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1. 发明授权

US07394592B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07394592B2
公开(公告)日：2008-07-01
申请号：US10557461
申请日：2004-05-20
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope, which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition.
摘要翻译：共焦成像显微镜，特别适用于选定位置的皮肤细胞成像。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从头部延伸的共焦物镜（116）精确地放置在患者皮肤上。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。头部（28）包含显微镜的光学和机械部件的集成组件，其控制扫描并且还可以控制被成像位置的精细定位。头部（28）可从手臂上拆下来进行手动配置。

2. 发明授权

US07859749B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07859749B2
公开(公告)日：2010-12-28
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底盘（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

3. 发明申请

US20080239474A1 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US20080239474A1
公开(公告)日：2008-10-02
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient while providing for patient comfort. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The station (10) also supports a personal computer (PC) (26) for processing signals providing the images on the display and controlling the microscope. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. Controls (50) for the fine positioning and focusing are on the head (28) for ease of use. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从选定位置延伸的聚焦物镜（116）精确地放置在患者皮肤上，同时提供患者舒适度。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。站（10）还支持个人计算机（PC）（26），用于处理在显示器上提供图像并控制显微镜的信号。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底板（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。用于精细定位和聚焦的控制器（50）位于头部（28）上以便于使用。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

4. 发明授权

US09229210B2 Tissue specimen stage for an optical sectioning microscope 有权
标题翻译：用于光学切片显微镜的组织样品台
公开(公告)号：US09229210B2
公开(公告)日：2016-01-05
申请号：US13778083
申请日：2013-02-26
申请人： William J. Fox , Christopher C. DiStasio
发明人： William J. Fox , Christopher C. DiStasio
IPC分类号： G02B21/26 , G02B21/34
CPC分类号： G02B21/26 , G02B21/34
摘要： A tissue specimen stage is provided having a window with surface curvature upon which an excised tissue specimen is locatable, a carriage having a tissue specimen receptacle to which the window is mounted, and a platform supporting the carriage and presenting the window to the objective lens of an optical sectioning microscope. The carriage is mounted to the platform for movement along two rotational axes so that the carriage's movement follows the curvature of all or part of the window while maintaining the same optical geometry of the window with respect to the objective lens. The window has surface curvature adapted to at least approximate the shape or curvature of the non-histologically prepared tissue specimen to be placed thereupon.
摘要翻译：提供组织样本台，其具有具有表面曲率的窗口，切割的组织样本可定位在其上，具有安装窗口的组织样本容器的滑架和支撑滑架并将窗口呈现到物镜的平台光学切片显微镜。滑架安装到平台上以沿着两个旋转轴线移动，使得滑架的运动遵循窗口的全部或部分的曲率，同时保持窗口相对于物镜的相同光学几何形状。窗口具有适于至少近似待放置在其上的非组织学准备的组织样本的形状或曲率的表面曲率。

5. 发明申请

US20130222899A1 TISSUE SPECIMEN STAGE FOR AN OPTICAL SECTIONING MICROSCOPE 有权
标题翻译：用于光学分段显微镜的组织样本阶段
公开(公告)号：US20130222899A1
公开(公告)日：2013-08-29
申请号：US13778083
申请日：2013-02-26
申请人： William J. Fox , Christopher C. DiStasio
发明人： William J. Fox , Christopher C. DiStasio
IPC分类号： G02B21/26
CPC分类号： G02B21/26 , G02B21/34
摘要： A tissue specimen stage is provided having a window with surface curvature upon which an excised tissue specimen is locatable, a carriage having a tissue specimen receptacle to which the window is mounted, and a platform supporting the carriage and presenting the window to the objective lens of an optical sectioning microscope. The carriage is mounted to the platform for movement along two rotational axes so that the carriage's movement follows the curvature of all or part of the window while maintaining the same optical geometry of the window with respect to the objective lens. The window has surface curvature adapted to at least approximate the shape or curvature of the non-histologically prepared tissue specimen to be placed thereupon.
摘要翻译：提供组织样本台，其具有具有表面曲率的窗口，切割的组织样本可定位在其上，具有安装窗口的组织样本容器的滑架和支撑滑架并将窗口呈现到物镜的平台光学切片显微镜。滑架安装到平台上以沿着两个旋转轴线移动，使得滑架的运动遵循窗口的全部或部分的曲率，同时保持窗口相对于物镜的相同光学几何形状。窗口具有适于至少近似待放置在其上的非组织学准备的组织样本的形状或曲率的表面曲率。

6. 发明授权

US06430474B1 Tooling adapter for allowing selected manipulation of a workpiece 有权
标题翻译：用于允许选择对工件进行操作的模具适配器
公开(公告)号：US06430474B1
公开(公告)日：2002-08-06
申请号：US09825586
申请日：2001-04-03
申请人： Christopher C. DiStasio , Nathaniel W. Haslam
发明人： Christopher C. DiStasio , Nathaniel W. Haslam
IPC分类号： G06F1900
CPC分类号： B25J9/1697 , G05B2219/39558 , G05B2219/39566 , G05B2219/49271
摘要： A system for manipulating a workpiece in an industrial robot system having a manipulator device for manipulating the workpiece, a tooling adapter coupled to the manipulator device for manipulating the workpiece, and an image referencing system for acquiring image data corresponding to the workpiece without interference from the manipulator device.
摘要翻译：一种用于在具有用于操纵工件的操纵器装置的工业机器人系统中操作工件的系统，联接到用于操纵工件的操纵器装置的工具适配器和用于获取与工件相对应的图像数据的图像参考系统，机械手装置。

7. 外观设计

USD492997S1 Confocal microscope having a positionable imaging head for cellular imaging of skin, other living tissue and biological processes 失效
标题翻译：共焦显微镜具有用于皮肤细胞成像的定位成像头，其他生物组织和生物过程
公开(公告)号：USD492997S1
公开(公告)日：2004-07-13
申请号：US29182119
申请日：2003-05-20
申请人： Christopher C. DiStasio
设计人： Christopher C. DiStasio

8. 发明授权

US06466841B2 Apparatus and method for determining a reference position for an industrial robot 有权
公开(公告)号：US06466841B2
公开(公告)日：2002-10-15
申请号：US09783336
申请日：2001-02-14
申请人： Christopher C. DiStasio , Nathaniel E. Haslam
发明人： Christopher C. DiStasio , Nathaniel E. Haslam
IPC分类号： G06F700
CPC分类号： B25J9/1697
摘要： An imaging reference system is provided for increasing the placement accuracy of an industrial robot system. The system can employ an air bearing assembly for allowing a workpiece holder to move therealong. The imaging reference system can be coupled to the air bearing assembly or integrated into the manipulator.

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