adjacent sides of the window than adjacent the center in order to provide a substantially uniform flux density across the electrode surface.
摘要翻译：聚合物材料的片材（30）限定了袖带部分（A），接触部分（B）和互连的细长引线部分（C）。使用物理气相沉积（PVD），化学气相沉积（CVD）或其它薄膜沉积技术，多个电极（12），接触焊盘（16）和互连引线（14）沉积在基层上。弹性体覆盖层（18）层压到基层。弹性体覆盖层在层压之前沿着方向（24）被拉伸，使得至少袖带部分被弹性偏置以卷曲成螺旋。窗口20限定在弹性体部分中以提供电极（12）和袖带电极所围绕的神经组织之间的导电。电极被弧形（图6），使得它们比邻近中心更靠近窗口的凹陷侧面，以便在电极表面上提供基本均匀的通量密度。

4. 发明申请

US20100274072A1 SPHINCTERIC CONTROL SYSTEM 审中-公开
标题翻译：气球控制系统
公开(公告)号：US20100274072A1
公开(公告)日：2010-10-28
申请号：US12831916
申请日：2010-07-07
申请人： Graham H. Creasey , Jim Patrick
发明人： Graham H. Creasey , Jim Patrick
IPC分类号： A61F2/48 , A61N1/36
CPC分类号： A61N1/36007 , A61F2/0036 , Y10S128/25
摘要： A sphincteric control system for controlling the function of a bodily organ, such as the bladder. The system includes a first implanted sphincter disposed about a portion of the bodily organ, a second implanted sphincter disposed about a portion of the bodily organ, and a stimulator unit that is adapted to apply electrical stimulation to each of the first and second implanted sphincters. One of the first or second implanted sphincters is made from a smooth muscle and the other of the first or second implanted sphincters is made from a striated muscle.
摘要翻译：用于控制诸如膀胱的身体器官的功能的括约肌控制系统。系统包括设置在身体器官的一部分周围的第一植入括约肌，设置在身体器官的一部分上的第二植入括约肌，以及适于对第一和第二植入括约肌中的每一个施加电刺激的刺激器单元。第一或第二植入括约肌之一由平滑肌制成，第一或第二植入括约肌中的另一个由横纹肌制成。

5. 发明授权

US10307591B2 Topical neurological stimulation 有权
公开(公告)号：US10307591B2
公开(公告)日：2019-06-04
申请号：US15650228
申请日：2017-07-14
申请人： Graham H. Creasey , Hoo-Min Toong
发明人： Graham H. Creasey , Hoo-Min Toong
IPC分类号： A61N1/36 , A61N1/04 , A61B5/00 , A61B5/04
摘要： A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

6. 发明申请

US20170312512A1 Topical Neurological Stimulation 审中-公开
公开(公告)号：US20170312512A1
公开(公告)日：2017-11-02
申请号：US15650228
申请日：2017-07-14
申请人： Graham H. Creasey , Hoo-Min Toong
发明人： Graham H. Creasey , Hoo-Min Toong
IPC分类号： A61N1/36 , A61N1/04 , A61B5/04 , A61B5/00
CPC分类号： A61N1/36014 , A61B5/04001 , A61B5/4836 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36003 , A61N1/36007 , A61N1/36021
摘要： A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

7. 发明授权

US5199430A Micturitional assist device 失效
标题翻译： MICTURITIONAL ASSIST设备
公开(公告)号：US5199430A
公开(公告)日：1993-04-06
申请号：US667523
申请日：1991-03-11
申请人： Zi-Ping Fang , J. Thomas Mortimer , Graham H. Creasey
发明人： Zi-Ping Fang , J. Thomas Mortimer , Graham H. Creasey
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/0556
摘要： Cuff electrodes (40a, 40b) are surgically implanted around S.sub.3 sacral ventral root nerve trunks (16a, 16b). The sacral ventral roots have smaller diameter nerve fibers (20a, 20b) which convey action potentials to cause detrusor activation to contract the bladder (10) and larger diameter nerve fibers (18a, 18 b) which carry action potentials for causing contraction of a urethral sphincter (12) to block the flow of urine from the bladder. A current source (50) causes current pulses (52) between such electrical contacts (46, 48) and a central electrical contact (44). The current pulses have an appropriate amplitude and waveform to initiate action potentials adjacent the central contact and to block the propagation of action potentials adjacent the end electrodes along the larger diameter nerve fibers (which have fewer nodes between the contacts) but not the smaller diameter nerve fibers (which have more nodes between the electrodes). In this manner, action potentials are electrically excited to propagate at least downstream on the smaller diameter nerve fibers causing contraction of the bladder. Concurrently, blocking action potentials are allowed to propagate upstream on at least the larger diameter nerve fibers, collision blocking naturally occurring action potentials propagating downstream. The transmission of action potentials downstream on the larger diameter nerve fibers is blocked by the current pulses allowing the urinary sphincter to relax.
摘要翻译：袖带电极（40a，40b）通过外科手术植入S3骶神经根神经干（16a，16b）周围。骶腹根具有较小直径的神经纤维（20a，20b），其传达动作电位以引起逼尿肌激活以收缩膀胱（10）和较大直径的神经纤维（18a，18b），其具有引起尿道收缩的动作电位括约肌（12）阻止尿液从膀胱流出。电流源（50）在这种电触头（46,48）和中心电触点（44）之间引起电流脉冲（52）。电流脉冲具有适当的幅度和波形，以引发邻近中心触点的动作电位，并阻止沿着较大直径的神经纤维（其中在触点之间具有较少节点）的端电极附近的动作电位的传播，而不是较小直径的神经光纤（电极之间具有更多的节点）。以这种方式，动作电位被电激励，至少在较小直径的神经纤维的下游传播，引起膀胱收缩。同时，阻塞动作电位允许在至少较大直径的神经纤维上游传播，碰撞阻止在下游传播的自然发生的动作电位。在较大直径的神经纤维下游的动作电位的传递被允许尿括约肌松弛的电流脉冲阻止。

8. 发明授权

US10016600B2 Topical neurological stimulation 有权
公开(公告)号：US10016600B2
公开(公告)日：2018-07-10
申请号：US14893946
申请日：2014-05-30
申请人： Graham H. Creasey , Hoo-Min Toong
发明人： Graham H. Creasey , Hoo-Min Toong
IPC分类号： A61N1/36 , A61N1/04 , A61B5/00 , A61B5/04
CPC分类号： A61N1/36014 , A61B5/04001 , A61B5/4836 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36003 , A61N1/36007 , A61N1/36021
摘要： A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

9. 发明申请

US20160129248A1 Topical Neurological Stimulation 有权
标题翻译：局部神经刺激
公开(公告)号：US20160129248A1
公开(公告)日：2016-05-12
申请号：US14893946
申请日：2014-05-30
申请人： Graham H. CREASEY , Hoo-Min TOONG
发明人： Graham H. Creasey , Hoo-Min Toong
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36014 , A61B5/04001 , A61B5/4836 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36003 , A61N1/36007 , A61N1/36021
摘要： A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.
摘要翻译：提供局部神经刺激器贴片和系统，其包括皮肤贴片; 与所述贴片相关联的电信号发生器; 用于激活电信号发生器的信号接收器; 用于与所述贴片相关联的电信号发生器的电源; 电信号激活装置; 和神经反馈传感器。

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