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1. 发明授权

US08825163B2 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分的系统和方法以实现选择性生理反应
公开(公告)号：US08825163B2
公开(公告)日：2014-09-02
申请号：US12579581
申请日：2009-10-15
申请人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
发明人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。系统和方法使用放置在阴部神经上，旁边或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

2. 发明授权

US06907293B2 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分的系统和方法以实现选择性生理反应
公开(公告)号：US06907293B2
公开(公告)日：2005-06-14
申请号：US10113828
申请日：2002-03-29
申请人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
发明人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
IPC分类号： A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。这些系统和方法使用放置在阴部神经中，外侧或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

3. 发明授权

US07047078B2 Methods for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的方法
公开(公告)号：US07047078B2
公开(公告)日：2006-05-16
申请号：US10662055
申请日：2003-09-12
申请人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Systems and methods control physiological functions of the urinary tract using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve. The systems and methods apply an electrical signal to the electrode at a selected frequency to stimulate the targeted component. The selected frequency is a first frequency or range of frequencies for achieving a first physiologic response (e.g., controlling urinary continence) and a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).
摘要翻译：系统和方法使用至少一个电极来控制泌尿道的生理功能，所述至少一个电极的尺寸和构型设置成位于阴部神经的目标成分中，附近或其附近。系统和方法以选定的频率将电信号施加到电极以刺激目标成分。所选择的频率是用于实现与第一生理学不同的第一生理反应（例如，控制尿路）和频率不同于第一频率的第二频率或频率范围的第一频率或频率范围反应（例如控制排尿）。

4. 发明授权

US08396555B2 Apparatus for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的装置
公开(公告)号：US08396555B2
公开(公告)日：2013-03-12
申请号：US12490611
申请日：2009-06-24
申请人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Apparatus to control physiological functions, including urinary track physiological functions are described. The apparatus includes an electrode(s) configured to be placed on or in a targeted component of a pudendal nerve and to stimulate the targeted pudendal nerve pudendal. The targeted component of the pudendal nerve includes a pudendal nerve urethral afferent, and afferent nerve fibers in the deep perineal nerve. The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude and a selected frequency chosen to stimulate the targeted component. The controller operates in a first mode to apply a first frequency without substantially changing the amplitude for achieving a first physiologic response and the controller operates in a second mode to apply a second frequency, different than the first frequency, for achieving a second physiologic response different than the first physiologic response.
摘要翻译：描述了用于控制生理功能的装置，包括尿道生理功能。该装置包括构造成放置在阴部神经的目标部件上或其中的电极，并刺激目标阴部神经阴部。阴部神经的目标成分包括阴部神经尿道传入和深会阴神经中的传入神经纤维。该装置包括耦合到电极的控制器，以施加具有选择的振幅和选定频率的电信号，以刺激目标成分。控制器以第一模式操作以施加第一频率而基本上不改变幅度以实现第一生理响应，并且控制器以第二模式操作以施加与第一频率不同的第二频率，以实现不同于第二频率的第二生理响应比第一次生理反应。

5. 发明授权

US07571000B2 Apparatus for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的装置
公开(公告)号：US07571000B2
公开(公告)日：2009-08-04
申请号：US11402036
申请日：2006-04-11
申请人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Apparatus for control of physiological functions, including physiological functions of the urinary tract, using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve, and/or its branch(es), and/or its spinal root(s). The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude to the electrode at a selected frequency to stimulate the targeted component. The controller operates in a first mode to apply a first frequency or range of frequencies without substantially changing the amplitude for achieving a first physiologic response (e.g., controlling urinary continence) and the controller operates in a second mode to apply a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).
摘要翻译：用于控制生理功能的装置，包括尿道的生理功能，使用至少一个尺寸和构造为位于阴部神经和/或其分支的目标组分中，附近或附近的电极和/或其分支，以及 /或其脊髓根部。该装置包括耦合到该电极的控制器，以一选定频率将具有振幅的电信号施加到该电极上以刺激该目标部件。控制器以第一模式操作以施加第一频率或频率范围，而基本上不改变振幅以实现第一生理响应（例如，控制尿路），并且控制器以第二模式操作以施加第二频率或范围频率，不同于第一频率，用于实现与第一生理反应不同的第二生理反应（例如，控制排尿）。

6. 发明申请

US20090326603A1 APPARATUS FOR STIMULATING COMPONENTS IN, ON, OR NEAR THE PUDENDAL NERVE OR ITS BRANCHES TO ACHIEVE SELECTIVE PHYSIOLOGIC RESPONSES 有权
标题翻译：用于刺激组件，附近或附近组件或其分支机构以获得选择性生理反应的装置
公开(公告)号：US20090326603A1
公开(公告)日：2009-12-31
申请号：US12490611
申请日：2009-06-24
申请人： Joseph W. BOGGS, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. BOGGS, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Apparatus to control physiological functions, including urinary track physiological functions are described. The apparatus includes an electrode(s) configured to be placed on or in a targeted component of a pudendal nerve and to stimulate the targeted pudendal nerve pudendal. The targeted component of the pudendal nerve includes a pudendal nerve urethral afferent, and afferent nerve fibers in the deep perineal nerve. The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude and a selected frequency chosen to stimulate the targeted component. The controller operates in a first mode to apply a first frequency without substantially changing the amplitude for achieving a first physiologic response and the controller operates in a second mode to apply a second frequency, different than the first frequency, for achieving a second physiologic response different than the first physiologic response.
摘要翻译：描述了用于控制生理功能的装置，包括尿道生理功能。该装置包括构造成放置在阴部神经的目标部件上或其中的电极，并刺激目标阴部神经阴部。阴部神经的目标成分包括阴部神经尿道传入和深会阴神经中的传入神经纤维。该装置包括耦合到电极的控制器，以施加具有选择的振幅和选定频率的电信号，以刺激目标成分。控制器以第一模式操作以施加第一频率而基本上不改变振幅以实现第一生理响应，并且控制器以第二模式操作以施加与第一频率不同的第二频率，以实现不同于第二频率的第二生理响应比第一次生理反应。

7. 发明申请

US20090254144A1 System and Method of Bladder and Sphincter Control 审中-公开
标题翻译：膀胱和括约肌控制系统与方法
公开(公告)号：US20090254144A1
公开(公告)日：2009-10-08
申请号：US12417529
申请日：2009-04-02
申请人： Narendra Bhadra , Kenneth J. Gustafson , Timothy M. Bruns , Timothy Y. Mariano
发明人： Narendra Bhadra , Kenneth J. Gustafson , Timothy M. Bruns , Timothy Y. Mariano
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： A method and system for bladder control are disclosed. In embodiments, a method for bladder control is provided that comprises coupling an electrode to an afferent nerve that is related to the bladder. Applying a plurality of pulse burst stimulations via the electrode causes voiding of urine from the bladder. In embodiments, the plurality of pulse burst stimulations to the afferent nerve reduces external urethral sphincter (EUS) contractions and evokes bladder contractions to expel urine from the subject. In embodiments, the plurality of pulse burst stimulations to the afferent nerve evokes bladder contractions alone to expel urine from the subject. In embodiments, a system for bladder control is provided that comprises an electrode for applying a pulse burst stimulus to an afferent nerve or dermatome to reduce reflex contractions and a signal generator for generating the pulse burst stimulus.
摘要翻译：公开了一种用于膀胱控制的方法和系统。在实施例中，提供了一种用于膀胱控制的方法，其包括将电极耦合到与膀胱相关的传入神经。通过电极施加多个脉冲爆发刺激导致尿液从膀胱排出。在实施例中，对传入神经的多个脉冲突发刺激减少了外部尿道括约肌（EUS）收缩并引起膀胱收缩以从受试者排出尿液。在实施例中，对传入神经的多个脉冲突发刺激单独引起膀胱收缩以从受试者排出尿液。在实施例中，提供了一种用于膀胱控制的系统，其包括用于将脉冲突发刺激施加到传入神经或皮肤病以减少反射收缩的电极和用于产生脉冲脉冲串刺激的信号发生器。

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